ZA200308930B - Novel phthalazinones. - Google Patents
Novel phthalazinones. Download PDFInfo
- Publication number
- ZA200308930B ZA200308930B ZA200308930A ZA200308930A ZA200308930B ZA 200308930 B ZA200308930 B ZA 200308930B ZA 200308930 A ZA200308930 A ZA 200308930A ZA 200308930 A ZA200308930 A ZA 200308930A ZA 200308930 B ZA200308930 B ZA 200308930B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- phenyl
- alkoxy
- mono
- compounds
- Prior art date
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- -1 N-methylpiperidyl Chemical group 0.000 claims description 113
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| EP01110228 | 2001-04-25 |
Publications (1)
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| ZA200308930B true ZA200308930B (en) | 2004-06-09 |
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| EE05386B1 (et) | 2001-02-15 | 2011-02-15 | ALTANA�Pharma�AG | Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim |
| EP1385838A1 (en) * | 2001-04-25 | 2004-02-04 | ALTANA Pharma AG | Piperazino-derivatives and their use as pde4 inhibitor |
| WO2004018457A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| WO2004018450A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| US20060167001A1 (en) * | 2002-08-10 | 2006-07-27 | Sterk Jan G | Pyridazinone-derivatives as pde4 inhibitors |
| JP4778449B2 (ja) * | 2004-02-04 | 2011-09-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｐｄｅ４インヒビターとしての２−（ピペリジン−４−イル）−４，５−ジヒドロ−２ｈ−ピリダジン−３−オン誘導体 |
| EP1716123A1 (en) * | 2004-02-04 | 2006-11-02 | Altana Pharma AG | Pyridazinone derivatives and their use as pde4 inhibitors |
| WO2006004188A1 (en) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Pyrazolopyridine derivatives |
| RU2007143049A (ru) * | 2005-04-21 | 2009-05-27 | Ниппон Синяку Ко., Лтд. (Jp) | Производное фталазинона и содержащая его фармацевтическая композиция |
| ES2308916B1 (es) | 2007-03-22 | 2009-10-29 | Consejo Superior De Investigaciones Cientificas | Compuesto inhibidor dual de las enzimas pde7 y/o pde4, composiciones farmaceuticas y sus aplicaciones. |
| US8637528B2 (en) * | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| US20080260643A1 (en) * | 2007-03-27 | 2008-10-23 | Omeros Corporation | Use of pde7 inhibitors for the treatment of movement disorders |
| ES2374337T3 (es) | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | Derivados de pirazolona como inhibidores de pde4. |
| AR074318A1 (es) | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| ES2392488T3 (es) | 2008-11-20 | 2012-12-11 | Genentech, Inc. | Compuestos inhibidores de PI3K de tipo pirazolopiridina y sus procedimientos de uso |
| AU2011326173B2 (en) | 2010-11-08 | 2015-08-27 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| ME02598B (me) | 2011-02-07 | 2017-06-20 | Scipharm Sarl | Nova kompozicija za lečenje cistične fibroze |
| BR112013031791A2 (pt) | 2011-06-17 | 2017-01-31 | Takeda Gmbh | derivados de ftalazinona-pirrolopirimidinacarboxamida |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CN102964340B (zh) * | 2012-12-12 | 2015-10-07 | 中国药科大学 | 一类治疗阿尔茨海默病的选择性多巴胺d1受体激动剂 |
| CA2906008C (en) | 2013-03-13 | 2019-07-09 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
| CN112876460B (zh) * | 2021-02-05 | 2022-05-31 | 山西大学 | 7-二乙胺基-3-乙酰基香豆素衍生物及其合成方法和应用 |
| WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
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| DK0612321T3 (da) * | 1991-10-09 | 1999-12-13 | Syntex Inc | Pyridopyridazinon- og pyridazinthionforbindelser med PDE IV inhiberende aktivitet |
| US5716954A (en) | 1991-10-09 | 1998-02-10 | Syntex U.S.A. Inc. | Benzopyridazinone and pyridopyridazinone compounds |
| DE69332762T2 (de) | 1992-12-02 | 2003-08-14 | Pfizer Inc., New York | Cathecoldiether als selektive pde iv hemmungsmittel |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| ATE233247T1 (de) * | 1997-01-15 | 2003-03-15 | Altana Pharma Ag | Phtalazinonen |
| AU1760399A (en) * | 1997-12-15 | 1999-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| AU753576B2 (en) | 1997-12-15 | 2002-10-24 | Altana Pharma Ag | Dihydrobenzofurans |
| EP0934933A1 (en) | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
| ES2224628T3 (es) * | 1998-03-14 | 2005-03-01 | Altana Pharma Ag | Inhibidores de pde iii/iv a base de ftalazinonas. |
| WO2001019818A1 (en) | 1999-09-14 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| IL148807A0 (en) | 1999-10-25 | 2002-09-12 | Byk Gulden Lomberg Chem Fab | Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same |
| ATE374189T1 (de) * | 1999-10-25 | 2007-10-15 | Nycomed Gmbh | Phthalazinon-derivate als pde 4 hemmer |
| PL358057A1 (en) | 2000-06-05 | 2004-08-09 | Altana Pharma Ag | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
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Also Published As
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| WO2002085906A3 (en) | 2002-12-19 |
| KR20040008162A (ko) | 2004-01-28 |
| CN1503792A (zh) | 2004-06-09 |
| BG108294A (bg) | 2004-09-30 |
| AU2002317733B2 (en) | 2007-12-13 |
| WO2002085906A2 (en) | 2002-10-31 |
| EE200300514A (et) | 2004-02-16 |
| HRP20030868A2 (en) | 2005-08-31 |
| MXPA03009583A (es) | 2004-02-12 |
| PL363312A1 (en) | 2004-11-15 |
| SK14342003A3 (sk) | 2004-05-04 |
| EA200301100A1 (ru) | 2004-06-24 |
| US20040127707A1 (en) | 2004-07-01 |
| CZ299347B6 (cs) | 2008-06-25 |
| BR0209149A (pt) | 2004-07-13 |
| EP1385848A2 (en) | 2004-02-04 |
| IL157908A0 (en) | 2004-03-28 |
| HUP0303998A3 (en) | 2007-03-28 |
| CZ20033206A3 (cs) | 2004-02-18 |
| US7186710B2 (en) | 2007-03-06 |
| NO20034773D0 (no) | 2003-10-24 |
| HUP0303998A2 (hu) | 2004-05-28 |
| NO20034773L (no) | 2003-12-10 |
| CA2445233A1 (en) | 2002-10-31 |
| NZ529221A (en) | 2005-04-29 |
| JP2004526789A (ja) | 2004-09-02 |
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