ZA200404744B - Diazabicyclo alkane derivatives with nk, antagonistic activity. - Google Patents
Diazabicyclo alkane derivatives with nk, antagonistic activity. Download PDFInfo
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- ZA200404744B ZA200404744B ZA200404744A ZA200404744A ZA200404744B ZA 200404744 B ZA200404744 B ZA 200404744B ZA 200404744 A ZA200404744 A ZA 200404744A ZA 200404744 A ZA200404744 A ZA 200404744A ZA 200404744 B ZA200404744 B ZA 200404744B
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- 230000003042 antagnostic effect Effects 0.000 title description 8
- 150000001335 aliphatic alkanes Chemical class 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 60
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- 150000003839 salts Chemical class 0.000 claims description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076405 | 2002-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200404744B true ZA200404744B (en) | 2005-09-21 |
Family
ID=28685940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200404744A ZA200404744B (en) | 2002-04-04 | 2004-06-15 | Diazabicyclo alkane derivatives with nk, antagonistic activity. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7202238B2 (pt) |
| EP (1) | EP1495022B1 (pt) |
| JP (1) | JP2005525395A (pt) |
| KR (1) | KR20040095361A (pt) |
| CN (1) | CN1279041C (pt) |
| AR (1) | AR039192A1 (pt) |
| AT (1) | ATE435863T1 (pt) |
| AU (1) | AU2003224162B2 (pt) |
| BR (1) | BR0306148A (pt) |
| CA (1) | CA2462708A1 (pt) |
| DE (1) | DE60328272D1 (pt) |
| HK (1) | HK1070356A1 (pt) |
| HR (1) | HRP20040273A2 (pt) |
| IL (2) | IL160943A0 (pt) |
| MX (1) | MXPA04004812A (pt) |
| NO (1) | NO20044775L (pt) |
| PL (1) | PL371378A1 (pt) |
| RU (1) | RU2310656C2 (pt) |
| UA (1) | UA77515C2 (pt) |
| WO (1) | WO2003084955A1 (pt) |
| ZA (1) | ZA200404744B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060205724A1 (en) * | 2002-05-29 | 2006-09-14 | The Regents Of The University Of California | Antagonizing nk-1 receptors inhibits consumption of substances of abuse |
| SA04250304B1 (ar) * | 2003-09-26 | 2009-03-11 | سولفاي فارماسوتيكالز بي . في | مشتقات هكسا - واوكتاهيدرو - بيريدو {1،2-a} بيرازين ذات نشاط مضاد لـ nk1 |
| WO2006013205A1 (en) * | 2004-08-04 | 2006-02-09 | Solvay Pharmaceuticals B.V. | Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation |
| DE102006049452A1 (de) * | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
| WO2010011912A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Trpv4 antagonists |
| EP2312947B1 (en) * | 2008-07-25 | 2014-01-01 | GlaxoSmithKline LLC | Trpv4 antagonists |
| WO2013049174A1 (en) | 2011-09-29 | 2013-04-04 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers |
| WO2013049164A1 (en) * | 2011-09-29 | 2013-04-04 | Abbvie Inc. | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS |
| US9181259B2 (en) * | 2012-02-22 | 2015-11-10 | Leo Pharma A/S | Substituted pyrrolo[1,2-a]piperazines and pyrrolo[1,2-a][1,4]diazepines as neurokinin 1 receptor antagonists |
| BR112015013948A2 (pt) | 2012-12-12 | 2017-07-11 | Abbvie Inc | derivados diazepínicos úteis como bloqueadores do canal de cálcio no tratamento de dor |
| WO2015013397A2 (en) * | 2013-07-25 | 2015-01-29 | Neuren Pharmaceuticals Limited | Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders |
| WO2015024203A1 (en) * | 2013-08-20 | 2015-02-26 | Leo Pharma A/S | Novel neurokinin 1 receptor antagonist compounds ii |
| ES2966369T3 (es) | 2017-03-20 | 2024-04-22 | Broad Inst Inc | Compuestos y métodos para el tratamiento de enfermedades parasitarias |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1125112A (en) * | 1966-01-07 | 1968-08-28 | Science Union & Cie | New derivatives of diazabicyclo-decane and process for preparing them |
| IL111730A (en) | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
| ATE208766T1 (de) * | 1995-05-23 | 2001-11-15 | Janssen Pharmaceutica Nv | (2-morpholinylmethyl)benzamid-derivate |
| CN1072220C (zh) | 1995-05-25 | 2001-10-03 | 藤泽药品工业株式会社 | 作为神经激肽受体拮抗剂的1－苯甲酰基－2－(吲哚基－3－烷基)－哌嗪衍生物 |
| GB9510600D0 (en) | 1995-05-25 | 1995-07-19 | Fujisawa Pharmaceutical Co | Piperazine derivatives |
| JP2000502100A (ja) | 1995-12-18 | 2000-02-22 | 藤沢薬品工業株式会社 | タキキニン拮抗薬としてのピペラジン誘導体 |
| AUPO735997A0 (en) * | 1997-06-17 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| DE59814233D1 (de) | 1997-08-27 | 2008-07-03 | Solvay Pharm Gmbh | Indolmethyl-N,N'-bisacylpiperazine als Neurokininrezeptorantagonisten |
| EP0982030A3 (en) * | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
| CA2354875A1 (en) | 1998-12-14 | 2000-06-22 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives |
| DE10036818A1 (de) | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
-
2003
- 2003-02-04 UA UA20041108912A patent/UA77515C2/uk unknown
- 2003-03-28 AR ARP030101105A patent/AR039192A1/es unknown
- 2003-04-02 US US10/490,364 patent/US7202238B2/en not_active Expired - Lifetime
- 2003-04-02 JP JP2003582152A patent/JP2005525395A/ja active Pending
- 2003-04-02 IL IL16094303A patent/IL160943A0/xx unknown
- 2003-04-02 KR KR10-2004-7015635A patent/KR20040095361A/ko not_active Application Discontinuation
- 2003-04-02 AU AU2003224162A patent/AU2003224162B2/en not_active Ceased
- 2003-04-02 PL PL03371378A patent/PL371378A1/xx not_active Application Discontinuation
- 2003-04-02 MX MXPA04004812A patent/MXPA04004812A/es active IP Right Grant
- 2003-04-02 AT AT03720571T patent/ATE435863T1/de not_active IP Right Cessation
- 2003-04-02 BR BR0306148-5A patent/BR0306148A/pt not_active IP Right Cessation
- 2003-04-02 RU RU2004112415/04A patent/RU2310656C2/ru active
- 2003-04-02 WO PCT/EP2003/050086 patent/WO2003084955A1/en active Application Filing
- 2003-04-02 CN CNB038015595A patent/CN1279041C/zh not_active Expired - Fee Related
- 2003-04-02 EP EP03720571A patent/EP1495022B1/en not_active Expired - Lifetime
- 2003-04-02 CA CA002462708A patent/CA2462708A1/en not_active Abandoned
- 2003-04-02 DE DE60328272T patent/DE60328272D1/de not_active Expired - Fee Related
-
2004
- 2004-03-18 IL IL160943A patent/IL160943A/en not_active IP Right Cessation
- 2004-03-19 HR HR20040273A patent/HRP20040273A2/xx not_active Application Discontinuation
- 2004-06-15 ZA ZA200404744A patent/ZA200404744B/en unknown
- 2004-11-03 NO NO20044775A patent/NO20044775L/no not_active Application Discontinuation
-
2005
- 2005-04-08 HK HK05102968A patent/HK1070356A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| UA77515C2 (en) | 2006-12-15 |
| EP1495022A1 (en) | 2005-01-12 |
| WO2003084955A1 (en) | 2003-10-16 |
| US7202238B2 (en) | 2007-04-10 |
| CA2462708A1 (en) | 2003-10-16 |
| DE60328272D1 (de) | 2009-08-20 |
| CN1279041C (zh) | 2006-10-11 |
| NO20044775L (no) | 2004-12-16 |
| CN1592747A (zh) | 2005-03-09 |
| EP1495022B1 (en) | 2009-07-08 |
| BR0306148A (pt) | 2004-10-19 |
| ATE435863T1 (de) | 2009-07-15 |
| KR20040095361A (ko) | 2004-11-12 |
| RU2004112415A (ru) | 2005-03-27 |
| AU2003224162A1 (en) | 2003-10-20 |
| PL371378A1 (en) | 2005-06-13 |
| JP2005525395A (ja) | 2005-08-25 |
| IL160943A0 (en) | 2004-08-31 |
| MXPA04004812A (es) | 2004-08-11 |
| AU2003224162B2 (en) | 2008-06-12 |
| HK1070356A1 (en) | 2005-06-17 |
| HRP20040273A2 (en) | 2005-02-28 |
| IL160943A (en) | 2008-11-03 |
| RU2310656C2 (ru) | 2007-11-20 |
| US20050119267A1 (en) | 2005-06-02 |
| AR039192A1 (es) | 2005-02-09 |
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