ZA200407799B - Lansoprazole polymorphs and processes for preparation thereof - Google Patents
Lansoprazole polymorphs and processes for preparation thereof Download PDFInfo
- Publication number
- ZA200407799B ZA200407799B ZA200407799A ZA200407799A ZA200407799B ZA 200407799 B ZA200407799 B ZA 200407799B ZA 200407799 A ZA200407799 A ZA 200407799A ZA 200407799 A ZA200407799 A ZA 200407799A ZA 200407799 B ZA200407799 B ZA 200407799B
- Authority
- ZA
- South Africa
- Prior art keywords
- lansoprazole
- crystalline solid
- solid form
- crystalline
- preparing
- Prior art date
Links
- 229960003174 lansoprazole Drugs 0.000 title claims description 250
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 title claims description 249
- 238000000034 method Methods 0.000 title claims description 75
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- 229960000540 polacrilin potassium Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 229960004157 rabeprazole Drugs 0.000 description 1
- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229940057977 zinc stearate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36782002P | 2002-03-27 | 2002-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200407799B true ZA200407799B (en) | 2006-07-26 |
Family
ID=28675405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200407799A ZA200407799B (en) | 2002-03-27 | 2004-09-28 | Lansoprazole polymorphs and processes for preparation thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20040010151A1 (hr) |
| EP (1) | EP1476442A2 (hr) |
| JP (1) | JP2005533755A (hr) |
| KR (1) | KR20040093187A (hr) |
| CN (1) | CN1681802A (hr) |
| AU (1) | AU2003224779A1 (hr) |
| CA (1) | CA2480352A1 (hr) |
| HR (1) | HRP20040979A2 (hr) |
| IL (1) | IL164153A0 (hr) |
| IS (1) | IS7467A (hr) |
| MX (1) | MXPA04009384A (hr) |
| NO (1) | NO20044606L (hr) |
| PL (1) | PL373539A1 (hr) |
| WO (1) | WO2003082857A2 (hr) |
| ZA (1) | ZA200407799B (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| ES2534713T3 (es) * | 2002-10-16 | 2015-04-27 | Takeda Pharmaceutical Company Limited | Preparaciones sólidas estables |
| EP1790647B1 (en) | 2004-09-13 | 2013-05-08 | Takeda Pharmaceutical Company Limited | Method for producing oxidized compound |
| EP1681056A1 (en) | 2005-01-14 | 2006-07-19 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for preparing lansoprazole |
| KR100758600B1 (ko) * | 2006-01-05 | 2007-09-13 | 주식회사 대웅제약 | 란소프라졸 결정형 ａ의 제조방법 |
| US20070270590A1 (en) * | 2006-04-20 | 2007-11-22 | Marioara Mendelovici | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
| EP2089379A4 (en) * | 2006-12-07 | 2010-04-21 | Hetero Drugs Ltd | NEW CRYSTALLINE SHAPE OF LANSOPRAZOLE |
| PT2102192E (pt) | 2006-12-29 | 2013-01-23 | Il Yang Pharmaceutical Company Ltd | Formas de estado sólido de ilaprazole racémico |
| IT1391758B1 (it) * | 2008-11-11 | 2012-01-27 | Dipharma Francis Srl | Procedimento per la preparazione di dexlansoprazolo amorfo |
| IT1392813B1 (it) * | 2009-02-06 | 2012-03-23 | Dipharma Francis Srl | Forme cristalline di dexlansoprazolo |
| KR20100101405A (ko) * | 2009-03-09 | 2010-09-17 | 한미홀딩스 주식회사 | 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트 |
| WO2011004387A2 (en) * | 2009-06-18 | 2011-01-13 | Matrix Laboratories Ltd | Process for the preparation of dexlansoprazole polymorphic forms |
| CN102108076B (zh) * | 2009-12-23 | 2014-07-23 | 江苏豪森医药集团有限公司 | 制备无定形右兰索拉唑的方法 |
| WO2011121548A1 (en) * | 2010-03-31 | 2011-10-06 | Ranbaxy Laboratories Limited | Process for the preparation of dexlansoprazole |
| EP2663306A4 (en) * | 2011-01-12 | 2014-01-01 | Hetero Research Foundation | POLYMORPHS OF DEXLANSOPRAZOLE SALTS |
| CR20160222U (es) | 2013-11-15 | 2016-08-26 | Akebia Therapeutics Inc | Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas |
| CN103664889B (zh) * | 2013-12-19 | 2014-11-19 | 悦康药业集团有限公司 | 一种兰索拉唑化合物 |
| CN104844576B (zh) * | 2015-04-28 | 2017-03-08 | 山东罗欣药业集团股份有限公司 | 一种兰索拉唑或右旋兰索拉唑晶型化合物及其制备方法 |
| CN104829594A (zh) * | 2015-05-15 | 2015-08-12 | 苗怡文 | 一种治疗胃溃疡的药物兰索拉唑化合物 |
| CN104958276A (zh) * | 2015-07-30 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗胃溃疡的药物兰索拉唑组合物胶囊 |
| CN104997738A (zh) * | 2015-08-10 | 2015-10-28 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗胃病的药物兰索拉唑组合物干混悬剂 |
| CN107011328B (zh) * | 2017-05-05 | 2019-10-15 | 广州大光制药有限公司 | 一种兰索拉唑化合物的晶型及其结晶制备方法 |
| CN108794450B (zh) * | 2018-07-24 | 2022-08-19 | 浙江恒康药业股份有限公司 | 制备无定型右旋兰索拉唑的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK171989B1 (da) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| TW385306B (en) * | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| TWI275587B (en) * | 1999-06-17 | 2007-03-11 | Takeda Chemical Industries Ltd | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| PL333847A1 (en) * | 1999-06-18 | 2001-01-02 | Inst Farmaceutyczny | Crystalline forms of lansoprozole and method of obtaining lansoprazole in pharmacologically advanthageous crystalline form |
| AU5705700A (en) * | 1999-06-30 | 2001-01-22 | Takeda Chemical Industries Ltd. | Crystals of benzimidazole compounds |
| EP1337525B8 (en) * | 2000-12-01 | 2011-10-05 | Takeda Pharmaceutical Company Limited | Process for the crystallization of (r)- or (s)-lansoprazole |
| MXPA03006904A (es) * | 2001-02-02 | 2004-12-06 | Teva Pharma | Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos. |
-
2003
- 2003-03-27 EP EP03721469A patent/EP1476442A2/en not_active Withdrawn
- 2003-03-27 KR KR10-2004-7015088A patent/KR20040093187A/ko not_active Application Discontinuation
- 2003-03-27 CN CNA038120372A patent/CN1681802A/zh active Pending
- 2003-03-27 MX MXPA04009384A patent/MXPA04009384A/es not_active Application Discontinuation
- 2003-03-27 AU AU2003224779A patent/AU2003224779A1/en not_active Abandoned
- 2003-03-27 CA CA002480352A patent/CA2480352A1/en not_active Abandoned
- 2003-03-27 JP JP2003580323A patent/JP2005533755A/ja active Pending
- 2003-03-27 US US10/401,057 patent/US20040010151A1/en not_active Abandoned
- 2003-03-27 IL IL16415303A patent/IL164153A0/xx unknown
- 2003-03-27 PL PL03373539A patent/PL373539A1/xx not_active Application Discontinuation
- 2003-03-27 WO PCT/US2003/009261 patent/WO2003082857A2/en active Application Filing
-
2004
- 2004-09-23 IS IS7467A patent/IS7467A/is unknown
- 2004-09-28 ZA ZA200407799A patent/ZA200407799B/en unknown
- 2004-10-18 HR HR20040979A patent/HRP20040979A2/hr not_active Application Discontinuation
- 2004-10-26 NO NO20044606A patent/NO20044606L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1476442A2 (en) | 2004-11-17 |
| CN1681802A (zh) | 2005-10-12 |
| IS7467A (is) | 2004-09-23 |
| WO2003082857A3 (en) | 2003-12-18 |
| IL164153A0 (en) | 2005-12-18 |
| AU2003224779A1 (en) | 2003-10-13 |
| MXPA04009384A (es) | 2005-01-25 |
| PL373539A1 (en) | 2005-09-05 |
| NO20044606L (no) | 2004-10-26 |
| WO2003082857A2 (en) | 2003-10-09 |
| JP2005533755A (ja) | 2005-11-10 |
| CA2480352A1 (en) | 2003-10-09 |
| HRP20040979A2 (en) | 2005-06-30 |
| KR20040093187A (ko) | 2004-11-04 |
| US20040010151A1 (en) | 2004-01-15 |
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