AU2001233918A1 - Pyridinylimidazoles - Google Patents

Pyridinylimidazoles

Info

Publication number
AU2001233918A1
AU2001233918A1 AU2001233918A AU2001233918A AU2001233918A1 AU 2001233918 A1 AU2001233918 A1 AU 2001233918A1 AU 2001233918 A AU2001233918 A AU 2001233918A AU 2001233918 A AU2001233918 A AU 2001233918A AU 2001233918 A1 AU2001233918 A1 AU 2001233918A1
Authority
AU
Australia
Prior art keywords
pyridinylimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2001233918A
Other versions
AU2001233918B2 (en
Inventor
Laramie Mary Gaster
Michael Stewart Hadley
John David Harling
Frank Peter Harrington
Jag Paul Heer
Thomas Daniel Heightman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0004053A priority Critical patent/GB0004053D0/en
Priority to GB0004053.5 priority
Priority to GB0015902A priority patent/GB0015902D0/en
Priority to GB0015902.0 priority
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to PCT/GB2001/000736 priority patent/WO2001062756A1/en
Publication of AU2001233918A1 publication Critical patent/AU2001233918A1/en
Application granted granted Critical
Publication of AU2001233918B2 publication Critical patent/AU2001233918B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

AU2001233918A 2000-02-21 2001-02-21 Pyridinylimidazoles Ceased AU2001233918B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB0004053A GB0004053D0 (en) 2000-02-21 2000-02-21 Compounds
GB0004053.5 2000-02-21
GB0015902A GB0015902D0 (en) 2000-06-28 2000-06-28 Compounds
GB0015902.0 2000-06-28
PCT/GB2001/000736 WO2001062756A1 (en) 2000-02-21 2001-02-21 Pyridinylimidazoles

Publications (2)

Publication Number Publication Date
AU2001233918A1 true AU2001233918A1 (en) 2001-11-15
AU2001233918B2 AU2001233918B2 (en) 2004-06-24

Family

ID=26243690

Family Applications (2)

Application Number Title Priority Date Filing Date
AU3391801A Pending AU3391801A (en) 2000-02-21 2001-02-21 Pyridinylimidazoles
AU2001233918A Ceased AU2001233918B2 (en) 2000-02-21 2001-02-21 Pyridinylimidazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU3391801A Pending AU3391801A (en) 2000-02-21 2001-02-21 Pyridinylimidazoles

Country Status (18)

Country Link
US (2) US20030166633A1 (en)
EP (1) EP1257543A1 (en)
JP (1) JP2003524010A (en)
KR (1) KR20020073597A (en)
CN (1) CN1404478A (en)
AR (1) AR029803A1 (en)
AU (2) AU3391801A (en)
BR (1) BR0108437A (en)
CA (1) CA2401036A1 (en)
CO (1) CO5271680A1 (en)
CZ (1) CZ20022852A3 (en)
HU (1) HU0204514A3 (en)
IL (1) IL151319D0 (en)
MX (1) MXPA02008082A (en)
NO (1) NO20023953L (en)
NZ (1) NZ520753A (en)
PL (1) PL357420A1 (en)
WO (1) WO2001062756A1 (en)

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AU2003268447B2 (en) 2002-09-06 2008-07-24 Biogen Idec Ma Inc. Pyrazolopyridines and method of making and using the same
CN1694871B (en) * 2002-09-06 2010-06-16 比奥根艾迪克Ma公司 Imidazolopyridines and methods of making and using the same
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MXPA05002332A (en) 2002-09-18 2005-06-08 Pfizer Prod Inc Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors.
BR0314302A (en) 2002-09-18 2005-07-05 Pfizer Producs Inc Pyrazole Compounds as Transforming Growth Factor (TGF) Inhibitors
EA200500286A1 (en) 2002-09-18 2005-08-25 Пфайзер Продактс Инк. New isotiazole and isoxasolic compounds as an inhibitors transforming growth factor (tgf)
OA12928A (en) 2002-09-18 2006-10-13 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGF) inhibitors.
PA8595001A1 (en) 2003-03-04 2004-09-28 Pfizer Prod Inc New heteroaromatic compounds are condensates inhibitors transforante factor (TGF)
US7368445B2 (en) 2004-03-01 2008-05-06 Eli Lilly And Company Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
BRPI0508397A (en) * 2004-03-05 2007-08-07 Taisho Pharma Co Ltd thiazole derivative or a pharmaceutically acceptable salt thereof, alk5 inhibitor, hair follicle proliferation enhancer, and hair growth enhancer or a hair growth agent
CN100584842C (en) 2004-03-05 2010-01-27 大正制药株式会社 Thiazole derivative
KR100749566B1 (en) * 2004-04-21 2007-08-16 에스케이케미칼주식회사 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 and/or ALK4 INHIBITORS
US20080319012A1 (en) 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2006028029A1 (en) * 2004-09-07 2006-03-16 Sankyo Company, Limited Substituted biphenyl derivative
KR20080040677A (en) * 2005-06-24 2008-05-08 제네랩스 테크놀로지스, 인코포레이티드 Heteroaryl derivatives for treating viruses
KR100694181B1 (en) * 2005-11-25 2007-03-12 연세대학교 산학협력단 Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compound useful for inducing neuron differentiation
WO2008071605A2 (en) * 2006-12-15 2008-06-19 F. Hoffmann-La Roche Ag Methods of treating inflammatory diseases
TW200911237A (en) 2007-08-03 2009-03-16 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
WO2009047163A1 (en) * 2007-10-10 2009-04-16 F. Hoffmann-La Roche Ag Methods of treating inflammatory diseases
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
AU2009227013B2 (en) * 2008-03-21 2013-01-10 Novartis Ag Novel heterocyclic compounds and uses therof
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
US8513222B2 (en) 2010-06-29 2013-08-20 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
AR083868A1 (en) 2010-12-03 2013-03-27 Lilly Co Eli Oxazole compounds [5,4-b] pyridin-5-yl
TR201808033T4 (en) 2011-07-13 2018-06-21 Tiumbio Co Ltd as ALK5 or ALK4 inhibitors and 2-pyridyl substituted imidazoles.
MX350442B (en) * 2011-07-29 2017-09-06 Karyopharm Therapeutics Inc Nuclear transport modulators and uses thereof.
PE20141170A1 (en) 2011-07-29 2014-09-16 Karyopharm Therapeutics Inc Nuclear transport modulators containing hydrazide and its uses
SG11201407268SA (en) 2012-05-09 2015-01-29 Karyopharm Therapeutics Inc Nuclear transport modulators and uses thereof
US9637723B2 (en) 2012-05-30 2017-05-02 Cornell University Q Generation of functional and durable endothelial cells from human amniotic fluid-derived cells
AU2013313282B2 (en) 2012-08-01 2018-02-01 Ikaika Therapeutics, Llc Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (LTBP4)
CN105229144A (en) 2013-02-22 2016-01-06 细胞动力学国际有限公司 By combination genetic engineering and chemical engineering via forward programming produce liver cell
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
WO2014144772A1 (en) 2013-03-15 2014-09-18 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
US9738624B2 (en) 2013-06-21 2017-08-22 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US20170107486A1 (en) 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
WO2015162084A1 (en) 2014-04-22 2015-10-29 Universitaet Basel Novel manufacturing process for triazine, pyrimidine and pyridine derivatives
AU2015301484B2 (en) 2014-08-15 2020-02-20 Karyopharm Therapeutics Inc. Polymorphs of selinexor
UY36294A (en) 2014-09-12 2016-04-29 Novartis Ag Compounds and compositions as kinase inhibitors
WO2017117535A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
EP3397633A1 (en) 2015-12-31 2018-11-07 Karyopharm Therapeutics, Inc. Nuclear transport modulators and uses thereof
WO2018132279A1 (en) * 2017-01-05 2018-07-19 Bristol-Myers Squibb Company Tgf beta receptor antagonists
WO2020132647A1 (en) 2018-12-21 2020-06-25 Northwestern University Use of annexins in preventing and treating muscle membrane injury

Family Cites Families (7)

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CH561717A5 (en) * 1971-05-10 1975-05-15 Ciba Geigy Ag
MX9300141A (en) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Imidazole compounds of novel, process for their preparation and pharmaceutical compositions containing it.
WO1995003297A1 (en) * 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
JPH09124640A (en) * 1995-08-25 1997-05-13 Nippon Soda Co Ltd Pyridylimidazole compound, production thereof and fungicide for agricultural and horticultural use
IL133766D0 (en) * 1997-06-30 2001-04-30 Ortho Mcneil Pharm Inc 2-substituted imidazoles useful in the treatment of inflammatory diseases
US6207687B1 (en) * 1998-07-31 2001-03-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity

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