ZA200308930B - Novel phthalazinones. - Google Patents
Novel phthalazinones. Download PDFInfo
- Publication number
- ZA200308930B ZA200308930B ZA200308930A ZA200308930A ZA200308930B ZA 200308930 B ZA200308930 B ZA 200308930B ZA 200308930 A ZA200308930 A ZA 200308930A ZA 200308930 A ZA200308930 A ZA 200308930A ZA 200308930 B ZA200308930 B ZA 200308930B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- phenyl
- alkoxy
- mono
- compounds
- Prior art date
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- -1 N-methylpiperidyl Chemical group 0.000 claims description 113
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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| EP01110228 | 2001-04-25 |
Publications (1)
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| ZA200308930B true ZA200308930B (en) | 2004-06-09 |
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| JP (1) | JP2004526789A (de) |
| KR (1) | KR20040008162A (de) |
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| SK (1) | SK14342003A3 (de) |
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| ZA (1) | ZA200308930B (de) |
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| AU2002234634B2 (en) | 2001-02-15 | 2007-07-26 | Takeda Gmbh | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| CA2445236A1 (en) * | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Piperazino-derivatives and their use as pde4 inhibitor |
| CA2494643A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| WO2004018449A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
| US20060167001A1 (en) * | 2002-08-10 | 2006-07-27 | Sterk Jan G | Pyridazinone-derivatives as pde4 inhibitors |
| CA2494634A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Piperidine-pyridazones and phthalazones as pde4 inhibitors |
| WO2005075437A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Pyridazinone derivatives and their use as pde4 inhibitors |
| AU2005210042B2 (en) * | 2004-02-04 | 2011-04-21 | Takeda Gmbh | 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors |
| MXPA06014699A (es) * | 2004-07-05 | 2007-03-26 | Astellas Pharma Inc | Derivados de pirazolo-piridina. |
| WO2006115221A1 (ja) * | 2005-04-21 | 2006-11-02 | Nippon Shinyaku Co., Ltd. | フタラジノン誘導体及びその医薬 |
| ES2308916B1 (es) | 2007-03-22 | 2009-10-29 | Consejo Superior De Investigaciones Cientificas | Compuesto inhibidor dual de las enzimas pde7 y/o pde4, composiciones farmaceuticas y sus aplicaciones. |
| ES2533206T3 (es) * | 2007-03-27 | 2015-04-08 | Omeros Corporation | Inhibidores de PDE7 para uso en el tratamiento de trastornos del movimiento |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| RS52074B (en) | 2007-05-16 | 2012-06-30 | Nycomed Gmbh | PIRAZOLONE DERIVATED AS PDE4 INHIBITORS |
| AR074318A1 (es) | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| US8653098B2 (en) | 2008-11-20 | 2014-02-18 | Genentech, Inc. | Pyrazolopyridine PI3K inhibitor compounds and methods of use |
| MX2013004943A (es) | 2010-11-08 | 2013-09-02 | Omeros Corp | Tratamiento de trastornos de adicion y control de impulsos usando inhibidores de pde7. |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| SI2672957T1 (sl) | 2011-02-07 | 2017-03-31 | Scipharm Sarl | Nova sestava za zdravljenje cistične fibroze |
| WO2012171900A1 (en) | 2011-06-17 | 2012-12-20 | Nycomed Gmbh | Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CN102964340B (zh) * | 2012-12-12 | 2015-10-07 | 中国药科大学 | 一类治疗阿尔茨海默病的选择性多巴胺d1受体激动剂 |
| WO2014160440A1 (en) | 2013-03-13 | 2014-10-02 | Flatley Discovery Lab | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
| CN112876460B (zh) * | 2021-02-05 | 2022-05-31 | 山西大学 | 7-二乙胺基-3-乙酰基香豆素衍生物及其合成方法和应用 |
| WO2024038090A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
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| US5716954A (en) | 1991-10-09 | 1998-02-10 | Syntex U.S.A. Inc. | Benzopyridazinone and pyridopyridazinone compounds |
| PT100938B (pt) * | 1991-10-09 | 1999-10-29 | Syntex Inc | Compostos benzo e pirido piridazinona e piridazintiona, composicoes farmaceuticas que os contem, utilizacao dos referidos compostos e processo para a sua preparacao. |
| BR9307570A (pt) | 1992-12-02 | 1999-05-25 | Pfizer | Diéteres de catecol como inibidores seletivos de pdeiv |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| SI0971901T1 (en) * | 1997-01-15 | 2003-10-31 | Altana Pharma Ag | Phthalazinones |
| AU1760399A (en) * | 1997-12-15 | 1999-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| CA2314111A1 (en) | 1997-12-15 | 1999-06-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurans |
| EP0934933A1 (de) | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinone |
| AU3328499A (en) | 1998-03-14 | 1999-10-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone pde iii/iv inhibitors |
| WO2001019818A1 (en) | 1999-09-14 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinone derivatives as pd3/4 inhibitors |
| EP1244654A1 (de) | 1999-10-25 | 2002-10-02 | ALTANA Pharma AG | Tetrahydrothiopyranphthalazinon-derivate als pde 4 hemmer |
| AU781503B2 (en) | 1999-10-25 | 2005-05-26 | Altana Pharma Ag | Phthalazinone derivatives as PDE 4 inhibitors |
| KR20030031907A (ko) | 2000-06-05 | 2003-04-23 | 알타나 파마 아게 | β-2-아드레날린 수용체 작동물질로서 뿐만 아니라ＰＤＥ4-억제제로서 효과적인 화합물 |
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Also Published As
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| JP2004526789A (ja) | 2004-09-02 |
| CN1503792A (zh) | 2004-06-09 |
| BR0209149A (pt) | 2004-07-13 |
| EE200300514A (et) | 2004-02-16 |
| EA200301100A1 (ru) | 2004-06-24 |
| US7186710B2 (en) | 2007-03-06 |
| CZ299347B6 (cs) | 2008-06-25 |
| CZ20033206A3 (cs) | 2004-02-18 |
| US20040127707A1 (en) | 2004-07-01 |
| CA2445233A1 (en) | 2002-10-31 |
| EP1385848A2 (de) | 2004-02-04 |
| WO2002085906A2 (en) | 2002-10-31 |
| BG108294A (bg) | 2004-09-30 |
| SK14342003A3 (sk) | 2004-05-04 |
| WO2002085906A3 (en) | 2002-12-19 |
| HUP0303998A2 (hu) | 2004-05-28 |
| AU2002317733B2 (en) | 2007-12-13 |
| NO20034773L (no) | 2003-12-10 |
| NO20034773D0 (no) | 2003-10-24 |
| NZ529221A (en) | 2005-04-29 |
| HUP0303998A3 (en) | 2007-03-28 |
| IL157908A0 (en) | 2004-03-28 |
| HRP20030868A2 (en) | 2005-08-31 |
| MXPA03009583A (es) | 2004-02-12 |
| PL363312A1 (en) | 2004-11-15 |
| KR20040008162A (ko) | 2004-01-28 |
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