ZA200403199B - Method for the treatment of overactive bladder. - Google Patents
Method for the treatment of overactive bladder. Download PDFInfo
- Publication number
- ZA200403199B ZA200403199B ZA200403199A ZA200403199A ZA200403199B ZA 200403199 B ZA200403199 B ZA 200403199B ZA 200403199 A ZA200403199 A ZA 200403199A ZA 200403199 A ZA200403199 A ZA 200403199A ZA 200403199 B ZA200403199 B ZA 200403199B
- Authority
- ZA
- South Africa
- Prior art keywords
- dichloromethane
- compound
- butyl
- methanol
- solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 29
- 206010020853 Hypertonic bladder Diseases 0.000 title claims description 7
- 208000009722 Overactive Urinary Bladder Diseases 0.000 title claims description 7
- 208000020629 overactive bladder Diseases 0.000 title claims description 7
- 238000011282 treatment Methods 0.000 title description 30
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- 206010046543 Urinary incontinence Diseases 0.000 claims description 4
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- 229910052736 halogen Inorganic materials 0.000 claims description 2
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- VFFLTVRGXRGMBA-UHFFFAOYSA-N benzyl 4-(2-oxo-1,3-diazinan-1-yl)piperidine-1-carboxylate Chemical compound C1CC(N2C(NCCC2)=O)CCN1C(=O)OCC1=CC=CC=C1 VFFLTVRGXRGMBA-UHFFFAOYSA-N 0.000 description 1
- SRAHAKLADOCBPU-UHFFFAOYSA-N benzyl 4-(3-aminopropylamino)piperidine-1-carboxylate Chemical compound C1CC(NCCCN)CCN1C(=O)OCC1=CC=CC=C1 SRAHAKLADOCBPU-UHFFFAOYSA-N 0.000 description 1
- IVFJQKSDUPXBIB-UHFFFAOYSA-N benzyl 4-(3-ethyl-2-oxo-1,3-diazinan-1-yl)piperidine-1-carboxylate Chemical compound O=C1N(CC)CCCN1C1CCN(C(=O)OCC=2C=CC=CC=2)CC1 IVFJQKSDUPXBIB-UHFFFAOYSA-N 0.000 description 1
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- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
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- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical compound NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
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- 238000009533 lab test Methods 0.000 description 1
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- 238000001819 mass spectrum Methods 0.000 description 1
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- 230000027939 micturition Effects 0.000 description 1
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- 239000003681 muscarinic M3 receptor antagonist Substances 0.000 description 1
- 239000003149 muscarinic antagonist Substances 0.000 description 1
- IIXYKSFDBKSCCT-GJICFQLNSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-(2-sulfanylidene-1,3-diazinan-1-yl)piperidin-1-yl]butyl]-n-methylbenzamide;dihydrochloride Chemical compound Cl.Cl.C([C@H](CN(C)C(=O)C=1C=CC=CC=1)C=1C=C(Cl)C(Cl)=CC=1)CN(CC1)CCC1N1CCCNC1=S IIXYKSFDBKSCCT-GJICFQLNSA-N 0.000 description 1
- YJFVWVVVQRRXJG-OAQYLSRUSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-[4-[(2,2,2-trifluoroacetyl)-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]piperidin-1-yl]butyl]-n-methylbenzamide Chemical compound C([C@H](CN(C)C(=O)C=1C=CC=CC=1)C=1C=C(Cl)C(Cl)=CC=1)CN1CCC(N(CCNC(=O)C(F)(F)F)C(=O)C(F)(F)F)CC1 YJFVWVVVQRRXJG-OAQYLSRUSA-N 0.000 description 1
- VLQIYTMUXAIPJQ-CQSZACIVSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]benzamide Chemical compound C([C@@H](CCO)C=1C=C(Cl)C(Cl)=CC=1)NC(=O)C1=CC=CC=C1 VLQIYTMUXAIPJQ-CQSZACIVSA-N 0.000 description 1
- LWMHCPBJEGVKTA-MRXNPFEDSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-oxobutyl]-n-ethylbenzamide Chemical compound C1([C@H](CC=O)CN(CC)C(=O)C=2C=CC=CC=2)=CC=C(Cl)C(Cl)=C1 LWMHCPBJEGVKTA-MRXNPFEDSA-N 0.000 description 1
- LEEARGALTPRPLU-OAHLLOKOSA-N n-[(2s)-2-(3,4-dichlorophenyl)-4-oxobutyl]-n-methylbenzamide Chemical compound C1([C@H](CC=O)CN(C)C(=O)C=2C=CC=CC=2)=CC=C(Cl)C(Cl)=C1 LEEARGALTPRPLU-OAHLLOKOSA-N 0.000 description 1
- BGBXPWXYNLFUCK-LJQANCHMSA-N n-[(2s)-4-[tert-butyl(dimethyl)silyl]oxy-2-(3,4-dichlorophenyl)butyl]benzamide Chemical compound C([C@@H](CCO[Si](C)(C)C(C)(C)C)C=1C=C(Cl)C(Cl)=CC=1)NC(=O)C1=CC=CC=C1 BGBXPWXYNLFUCK-LJQANCHMSA-N 0.000 description 1
- WBLYPMDGNCCKLM-UHFFFAOYSA-N n-[2-(3,4-dichlorophenyl)-4-[4-(2-oxo-1,3-diazinan-1-yl)piperidin-1-yl]butyl]-n-ethylbenzamide Chemical compound C=1C=CC=CC=1C(=O)N(CC)CC(C=1C=C(Cl)C(Cl)=CC=1)CCN(CC1)CCC1N1CCCNC1=O WBLYPMDGNCCKLM-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011165 process development Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229960003510 propiverine Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
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- 239000000523 sample Substances 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
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- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
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- 230000004936 stimulating effect Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
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- 230000002889 sympathetic effect Effects 0.000 description 1
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- 102100021774 tRNA-splicing endonuclease subunit Sen2 Human genes 0.000 description 1
- GKWHADZLLZJSEA-GFCCVEGCSA-N tert-butyl n-[(2s)-2-(3,4-dichlorophenyl)-4-hydroxybutyl]-n-methylcarbamate Chemical compound CC(C)(C)OC(=O)N(C)C[C@@H](CCO)C1=CC=C(Cl)C(Cl)=C1 GKWHADZLLZJSEA-GFCCVEGCSA-N 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- LJJKNPQAGWVLDQ-SNVBAGLBSA-N thiorphan Chemical compound OC(=O)CNC(=O)[C@@H](CS)CC1=CC=CC=C1 LJJKNPQAGWVLDQ-SNVBAGLBSA-N 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
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- 230000002485 urinary effect Effects 0.000 description 1
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- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0103668A SE0103668D0 (sv) | 2001-11-02 | 2001-11-02 | Method for the treatment of overactive blader |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200403199B true ZA200403199B (en) | 2005-02-09 |
Family
ID=20285870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200403199A ZA200403199B (en) | 2001-11-02 | 2004-04-28 | Method for the treatment of overactive bladder. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040248914A1 (ja) |
| EP (1) | EP1450805A1 (ja) |
| JP (1) | JP2005511561A (ja) |
| KR (1) | KR20050042211A (ja) |
| CN (1) | CN1622806A (ja) |
| BR (1) | BR0213776A (ja) |
| CA (1) | CA2465140A1 (ja) |
| IL (1) | IL161599A0 (ja) |
| MX (1) | MXPA04004071A (ja) |
| NO (1) | NO20042139L (ja) |
| SE (1) | SE0103668D0 (ja) |
| WO (1) | WO2003037341A1 (ja) |
| ZA (1) | ZA200403199B (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006121389A1 (en) * | 2005-05-10 | 2006-11-16 | Astrazeneca Ab | Use of a neurokinin-2 receptor antagonist for treating or preventing detrusor overactivity |
| US10441620B2 (en) * | 2016-09-21 | 2019-10-15 | Wellstrong Biotech Co., Ltd. | Method for protection of bladder from damage |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1170417B (de) * | 1960-11-08 | 1964-05-21 | Recip Ab | Verfahren zur Herstellung eines Diphenyl-butylamins mit die Coronargefaesse erweiternder Wirkung |
| US5382600A (en) * | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| GB9310713D0 (en) * | 1993-05-24 | 1993-07-07 | Zeneca Ltd | Aryl substituted heterocycles |
| GB9317104D0 (en) * | 1993-08-17 | 1993-09-29 | Zeneca Ltd | Therapeutic heterocycles |
| US6008223A (en) * | 1994-10-27 | 1999-12-28 | Zeneca Limited | Therapeutic compounds |
| GB9505084D0 (en) * | 1995-03-14 | 1995-05-03 | Pfizer Ltd | Benzamide derivative |
| GB9922519D0 (en) * | 1998-10-07 | 1999-11-24 | Zeneca Ltd | Compounds |
| GB9924141D0 (en) * | 1998-10-30 | 1999-12-15 | Zeneca Ltd | Treatment of gastric asthma |
| GB9826941D0 (en) * | 1998-12-09 | 1999-02-03 | Zeneca Pharmaceuticals | Compounds |
| GB0015246D0 (en) * | 2000-06-22 | 2000-08-16 | Astrazeneca Ab | Method for the treatment of urinary incontinence |
-
2001
- 2001-11-02 SE SE0103668A patent/SE0103668D0/xx unknown
-
2002
- 2002-11-01 EP EP02783903A patent/EP1450805A1/en not_active Withdrawn
- 2002-11-01 IL IL16159902A patent/IL161599A0/xx unknown
- 2002-11-01 US US10/494,387 patent/US20040248914A1/en not_active Abandoned
- 2002-11-01 KR KR1020047006519A patent/KR20050042211A/ko not_active Application Discontinuation
- 2002-11-01 MX MXPA04004071A patent/MXPA04004071A/es unknown
- 2002-11-01 CN CNA028266005A patent/CN1622806A/zh active Pending
- 2002-11-01 JP JP2003539684A patent/JP2005511561A/ja active Pending
- 2002-11-01 BR BR0213776-3A patent/BR0213776A/pt not_active IP Right Cessation
- 2002-11-01 CA CA002465140A patent/CA2465140A1/en not_active Abandoned
- 2002-11-01 WO PCT/SE2002/001990 patent/WO2003037341A1/en active Application Filing
-
2004
- 2004-04-28 ZA ZA200403199A patent/ZA200403199B/en unknown
- 2004-05-25 NO NO20042139A patent/NO20042139L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005511561A (ja) | 2005-04-28 |
| SE0103668D0 (sv) | 2001-11-02 |
| BR0213776A (pt) | 2004-11-09 |
| US20040248914A1 (en) | 2004-12-09 |
| CN1622806A (zh) | 2005-06-01 |
| CA2465140A1 (en) | 2003-05-08 |
| IL161599A0 (en) | 2004-09-27 |
| EP1450805A1 (en) | 2004-09-01 |
| WO2003037341A1 (en) | 2003-05-08 |
| NO20042139L (no) | 2004-06-25 |
| KR20050042211A (ko) | 2005-05-06 |
| MXPA04004071A (es) | 2004-09-06 |
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| WO1996032370A1 (fr) | Derives du 4-amino-5-oxy-2,6,6-trimethyl-2-cycloheptene |