ZA200404744B - Diazabicyclo alkane derivatives with nk, antagonistic activity. - Google Patents
Diazabicyclo alkane derivatives with nk, antagonistic activity. Download PDFInfo
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- ZA200404744B ZA200404744B ZA200404744A ZA200404744A ZA200404744B ZA 200404744 B ZA200404744 B ZA 200404744B ZA 200404744 A ZA200404744 A ZA 200404744A ZA 200404744 A ZA200404744 A ZA 200404744A ZA 200404744 B ZA200404744 B ZA 200404744B
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- 230000003042 antagnostic effect Effects 0.000 title description 8
- 150000001335 aliphatic alkanes Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 60
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- 150000003839 salts Chemical class 0.000 claims description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076405 | 2002-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200404744B true ZA200404744B (en) | 2005-09-21 |
Family
ID=28685940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200404744A ZA200404744B (en) | 2002-04-04 | 2004-06-15 | Diazabicyclo alkane derivatives with nk, antagonistic activity. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7202238B2 (zh) |
| EP (1) | EP1495022B1 (zh) |
| JP (1) | JP2005525395A (zh) |
| KR (1) | KR20040095361A (zh) |
| CN (1) | CN1279041C (zh) |
| AR (1) | AR039192A1 (zh) |
| AT (1) | ATE435863T1 (zh) |
| AU (1) | AU2003224162B2 (zh) |
| BR (1) | BR0306148A (zh) |
| CA (1) | CA2462708A1 (zh) |
| DE (1) | DE60328272D1 (zh) |
| HK (1) | HK1070356A1 (zh) |
| HR (1) | HRP20040273A2 (zh) |
| IL (2) | IL160943A0 (zh) |
| MX (1) | MXPA04004812A (zh) |
| NO (1) | NO20044775L (zh) |
| PL (1) | PL371378A1 (zh) |
| RU (1) | RU2310656C2 (zh) |
| UA (1) | UA77515C2 (zh) |
| WO (1) | WO2003084955A1 (zh) |
| ZA (1) | ZA200404744B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060205724A1 (en) * | 2002-05-29 | 2006-09-14 | The Regents Of The University Of California | Antagonizing nk-1 receptors inhibits consumption of substances of abuse |
| AR045796A1 (es) * | 2003-09-26 | 2005-11-16 | Solvay Pharm Bv | Derivados de hexa y octahidro - pirido (1,2-a) pirazina con actividad antagonista de nk1. composiciones farmaceuticas. |
| WO2006013205A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
| DE102006049452A1 (de) * | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| WO2010011912A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Trpv4 antagonists |
| JP5607046B2 (ja) * | 2008-07-25 | 2014-10-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｔｒｐｖ４拮抗薬 |
| US8669255B2 (en) | 2011-09-29 | 2014-03-11 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers |
| AR088064A1 (es) | 2011-09-29 | 2014-05-07 | Abbvie Inc | Octahidropirrolo[1,2-a]pirazina sulfonamidas sustituidas como bloqueadores de canales de calcio |
| PL2817312T3 (pl) * | 2012-02-22 | 2016-08-31 | Leo Pharma As | Nowe związki będące antagonistami receptora neurokininy 1 |
| KR20150093237A (ko) | 2012-12-12 | 2015-08-17 | 애브비 인코포레이티드 | 통증 치료시 칼슘 채널 차단제로서 유용한 디아제핀 유도체 |
| JP6574769B2 (ja) * | 2013-07-25 | 2019-09-11 | ニューレン ファーマシューティカルズ リミテッド | 二環式化合物ならびに自閉症スペクトラム障害および神経発達障害の治療におけるそれらの使用方法 |
| WO2015024203A1 (en) * | 2013-08-20 | 2015-02-26 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds ii |
| JP7306997B2 (ja) | 2017-03-20 | 2023-07-11 | ザ・ブロード・インスティテュート・インコーポレイテッド | 寄生虫性疾患の処置のための化合物および方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1125112A (en) * | 1966-01-07 | 1968-08-28 | Science Union & Cie | New derivatives of diazabicyclo-decane and process for preparing them |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
| EP0827500B1 (en) * | 1995-05-23 | 2001-11-14 | Janssen Pharmaceutica N.V. | (2-morpholinylmethyl)benzamide derivatives |
| GB9510600D0 (en) | 1995-05-25 | 1995-07-19 | Fujisawa Pharmaceutical Co | Piperazine derivatives |
| HUP9900822A3 (en) | 1995-05-25 | 1999-11-29 | Fujisawa Pharmaceutical Co | Piperazine derivatives, process for producing them, pharmaceutical compositions containing them and method for treating tachykinin-mediated diseases |
| EP0873320B1 (en) | 1995-12-18 | 2002-06-12 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives as tachykinin antagonists |
| AUPO735997A0 (en) | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| DE59814233D1 (de) | 1997-08-27 | 2008-07-03 | Solvay Pharm Gmbh | Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten |
| EP0982030A3 (en) * | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
| JP3454427B2 (ja) * | 1998-12-14 | 2003-10-06 | 藤沢薬品工業株式会社 | ピペラジン誘導体 |
| DE10036818A1 (de) | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
-
2003
- 2003-02-04 UA UA20041108912A patent/UA77515C2/uk unknown
- 2003-03-28 AR ARP030101105A patent/AR039192A1/es unknown
- 2003-04-02 PL PL03371378A patent/PL371378A1/xx not_active Application Discontinuation
- 2003-04-02 CA CA002462708A patent/CA2462708A1/en not_active Abandoned
- 2003-04-02 WO PCT/EP2003/050086 patent/WO2003084955A1/en active Application Filing
- 2003-04-02 US US10/490,364 patent/US7202238B2/en not_active Expired - Lifetime
- 2003-04-02 MX MXPA04004812A patent/MXPA04004812A/es active IP Right Grant
- 2003-04-02 IL IL16094303A patent/IL160943A0/xx unknown
- 2003-04-02 RU RU2004112415/04A patent/RU2310656C2/ru active
- 2003-04-02 EP EP03720571A patent/EP1495022B1/en not_active Expired - Lifetime
- 2003-04-02 KR KR10-2004-7015635A patent/KR20040095361A/ko not_active Application Discontinuation
- 2003-04-02 DE DE60328272T patent/DE60328272D1/de not_active Expired - Fee Related
- 2003-04-02 BR BR0306148-5A patent/BR0306148A/pt not_active IP Right Cessation
- 2003-04-02 CN CNB038015595A patent/CN1279041C/zh not_active Expired - Fee Related
- 2003-04-02 JP JP2003582152A patent/JP2005525395A/ja active Pending
- 2003-04-02 AU AU2003224162A patent/AU2003224162B2/en not_active Ceased
- 2003-04-02 AT AT03720571T patent/ATE435863T1/de not_active IP Right Cessation
-
2004
- 2004-03-18 IL IL160943A patent/IL160943A/en not_active IP Right Cessation
- 2004-03-19 HR HR20040273A patent/HRP20040273A2/xx not_active Application Discontinuation
- 2004-06-15 ZA ZA200404744A patent/ZA200404744B/en unknown
- 2004-11-03 NO NO20044775A patent/NO20044775L/no not_active Application Discontinuation
-
2005
- 2005-04-08 HK HK05102968A patent/HK1070356A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1495022B1 (en) | 2009-07-08 |
| HK1070356A1 (en) | 2005-06-17 |
| AR039192A1 (es) | 2005-02-09 |
| DE60328272D1 (de) | 2009-08-20 |
| WO2003084955A1 (en) | 2003-10-16 |
| RU2310656C2 (ru) | 2007-11-20 |
| JP2005525395A (ja) | 2005-08-25 |
| MXPA04004812A (es) | 2004-08-11 |
| AU2003224162B2 (en) | 2008-06-12 |
| ATE435863T1 (de) | 2009-07-15 |
| PL371378A1 (en) | 2005-06-13 |
| KR20040095361A (ko) | 2004-11-12 |
| IL160943A0 (en) | 2004-08-31 |
| CN1279041C (zh) | 2006-10-11 |
| CA2462708A1 (en) | 2003-10-16 |
| RU2004112415A (ru) | 2005-03-27 |
| UA77515C2 (en) | 2006-12-15 |
| EP1495022A1 (en) | 2005-01-12 |
| US20050119267A1 (en) | 2005-06-02 |
| AU2003224162A1 (en) | 2003-10-20 |
| HRP20040273A2 (en) | 2005-02-28 |
| CN1592747A (zh) | 2005-03-09 |
| NO20044775L (no) | 2004-12-16 |
| BR0306148A (pt) | 2004-10-19 |
| US7202238B2 (en) | 2007-04-10 |
| IL160943A (en) | 2008-11-03 |
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