ZA200309287B - Process for the preparation of amorphous cilastatin sodium. - Google Patents
Process for the preparation of amorphous cilastatin sodium. Download PDFInfo
- Publication number
- ZA200309287B ZA200309287B ZA200309287A ZA200309287A ZA200309287B ZA 200309287 B ZA200309287 B ZA 200309287B ZA 200309287 A ZA200309287 A ZA 200309287A ZA 200309287 A ZA200309287 A ZA 200309287A ZA 200309287 B ZA200309287 B ZA 200309287B
- Authority
- ZA
- South Africa
- Prior art keywords
- cilastatin
- solvent
- sodium
- cilastatin sodium
- solution
- Prior art date
Links
- 229960003716 cilastatin sodium Drugs 0.000 title claims description 43
- JSAKRLDIZOGQTN-UHFFFAOYSA-M 4-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate Chemical compound OC1=C(C2=CC=CC=C2C=C1)N=NC1=CC=C(C2=CC=CC=C12)S(=O)(=O)[O-] JSAKRLDIZOGQTN-UHFFFAOYSA-M 0.000 title claims description 42
- 238000000034 method Methods 0.000 title claims description 30
- 238000002360 preparation method Methods 0.000 title claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 39
- 239000002904 solvent Substances 0.000 claims description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 20
- 239000012296 anti-solvent Substances 0.000 claims description 12
- 229960004912 cilastatin Drugs 0.000 claims description 10
- DHSUYTOATWAVLW-WFVMDLQDSA-N cilastatin Chemical compound CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O DHSUYTOATWAVLW-WFVMDLQDSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 5
- 239000008240 homogeneous mixture Substances 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000011541 reaction mixture Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 description 6
- 238000004108 freeze drying Methods 0.000 description 5
- 239000002002 slurry Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- NCCJWSXETVVUHK-ZYSAIPPVSA-N (z)-7-[(2r)-2-amino-2-carboxyethyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(5r,6s)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound C1C(SCC\N=C/N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21.CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O NCCJWSXETVVUHK-ZYSAIPPVSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- YURNCBVQZBJDAJ-UHFFFAOYSA-N 2-heptenoic acid Chemical compound CCCCC=CC(O)=O YURNCBVQZBJDAJ-UHFFFAOYSA-N 0.000 description 1
- 206010005940 Bone and joint infections Diseases 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 208000002633 Febrile Neutropenia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- XFDKZPGJKMURRP-UHFFFAOYSA-M [Na+].NC(C(=O)[O-])=CCCCC Chemical compound [Na+].NC(C(=O)[O-])=CCCCC XFDKZPGJKMURRP-UHFFFAOYSA-M 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 1
- 229940041011 carbapenems Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 125000000774 cystein-S-yl group Chemical group 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 1
- 229960002182 imipenem Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/02—Monohydroxylic acyclic alcohols
- C07C31/04—Methanol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN593DE2001 | 2001-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200309287B true ZA200309287B (en) | 2004-07-22 |
Family
ID=11097060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200309287A ZA200309287B (en) | 2001-05-18 | 2003-11-28 | Process for the preparation of amorphous cilastatin sodium. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20040152780A1 (no) |
| EP (1) | EP1395530A4 (no) |
| JP (1) | JP2004526805A (no) |
| KR (1) | KR20040044409A (no) |
| CN (1) | CN1522235A (no) |
| AP (2) | AP1511A (no) |
| AR (1) | AR036017A1 (no) |
| BG (1) | BG108447A (no) |
| BR (1) | BR0209843A (no) |
| CA (1) | CA2447788A1 (no) |
| CZ (1) | CZ20033352A3 (no) |
| EA (1) | EA005947B1 (no) |
| EE (1) | EE200300567A (no) |
| HR (1) | HRP20031052A2 (no) |
| HU (1) | HUP0400825A2 (no) |
| IL (1) | IL158945A0 (no) |
| MX (1) | MXPA03010547A (no) |
| NO (1) | NO20035138D0 (no) |
| NZ (1) | NZ529625A (no) |
| OA (1) | OA12607A (no) |
| PL (1) | PL367937A1 (no) |
| SK (1) | SK15082003A3 (no) |
| WO (1) | WO2002094742A1 (no) |
| ZA (1) | ZA200309287B (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2402312B1 (en) | 2005-11-09 | 2013-07-17 | Orchid Chemicals&Pharmaceuticals Limited | An improved process for the preparation of cilastatin acid |
| WO2011080648A1 (en) * | 2010-01-01 | 2011-07-07 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of cilastatin sodium |
| CN102675175B (zh) * | 2011-03-08 | 2014-02-19 | 深圳市海滨制药有限公司 | 一种西司他丁的分离纯化方法 |
| US11324804B2 (en) | 2016-11-18 | 2022-05-10 | Sepsia Therapeutics, S.L. | Combined CD6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5147868A (en) * | 1978-07-24 | 1992-09-15 | Merck & Co., Inc. | Thienamycin renal peptidase inhibitors |
| US4292436A (en) * | 1980-06-25 | 1981-09-29 | Merck & Co., Inc. | Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol |
| EP0441371B1 (en) * | 1990-02-08 | 1995-01-25 | Sumitomo Chemical Company, Limited | Process for preparing haloketo acid derivatives |
| US5166417A (en) * | 1990-09-04 | 1992-11-24 | Lonza Ltd. | Process for resolution of racemates of 2,2-dimethylcyclopropanecarboxylic acid |
| CA2056840A1 (en) * | 1990-12-17 | 1992-06-18 | Thomas Meul | Process for the production of dimethylcyclopropanecarboxylic acid |
| DE59209523D1 (de) * | 1991-07-26 | 1998-11-19 | Lonza Ag | Gentechnologisches Verfahren zur Herstellung von S-(+)-2,2-Dimethylcyclopropancarboxamid mittels Mikroorganismen |
| US5245069A (en) * | 1992-10-27 | 1993-09-14 | Merck & Co., Inc. | Process for the preparation of bis(aryl)-phosphorohalidates |
| IN191798B (no) * | 2000-11-03 | 2004-01-03 | Ranbaxy Lab Ltd |
-
2002
- 2002-05-17 BR BR0209843-1A patent/BR0209843A/pt not_active IP Right Cessation
- 2002-05-17 OA OA1200300301A patent/OA12607A/en unknown
- 2002-05-17 WO PCT/IB2002/001696 patent/WO2002094742A1/en not_active Application Discontinuation
- 2002-05-17 PL PL02367937A patent/PL367937A1/xx not_active Application Discontinuation
- 2002-05-17 CN CNA028131096A patent/CN1522235A/zh active Pending
- 2002-05-17 CA CA002447788A patent/CA2447788A1/en not_active Abandoned
- 2002-05-17 EP EP02727916A patent/EP1395530A4/en not_active Withdrawn
- 2002-05-17 EA EA200301225A patent/EA005947B1/ru not_active IP Right Cessation
- 2002-05-17 MX MXPA03010547A patent/MXPA03010547A/es not_active Application Discontinuation
- 2002-05-17 CZ CZ20033352A patent/CZ20033352A3/cs unknown
- 2002-05-17 HU HU0400825A patent/HUP0400825A2/hu unknown
- 2002-05-17 AP APAP/P/2003/002913A patent/AP1511A/en active
- 2002-05-17 IL IL15894502A patent/IL158945A0/xx unknown
- 2002-05-17 JP JP2002591417A patent/JP2004526805A/ja not_active Withdrawn
- 2002-05-17 AP APAP/P/2003/002912A patent/AP2003002912A0/en unknown
- 2002-05-17 KR KR10-2003-7015042A patent/KR20040044409A/ko not_active Application Discontinuation
- 2002-05-17 NZ NZ529625A patent/NZ529625A/en unknown
- 2002-05-17 US US10/478,081 patent/US20040152780A1/en not_active Abandoned
- 2002-05-17 SK SK1508-2003A patent/SK15082003A3/sk unknown
- 2002-05-17 EE EEP200300567A patent/EE200300567A/xx unknown
- 2002-05-20 AR ARP020101853A patent/AR036017A1/es not_active Application Discontinuation
-
2003
- 2003-11-18 NO NO20035138A patent/NO20035138D0/no not_active Application Discontinuation
- 2003-11-28 ZA ZA200309287A patent/ZA200309287B/en unknown
- 2003-12-12 BG BG108447A patent/BG108447A/xx unknown
- 2003-12-17 HR HR20031052A patent/HRP20031052A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA005947B1 (ru) | 2005-08-25 |
| MXPA03010547A (es) | 2004-05-27 |
| CN1522235A (zh) | 2004-08-18 |
| EA200301225A1 (ru) | 2004-06-24 |
| AR036017A1 (es) | 2004-08-04 |
| PL367937A1 (en) | 2005-03-07 |
| EE200300567A (et) | 2004-04-15 |
| EP1395530A1 (en) | 2004-03-10 |
| US20040152780A1 (en) | 2004-08-05 |
| SK15082003A3 (sk) | 2004-06-08 |
| NO20035138D0 (no) | 2003-11-18 |
| CA2447788A1 (en) | 2002-11-28 |
| BG108447A (en) | 2005-03-31 |
| AP2003002913A0 (en) | 2003-12-31 |
| OA12607A (en) | 2006-06-08 |
| CZ20033352A3 (en) | 2004-06-16 |
| HUP0400825A2 (hu) | 2004-08-30 |
| IL158945A0 (en) | 2004-05-12 |
| EP1395530A4 (en) | 2006-01-18 |
| BR0209843A (pt) | 2004-08-24 |
| HRP20031052A2 (en) | 2004-06-30 |
| KR20040044409A (ko) | 2004-05-28 |
| AP2003002912A0 (en) | 2002-05-17 |
| JP2004526805A (ja) | 2004-09-02 |
| NZ529625A (en) | 2006-02-24 |
| WO2002094742A1 (en) | 2002-11-28 |
| AP1511A (en) | 2005-12-20 |
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