ZA200305655B - A virus causing respiratory tract illness in susceptible mammals. - Google Patents
A virus causing respiratory tract illness in susceptible mammals. Download PDFInfo
- Publication number
- ZA200305655B ZA200305655B ZA200305655A ZA200305655A ZA200305655B ZA 200305655 B ZA200305655 B ZA 200305655B ZA 200305655 A ZA200305655 A ZA 200305655A ZA 200305655 A ZA200305655 A ZA 200305655A ZA 200305655 B ZA200305655 B ZA 200305655B
- Authority
- ZA
- South Africa
- Prior art keywords
- protein
- mpv
- amino acid
- virus
- acid sequence
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims description 416
- 241000124008 Mammalia Species 0.000 title claims description 39
- 210000002345 respiratory system Anatomy 0.000 title claims description 15
- 108090000623 proteins and genes Proteins 0.000 claims description 297
- 108700026244 Open Reading Frames Proteins 0.000 claims description 287
- 241001519465 Avian metapneumovirus Species 0.000 claims description 260
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 188
- 102000004169 proteins and genes Human genes 0.000 claims description 175
- 238000000034 method Methods 0.000 claims description 129
- 208000015181 infectious disease Diseases 0.000 claims description 117
- 239000012634 fragment Substances 0.000 claims description 116
- 150000007523 nucleic acids Chemical group 0.000 claims description 113
- 241000351643 Metapneumovirus Species 0.000 claims description 97
- 108020004707 nucleic acids Proteins 0.000 claims description 93
- 102000039446 nucleic acids Human genes 0.000 claims description 93
- 238000003556 assay Methods 0.000 claims description 86
- 210000004027 cell Anatomy 0.000 claims description 82
- 239000002773 nucleotide Substances 0.000 claims description 78
- 125000003729 nucleotide group Chemical group 0.000 claims description 78
- 238000004458 analytical method Methods 0.000 claims description 60
- 239000000427 antigen Substances 0.000 claims description 60
- 102000036639 antigens Human genes 0.000 claims description 60
- 108091007433 antigens Proteins 0.000 claims description 60
- 230000003612 virological effect Effects 0.000 claims description 58
- 150000001413 amino acids Chemical class 0.000 claims description 55
- 108091006027 G proteins Proteins 0.000 claims description 47
- 108091000058 GTP-Binding Proteins 0.000 claims description 47
- 230000000120 cytopathologic effect Effects 0.000 claims description 46
- 241000711904 Pneumoviridae Species 0.000 claims description 45
- 238000012360 testing method Methods 0.000 claims description 45
- 241000271566 Aves Species 0.000 claims description 43
- 241000282414 Homo sapiens Species 0.000 claims description 43
- 241000711504 Paramyxoviridae Species 0.000 claims description 42
- 102000030782 GTP binding Human genes 0.000 claims description 41
- 241001465754 Metazoa Species 0.000 claims description 41
- 238000001514 detection method Methods 0.000 claims description 40
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 38
- 101150039699 M2-1 gene Proteins 0.000 claims description 35
- 241001493065 dsRNA viruses Species 0.000 claims description 35
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 33
- 101710141454 Nucleoprotein Proteins 0.000 claims description 33
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims description 32
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims description 32
- 101150103632 M2-2 gene Proteins 0.000 claims description 28
- 101710181008 P protein Proteins 0.000 claims description 27
- 101710177166 Phosphoprotein Proteins 0.000 claims description 27
- 102100034574 P protein Human genes 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 26
- 101710085938 Matrix protein Proteins 0.000 claims description 24
- 101710127721 Membrane protein Proteins 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 239000013598 vector Substances 0.000 claims description 23
- 238000004113 cell culture Methods 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 206010051497 Rhinotracheitis Diseases 0.000 claims description 17
- 239000003443 antiviral agent Substances 0.000 claims description 14
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims description 14
- 241000711404 Avian avulavirus 1 Species 0.000 claims description 12
- 230000002458 infectious effect Effects 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 241000712461 unidentified influenza virus Species 0.000 claims description 12
- 241000711408 Murine respirovirus Species 0.000 claims description 11
- 241000711502 Paramyxovirinae Species 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 230000000241 respiratory effect Effects 0.000 claims description 11
- 230000002265 prevention Effects 0.000 claims description 10
- 238000007476 Maximum Likelihood Methods 0.000 claims description 9
- 241000712045 Morbillivirus Species 0.000 claims description 9
- 230000002238 attenuated effect Effects 0.000 claims description 9
- 108020004414 DNA Proteins 0.000 claims description 8
- 238000009007 Diagnostic Kit Methods 0.000 claims description 8
- 108010067390 Viral Proteins Proteins 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 241000526636 Nipah henipavirus Species 0.000 claims description 7
- 241000342334 Human metapneumovirus Species 0.000 claims description 6
- 238000002405 diagnostic procedure Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000009396 hybridization Methods 0.000 claims description 6
- 241000711386 Mumps virus Species 0.000 claims description 5
- 238000012217 deletion Methods 0.000 claims description 5
- 230000037430 deletion Effects 0.000 claims description 5
- 241001068295 Replication defective viruses Species 0.000 claims description 4
- 238000010171 animal model Methods 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 239000002356 single layer Substances 0.000 claims description 4
- 210000003501 vero cell Anatomy 0.000 claims description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 3
- 241000893570 Hendra henipavirus Species 0.000 claims description 3
- 241001559177 Mapuera rubulavirus Species 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 238000003757 reverse transcription PCR Methods 0.000 claims description 3
- 230000017960 syncytium formation Effects 0.000 claims description 3
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims 4
- 238000002856 computational phylogenetic analysis Methods 0.000 claims 3
- 229920001917 Ficoll Polymers 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241001329715 Tupaia virus Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 241000972773 Aulopiformes Species 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 206010066226 Metapneumovirus infection Diseases 0.000 claims 1
- 101100238304 Mus musculus Morc1 gene Proteins 0.000 claims 1
- 238000003271 compound fluorescence assay Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 114
- 241000711920 Human orthopneumovirus Species 0.000 description 88
- 241000724205 Rice stripe tenuivirus Species 0.000 description 88
- 241000711902 Pneumovirus Species 0.000 description 83
- 235000001014 amino acid Nutrition 0.000 description 52
- 229940024606 amino acid Drugs 0.000 description 50
- 238000002965 ELISA Methods 0.000 description 48
- 241000711895 Bovine orthopneumovirus Species 0.000 description 44
- 238000006386 neutralization reaction Methods 0.000 description 43
- 241000700198 Cavia Species 0.000 description 40
- 241000725643 Respiratory syncytial virus Species 0.000 description 28
- 238000013081 phylogenetic analysis Methods 0.000 description 28
- 239000000523 sample Substances 0.000 description 26
- 241000282412 Homo Species 0.000 description 24
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 23
- 108090000288 Glycoproteins Proteins 0.000 description 22
- 101710144128 Non-structural protein 2 Proteins 0.000 description 22
- 101710199667 Nuclear export protein Proteins 0.000 description 22
- 102000003886 Glycoproteins Human genes 0.000 description 21
- 108060003393 Granulin Proteins 0.000 description 21
- 210000002966 serum Anatomy 0.000 description 21
- 241000282553 Macaca Species 0.000 description 20
- 230000000890 antigenic effect Effects 0.000 description 20
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 20
- 230000005764 inhibitory process Effects 0.000 description 19
- 241000711941 Murine orthopneumovirus Species 0.000 description 18
- 230000002209 hydrophobic effect Effects 0.000 description 18
- 238000002955 isolation Methods 0.000 description 18
- 238000010790 dilution Methods 0.000 description 17
- 239000012895 dilution Substances 0.000 description 17
- 108020001507 fusion proteins Proteins 0.000 description 17
- 102000037865 fusion proteins Human genes 0.000 description 17
- 108010061100 Nucleoproteins Proteins 0.000 description 16
- 230000002068 genetic effect Effects 0.000 description 16
- 239000006228 supernatant Substances 0.000 description 16
- 102000011931 Nucleoproteins Human genes 0.000 description 15
- 230000014509 gene expression Effects 0.000 description 15
- 230000000405 serological effect Effects 0.000 description 15
- 241000282341 Mustela putorius furo Species 0.000 description 14
- 108010089430 Phosphoproteins Proteins 0.000 description 14
- 238000012300 Sequence Analysis Methods 0.000 description 13
- 238000003745 diagnosis Methods 0.000 description 13
- 108020004999 messenger RNA Proteins 0.000 description 13
- 230000004044 response Effects 0.000 description 13
- 241000283690 Bos taurus Species 0.000 description 12
- 241000700199 Cavia porcellus Species 0.000 description 12
- 102000007982 Phosphoproteins Human genes 0.000 description 12
- 238000012512 characterization method Methods 0.000 description 12
- 230000037029 cross reaction Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 238000011081 inoculation Methods 0.000 description 12
- 230000010076 replication Effects 0.000 description 12
- 238000012163 sequencing technique Methods 0.000 description 12
- 101150062031 L gene Proteins 0.000 description 11
- 230000004988 N-glycosylation Effects 0.000 description 11
- 208000035415 Reinfection Diseases 0.000 description 11
- 230000036961 partial effect Effects 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 229960005486 vaccine Drugs 0.000 description 11
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000002299 complementary DNA Substances 0.000 description 10
- 238000010166 immunofluorescence Methods 0.000 description 10
- 101150034814 F gene Proteins 0.000 description 9
- 241000712003 Human respirovirus 3 Species 0.000 description 9
- 108091034117 Oligonucleotide Proteins 0.000 description 9
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 9
- 108091081024 Start codon Proteins 0.000 description 9
- 229930006000 Sucrose Natural products 0.000 description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 9
- 230000004927 fusion Effects 0.000 description 9
- 239000005720 sucrose Substances 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 241000287828 Gallus gallus Species 0.000 description 8
- 241000712079 Measles morbillivirus Species 0.000 description 8
- 241000282849 Ruminantia Species 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 235000013330 chicken meat Nutrition 0.000 description 8
- 230000009260 cross reactivity Effects 0.000 description 8
- 230000001900 immune effect Effects 0.000 description 8
- 244000052769 pathogen Species 0.000 description 8
- 229920000136 polysorbate Polymers 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 241000894007 species Species 0.000 description 8
- 238000013518 transcription Methods 0.000 description 8
- 230000035897 transcription Effects 0.000 description 8
- 241001308709 unidentified virus Species 0.000 description 8
- 241000282339 Mustela Species 0.000 description 7
- 108091034135 Vault RNA Proteins 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 230000001717 pathogenic effect Effects 0.000 description 7
- 241000701447 unidentified baculovirus Species 0.000 description 7
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 6
- 241000283707 Capra Species 0.000 description 6
- 241000282693 Cercopithecidae Species 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 241000283216 Phocidae Species 0.000 description 6
- 206010035664 Pneumonia Diseases 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 6
- 239000004473 Threonine Substances 0.000 description 6
- 239000012228 culture supernatant Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 238000010369 molecular cloning Methods 0.000 description 6
- 239000013642 negative control Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 244000144977 poultry Species 0.000 description 6
- 235000013594 poultry meat Nutrition 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 6
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 6
- 230000002441 reversible effect Effects 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 239000008399 tap water Substances 0.000 description 6
- 235000020679 tap water Nutrition 0.000 description 6
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 5
- 101150046652 M2 gene Proteins 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 5
- 241001494479 Pecora Species 0.000 description 5
- 241000286209 Phasianidae Species 0.000 description 5
- 108010076504 Protein Sorting Signals Proteins 0.000 description 5
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 description 5
- 206010057190 Respiratory tract infections Diseases 0.000 description 5
- 101710200413 Small hydrophobic protein Proteins 0.000 description 5
- 108020000999 Viral RNA Proteins 0.000 description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 230000003321 amplification Effects 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 210000004899 c-terminal region Anatomy 0.000 description 5
- 238000003776 cleavage reaction Methods 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 238000010324 immunological assay Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 230000007017 scission Effects 0.000 description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
- 241001559187 Human rubulavirus 2 Species 0.000 description 4
- 108091029795 Intergenic region Proteins 0.000 description 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 241001137886 Ovine respiratory syncytial virus Species 0.000 description 4
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 238000012181 QIAquick gel extraction kit Methods 0.000 description 4
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 description 4
- 101710172711 Structural protein Proteins 0.000 description 4
- 239000011543 agarose gel Substances 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000010460 detection of virus Effects 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 230000001492 haemagglutinating effect Effects 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 238000012809 post-inoculation Methods 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 208000023504 respiratory system disease Diseases 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 238000001890 transfection Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 230000009385 viral infection Effects 0.000 description 4
- 239000013603 viral vector Substances 0.000 description 4
- VHJLVAABSRFDPM-UHFFFAOYSA-N 1,4-dithiothreitol Chemical compound SCC(O)C(O)CS VHJLVAABSRFDPM-UHFFFAOYSA-N 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 3
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 3
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 3
- 101150082239 G gene Proteins 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 241000726041 Human respirovirus 1 Species 0.000 description 3
- 102100034349 Integrase Human genes 0.000 description 3
- 235000019687 Lamb Nutrition 0.000 description 3
- 201000005505 Measles Diseases 0.000 description 3
- 241000711513 Mononegavirales Species 0.000 description 3
- 208000005647 Mumps Diseases 0.000 description 3
- 101150084044 P gene Proteins 0.000 description 3
- 238000002123 RNA extraction Methods 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 241000288669 Tupaia Species 0.000 description 3
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 3
- 230000010530 Virus Neutralization Effects 0.000 description 3
- 239000013592 cell lysate Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000001351 cycling effect Effects 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000000464 low-speed centrifugation Methods 0.000 description 3
- 208000010805 mumps infectious disease Diseases 0.000 description 3
- 230000007170 pathology Effects 0.000 description 3
- 239000013600 plasmid vector Substances 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000272525 Anas platyrhynchos Species 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241001466804 Carnivora Species 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 241000711950 Filoviridae Species 0.000 description 2
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 108060004795 Methyltransferase Proteins 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- 102100032965 Myomesin-2 Human genes 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 108010015724 Prephenate Dehydratase Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 238000010357 RNA editing Methods 0.000 description 2
- 238000010802 RNA extraction kit Methods 0.000 description 2
- 230000026279 RNA modification Effects 0.000 description 2
- 230000006819 RNA synthesis Effects 0.000 description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 101150107578 SH gene Proteins 0.000 description 2
- 108091005956 Type II transmembrane proteins Proteins 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 241001428384 Zamora Species 0.000 description 2
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 238000003277 amino acid sequence analysis Methods 0.000 description 2
- 230000027645 antigenic variation Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000012754 cardiac puncture Methods 0.000 description 2
- 230000002867 ciliostatic effect Effects 0.000 description 2
- 210000003555 cloaca Anatomy 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 208000037798 influenza B Diseases 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000034217 membrane fusion Effects 0.000 description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000001236 prokaryotic cell Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000002864 sequence alignment Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 230000005029 transcription elongation Effects 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 108010088577 zinc-binding protein Proteins 0.000 description 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
- 101710159080 Aconitate hydratase A Proteins 0.000 description 1
- 101710159078 Aconitate hydratase B Proteins 0.000 description 1
- 101150019028 Antp gene Proteins 0.000 description 1
- 101000849579 Arabidopsis thaliana 30S ribosomal protein S13, chloroplastic Proteins 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 240000003291 Armoracia rusticana Species 0.000 description 1
- 235000011330 Armoracia rusticana Nutrition 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 201000005947 Carney Complex Diseases 0.000 description 1
- 206010061041 Chlamydial infection Diseases 0.000 description 1
- 241000724565 Chorella virus Species 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
- 102100029764 DNA-directed DNA/RNA polymerase mu Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 101710121417 Envelope glycoprotein Proteins 0.000 description 1
- 102100027286 Fanconi anemia group C protein Human genes 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 101000833492 Homo sapiens Jouberin Proteins 0.000 description 1
- 101000651236 Homo sapiens NCK-interacting protein with SH3 domain Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 102100024407 Jouberin Human genes 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
- 101710169105 Minor spike protein Proteins 0.000 description 1
- 101710081079 Minor spike protein H Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 241000283150 Phoca vitulina Species 0.000 description 1
- 241000711899 Phocine morbillivirus Species 0.000 description 1
- 101710182846 Polyhedrin Proteins 0.000 description 1
- 102000015623 Polynucleotide Adenylyltransferase Human genes 0.000 description 1
- 108010024055 Polynucleotide adenylyltransferase Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 1
- 101710105008 RNA-binding protein Proteins 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 206010062106 Respiratory tract infection viral Diseases 0.000 description 1
- 241000606651 Rickettsiales Species 0.000 description 1
- 241001533467 Rubulavirus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000271567 Struthioniformes Species 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 240000003864 Ulex europaeus Species 0.000 description 1
- 235000010730 Ulex europaeus Nutrition 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 108010059722 Viral Fusion Proteins Proteins 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 108010065667 Viral Matrix Proteins Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000019552 anatomical structure morphogenesis Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 108010088716 attachment protein G Proteins 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000003115 checkerboard titration Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000004186 co-expression Effects 0.000 description 1
- 229940001442 combination vaccine Drugs 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000005546 dideoxynucleotide Substances 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000000521 hyperimmunizing effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 208000037799 influenza C Diseases 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000002761 liquid phase assay Methods 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 238000002862 phylogeny inference package Methods 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000012070 reactive reagent Substances 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 208000026425 severe pneumonia Diseases 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000002764 solid phase assay Methods 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940031626 subunit vaccine Drugs 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000013715 transcription antitermination Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 230000006490 viral transcription Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
- C12N2760/18321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
- C12N2760/18322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
- C12N2760/18334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
- C12N2760/18341—Use of virus, viral particle or viral elements as a vector
- C12N2760/18343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01200213 | 2001-01-19 | ||
EP01203985 | 2001-10-18 | ||
PCT/NL2002/000040 WO2002057302A2 (fr) | 2001-01-19 | 2002-01-18 | Virus provoquant des maladies respiratoires chez des mammiferes y etant sensibles |
US46681104A | 2004-03-04 | 2004-03-04 | |
US14/553,957 US9334543B2 (en) | 2001-01-19 | 2014-11-25 | Virus causing respiratory tract illness in susceptible mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200305655B true ZA200305655B (en) | 2004-07-22 |
Family
ID=26076820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200305655A ZA200305655B (en) | 2001-01-19 | 2003-07-22 | A virus causing respiratory tract illness in susceptible mammals. |
Country Status (22)
Country | Link |
---|---|
US (10) | US8927206B2 (fr) |
EP (1) | EP1351981B1 (fr) |
JP (3) | JP5503096B2 (fr) |
KR (4) | KR100964413B1 (fr) |
CN (2) | CN1524088B (fr) |
AU (1) | AU2002228471B2 (fr) |
BR (1) | BR0206591A (fr) |
CA (1) | CA2435180C (fr) |
DK (1) | DK1351981T3 (fr) |
EA (1) | EA006879B1 (fr) |
ES (1) | ES2393468T3 (fr) |
HK (1) | HK1068898A1 (fr) |
HU (1) | HUP0500244A3 (fr) |
IL (1) | IL157003A0 (fr) |
MX (1) | MXPA03006430A (fr) |
NO (1) | NO335551B1 (fr) |
NZ (2) | NZ527221A (fr) |
PL (1) | PL213926B1 (fr) |
SG (1) | SG149684A1 (fr) |
UA (1) | UA93981C2 (fr) |
WO (1) | WO2002057302A2 (fr) |
ZA (1) | ZA200305655B (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060094105A1 (en) | 1998-04-24 | 2006-05-04 | University Hospitals Of Cleveland | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses |
JP5503096B2 (ja) | 2001-01-19 | 2014-05-28 | ヴィロノヴァティブ,ベスローテン ヴェンノートシャップ | 感受性哺乳動物において気道疾患を引き起こすウイルス |
US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
CA2477235A1 (fr) | 2002-02-21 | 2003-09-04 | Medimmune Vaccines, Inc. | Systemes d'expression de virus recombinant parainfluenza et vaccins comprenant des antigenes heterologues derives de metapneumovirus |
DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
JP2005533861A (ja) * | 2002-07-25 | 2005-11-10 | メデュームン,インコーポレーテッド | 抗RSV、抗hMPV、および抗PIV抗体を使用するRSV、hMPV、およびPIVの治療法と予防法 |
CA2508378A1 (fr) * | 2002-12-02 | 2004-06-17 | University Of Maryland, College Park | Genes du pneumovirus aviaire, pneumovirus aviaires recombines et procedes de fabrication associes |
WO2004057021A2 (fr) * | 2002-12-19 | 2004-07-08 | UNIVERSITé LAVAL | Procedes et compositions moleculaires pour la detection et la quantification de virus des voies respiratoires |
WO2005014626A2 (fr) | 2003-02-28 | 2005-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metapneumovirus humain recombinant et utilisation associee |
WO2004085650A1 (fr) | 2003-03-24 | 2004-10-07 | The University Of Hong Kong | Essai diagnostique haute vitesse pour la detection du virus humain provoquant le syndrome respiratoire aigu severe (sras) |
JP4783726B2 (ja) * | 2003-03-28 | 2011-09-28 | メディミューン,エルエルシー | 呼吸器合胞体ウイルスサブグループb株9320に関連する組成物および方法 |
AU2004229501B2 (en) | 2003-04-11 | 2011-08-18 | Medimmune, Llc | Recombinant IL-9 antibodies and uses thereof |
KR20110097971A (ko) * | 2003-04-25 | 2011-08-31 | 메디뮨 백신즈, 인코포레이티드 | 메타뉴모바이러스 유래 이종 항원을 포함하는 재조합 파라인플루엔자 바이러스 발현 시스템 및 백신 |
CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
EP1473037A1 (fr) * | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Ribavirin pour le traitement des infections dues au hMPV |
WO2005028673A1 (fr) * | 2003-09-22 | 2005-03-31 | Institut Pasteur | Procede de detection du virus nipah et procede permettant d'obtenir une protection immunologique contre les henipavirus |
US7691379B2 (en) | 2004-04-12 | 2010-04-06 | Medimmune, Llc | Anti-IL-9 antibody formulations |
JP4546212B2 (ja) * | 2004-10-21 | 2010-09-15 | 三菱化学メディエンス株式会社 | 抗原蛋白質を発現した細胞を利用する抗体測定方法 |
AU2006223138B2 (en) * | 2005-03-10 | 2012-04-05 | Medimmune, Llc | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
US8492097B2 (en) | 2006-04-24 | 2013-07-23 | Diagnostic Hybrids, Inc. | Compositions and methods for human metapneumovirus monoclonal antibodies |
EP2069485A4 (fr) * | 2007-07-13 | 2011-05-25 | Medimmune Llc | Préparation de virus d'arn à brin négatif par électroporation |
WO2009062532A1 (fr) * | 2007-11-16 | 2009-05-22 | Vironovative Bv | Souches de métapneumovirus atténués vivants et leur utilisation dans des formulations de vaccin et souches de métapneumovirus chimériques |
US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
EP2350270B1 (fr) | 2008-10-24 | 2018-03-07 | The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services | Espèce de virus ebola humain et compositions et procédés associés |
KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 b형 조류메타뉴모바이러스 sc1509주 및 이의 용도 |
CN101880732B (zh) * | 2010-06-29 | 2012-10-10 | 中国药品生物制品检定所 | 猴副流感病毒5型的rt-pcr检测方法及试剂盒 |
EP3578205A1 (fr) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale |
WO2012045082A2 (fr) | 2010-10-01 | 2012-04-05 | Jason Schrum | Synthèse d'acides nucléiques et méthodes d'utilisation associées |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP3682905B1 (fr) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Nucléosides, nucléotides et acides nucléiques modifiés et leurs utilisations |
DK2791160T3 (da) | 2011-12-16 | 2022-05-30 | Modernatx Inc | Modificerede mrna-sammensætninger |
US9498531B2 (en) | 2012-03-20 | 2016-11-22 | Humabs Biomed Sa | Antibodies that neutralize RSV, MPV and PVM and uses thereof |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
CN102676701B (zh) * | 2012-06-11 | 2013-08-14 | 广东温氏食品集团股份有限公司 | 禽肺病毒通用型rt-pcr检测引物及检测方法 |
HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
US20150322137A1 (en) | 2013-01-28 | 2015-11-12 | Evec Inc. | Human antibody specific to human metapneumovirus, or antigen-binding fragment thereof |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
CN103360472B (zh) * | 2013-07-30 | 2015-02-25 | 北京市农林科学院 | 禽偏肺病毒抗体elisa检测试剂盒 |
WO2015048744A2 (fr) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
CL2013002829A1 (es) | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
EP3052521A1 (fr) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucléotides codant pour un récepteur de lipoprotéines de faible densité |
US10774114B2 (en) * | 2014-03-10 | 2020-09-15 | Fondation The Ark | Respiratory syncytial virus (RSV) replication inhibitors |
PT3718565T (pt) | 2015-10-22 | 2022-07-20 | Modernatx Inc | Vacinas contra vírus respiratórios |
DE102016215118A1 (de) | 2016-08-12 | 2018-02-15 | Anicon Labor Gmbh | Infektiöse Bronchitis (IB)-Virus Varianten und diesbezügliche Zusammensetzungen, Verwendungen und Verfahren |
SG11201805192QA (en) * | 2016-10-31 | 2018-07-30 | Wuhan Sanli Biotechnology Co Ltd | Respiratory syncytial virus vaccine |
EP3551193A4 (fr) | 2016-12-08 | 2020-08-19 | Modernatx, Inc. | Vaccins à acide nucléique contre des virus respiratoires |
MA47790A (fr) | 2017-03-17 | 2021-05-05 | Modernatx Inc | Vaccins à base d'arn contre des maladies zoonotiques |
AU2019261570A1 (en) * | 2018-04-23 | 2020-11-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric vectors |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
US20240279610A1 (en) | 2021-06-09 | 2024-08-22 | Universität Duisburg-Essen | Method for immortalising vesicle-secreting cells |
WO2023004307A1 (fr) * | 2021-07-19 | 2023-01-26 | Epivax, Inc. | Épitopes de lymphocytes t et compositions associées utiles dans la prévention et le traitement d'une infection par le virus respiratoire syncytial |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE105334T1 (de) | 1988-04-22 | 1994-05-15 | Upjohn Co | Schimaerische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3. |
US5137819A (en) | 1988-07-08 | 1992-08-11 | University Of British Columbia | Cellulose binding fusion proteins for immobilization and purification of polypeptides |
US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
ES2129199T3 (es) | 1994-04-19 | 1999-06-01 | Sanquin Bloedvoorziening | Procedimientos de discriminacion entre las variantes del virus de la inmunodeficiencia humana que inducen el sincitio y los que no inducen el sincitio y cebadores para la utilizacion en los procedimientos. |
SE504386C2 (sv) | 1994-05-30 | 1997-01-27 | Bengt Wilhelm Toernqvist | Bottenkonstruktion på ett deplacementfartygsskrov |
DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
DE69510207T3 (de) | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
AU727923B2 (en) | 1995-09-27 | 2001-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
ES2109189B1 (es) | 1996-03-14 | 1998-05-16 | Iberica Cyanamid | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
US6180398B1 (en) * | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
BR9710363A (pt) | 1996-07-15 | 2000-01-11 | Us Gov Health & Human Serv | "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante" |
EP0932684A2 (fr) | 1996-09-27 | 1999-08-04 | American Cyanamid Company | Region promotrice 3' du genome et mutations du gene polymerase responsables de l'attenuation dans des virus de l'ordre appele mononegavirales |
US5817494A (en) | 1997-05-21 | 1998-10-06 | Incyte Pharmaceuticals, Inc. | Ubiquitin conjugation proteins |
US7192593B2 (en) * | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
AU7797798A (en) | 1997-05-23 | 1998-12-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
EP1012244B1 (fr) | 1997-07-11 | 2007-05-09 | Yale University | Rhabdovirus a enveloppes remanipulees |
EP1015594A1 (fr) | 1997-09-19 | 2000-07-05 | American Cyanamid Company | Virus syncytiaux respiratoires attenues |
US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
AU6200399A (en) * | 1998-10-05 | 2000-04-26 | Akzo Nobel N.V. | Avian pneumovirus vaccine and diagnostic agent |
AU4614600A (en) | 1999-05-18 | 2000-12-05 | Dnavec Research Inc. | Paramyxoviridae virus vector defective in envelope gene |
CA2378661A1 (fr) | 1999-07-09 | 2001-01-18 | Alexander C. Schmidt | Vaccins attenues de virus chimeres de parainfluenza humain-bovin (piv) |
DE50001408D1 (de) | 1999-07-29 | 2003-04-10 | Hatebur Umformmaschinen Ag Rei | Vorrichtung zur erzeugung einer hebe- und senkbewegung |
FR2801607B1 (fr) | 1999-11-26 | 2001-12-28 | Merial Sas | Pneumovirus du canard et vaccins correspondants |
EP1103610A1 (fr) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production de vaccins de lignées de cellules mammifère immortalisées |
MXPA01008108A (es) | 1999-12-10 | 2004-11-12 | Health | Uso de virus de parainfluenza recombinante (pivs) como vectores para la proteccioncontra la infeccion y enfermedad provocadas por piv y otros patogenos humanos. |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
US6387586B1 (en) | 2000-11-06 | 2002-05-14 | Eastman Kodak Company | High contrast visually adaptive radiographic film and imaging assembly for thoracic imaging |
PT1480671E (pt) | 2000-11-28 | 2007-11-20 | Medimmune Vaccines Inc | Sistemas de expressão de vírus rsv recombinante e vacinas |
US6632459B2 (en) | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
US20030232061A1 (en) | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
JP5503096B2 (ja) * | 2001-01-19 | 2014-05-28 | ヴィロノヴァティブ,ベスローテン ヴェンノートシャップ | 感受性哺乳動物において気道疾患を引き起こすウイルス |
AU2002364121C1 (en) * | 2001-11-21 | 2010-02-18 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Recovery of recombinant human parainfluenza virus type 1 (HPIVI) from cDNA |
CA2477235A1 (fr) | 2002-02-21 | 2003-09-04 | Medimmune Vaccines, Inc. | Systemes d'expression de virus recombinant parainfluenza et vaccins comprenant des antigenes heterologues derives de metapneumovirus |
DE10221836A1 (de) | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
JP2005533861A (ja) | 2002-07-25 | 2005-11-10 | メデュームン,インコーポレーテッド | 抗RSV、抗hMPV、および抗PIV抗体を使用するRSV、hMPV、およびPIVの治療法と予防法 |
US6605283B1 (en) * | 2002-11-01 | 2003-08-12 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleotide sequence for the Avian Metapneumovirus (Colorado) attachment glycoprotein gene |
WO2004057021A2 (fr) | 2002-12-19 | 2004-07-08 | UNIVERSITé LAVAL | Procedes et compositions moleculaires pour la detection et la quantification de virus des voies respiratoires |
WO2005014626A2 (fr) | 2003-02-28 | 2005-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metapneumovirus humain recombinant et utilisation associee |
JP2006519457A (ja) | 2003-03-05 | 2006-08-24 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 光媒体における情報書き込み/消去用パワーパラメータを決定する装置及び方法 |
TW200508247A (en) | 2003-04-08 | 2005-03-01 | Vironovative Bv | Sars |
KR20110097971A (ko) | 2003-04-25 | 2011-08-31 | 메디뮨 백신즈, 인코포레이티드 | 메타뉴모바이러스 유래 이종 항원을 포함하는 재조합 파라인플루엔자 바이러스 발현 시스템 및 백신 |
CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
US20040229219A1 (en) * | 2003-04-30 | 2004-11-18 | Gallaher William R. | Method of inhibiting human metapneumovirus and human coronavirus in the prevention and treatment of severe acute respiratory syndrome (SARS) |
EP1533370A1 (fr) | 2003-11-18 | 2005-05-25 | ViroNovative B.V. | Nouveau virus provoquant une pneumonie atypique |
EP1548748A1 (fr) | 2003-12-17 | 2005-06-29 | Interuniversitaire Microelectronica Centrum vzw ( IMEC) | Procédé de fabrication de sondes pour microscopie à force atomique |
WO2005080991A1 (fr) | 2004-02-20 | 2005-09-01 | Erasmus Universiteit Rotterdam | Procede de detection de l'activite cytolytique specifique de l'antigene |
US8318423B2 (en) | 2004-07-06 | 2012-11-27 | Focus Diagnostics, Inc. | Methods and compositions for detecting rhinoviruses |
US20080292658A1 (en) | 2004-11-11 | 2008-11-27 | Emmie De Wit | Defective Influenza Virus Particles |
RU2435855C2 (ru) | 2004-12-24 | 2011-12-10 | Солвей Байолоджикалз Б.В. | Способ продуцирования репликативной частицы вируса гриппа, композиция клеток (варианты), композиция клеточной культуры и ее применение |
AU2006223138B2 (en) * | 2005-03-10 | 2012-04-05 | Medimmune, Llc | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
JP4976376B2 (ja) * | 2005-04-08 | 2012-07-18 | メディミューン,エルエルシー | 哺乳動物メタニューモウイルスに対する抗体 |
EP1748447B1 (fr) | 2005-07-28 | 2008-10-22 | Interuniversitair Microelektronica Centrum ( Imec) | Sonde pour microscope à force atomique avec deux pointes et son procédé de fabrication. |
EP1925318A1 (fr) | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Vaccin à base de virus modifié de vaccin Ankara (MVA) recombinant contre la grippe aviaire |
US20090186050A1 (en) | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
CA2805741C (fr) | 2010-07-23 | 2019-08-13 | Karin Bengtsson Loevgren | Composition renfermant une matrice isocom et des ectodomaines |
JP5923723B2 (ja) | 2011-06-02 | 2016-05-25 | パナソニックIpマネジメント株式会社 | 人物属性推定システム、人物属性推定装置、及び人物属性推定方法 |
WO2014045254A2 (fr) | 2012-09-23 | 2014-03-27 | Erasmus University Medical Center Rotterdam | Lignée c de coronavirus bêta humains et identification de la peptidase dipeptidylique n-terminale en tant que récepteur viral |
CN109402065B (zh) * | 2018-08-08 | 2021-07-30 | 温氏食品集团股份有限公司 | 一种番鸭c亚型禽偏肺病毒弱毒株及其制备和应用 |
-
2002
- 2002-01-18 JP JP2002557978A patent/JP5503096B2/ja not_active Expired - Lifetime
- 2002-01-18 NZ NZ527221A patent/NZ527221A/en not_active IP Right Cessation
- 2002-01-18 IL IL15700302A patent/IL157003A0/xx active IP Right Grant
- 2002-01-18 CN CN028067630A patent/CN1524088B/zh not_active Expired - Fee Related
- 2002-01-18 KR KR1020087031511A patent/KR100964413B1/ko active IP Right Grant
- 2002-01-18 NZ NZ555567A patent/NZ555567A/en not_active IP Right Cessation
- 2002-01-18 MX MXPA03006430A patent/MXPA03006430A/es active IP Right Grant
- 2002-01-18 CA CA2435180A patent/CA2435180C/fr not_active Expired - Lifetime
- 2002-01-18 KR KR1020107005359A patent/KR101105984B1/ko active IP Right Grant
- 2002-01-18 US US10/466,811 patent/US8927206B2/en active Active
- 2002-01-18 KR KR10-2003-7009602A patent/KR20040002853A/ko not_active Application Discontinuation
- 2002-01-18 EA EA200300810A patent/EA006879B1/ru not_active IP Right Cessation
- 2002-01-18 SG SG200504408-6A patent/SG149684A1/en unknown
- 2002-01-18 UA UA2003087814A patent/UA93981C2/ru unknown
- 2002-01-18 DK DK02710551.9T patent/DK1351981T3/da active
- 2002-01-18 WO PCT/NL2002/000040 patent/WO2002057302A2/fr active Application Filing
- 2002-01-18 PL PL367826A patent/PL213926B1/pl unknown
- 2002-01-18 KR KR1020117020851A patent/KR101412317B1/ko active IP Right Grant
- 2002-01-18 AU AU2002228471A patent/AU2002228471B2/en not_active Expired
- 2002-01-18 BR BR0206591-6A patent/BR0206591A/pt not_active Application Discontinuation
- 2002-01-18 HU HU0500244A patent/HUP0500244A3/hu unknown
- 2002-01-18 EP EP02710551A patent/EP1351981B1/fr not_active Revoked
- 2002-01-18 ES ES02710551T patent/ES2393468T3/es not_active Expired - Lifetime
- 2002-01-18 CN CN2009102062092A patent/CN101921732A/zh active Pending
-
2003
- 2003-02-21 US US10/371,122 patent/US7531342B2/en not_active Expired - Lifetime
- 2003-07-18 NO NO20033272A patent/NO335551B1/no not_active IP Right Cessation
- 2003-07-22 ZA ZA200305655A patent/ZA200305655B/en unknown
-
2005
- 2005-02-18 HK HK05101405.2A patent/HK1068898A1/xx not_active IP Right Cessation
-
2008
- 2008-12-31 US US12/319,152 patent/US8722341B2/en not_active Expired - Lifetime
-
2011
- 2011-03-09 JP JP2011050982A patent/JP2011177173A/ja active Pending
-
2013
- 2013-07-08 JP JP2013142224A patent/JP5813060B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-05 US US14/270,237 patent/US9376726B2/en not_active Expired - Fee Related
- 2014-11-25 US US14/553,957 patent/US9334543B2/en not_active Expired - Fee Related
-
2016
- 2016-05-05 US US15/147,653 patent/US9593386B2/en not_active Expired - Lifetime
-
2017
- 2017-03-08 US US15/453,764 patent/US9803252B2/en not_active Expired - Lifetime
- 2017-10-27 US US15/796,500 patent/US10167524B2/en not_active Expired - Fee Related
-
2018
- 2018-12-28 US US16/235,030 patent/US10519517B2/en not_active Expired - Fee Related
-
2019
- 2019-12-30 US US16/730,429 patent/US11162148B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11162148B2 (en) | Virus causing respiratory tract illness in susceptible mammals | |
AU2002228471A1 (en) | A virus causing respiratory tract illness in susceptible mammals | |
CA2477234C (fr) | Souches de metapneumovirus et leur utilisation dans des preparations vaccinales et comme vecteurs d'expression de sequences antigeniques | |
US8715922B2 (en) | Virus causing respiratory tract illness in susceptible mammals | |
AU2008202111B2 (en) | A virus causing respiratory tract illness in susceptible mammals | |
DE et al. | Patent 2435180 Summary |