ZA200404999B - Fluoro substituted cycloalkanoindoles and their use as prostaglandin D2 receptor antagonists - Google Patents

Fluoro substituted cycloalkanoindoles and their use as prostaglandin D2 receptor antagonists Download PDF

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Publication number
ZA200404999B
ZA200404999B ZA200404999A ZA200404999A ZA200404999B ZA 200404999 B ZA200404999 B ZA 200404999B ZA 200404999 A ZA200404999 A ZA 200404999A ZA 200404999 A ZA200404999 A ZA 200404999A ZA 200404999 B ZA200404999 B ZA 200404999B
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South Africa
Prior art keywords
compound
acid
fluoro
pharmaceutically acceptable
chlorobenzyl
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ZA200404999A
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English (en)
Inventor
Carl Berthelette
Nicolas Lahcance
Lianhai Li
Claudio Sturino
Zhaoyin Wang
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Merck Frosst Canada Inc
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Publication of ZA200404999B publication Critical patent/ZA200404999B/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

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ZA200404999A 2002-01-24 2004-06-24 Fluoro substituted cycloalkanoindoles and their use as prostaglandin D2 receptor antagonists ZA200404999B (en)

Applications Claiming Priority (1)

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US35138402P 2002-01-24 2002-01-24

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ZA200404999B true ZA200404999B (en) 2006-05-31

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US (6) US20030158246A1 (ja)
EP (3) EP2295409B1 (ja)
JP (2) JP4008885B2 (ja)
KR (2) KR100859230B1 (ja)
CN (3) CN1902176A (ja)
AR (1) AR038136A1 (ja)
AT (1) ATE414690T1 (ja)
AU (1) AU2003202343B2 (ja)
BR (1) BR0307050A (ja)
CA (1) CA2471952C (ja)
CY (3) CY1108841T1 (ja)
DE (2) DE60324767D1 (ja)
DK (2) DK2045241T3 (ja)
DO (1) DOP2003000566A (ja)
EA (1) EA006134B1 (ja)
EC (1) ECSP045203A (ja)
EG (1) EG24978A (ja)
ES (2) ES2391747T3 (ja)
FR (1) FR09C0010I2 (ja)
GE (1) GEP20074078B (ja)
HR (1) HRP20040665B1 (ja)
IL (3) IL162825A0 (ja)
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NL (1) NL300377I2 (ja)
NO (3) NO327322B1 (ja)
NZ (1) NZ533786A (ja)
PE (1) PE20030982A1 (ja)
PL (1) PL208527B1 (ja)
PT (2) PT2045241E (ja)
RS (2) RS51672B (ja)
SI (2) SI2045241T1 (ja)
TW (1) TWI259080B (ja)
UA (1) UA75520C2 (ja)
WO (1) WO2003062200A2 (ja)
ZA (1) ZA200404999B (ja)

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