ZA200500071B - Pyridazine derivatives - Google Patents
Pyridazine derivatives Download PDFInfo
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- ZA200500071B ZA200500071B ZA200500071A ZA200500071A ZA200500071B ZA 200500071 B ZA200500071 B ZA 200500071B ZA 200500071 A ZA200500071 A ZA 200500071A ZA 200500071 A ZA200500071 A ZA 200500071A ZA 200500071 B ZA200500071 B ZA 200500071B
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- South Africa
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US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
IN2012DN01961A (fr) | 2009-08-17 | 2015-08-21 | Intellikine Llc | |
CA2771432A1 (fr) | 2009-08-20 | 2011-02-24 | Novartis Ag | Composes d'oximes heterocycliques |
EP2490689A4 (fr) * | 2009-10-19 | 2013-03-06 | Panmira Pharmaceuticals Llc | Formulations injectables pour administration intra-articulaire ou péri-articulaire |
EP2490687A1 (fr) | 2009-10-22 | 2012-08-29 | Vertex Pharmaceuticals Incorporated | Compositions destinées au traitement de la mucoviscidose et d'autres maladies chroniques |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
WO2012034095A1 (fr) | 2010-09-09 | 2012-03-15 | Irm Llc | Composés et compositions comme inhibiteurs de trk |
US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
WO2012107500A1 (fr) | 2011-02-10 | 2012-08-16 | Novartis Ag | Composés de [1, 2, 4] triazolo [4, 3 -b] pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met |
EP2678016B1 (fr) | 2011-02-23 | 2016-08-10 | Intellikine, LLC | Composés hétérocycliques et leurs utilisations |
BR112013021638A2 (pt) | 2011-02-25 | 2016-08-02 | Irm Llc | "compostos inibidores de trk, seu uso e composições que os compreendem" |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
MX339302B (es) | 2011-09-15 | 2016-05-19 | Novartis Ag | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. |
WO2013038386A1 (fr) | 2011-09-16 | 2013-03-21 | Novartis Ag | Composés hétérocycliques destinés au traitement de la mucosviscidose |
JP6165733B2 (ja) | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | N−置換ヘテロシクリルカルボキサミド類 |
WO2013038381A1 (fr) | 2011-09-16 | 2013-03-21 | Novartis Ag | Dérivés d'amide pyridine/pyrazine |
WO2013038378A1 (fr) | 2011-09-16 | 2013-03-21 | Novartis Ag | Dérivés pyridinamides |
WO2013038373A1 (fr) | 2011-09-16 | 2013-03-21 | Novartis Ag | Dérivés pyrimidinamides |
WO2013078440A2 (fr) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Régimes de traitement améliorés utilisant des inhibiteurs de mtor |
US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
ES2894830T3 (es) | 2012-04-03 | 2022-02-16 | Novartis Ag | Productos combinados con inhibidores de tirosina·cinasa y su uso |
KR20150046259A (ko) | 2012-08-23 | 2015-04-29 | 앨리오스 바이오파마 인크. | 파라믹소바이러스 바이러스성 감염의 치료용 화합물 |
US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
WO2014151147A1 (fr) | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combinaison d'inhibiteurs de kinase et ses utilisations |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
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JP6404944B2 (ja) | 2014-04-24 | 2018-10-17 | ノバルティス アーゲー | ホスファチジルイノシトール3−キナーゼ阻害薬としてのピラジン誘導体 |
MX2016013981A (es) | 2014-04-24 | 2016-11-15 | Novartis Ag | Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa. |
WO2016011658A1 (fr) | 2014-07-25 | 2016-01-28 | Novartis Ag | Polythérapie |
US10195208B2 (en) | 2014-07-31 | 2019-02-05 | Novartis Ag | Combination therapy |
EP3268085A4 (fr) | 2015-03-13 | 2018-10-31 | The Board of Trustees of The Leland Stanford Junior University | Inhibition de ltb4 pour prévenir et traiter le lymphoedème humain |
WO2018001948A1 (fr) * | 2016-06-29 | 2018-01-04 | F. Hoffmann-La Roche Ag | Inhibiteurs antigrippaux à large spectre à base de pyridazinone |
KR20220019015A (ko) | 2019-06-10 | 2022-02-15 | 노파르티스 아게 | Cf, copd, 및 기관지확장증 치료를 위한 피리딘 및 피라진 유도체 |
WO2021038426A1 (fr) | 2019-08-28 | 2021-03-04 | Novartis Ag | Dérivés de 1,3-phényl hétéroaryle substitués et leur utilisation dans le traitement d'une maladie |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
US11844792B2 (en) * | 2020-07-10 | 2023-12-19 | Sean Downing | Treatment for severe acute respiratory illness associated with coronavirus |
CN113143899A (zh) * | 2021-05-13 | 2021-07-23 | 中国人民解放军陆军军医大学第二附属医院 | 辣椒素在制备治疗溃疡性结肠炎药物中的应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
DE19826841A1 (de) | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
ATE269860T1 (de) | 2000-01-31 | 2004-07-15 | Pfizer Prod Inc | Pyrimidinylcarboxamiden als inhibitoren der pde4 isoenzyme |
-
2002
- 2002-06-05 DE DE10224888A patent/DE10224888A1/de not_active Withdrawn
-
2003
- 2003-05-12 KR KR10-2004-7019787A patent/KR20050009735A/ko not_active Application Discontinuation
- 2003-05-12 RU RU2004139032/04A patent/RU2004139032A/ru not_active Application Discontinuation
- 2003-05-12 PL PL03371918A patent/PL371918A1/xx unknown
- 2003-05-12 JP JP2004511274A patent/JP4511925B2/ja not_active Expired - Fee Related
- 2003-05-12 MX MXPA04012009A patent/MXPA04012009A/es not_active Application Discontinuation
- 2003-05-12 WO PCT/EP2003/004930 patent/WO2003104204A1/fr active Application Filing
- 2003-05-12 BR BR0311343-4A patent/BR0311343A/pt not_active Application Discontinuation
- 2003-05-12 DE DE50311783T patent/DE50311783D1/de not_active Expired - Lifetime
- 2003-05-12 AU AU2003227746A patent/AU2003227746B2/en not_active Ceased
- 2003-05-12 CN CN038128470A patent/CN1659147A/zh active Pending
- 2003-05-12 US US10/516,876 patent/US7129241B2/en not_active Expired - Fee Related
- 2003-05-12 ES ES03725186T patent/ES2329670T3/es not_active Expired - Lifetime
- 2003-05-12 EP EP03725186A patent/EP1509506B1/fr not_active Expired - Lifetime
- 2003-05-12 CA CA2488372A patent/CA2488372C/fr not_active Expired - Fee Related
- 2003-05-12 AT AT03725186T patent/ATE438628T1/de not_active IP Right Cessation
- 2003-06-04 AR ARP030101978A patent/AR040141A1/es not_active Application Discontinuation
-
2005
- 2005-01-04 ZA ZA200500071A patent/ZA200500071B/en unknown
-
2006
- 2006-08-02 US US11/497,241 patent/US7563790B2/en not_active Expired - Fee Related
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EP1509506B1 (fr) | 2009-08-05 |
RU2004139032A (ru) | 2005-08-20 |
US20060270681A1 (en) | 2006-11-30 |
AU2003227746B2 (en) | 2009-03-19 |
MXPA04012009A (es) | 2005-03-07 |
CA2488372C (fr) | 2012-02-21 |
CA2488372A1 (fr) | 2003-12-18 |
US7129241B2 (en) | 2006-10-31 |
US7563790B2 (en) | 2009-07-21 |
DE10224888A1 (de) | 2003-12-24 |
ES2329670T3 (es) | 2009-11-30 |
KR20050009735A (ko) | 2005-01-25 |
JP2005534660A (ja) | 2005-11-17 |
EP1509506A1 (fr) | 2005-03-02 |
ATE438628T1 (de) | 2009-08-15 |
US20050176714A1 (en) | 2005-08-11 |
BR0311343A (pt) | 2005-03-22 |
CN1659147A (zh) | 2005-08-24 |
JP4511925B2 (ja) | 2010-07-28 |
PL371918A1 (en) | 2005-07-11 |
AU2003227746A1 (en) | 2003-12-22 |
WO2003104204A1 (fr) | 2003-12-18 |
AR040141A1 (es) | 2005-03-16 |
DE50311783D1 (de) | 2009-09-17 |
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