ZA200306727B - Aryl and biaryl compounds having MCH modulatory activity. - Google Patents
Aryl and biaryl compounds having MCH modulatory activity. Download PDFInfo
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- ZA200306727B ZA200306727B ZA200306727A ZA200306727A ZA200306727B ZA 200306727 B ZA200306727 B ZA 200306727B ZA 200306727 A ZA200306727 A ZA 200306727A ZA 200306727 A ZA200306727 A ZA 200306727A ZA 200306727 B ZA200306727 B ZA 200306727B
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- South Africa
- Prior art keywords
- compound
- composition
- group
- prodrug
- pharmaceutically acceptable
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- -1 biaryl compounds Chemical class 0.000 title claims description 31
- 125000003118 aryl group Chemical group 0.000 title claims description 14
- 230000000694 effects Effects 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 191
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- 239000000651 prodrug Substances 0.000 claims description 47
- 229940002612 prodrug Drugs 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 45
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Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
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- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07D207/12—Oxygen or sulfur atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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- Organic Chemistry (AREA)
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- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
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FR2676054B1 (fr) | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
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- 2002-03-19 CA CA2441235A patent/CA2441235C/en not_active Expired - Fee Related
- 2002-03-19 IL IL15745602A patent/IL157456A0/xx unknown
- 2002-03-19 JP JP2002576192A patent/JP4557492B2/ja not_active Expired - Fee Related
- 2002-03-19 EP EP02715150A patent/EP1370520A1/en not_active Withdrawn
- 2002-03-19 US US10/101,136 patent/US7034056B2/en not_active Expired - Fee Related
- 2002-03-19 WO PCT/US2002/008300 patent/WO2002076929A1/en active IP Right Grant
- 2002-03-19 HU HU0400252A patent/HUP0400252A3/hu unknown
- 2002-03-19 NZ NZ527680A patent/NZ527680A/en unknown
- 2002-03-19 AU AU2002247367A patent/AU2002247367B2/en not_active Expired - Fee Related
- 2002-03-19 CN CNB028068955A patent/CN100537527C/zh not_active Expired - Fee Related
- 2002-03-19 MX MXPA03008484A patent/MXPA03008484A/es active IP Right Grant
- 2002-03-19 KR KR10-2003-7012219A patent/KR20030093257A/ko not_active Application Discontinuation
-
2003
- 2003-08-28 ZA ZA200306727A patent/ZA200306727B/en unknown
-
2009
- 2009-10-05 JP JP2009232046A patent/JP2010001316A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
HUP0400252A2 (hu) | 2004-08-30 |
HUP0400252A3 (en) | 2011-09-28 |
IL157456A0 (en) | 2004-03-28 |
JP2004526736A (ja) | 2004-09-02 |
CN1498205A (zh) | 2004-05-19 |
CA2441235C (en) | 2011-05-24 |
US7034056B2 (en) | 2006-04-25 |
KR20030093257A (ko) | 2003-12-06 |
NZ527680A (en) | 2005-07-29 |
CN100537527C (zh) | 2009-09-09 |
WO2002076929A1 (en) | 2002-10-03 |
AU2002247367B2 (en) | 2005-10-27 |
CA2441235A1 (en) | 2002-10-03 |
JP4557492B2 (ja) | 2010-10-06 |
US20030092715A1 (en) | 2003-05-15 |
JP2010001316A (ja) | 2010-01-07 |
EP1370520A1 (en) | 2003-12-17 |
MXPA03008484A (es) | 2003-12-08 |
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