ZA200403737B - Use of an farsenyl protein transferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer. - Google Patents
Use of an farsenyl protein transferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer. Download PDFInfo
- Publication number
- ZA200403737B ZA200403737B ZA200403737A ZA200403737A ZA200403737B ZA 200403737 B ZA200403737 B ZA 200403737B ZA 200403737 A ZA200403737 A ZA 200403737A ZA 200403737 A ZA200403737 A ZA 200403737A ZA 200403737 B ZA200403737 B ZA 200403737B
- Authority
- ZA
- South Africa
- Prior art keywords
- fpt inhibitor
- treatment
- administered
- amount
- substance
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims description 56
- 238000004519 manufacturing process Methods 0.000 title claims description 38
- 206010028980 Neoplasm Diseases 0.000 title claims description 33
- 201000011510 cancer Diseases 0.000 title claims description 27
- 229940123468 Transferase inhibitor Drugs 0.000 title description 2
- 239000003558 transferase inhibitor Substances 0.000 title description 2
- 229960003552 other antineoplastic agent in atc Drugs 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 claims description 155
- 238000011282 treatment Methods 0.000 claims description 93
- 238000000034 method Methods 0.000 claims description 64
- 239000002246 antineoplastic agent Substances 0.000 claims description 47
- 229940034982 antineoplastic agent Drugs 0.000 claims description 47
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 42
- 229960004562 carboplatin Drugs 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 30
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 26
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 26
- 229930012538 Paclitaxel Natural products 0.000 claims description 23
- 229960001592 paclitaxel Drugs 0.000 claims description 23
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 23
- 229960005277 gemcitabine Drugs 0.000 claims description 21
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 21
- 229910052697 platinum Inorganic materials 0.000 claims description 21
- 229940123237 Taxane Drugs 0.000 claims description 20
- 230000000259 anti-tumor effect Effects 0.000 claims description 19
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 18
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 17
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 17
- 229960004316 cisplatin Drugs 0.000 claims description 17
- 229960003668 docetaxel Drugs 0.000 claims description 17
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 16
- 150000003384 small molecules Chemical class 0.000 claims description 15
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 15
- 208000034578 Multiple myelomas Diseases 0.000 claims description 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 11
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 11
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims description 10
- 229960003433 thalidomide Drugs 0.000 claims description 10
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 8
- 229960004641 rituximab Drugs 0.000 claims description 8
- 229960000435 oblimersen Drugs 0.000 claims description 7
- MIMNFCVQODTQDP-NDLVEFNKSA-N oblimersen Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(S)(=O)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)CO)[C@@H](O)C1 MIMNFCVQODTQDP-NDLVEFNKSA-N 0.000 claims description 7
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims description 7
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims description 7
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims description 6
- 229940080856 gleevec Drugs 0.000 claims description 6
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 6
- 239000002525 vasculotropin inhibitor Substances 0.000 claims description 6
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims description 5
- 229940043355 kinase inhibitor Drugs 0.000 claims description 5
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 5
- 229940102550 Estrogen receptor antagonist Drugs 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 4
- 102000006495 integrins Human genes 0.000 claims description 4
- 108010044426 integrins Proteins 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical group O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 3
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims description 3
- 229940084651 iressa Drugs 0.000 claims description 3
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 2
- 229940127395 Ribonucleotide Reductase Inhibitors Drugs 0.000 claims description 2
- 229940122803 Vinca alkaloid Drugs 0.000 claims description 2
- 229960000074 biopharmaceutical Drugs 0.000 claims description 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 2
- 229930013356 epothilone Natural products 0.000 claims description 2
- HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 claims description 2
- 229960000390 fludarabine Drugs 0.000 claims description 2
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical group C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 2
- 229940120982 tarceva Drugs 0.000 claims description 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 62
- 190000008236 Carboplatin Chemical compound 0.000 claims 33
- 239000002777 nucleoside Substances 0.000 claims 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims 5
- 208000026037 malignant tumor of neck Diseases 0.000 claims 5
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 5
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- 229940022353 herceptin Drugs 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 229960000684 cytarabine Drugs 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 7
- 101800003838 Epidermal growth factor Proteins 0.000 description 6
- 229940116977 epidermal growth factor Drugs 0.000 description 6
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 description 6
- DVQHYTBCTGYNNN-UHFFFAOYSA-N azane;cyclobutane-1,1-dicarboxylic acid;platinum Chemical compound N.N.[Pt].OC(=O)C1(C(O)=O)CCC1 DVQHYTBCTGYNNN-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 4
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 4
- DHMTURDWPRKSOA-RUZDIDTESA-N lonafarnib Chemical compound C1CN(C(=O)N)CCC1CC(=O)N1CCC([C@@H]2C3=C(Br)C=C(Cl)C=C3CCC3=CC(Br)=CN=C32)CC1 DHMTURDWPRKSOA-RUZDIDTESA-N 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 2
- 102000004357 Transferases Human genes 0.000 description 2
- 108090000992 Transferases Proteins 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006126 farnesylation Effects 0.000 description 2
- -1 gemcitabine) Chemical class 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229940127084 other anti-cancer agent Drugs 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 229960001603 tamoxifen Drugs 0.000 description 2
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 1
- 229940122815 Aromatase inhibitor Drugs 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 102100020977 DnaJ homolog subfamily A member 1 Human genes 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 description 1
- 229940123414 Folate antagonist Drugs 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101000931227 Homo sapiens DnaJ homolog subfamily A member 1 Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000003886 aromatase inhibitor Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000009261 endocrine therapy Methods 0.000 description 1
- 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 description 1
- 229960001433 erlotinib Drugs 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- GKFPROVOIQKYTO-UZLBHIALSA-N methyl (2s)-2-[[4-[[(2r)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate Chemical compound CSCC[C@@H](C(=O)OC)NC(=O)C1=CC=C(NC[C@@H](N)CS)C=C1C1=CC=CC=C1 GKFPROVOIQKYTO-UZLBHIALSA-N 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 108010075398 prelamin A Proteins 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- RCINICONZNJXQF-XAZOAEDWSA-N taxol® Chemical compound O([C@@H]1[C@@]2(CC(C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3(C21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-XAZOAEDWSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33441101P | 2001-11-30 | 2001-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403737B true ZA200403737B (en) | 2005-05-23 |
Family
ID=23307076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403737A ZA200403737B (en) | 2001-11-30 | 2004-05-14 | Use of an farsenyl protein transferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20030185831A1 (https=) |
| EP (1) | EP1448268A2 (https=) |
| JP (1) | JP2005511663A (https=) |
| CN (2) | CN101181269A (https=) |
| AU (1) | AU2002352941A1 (https=) |
| BR (1) | BR0214564A (https=) |
| CA (1) | CA2468839A1 (https=) |
| HU (1) | HUP0402401A2 (https=) |
| MX (1) | MXPA04005207A (https=) |
| NO (1) | NO20042730L (https=) |
| NZ (1) | NZ532562A (https=) |
| WO (1) | WO2003047697A2 (https=) |
| ZA (1) | ZA200403737B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0312821A (pt) * | 2002-07-24 | 2005-04-19 | Akira Ohtsuru | 4-(4-metil-piperazin-1-il-metil)-n-[(4-metil-3-(4-piridin-3-i l)-pirimidin-2-il-amino)-fenil]-benzamida para tratar câncer anaplásico da tireóide |
| CA2439440A1 (en) * | 2002-09-05 | 2004-03-05 | Emory University | Treatment of tuberous sclerosis associated neoplasms |
| JP2007510661A (ja) * | 2003-11-06 | 2007-04-26 | シェーリング コーポレイション | 乳癌の治療のための、ファルネシルトランスフェラーゼインヒビターと抗ホルモン剤との組合せ |
| EP1732583A4 (en) * | 2004-02-26 | 2009-08-12 | Penn State Res Found | COMBINATORIES THERAPY FOR THE TREATMENT OF NEOPLASIA USING OPIOID GROWTH FACTOR RECEPTORS |
| US20060205810A1 (en) * | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| US20080255171A1 (en) * | 2005-10-07 | 2008-10-16 | Manley Paul W | Combination of Nilotinib with Farnesyl Transferase Inhibitors |
| US20100104661A1 (en) * | 2006-10-25 | 2010-04-29 | Susan Arbuck | Discontinuous methods of treating cancer |
| EP2088862A4 (en) * | 2006-11-28 | 2009-12-02 | Smithkline Beecham Cork Ltd | METHOD OF TREATING CANCER |
| KR20230098281A (ko) * | 2020-10-27 | 2023-07-03 | 위스콘신 얼럼나이 리서어치 화운데이션 | 조합 면역요법을 위한 모듈형 덴드론 미셀 |
| KR20250102088A (ko) | 2022-11-09 | 2025-07-04 | 메르크 파텐트 게엠베하 | 선천성 항종양 면역을 유발시키기 위한 면역-자극제로서 Toll-유사 수용체 7 효현제 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874442A (en) * | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| PE20000042A1 (es) * | 1997-12-22 | 2000-02-17 | Schering Corp | Uso combinado de un inhibidor de farnesilo transferasa y un agente antineoplasico y/o terapia de radiacion para el tratamiento de enfermedades proliferativas |
| US6096757A (en) * | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| US6316462B1 (en) * | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| SI1255537T1 (sl) * | 2000-02-04 | 2006-10-31 | Janssen Pharmaceutica Nv | Inhibitorji farnezil protein transferaze za zdravljenje raka dojk |
| ATE375794T1 (de) * | 2000-02-24 | 2007-11-15 | Janssen Pharmaceutica Nv | Dosierschema enthaldend farnesyl protein transferase inhibitoren für die behandlung von krebs |
| WO2001064252A2 (en) * | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with further anti-cancer agents |
| EP1265611A2 (en) * | 2000-02-29 | 2002-12-18 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with taxane compounds |
| AR033680A1 (es) * | 2000-08-30 | 2004-01-07 | Schering Corp | Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales |
| CA2424797C (en) * | 2000-10-05 | 2009-12-29 | George Q. Daley | Methods of inducing cancer cell death and tumor regression |
-
2002
- 2002-11-25 WO PCT/US2002/037954 patent/WO2003047697A2/en not_active Ceased
- 2002-11-25 CN CNA2007101860344A patent/CN101181269A/zh active Pending
- 2002-11-25 EP EP02789901A patent/EP1448268A2/en not_active Withdrawn
- 2002-11-25 CN CNA028239202A patent/CN1617755A/zh active Pending
- 2002-11-25 US US10/303,259 patent/US20030185831A1/en not_active Abandoned
- 2002-11-25 JP JP2003548949A patent/JP2005511663A/ja not_active Withdrawn
- 2002-11-25 CA CA002468839A patent/CA2468839A1/en not_active Abandoned
- 2002-11-25 HU HU0402401A patent/HUP0402401A2/hu unknown
- 2002-11-25 MX MXPA04005207A patent/MXPA04005207A/es unknown
- 2002-11-25 AU AU2002352941A patent/AU2002352941A1/en not_active Abandoned
- 2002-11-25 NZ NZ532562A patent/NZ532562A/en unknown
- 2002-11-25 BR BR0214564-2A patent/BR0214564A/pt not_active IP Right Cessation
-
2004
- 2004-05-14 ZA ZA200403737A patent/ZA200403737B/en unknown
- 2004-06-29 NO NO20042730A patent/NO20042730L/no not_active Application Discontinuation
-
2006
- 2006-04-03 US US11/396,892 patent/US20060183765A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003047697A2 (en) | 2003-06-12 |
| AU2002352941A1 (en) | 2003-06-17 |
| BR0214564A (pt) | 2004-11-09 |
| EP1448268A2 (en) | 2004-08-25 |
| WO2003047697A3 (en) | 2003-10-30 |
| US20030185831A1 (en) | 2003-10-02 |
| NO20042730L (no) | 2004-06-29 |
| CN101181269A (zh) | 2008-05-21 |
| MXPA04005207A (es) | 2004-08-19 |
| HUP0402401A2 (hu) | 2005-03-29 |
| CA2468839A1 (en) | 2003-06-12 |
| US20060183765A1 (en) | 2006-08-17 |
| CN1617755A (zh) | 2005-05-18 |
| JP2005511663A (ja) | 2005-04-28 |
| NZ532562A (en) | 2007-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN121466307A (zh) | 药物组合物、其用途及癌症的治疗方法 | |
| JP2003533485A5 (https=) | ||
| TW200533339A (en) | Therapeutic synergy of anti-cancer compounds | |
| Spalding et al. | New and emerging radiosensitizers and radioprotectors | |
| KR20100126479A (ko) | 개선된 항종양 치료법들 | |
| JP2017516802A (ja) | がんの治療におけるエリブリンの使用 | |
| Hernandez-Aya et al. | Chemotherapy principles of managing stage IV breast cancer in the United States | |
| Baselga et al. | Targeting epidermal growth factor receptor in lung cancer | |
| ZA200403737B (en) | Use of an farsenyl protein transferase inhibitor in combination with other antineoplastic agents for the manufacture of a medicament against cancer. | |
| WO2001064252A2 (en) | Farnesyl protein transferase inhibitor combinations with further anti-cancer agents | |
| JP2009536956A (ja) | 抗癌治療法 | |
| WO2015191576A1 (en) | Combination therapy comprising a liposomal prodrug of mitomycin c and radiotherapy | |
| JP2005511663A5 (https=) | ||
| KR20080081249A (ko) | 17-ａａｇ 또는 17-ａｇ, 또는 이 중 어느 하나의 전구약물과 ｈｅｒ２ 억제제의 조합을 사용하여 유방암을치료하는 방법 | |
| Mayerhofer et al. | Taxol as second-line treatment in patients with advanced ovarian cancer after platinum-based first-line chemotherapy | |
| CN101185652B (zh) | 肺癌治疗药 | |
| JP7468829B2 (ja) | 癌を処置するための、癌治療剤と組み合わせたＩＲＥ１α阻害剤 | |
| CN101355969B (zh) | 包含cyc-682和细胞毒性药物的抗增殖性组合 | |
| US20060160756A1 (en) | Treatment and prevention of multi-drug resistance | |
| CN101428034B (zh) | 具有增效减毒特点的抗肿瘤组合药物 | |
| Izquierdo et al. | A phase I clinical and pharmacokinetic study of paclitaxel and docetaxel given in combination in patients with solid tumours | |
| AU2007201079A1 (en) | Methods of treating cancer using an FPT inhibitor and antineoplastic agents | |
| KR20050116166A (ko) | 이리노테칸의 저항성 유방암 치료용 용도 | |
| Von Pawel | Topotecan (Hycamtin®): potent cytostatic action by selective topoisomerase I inhibition | |
| HK40046230A (en) | IRE1α INHIBITOR IN COMBINATION WITH CANCER THERAPEUTIC AGENT FOR CANCER TREATMENT |