ZA200301680B - Pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors. - Google Patents
Pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors. Download PDFInfo
- Publication number
- ZA200301680B ZA200301680B ZA200301680A ZA200301680A ZA200301680B ZA 200301680 B ZA200301680 B ZA 200301680B ZA 200301680 A ZA200301680 A ZA 200301680A ZA 200301680 A ZA200301680 A ZA 200301680A ZA 200301680 B ZA200301680 B ZA 200301680B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- mixtures
- group
- glycol
- sorbitan
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 25
- 239000002532 enzyme inhibitor Substances 0.000 title claims description 17
- 230000000699 topical effect Effects 0.000 title claims description 17
- 108010037462 Cyclooxygenase 2 Proteins 0.000 title claims description 7
- 102000010907 Cyclooxygenase 2 Human genes 0.000 title claims 2
- 239000000203 mixture Substances 0.000 claims description 115
- 239000003814 drug Substances 0.000 claims description 36
- 229940079593 drug Drugs 0.000 claims description 33
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- 239000002904 solvent Substances 0.000 claims description 24
- -1 varecoxib Chemical compound 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 20
- 239000003349 gelling agent Substances 0.000 claims description 20
- 230000035515 penetration Effects 0.000 claims description 15
- 239000000499 gel Substances 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 229940125532 enzyme inhibitor Drugs 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 239000004698 Polyethylene Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
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- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| IN779DE2000 IN191090B (enExample) | 2000-08-29 | 2000-08-29 |
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| ZA200301680B true ZA200301680B (en) | 2004-06-23 |
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| ZA200301680A ZA200301680B (en) | 2000-08-29 | 2003-02-28 | Pharmaceutical compositions for topical delivery of cyclooxygenase-2 enzyme inhibitors. |
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| EP (1) | EP1315500A4 (enExample) |
| JP (1) | JP2004525859A (enExample) |
| CN (1) | CN1227012C (enExample) |
| AU (1) | AU2001284321A1 (enExample) |
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| SK (1) | SK3622003A3 (enExample) |
| WO (1) | WO2002017923A1 (enExample) |
| ZA (1) | ZA200301680B (enExample) |
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| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
| WO2002096435A2 (en) * | 2001-05-31 | 2002-12-05 | Pharmacia Corporation | Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US6830744B2 (en) * | 2002-05-31 | 2004-12-14 | Aradigm Corporation | Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b |
| IL165383A0 (en) * | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
| AU2003238543B2 (en) * | 2002-06-25 | 2008-02-28 | Acrux Dds Pty Ltd | Transdermal aerosol compositions |
| AUPS317102A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Transdermal aerosol compositions |
| WO2004000263A1 (en) | 2002-06-25 | 2003-12-31 | Acrux Dds Pty Ltd | Transdermal delivery rate control using amorphous pharmaceutical compositions |
| JP4283507B2 (ja) * | 2002-08-02 | 2009-06-24 | 久光製薬株式会社 | 経皮投与用貼付剤 |
| US8183290B2 (en) * | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| AU2003265624B2 (en) * | 2003-08-21 | 2011-03-31 | Abeona Therapeutics Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| EP1682060A1 (en) * | 2003-10-14 | 2006-07-26 | Dermatrends, Inc. | Enhancing transdermal administration of hydrophilic drugs |
| US20070196301A1 (en) | 2005-12-21 | 2007-08-23 | L'oreal | Cosmetic composition with a volumizing effect |
| FR2894811B1 (fr) † | 2005-12-21 | 2008-02-22 | Oreal | Composition cosmetique a effet volumateur |
| HU227970B1 (en) * | 2007-07-10 | 2012-07-30 | Egis Gyogyszergyar Nyrt | Pharmaceutical compositions containing silicones of high volatility |
| MX2007009796A (es) * | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| WO2009076302A1 (en) * | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
| CA2823534C (en) * | 2010-12-28 | 2018-09-11 | Mary Kay Inc. | Topical composition comprising a psidium guajava extract and a kunzea ericoides extract for providing sebum control and treating acne |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045935B2 (en) * | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| US10045965B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| JP6495723B2 (ja) * | 2015-04-14 | 2019-04-03 | 帝國製薬株式会社 | セレコキシブの経皮吸収製剤 |
| CN105663032A (zh) * | 2016-02-23 | 2016-06-15 | 青岛科技大学 | 一种维他昔布软膏剂的制备方法 |
| IL298681A (en) | 2016-08-02 | 2023-01-01 | Univ Virginia Commonwealth | Preparations |
| CN107158407A (zh) * | 2017-06-17 | 2017-09-15 | 安徽仁之堂药业有限公司 | 一种中药提取所得挥发油的制剂助剂 |
| MX366086B (es) | 2017-08-15 | 2019-06-27 | Cell Therapy And Tech S A De C V | Composicion topica semisolida conteniendo un agente antimicrobiano y pirfenidona para el tratamiento de daños cronicos de la piel. |
| MX368750B (es) | 2018-08-31 | 2019-10-15 | Cell Therapy And Tech S A De C V | Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular. |
| CA3164165A1 (en) * | 2020-01-10 | 2021-07-15 | Robert Bruce Register | Topical compositions containing rofecoxib and methods of making and using the same |
Family Cites Families (14)
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|---|---|---|---|---|
| GB2075837B (en) * | 1980-05-14 | 1984-03-14 | Hisamitsu Pharmaceutical Co | Topical pharmaceutical gel containing anti-inflammatory analgesic agents |
| US4602040A (en) * | 1983-04-18 | 1986-07-22 | Warner-Lambert Company | Meclofenamic acid topical pharmaceutical composition |
| US5093133A (en) * | 1990-01-24 | 1992-03-03 | Mcneil-Ppc, Inc. | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel |
| US5807568A (en) * | 1994-12-27 | 1998-09-15 | Mcneil-Ppc, Inc. | Enhanced delivery of topical compositions containing flurbiprofen |
| JP3267300B2 (ja) * | 1995-02-13 | 2002-03-18 | ジー．ディー．サール アンド カンパニー | 炎症の治療のための置換イソオキサゾール |
| US6096728A (en) * | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| EP0863134A1 (en) * | 1997-03-07 | 1998-09-09 | Merck Frosst Canada Inc. | 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2 |
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| SE9703693D0 (sv) * | 1997-10-10 | 1997-10-10 | Astra Pharma Prod | Novel combination |
| US5998487A (en) * | 1998-04-08 | 1999-12-07 | Colgate-Palmolive Company | Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions |
| GB2340751B (en) * | 1998-08-12 | 2003-11-05 | Edko Trading Representation | Pharmaceutical compositions |
| SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
| WO2000072883A2 (en) * | 1999-06-02 | 2000-12-07 | Aviana Biopharm | Pharmaceutical transdermal compositions |
| IN191512B (enExample) * | 2000-01-21 | 2003-12-06 | Panacea Biotech |
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2000
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- 2001-08-28 JP JP2002522896A patent/JP2004525859A/ja active Pending
- 2001-08-28 WO PCT/IB2001/001557 patent/WO2002017923A1/en not_active Ceased
- 2001-08-28 CN CNB018172873A patent/CN1227012C/zh not_active Expired - Fee Related
- 2001-08-28 RU RU2003108335/15A patent/RU2003108335A/ru not_active Application Discontinuation
- 2001-08-28 US US10/363,326 patent/US20040029946A1/en not_active Abandoned
- 2001-08-28 BR BR0113661-5A patent/BR0113661A/pt not_active IP Right Cessation
- 2001-08-28 AU AU2001284321A patent/AU2001284321A1/en not_active Abandoned
- 2001-08-28 CA CA002420804A patent/CA2420804A1/en not_active Abandoned
- 2001-08-28 EP EP01963295A patent/EP1315500A4/en not_active Withdrawn
- 2001-08-28 CZ CZ2003822A patent/CZ2003822A3/cs unknown
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2003
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1469748A (zh) | 2004-01-21 |
| BR0113661A (pt) | 2004-07-06 |
| EP1315500A4 (en) | 2006-05-31 |
| JP2004525859A (ja) | 2004-08-26 |
| WO2002017923A1 (en) | 2002-03-07 |
| IN191090B (enExample) | 2003-09-20 |
| RU2003108335A (ru) | 2004-09-10 |
| EP1315500A1 (en) | 2003-06-04 |
| CN1227012C (zh) | 2005-11-16 |
| CZ2003822A3 (cs) | 2003-08-13 |
| CA2420804A1 (en) | 2002-03-07 |
| AU2001284321A1 (en) | 2002-03-13 |
| SK3622003A3 (en) | 2003-09-11 |
| US20040029946A1 (en) | 2004-02-12 |
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