HUP0400252A2 - MCH modulátor hatású aril- és biaril-vegyületek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra - Google Patents

MCH modulátor hatású aril- és biaril-vegyületek, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

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Publication number
HUP0400252A2
HUP0400252A2 HU0400252A HUP0400252A HUP0400252A2 HU P0400252 A2 HUP0400252 A2 HU P0400252A2 HU 0400252 A HU0400252 A HU 0400252A HU P0400252 A HUP0400252 A HU P0400252A HU P0400252 A2 HUP0400252 A2 HU P0400252A2
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Hungary
Prior art keywords
compounds
aryl
producing
pharmaceutical compositions
compositions containing
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HU0400252A
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English (en)
Inventor
Huizhong Gu
Tao Guo
Douglas W. Hobbs
Rachael C. Hunter
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Pharmacopeia, Inc.
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Application filed by Pharmacopeia, Inc. filed Critical Pharmacopeia, Inc.
Publication of HUP0400252A2 publication Critical patent/HUP0400252A2/hu
Publication of HUP0400252A3 publication Critical patent/HUP0400252A3/hu

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

A találmány tárgya új, MCH receptor antagonista aktivitással bíró, (I)általános képletű vegyületek, továbbá a vegyületek előállításieljárásai, egy vagy több ilyen típusú vegyületet, ezek izomereit vagysóit, valamint ezek mellett egyéb vegyületeket, például b3 agonistát,thiromimetikus szert, elhízás elleni szert vagy étvágycsökkentő szertés NPY antagonista szereket tartalmazó gyógyszerkészítmények, ezekelőállítása és alkalmazása képezi. A találmány szerinti vegyületeklegelőnyösebbje a képletű vegyület. Ó
HU0400252A 2001-03-21 2002-03-19 Aryl and biaryl compounds having mch modulatory activity, pharmaceutical compositions containing them and process for producing them HUP0400252A3 (en)

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IL157456A0 (en) 2004-03-28
JP4557492B2 (ja) 2010-10-06
NZ527680A (en) 2005-07-29
CN100537527C (zh) 2009-09-09
KR20030093257A (ko) 2003-12-06
WO2002076929A1 (en) 2002-10-03
CA2441235C (en) 2011-05-24
AU2002247367B2 (en) 2005-10-27
ZA200306727B (en) 2004-11-29
US20030092715A1 (en) 2003-05-15
HUP0400252A3 (en) 2011-09-28
JP2010001316A (ja) 2010-01-07
JP2004526736A (ja) 2004-09-02
CA2441235A1 (en) 2002-10-03
EP1370520A1 (en) 2003-12-17
CN1498205A (zh) 2004-05-19
MXPA03008484A (es) 2003-12-08

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