EA200301225A1 - Способ получения аморфного циластатин-натрия - Google Patents

Способ получения аморфного циластатин-натрия

Info

Publication number
EA200301225A1
EA200301225A1 EA200301225A EA200301225A EA200301225A1 EA 200301225 A1 EA200301225 A1 EA 200301225A1 EA 200301225 A EA200301225 A EA 200301225A EA 200301225 A EA200301225 A EA 200301225A EA 200301225 A1 EA200301225 A1 EA 200301225A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sodium
cylastatin
obtaining amorphous
amorphous
obtaining
Prior art date
Application number
EA200301225A
Other languages
English (en)
Other versions
EA005947B1 (ru
Inventor
Ятендра Кумар
Ом Дутт Тиаги
Амит Рохтаги
Original Assignee
Рэнбакси Лабораториз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рэнбакси Лабораториз Лимитед filed Critical Рэнбакси Лабораториз Лимитед
Publication of EA200301225A1 publication Critical patent/EA200301225A1/ru
Publication of EA005947B1 publication Critical patent/EA005947B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/02—Monohydroxylic acyclic alcohols
    • C07C31/04—Methanol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение относится к экономически эффективному и выгодному с точки зрения промышленного производства способу получения аморфного циластатин-натрия.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301225A 2001-05-18 2002-05-17 Способ получения аморфного циластатин-натрия EA005947B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN593DE2001 2001-05-18
PCT/IB2002/001696 WO2002094742A1 (en) 2001-05-18 2002-05-17 Process for the preparation of amorphous cilastatin sodium

Publications (2)

Publication Number Publication Date
EA200301225A1 true EA200301225A1 (ru) 2004-06-24
EA005947B1 EA005947B1 (ru) 2005-08-25

Family

ID=11097060

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301225A EA005947B1 (ru) 2001-05-18 2002-05-17 Способ получения аморфного циластатин-натрия

Country Status (24)

Country Link
US (1) US20040152780A1 (ru)
EP (1) EP1395530A4 (ru)
JP (1) JP2004526805A (ru)
KR (1) KR20040044409A (ru)
CN (1) CN1522235A (ru)
AP (2) AP1511A (ru)
AR (1) AR036017A1 (ru)
BG (1) BG108447A (ru)
BR (1) BR0209843A (ru)
CA (1) CA2447788A1 (ru)
CZ (1) CZ20033352A3 (ru)
EA (1) EA005947B1 (ru)
EE (1) EE200300567A (ru)
HR (1) HRP20031052A2 (ru)
HU (1) HUP0400825A2 (ru)
IL (1) IL158945A0 (ru)
MX (1) MXPA03010547A (ru)
NO (1) NO20035138D0 (ru)
NZ (1) NZ529625A (ru)
OA (1) OA12607A (ru)
PL (1) PL367937A1 (ru)
SK (1) SK15082003A3 (ru)
WO (1) WO2002094742A1 (ru)
ZA (1) ZA200309287B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009514939A (ja) * 2005-11-09 2009-04-09 オーキッド ケミカルズ アンド ファーマスーティカルズ リミテッド シラスタチン及びナトリウム塩の調製用の改善された工程
US20120253066A1 (en) * 2010-01-01 2012-10-04 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cilastatin sodium
CN102675175B (zh) * 2011-03-08 2014-02-19 深圳市海滨制药有限公司 一种西司他丁的分离纯化方法
JP2019535834A (ja) * 2016-11-18 2019-12-12 ユニベルシタ デ バルセロナ 感染症及び関連炎症プロセスの処置のためのｃｄ６及びイミペネムの併用療法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147868A (en) * 1978-07-24 1992-09-15 Merck & Co., Inc. Thienamycin renal peptidase inhibitors
US4292436A (en) * 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
DE69106897T2 (de) * 1990-02-08 1995-05-24 Sumitomo Chemical Co Verfahren zur Herstellung von Haloketosäureabkömmlingen.
US5166417A (en) * 1990-09-04 1992-11-24 Lonza Ltd. Process for resolution of racemates of 2,2-dimethylcyclopropanecarboxylic acid
CA2056840A1 (en) * 1990-12-17 1992-06-18 Thomas Meul Process for the production of dimethylcyclopropanecarboxylic acid
EP0524604B1 (de) * 1991-07-26 1998-10-14 Lonza A.G. Gentechnologisches Verfahren zur Herstellung von S-(+)-2,2-Dimethylcyclopropancarboxamid mittels Mikroorganismen
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (ru) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
PL367937A1 (en) 2005-03-07
BG108447A (en) 2005-03-31
NZ529625A (en) 2006-02-24
MXPA03010547A (es) 2004-05-27
HRP20031052A2 (en) 2004-06-30
EP1395530A1 (en) 2004-03-10
EA005947B1 (ru) 2005-08-25
AP2003002912A0 (en) 2002-05-17
OA12607A (en) 2006-06-08
US20040152780A1 (en) 2004-08-05
CN1522235A (zh) 2004-08-18
SK15082003A3 (sk) 2004-06-08
AR036017A1 (es) 2004-08-04
BR0209843A (pt) 2004-08-24
IL158945A0 (en) 2004-05-12
WO2002094742A1 (en) 2002-11-28
EP1395530A4 (en) 2006-01-18
JP2004526805A (ja) 2004-09-02
NO20035138D0 (no) 2003-11-18
HUP0400825A2 (hu) 2004-08-30
CZ20033352A3 (en) 2004-06-16
CA2447788A1 (en) 2002-11-28
AP2003002913A0 (en) 2003-12-31
ZA200309287B (en) 2004-07-22
KR20040044409A (ko) 2004-05-28
AP1511A (en) 2005-12-20
EE200300567A (et) 2004-04-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU