ZA200410411B - Use of cyclothlocarbamate derivatives in treatment of hormone-related conditions - Google Patents
Use of cyclothlocarbamate derivatives in treatment of hormone-related conditions Download PDFInfo
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- ZA200410411B ZA200410411B ZA200410411A ZA200410411A ZA200410411B ZA 200410411 B ZA200410411 B ZA 200410411B ZA 200410411 A ZA200410411 A ZA 200410411A ZA 200410411 A ZA200410411 A ZA 200410411A ZA 200410411 B ZA200410411 B ZA 200410411B
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- ZA
- South Africa
- Prior art keywords
- substituted
- alkyl
- group
- carbon
- formula
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims description 36
- 229940088597 hormone Drugs 0.000 title description 6
- 239000005556 hormone Substances 0.000 title description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 292
- 229910052799 carbon Inorganic materials 0.000 claims description 240
- 125000003545 alkoxy group Chemical group 0.000 claims description 127
- 229910052739 hydrogen Inorganic materials 0.000 claims description 121
- 125000005842 heteroatom Chemical group 0.000 claims description 112
- 125000000623 heterocyclic group Chemical group 0.000 claims description 112
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 95
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 88
- 125000003118 aryl group Chemical group 0.000 claims description 72
- 239000000203 mixture Substances 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 58
- 125000003107 substituted aryl group Chemical group 0.000 claims description 58
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 48
- 229910052736 halogen Inorganic materials 0.000 claims description 43
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims description 43
- 125000001424 substituent group Chemical group 0.000 claims description 42
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims description 40
- 125000004001 thioalkyl group Chemical group 0.000 claims description 40
- 229940002612 prodrug Drugs 0.000 claims description 38
- 239000000651 prodrug Substances 0.000 claims description 38
- -1 nafoxidene Chemical compound 0.000 claims description 37
- 150000003839 salts Chemical class 0.000 claims description 37
- 125000003342 alkenyl group Chemical group 0.000 claims description 36
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- 125000000304 alkynyl group Chemical group 0.000 claims description 28
- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 229910052717 sulfur Inorganic materials 0.000 claims description 21
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 125000002252 acyl group Chemical group 0.000 claims description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
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- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39187102P | 2002-06-25 | 2002-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200410411B true ZA200410411B (en) | 2007-06-27 |
Family
ID=30000766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200410411A ZA200410411B (en) | 2002-06-25 | 2004-12-23 | Use of cyclothlocarbamate derivatives in treatment of hormone-related conditions |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7192956B2 (ja) |
| EP (1) | EP1515725A4 (ja) |
| JP (1) | JP2005535624A (ja) |
| KR (1) | KR20050013247A (ja) |
| CN (1) | CN1662241A (ja) |
| AR (1) | AR040333A1 (ja) |
| AU (1) | AU2003247608A1 (ja) |
| BR (1) | BR0312024A (ja) |
| CA (1) | CA2489847A1 (ja) |
| CO (1) | CO5680438A2 (ja) |
| CR (1) | CR7611A (ja) |
| EC (1) | ECSP055576A (ja) |
| IL (1) | IL165396A0 (ja) |
| MX (1) | MXPA04012421A (ja) |
| NO (1) | NO20045216L (ja) |
| RU (1) | RU2005101638A (ja) |
| TW (1) | TW200404548A (ja) |
| WO (1) | WO2004000801A2 (ja) |
| ZA (1) | ZA200410411B (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| BR0312054A (pt) * | 2002-06-25 | 2005-10-18 | Wyeth Corp | Uso de derivados de tio-oxindol na preparação de medicamentos úteis no tratamento de condições relacionadas com hormÈnio, e kit farmacêutico |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| JP4869221B2 (ja) * | 2004-04-08 | 2012-02-08 | ワイス・エルエルシー | プロゲステロン受容体調節剤としてのチオアミド誘導体 |
| CN1938298B (zh) * | 2004-04-08 | 2013-02-06 | 惠氏公司 | 减少硫代酰胺杂质的方法 |
| CA2562160C (en) * | 2004-04-27 | 2013-05-28 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| BRPI0514273A (pt) | 2004-08-13 | 2008-06-10 | Wyeth Corp | composto, kit para monitorar terapia com tanaproget, método para detectar metabólitos de tanaproget, anticorpo, composição, kit para detectar metabólicos de tanaproget, e, uso de um derivado de glucuronìdeo de tanaproget ou um seu sal farmaceuticamente aceitável |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7496489B2 (en) | 2004-08-20 | 2009-02-24 | Wyeth | Design of progesterone receptor ligands |
| CN101166521A (zh) | 2005-04-28 | 2008-04-23 | 惠氏公司 | 通过湿制粒法制备包含微粒化他那普戈特的组合物 |
| AU2011203520B2 (en) * | 2005-04-28 | 2012-06-14 | Wyeth | Micronized tanaproget and compostions containing same |
| WO2006116498A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Purified form of tanaproget |
| CN101166736B (zh) * | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| WO2006116514A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget, compositions, and methods of preparing the same |
| AU2011226814B2 (en) * | 2005-04-28 | 2013-06-13 | Wyeth Llc | Micronized tanaproget, compositions, and methods of preparing the same |
| ES2340518T3 (es) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | Tanaproget micronizado y composiciones que lo contienen. |
| WO2006135638A2 (en) * | 2005-06-09 | 2006-12-21 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
| AU2007338102A1 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Processes for the preparation of (3R, 4R) -N- (4 -chlorophenyl) -1- (2, 2-difluoroethyl) -N' - [2-fluoro-4- (2-oxo-1 (2H) -pyridinyl) phenyl] -3, 4-pyrrolidinedicarboxamide |
| BRPI0819571A2 (pt) * | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2475366A1 (en) * | 2009-09-11 | 2012-07-18 | Bayer Pharma Aktiengesellschaft | Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs |
| RS56042B1 (sr) | 2010-06-10 | 2017-09-29 | Seragon Pharmaceuticals Inc | Modulatori estrogenih receptora i njihove upotrebe |
| US9193714B2 (en) | 2011-12-14 | 2015-11-24 | Seragon Pharmaceuticals, Inc. | Fluorinated estrogen receptor modulators and uses thereof |
| US20170014174A1 (en) * | 2015-07-17 | 2017-01-19 | Candela Corporation | Cryogenic Cylinder |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| EP0155934B1 (en) | 1983-07-29 | 1989-12-06 | Duke University | Pharmaceutical compositions for treating androgen-related disorders in humans |
| GB2310660A (en) | 1996-03-01 | 1997-09-03 | Merck & Co Inc | Benzoxazinone oxytocin receptor antagonists |
| US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| US6326392B1 (en) * | 1997-11-06 | 2001-12-04 | American Home Products Corporation | Anti-estrogen plus progestin containing oral contraceptives |
| DK1123082T3 (da) * | 1998-10-23 | 2006-06-26 | Aventis Pharma Sa | Præparater til topisk applikation af antiandrogent aktive forbindelser |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| WO2001030356A1 (fr) * | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| US20010034340A1 (en) * | 2000-03-20 | 2001-10-25 | American Home Products Corporation | Hormone replacement therapy |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| GB0010683D0 (en) * | 2000-05-03 | 2000-06-28 | Univ Bristol | Cancer therapy |
| FR2814074B1 (fr) * | 2000-09-15 | 2003-03-07 | Theramex | Nouvelles compositions estro-progestatives topiques a effet systemique |
-
2003
- 2003-06-23 EP EP03761263A patent/EP1515725A4/en not_active Withdrawn
- 2003-06-23 AR ARP030102237A patent/AR040333A1/es not_active Application Discontinuation
- 2003-06-23 CN CN038146819A patent/CN1662241A/zh active Pending
- 2003-06-23 RU RU2005101638/15A patent/RU2005101638A/ru not_active Application Discontinuation
- 2003-06-23 TW TW092116989A patent/TW200404548A/zh unknown
- 2003-06-23 KR KR10-2004-7021183A patent/KR20050013247A/ko not_active Application Discontinuation
- 2003-06-23 CA CA002489847A patent/CA2489847A1/en not_active Abandoned
- 2003-06-23 US US10/601,481 patent/US7192956B2/en not_active Expired - Fee Related
- 2003-06-23 WO PCT/US2003/019751 patent/WO2004000801A2/en not_active Application Discontinuation
- 2003-06-23 JP JP2004516143A patent/JP2005535624A/ja active Pending
- 2003-06-23 MX MXPA04012421A patent/MXPA04012421A/es not_active Application Discontinuation
- 2003-06-23 AU AU2003247608A patent/AU2003247608A1/en not_active Abandoned
- 2003-06-23 BR BR0312024-4A patent/BR0312024A/pt not_active IP Right Cessation
-
2004
- 2004-11-25 IL IL16539604A patent/IL165396A0/xx unknown
- 2004-11-29 NO NO20045216A patent/NO20045216L/no not_active Application Discontinuation
- 2004-12-08 CR CR7611A patent/CR7611A/es not_active Application Discontinuation
- 2004-12-23 ZA ZA200410411A patent/ZA200410411B/en unknown
-
2005
- 2005-01-20 CO CO05004450A patent/CO5680438A2/es not_active Application Discontinuation
- 2005-01-25 EC EC2005005576A patent/ECSP055576A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005535624A (ja) | 2005-11-24 |
| EP1515725A4 (en) | 2005-09-21 |
| WO2004000801A3 (en) | 2004-03-25 |
| ECSP055576A (es) | 2005-04-18 |
| CN1662241A (zh) | 2005-08-31 |
| NO20045216L (no) | 2005-01-24 |
| KR20050013247A (ko) | 2005-02-03 |
| WO2004000801A2 (en) | 2003-12-31 |
| AU2003247608A1 (en) | 2004-01-06 |
| RU2005101638A (ru) | 2006-01-20 |
| EP1515725A2 (en) | 2005-03-23 |
| CO5680438A2 (es) | 2006-09-29 |
| TW200404548A (en) | 2004-04-01 |
| MXPA04012421A (es) | 2005-04-19 |
| IL165396A0 (en) | 2006-01-15 |
| US20040006060A1 (en) | 2004-01-08 |
| BR0312024A (pt) | 2005-03-22 |
| US7192956B2 (en) | 2007-03-20 |
| AR040333A1 (es) | 2005-03-30 |
| CR7611A (es) | 2006-05-30 |
| CA2489847A1 (en) | 2003-12-31 |
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