ZA200207969B - Therapeutically useful new salts of CCK inhibitors, process for the preparation thereof and pharmaceutical preparations containing them. - Google Patents
Therapeutically useful new salts of CCK inhibitors, process for the preparation thereof and pharmaceutical preparations containing them. Download PDFInfo
- Publication number
- ZA200207969B ZA200207969B ZA200207969A ZA200207969A ZA200207969B ZA 200207969 B ZA200207969 B ZA 200207969B ZA 200207969 A ZA200207969 A ZA 200207969A ZA 200207969 A ZA200207969 A ZA 200207969A ZA 200207969 B ZA200207969 B ZA 200207969B
- Authority
- ZA
- South Africa
- Prior art keywords
- new
- polymorphs
- ethanolamine
- solvates
- composition
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000000825 pharmaceutical preparation Substances 0.000 title description 6
- 239000003112 inhibitor Substances 0.000 title description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 20
- 150000001875 compounds Chemical class 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 239000012453 solvate Substances 0.000 claims description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims description 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 8
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 210000005095 gastrointestinal system Anatomy 0.000 claims description 4
- 239000003586 protic polar solvent Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 235000013350 formula milk Nutrition 0.000 claims 10
- 239000000126 substance Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- COILIDFWUDVRLY-UHFFFAOYSA-N 2-aminoethanol;2-[2-[[4-(4-chloro-2,5-dimethoxyphenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethylindol-1-yl]acetic acid Chemical compound NCCO.C1=C(Cl)C(OC)=CC(C2=C(SC(NC(=O)C=3N(C4=C(C)C=C(C)C=C4C=3)CC(O)=O)=N2)CCC2CCCCC2)=C1OC COILIDFWUDVRLY-UHFFFAOYSA-N 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 description 10
- 239000013078 crystal Substances 0.000 description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 101710150887 Cholecystokinin A Proteins 0.000 description 3
- 239000000556 agonist Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000001270 agonistic effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0001417A HUP0001417A2 (hu) | 2000-04-07 | 2000-04-07 | Gyógyászatilag alkalmazható új sók, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200207969B true ZA200207969B (en) | 2004-02-10 |
Family
ID=89978239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200207969A ZA200207969B (en) | 2000-04-07 | 2002-10-03 | Therapeutically useful new salts of CCK inhibitors, process for the preparation thereof and pharmaceutical preparations containing them. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030176475A1 (no) |
| EP (1) | EP1274707A1 (no) |
| JP (1) | JP2003530396A (no) |
| KR (1) | KR20020084296A (no) |
| CN (1) | CN1420885A (no) |
| AU (1) | AU2001248656A1 (no) |
| BG (1) | BG107219A (no) |
| BR (1) | BR0109890A (no) |
| CA (1) | CA2405004A1 (no) |
| CZ (1) | CZ20023671A3 (no) |
| EA (1) | EA200201076A1 (no) |
| EE (1) | EE200200582A (no) |
| HU (2) | HUP0001417A2 (no) |
| IL (1) | IL152005A0 (no) |
| IS (1) | IS6577A (no) |
| MX (1) | MXPA02009887A (no) |
| NO (1) | NO20024802D0 (no) |
| PL (1) | PL362650A1 (no) |
| SK (1) | SK15052002A3 (no) |
| WO (1) | WO2001077108A1 (no) |
| ZA (1) | ZA200207969B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY142390A (en) | 2002-05-22 | 2010-11-30 | Glaxosmithkline Llc | 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
| US7164383B2 (en) | 2002-09-25 | 2007-01-16 | The Board Of Regents Of The University Of Oklahoma | Navigation system using locally augmented GPS |
| ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
| EP3127427B1 (en) | 2009-05-29 | 2020-01-08 | Novartis Ag | Methods of administration of thrombopoietin agonist compounds |
| ES2926790T3 (es) * | 2016-05-04 | 2022-10-28 | Youngene Therapeutics Co Ltd | Solvato de dietilamina del inhibidor del transportador de sodio-glucosa, y método de preparación y aplicación del mismo |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4970713A1 (es) * | 1997-09-19 | 2000-11-07 | Sanofi Synthelabo | Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen |
-
2000
- 2000-04-07 HU HU0001417A patent/HUP0001417A2/hu unknown
-
2001
- 2001-04-04 JP JP2001575581A patent/JP2003530396A/ja not_active Withdrawn
- 2001-04-04 EE EEP200200582A patent/EE200200582A/xx unknown
- 2001-04-04 EA EA200201076A patent/EA200201076A1/ru unknown
- 2001-04-04 PL PL01362650A patent/PL362650A1/xx not_active Application Discontinuation
- 2001-04-04 BR BR0109890-0A patent/BR0109890A/pt not_active IP Right Cessation
- 2001-04-04 HU HU0204476A patent/HUP0204476A2/hu unknown
- 2001-04-04 WO PCT/HU2001/000039 patent/WO2001077108A1/en not_active Application Discontinuation
- 2001-04-04 AU AU2001248656A patent/AU2001248656A1/en not_active Abandoned
- 2001-04-04 KR KR1020027013375A patent/KR20020084296A/ko not_active Application Discontinuation
- 2001-04-04 EP EP01921689A patent/EP1274707A1/en not_active Withdrawn
- 2001-04-04 US US10/240,698 patent/US20030176475A1/en not_active Abandoned
- 2001-04-04 CA CA002405004A patent/CA2405004A1/en not_active Abandoned
- 2001-04-04 MX MXPA02009887A patent/MXPA02009887A/es unknown
- 2001-04-04 CZ CZ20023671A patent/CZ20023671A3/cs unknown
- 2001-04-04 CN CN01807475A patent/CN1420885A/zh active Pending
- 2001-04-04 SK SK1505-2002A patent/SK15052002A3/sk unknown
- 2001-04-04 IL IL15200501A patent/IL152005A0/xx unknown
-
2002
- 2002-10-02 IS IS6577A patent/IS6577A/is unknown
- 2002-10-03 ZA ZA200207969A patent/ZA200207969B/en unknown
- 2002-10-04 NO NO20024802A patent/NO20024802D0/no not_active Application Discontinuation
- 2002-10-24 BG BG107219A patent/BG107219A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030176475A1 (en) | 2003-09-18 |
| AU2001248656A1 (en) | 2001-10-23 |
| HUP0204476A2 (en) | 2003-05-28 |
| NO20024802L (no) | 2002-10-04 |
| BR0109890A (pt) | 2003-06-03 |
| MXPA02009887A (es) | 2003-06-17 |
| EP1274707A1 (en) | 2003-01-15 |
| EA200201076A1 (ru) | 2003-04-24 |
| PL362650A1 (en) | 2004-11-02 |
| BG107219A (bg) | 2003-05-30 |
| SK15052002A3 (sk) | 2003-05-02 |
| HU0001417D0 (en) | 2000-06-28 |
| JP2003530396A (ja) | 2003-10-14 |
| CZ20023671A3 (cs) | 2003-05-14 |
| WO2001077108A1 (en) | 2001-10-18 |
| EE200200582A (et) | 2004-04-15 |
| IL152005A0 (en) | 2003-04-10 |
| KR20020084296A (ko) | 2002-11-04 |
| HUP0001417A2 (hu) | 2002-12-28 |
| IS6577A (is) | 2002-10-02 |
| NO20024802D0 (no) | 2002-10-04 |
| CN1420885A (zh) | 2003-05-28 |
| CA2405004A1 (en) | 2001-10-18 |
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