ZA200403487B - Phenyl substituted triazoles and their use as selective inhibitors of AKL5 kinase - Google Patents
Phenyl substituted triazoles and their use as selective inhibitors of AKL5 kinase Download PDFInfo
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- ZA200403487B ZA200403487B ZA200403487A ZA200403487A ZA200403487B ZA 200403487 B ZA200403487 B ZA 200403487B ZA 200403487 A ZA200403487 A ZA 200403487A ZA 200403487 A ZA200403487 A ZA 200403487A ZA 200403487 B ZA200403487 B ZA 200403487B
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- South Africa
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- compound
- disease
- optionally substituted
- phenyl
- alkyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Neurosurgery (AREA)
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- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
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- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0127430.7A GB0127430D0 (en) | 2001-11-15 | 2001-11-15 | Compounds |
Publications (1)
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| ZA200403487B true ZA200403487B (en) | 2006-05-31 |
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| ZA200403487A ZA200403487B (en) | 2001-11-15 | 2004-05-07 | Phenyl substituted triazoles and their use as selective inhibitors of AKL5 kinase |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20050014938A1 (ru) |
| EP (1) | EP1444232A1 (ru) |
| JP (1) | JP2005518352A (ru) |
| KR (1) | KR20050044476A (ru) |
| CN (1) | CN1608065A (ru) |
| BR (1) | BR0214160A (ru) |
| CA (1) | CA2467267A1 (ru) |
| GB (1) | GB0127430D0 (ru) |
| HU (1) | HUP0402227A2 (ru) |
| IL (1) | IL161852A0 (ru) |
| IS (1) | IS7252A (ru) |
| MX (1) | MXPA04004593A (ru) |
| NO (1) | NO20042244L (ru) |
| PL (1) | PL369605A1 (ru) |
| RU (1) | RU2004117862A (ru) |
| WO (1) | WO2003042211A1 (ru) |
| ZA (1) | ZA200403487B (ru) |
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| WO2003097639A1 (en) * | 2002-05-15 | 2003-11-27 | Smithkline Beecham Corporation | Benzoxazine and benzoxazinone substituted triazoles |
| GB0217787D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | C ompounds |
| GB0217780D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| WO2004014900A1 (en) * | 2002-08-09 | 2004-02-19 | Eli Lilly And Company | Benzimidazoles and benzothiazoles as inhibitors of map kinase |
| US7901874B2 (en) | 2003-09-11 | 2011-03-08 | Hubit Genomix, Inc. | Methods for identifying agents for preventing or treating proliferative diseases, and for inhibiting extracellular matrix or α1 type IV collagen |
| US7863310B2 (en) | 2004-02-03 | 2011-01-04 | Eli Lilly And Company | Kinase inhibitors |
| RU2007107177A (ru) * | 2004-07-28 | 2008-09-10 | Айрм Ллк (Bm) | Соединения и композиции, как модуляторы ядерных рецепторов стероидных гормонов |
| MX2007011850A (es) * | 2005-03-25 | 2007-10-03 | Tibotec Pharm Ltd | Inhibidores heterobiciclicos de virus de hepatitis c. |
| AR056347A1 (es) | 2005-05-12 | 2007-10-03 | Tibotec Pharm Ltd | Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas |
| DE102005061840A1 (de) | 2005-12-23 | 2007-06-28 | Merck Patent Gmbh | Triazolderivate |
| MX2008016542A (es) | 2006-06-30 | 2009-01-19 | Novartis Ag | Derivados de quinolina y sus composiciones farmaceuticas. |
| JP5616063B2 (ja) * | 2006-10-04 | 2014-10-29 | ヤンセン・アールアンドデイ・アイルランド | Ｈｃｖ阻害剤として有用なカルボキシアミド４−［（４−ピリジル）アミノ］ピリミジン |
| EP1921072A1 (en) * | 2006-11-10 | 2008-05-14 | Laboratorios del Dr. Esteve S.A. | 1,2,3-Triazole derivatives as cannabinoid-receptor modulators |
| US7678819B2 (en) * | 2006-12-07 | 2010-03-16 | The Trustees Of The University Of Pennsylvania | Acetylene derivatives and their use for binding and imaging amyloid plaques |
| KR101076628B1 (ko) | 2008-07-09 | 2011-10-27 | 포항공과대학교 산학협력단 | 불균일 구리 나노 촉매 및 그 제조방법 |
| JP5643197B2 (ja) | 2008-07-09 | 2014-12-17 | ポステック アカデミー−インダストリー ファンデーション | 不均一銅ナノ触媒およびその製造方法 |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| CN102443009B (zh) * | 2010-09-30 | 2014-04-16 | 山东轩竹医药科技有限公司 | 并环激酶抑制剂 |
| JP6445971B2 (ja) | 2012-05-30 | 2018-12-26 | コーネル ユニヴァーシティー | ヒト羊水由来細胞からの機能的かつ耐久性のある内皮細胞の生成 |
| EP3003290B1 (en) | 2013-06-05 | 2021-03-10 | AgeX Therapeutics, Inc. | Compositions for use in the treatment of wounds in mammalian species |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
| WO2022251359A1 (en) * | 2021-05-26 | 2022-12-01 | Theravance Biopharma R&D Ip, Llc | Bicyclic inhibitors of alk5 and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2341370A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| DE60001229T2 (de) * | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
| CO5271680A1 (es) * | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
| GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| AU2001253418A1 (en) * | 2000-04-12 | 2001-10-30 | Smith Kline Beecham Corporation | Compounds and methods |
| GB0027987D0 (en) * | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
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2001
- 2001-11-15 GB GBGB0127430.7A patent/GB0127430D0/en not_active Ceased
-
2002
- 2002-11-14 EP EP02803039A patent/EP1444232A1/en not_active Withdrawn
- 2002-11-14 CN CNA028259149A patent/CN1608065A/zh active Pending
- 2002-11-14 BR BR0214160-4A patent/BR0214160A/pt not_active Application Discontinuation
- 2002-11-14 PL PL02369605A patent/PL369605A1/xx not_active Application Discontinuation
- 2002-11-14 HU HU0402227A patent/HUP0402227A2/hu unknown
- 2002-11-14 RU RU2004117862/04A patent/RU2004117862A/ru not_active Application Discontinuation
- 2002-11-14 CA CA002467267A patent/CA2467267A1/en not_active Abandoned
- 2002-11-14 KR KR1020047007378A patent/KR20050044476A/ko not_active Application Discontinuation
- 2002-11-14 IL IL16185202A patent/IL161852A0/xx unknown
- 2002-11-14 US US10/495,414 patent/US20050014938A1/en not_active Abandoned
- 2002-11-14 MX MXPA04004593A patent/MXPA04004593A/es unknown
- 2002-11-14 WO PCT/EP2002/013482 patent/WO2003042211A1/en not_active Application Discontinuation
- 2002-11-14 JP JP2003544047A patent/JP2005518352A/ja not_active Withdrawn
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2004
- 2004-05-06 IS IS7252A patent/IS7252A/is unknown
- 2004-05-07 ZA ZA200403487A patent/ZA200403487B/en unknown
- 2004-05-28 NO NO20042244A patent/NO20042244L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS7252A (is) | 2004-05-06 |
| JP2005518352A (ja) | 2005-06-23 |
| BR0214160A (pt) | 2004-09-28 |
| CA2467267A1 (en) | 2003-05-22 |
| IL161852A0 (en) | 2005-11-20 |
| GB0127430D0 (en) | 2002-01-09 |
| US20050014938A1 (en) | 2005-01-20 |
| NO20042244L (no) | 2004-07-13 |
| KR20050044476A (ko) | 2005-05-12 |
| CN1608065A (zh) | 2005-04-20 |
| MXPA04004593A (es) | 2004-08-13 |
| HUP0402227A2 (hu) | 2005-02-28 |
| EP1444232A1 (en) | 2004-08-11 |
| RU2004117862A (ru) | 2006-01-10 |
| WO2003042211A1 (en) | 2003-05-22 |
| PL369605A1 (en) | 2005-05-02 |
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