ZA200306173B - Treatment of refactory tumors using epothilone derivatives. - Google Patents
Treatment of refactory tumors using epothilone derivatives. Download PDFInfo
- Publication number
- ZA200306173B ZA200306173B ZA200306173A ZA200306173A ZA200306173B ZA 200306173 B ZA200306173 B ZA 200306173B ZA 200306173 A ZA200306173 A ZA 200306173A ZA 200306173 A ZA200306173 A ZA 200306173A ZA 200306173 B ZA200306173 B ZA 200306173B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- dihydroxy
- thiazolyl
- ethenyl
- dione
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EE200300323A (et) | 2001-01-25 | 2003-10-15 | Bristol-Myers Squibb Company | Epotilooni analoogi sisaldav parenteraalne ravimpreparaat, meetod selle valmistamiseks ning kasutamine |
| WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| DK1506203T3 (da) * | 2002-08-23 | 2007-05-14 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| AU2003279911A1 (en) | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
| TW200503738A (en) * | 2003-07-16 | 2005-02-01 | Tzu Chi Buddhist General Hospital | Method for extracting antineoplastic components from bupleurum scorzonerifolium |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
| WO2006017761A2 (en) * | 2004-08-05 | 2006-02-16 | Emory University | Epothilone analogues as therapeutic agents |
| KR20070084325A (ko) * | 2004-11-18 | 2007-08-24 | 브리스톨-마이어스 스큅 컴퍼니 | 익사베필론을 포함하는 장용성 코팅된 비드 및 그의 제조방법 |
| US20060134214A1 (en) * | 2004-11-18 | 2006-06-22 | Ismat Ullah | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
| CN101535492A (zh) | 2005-02-11 | 2009-09-16 | 南加州大学 | 表达含有二硫键的蛋白质的方法 |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| US8463852B2 (en) * | 2006-10-06 | 2013-06-11 | Oracle International Corporation | Groupware portlets for integrating a portal with groupware systems |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| CA2927832C (en) | 2010-05-18 | 2021-03-23 | Cerulean Pharma Inc. | Cyclodextrin-containing polymer-therapeutic agent conjugates and their use |
| WO2021142202A1 (en) | 2020-01-10 | 2021-07-15 | R-Pharm Us Operating Llc | Compositions of ixabepilone |
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| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| WO1996006604A2 (en) * | 1994-08-31 | 1996-03-07 | Eli Lilly And Company | Methods for identifying and treating resistant tumors |
| ES2206607T3 (es) | 1995-11-17 | 2004-05-16 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Derivados de epotilones, preparacion y utilizacion. |
| DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
| DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
| AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
| US5969145A (en) | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
| DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
| DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
| DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
| BR9713363B1 (pt) | 1996-11-18 | 2011-02-08 | processo para preparação de epotilona d. | |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
| CZ298027B6 (cs) | 1997-02-25 | 2007-05-30 | Gesellschaft Fuer Biotechnologische Forschung Mbh(Gbf) | Zpusob prípravy epothilon-N-oxidu a N-oxidy epothilonu |
| CA2283442C (en) | 1997-03-06 | 2003-02-18 | Harry Nijenhuis Management B.V. | Terminal for transferring containers, and a container car |
| DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
| EP0975622B1 (de) | 1997-04-18 | 2002-10-09 | Studiengesellschaft Kohle mbH | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
| DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
| DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| AU8542898A (en) | 1997-07-16 | 1999-02-10 | Schering Aktiengesellschaft | Thiazole derivatives, method for their production and use |
| IL134419A0 (en) | 1997-08-09 | 2001-04-30 | Schering Ag | Epothilone derivatives, process for the preparation thereof and pharmaceutical compositions containing the same |
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| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| TW457095B (en) | 1998-02-05 | 2001-10-01 | Novartis Ag | Pharmaceutical formulations comprising epothilones and lyophilised compositions comprising epothilones |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
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| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| US6399638B1 (en) | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
| WO2000000485A1 (de) | 1998-06-30 | 2000-01-06 | Schering Aktiengesellschaft | Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung |
| WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| CA2352505C (en) | 1998-12-22 | 2009-04-07 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
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| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
| FR2793288B1 (fr) | 1999-05-06 | 2001-07-20 | Transrol | Rotule permettant la transmission d'un couple |
| US6518421B1 (en) | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
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| UA75365C2 (en) | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
| EE200300323A (et) | 2001-01-25 | 2003-10-15 | Bristol-Myers Squibb Company | Epotilooni analoogi sisaldav parenteraalne ravimpreparaat, meetod selle valmistamiseks ning kasutamine |
| NZ526871A (en) | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
| CN100341505C (zh) | 2001-01-25 | 2007-10-10 | 布里斯托尔-迈尔斯斯奎布公司 | 用于治疗癌症的埃博霉素类似物的给药方法 |
| WO2002072085A1 (en) | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| US7008936B2 (en) | 2002-06-14 | 2006-03-07 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| BRPI0314133A8 (pt) | 2002-09-23 | 2017-09-19 | Bristol Myers Squibb Co | Processo para isolamento de epotilona b, métodos para cultivo de microorganismo que produza epotilona a ou b e para purifiação de apotilona |
| US7460891B2 (en) | 2002-10-21 | 2008-12-02 | Microsoft Corporation | Method and system to shut down and control computer radios |
-
2002
- 2002-02-06 KR KR10-2003-7010871A patent/KR20040025895A/ko not_active Application Discontinuation
- 2002-02-06 HU HU0303175A patent/HUP0303175A2/hu unknown
- 2002-02-06 WO PCT/US2002/004255 patent/WO2002066038A1/en not_active Application Discontinuation
- 2002-02-06 RU RU2003128311/14A patent/RU2003128311A/ru not_active Application Discontinuation
- 2002-02-06 EP EP02714885A patent/EP1385529A4/en not_active Withdrawn
- 2002-02-06 CA CA002438610A patent/CA2438610A1/en not_active Abandoned
- 2002-02-06 JP JP2002565596A patent/JP2004522774A/ja active Pending
- 2002-02-06 CN CNA02805251XA patent/CN1774253A/zh active Pending
- 2002-02-06 MX MXPA03007394A patent/MXPA03007394A/es unknown
- 2002-02-06 EE EEP200300396A patent/EE200300396A/et unknown
- 2002-02-06 BR BR0207487-7A patent/BR0207487A/pt not_active Application Discontinuation
- 2002-02-06 IL IL15698802A patent/IL156988A0/xx unknown
- 2002-02-06 PL PL02363362A patent/PL363362A1/xx not_active Application Discontinuation
- 2002-02-08 US US10/072,123 patent/US6686380B2/en not_active Ceased
-
2003
- 2003-08-07 BG BG108075A patent/BG108075A/bg unknown
- 2003-08-08 ZA ZA200306173A patent/ZA200306173B/en unknown
- 2003-08-18 IS IS6918A patent/IS6918A/is unknown
- 2003-08-19 NO NO20033684A patent/NO20033684L/no not_active Application Discontinuation
-
2006
- 2006-02-02 US US11/346,579 patent/USRE41393E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1385529A1 (en) | 2004-02-04 |
| IL156988A0 (en) | 2004-02-08 |
| IS6918A (is) | 2003-08-18 |
| KR20040025895A (ko) | 2004-03-26 |
| BG108075A (bg) | 2005-04-30 |
| MXPA03007394A (es) | 2003-12-04 |
| RU2003128311A (ru) | 2005-03-10 |
| US20020165258A1 (en) | 2002-11-07 |
| WO2002066038A1 (en) | 2002-08-29 |
| NO20033684D0 (no) | 2003-08-19 |
| JP2004522774A (ja) | 2004-07-29 |
| EP1385529A4 (en) | 2007-05-09 |
| BR0207487A (pt) | 2004-08-10 |
| CN1774253A (zh) | 2006-05-17 |
| USRE41393E1 (en) | 2010-06-22 |
| NO20033684L (no) | 2003-10-13 |
| CA2438610A1 (en) | 2002-08-29 |
| HUP0303175A2 (hu) | 2003-12-29 |
| EE200300396A (et) | 2003-12-15 |
| PL363362A1 (en) | 2004-11-15 |
| US6686380B2 (en) | 2004-02-03 |
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