ZA200206957B - 4-amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell-cycle kinases. - Google Patents
4-amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell-cycle kinases. Download PDFInfo
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- ZA200206957B ZA200206957B ZA200206957A ZA200206957A ZA200206957B ZA 200206957 B ZA200206957 B ZA 200206957B ZA 200206957 A ZA200206957 A ZA 200206957A ZA 200206957 A ZA200206957 A ZA 200206957A ZA 200206957 B ZA200206957 B ZA 200206957B
- Authority
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- South Africa
- Prior art keywords
- sulphamoyl
- formula
- compound
- alkyl
- amino
- Prior art date
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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| US20030139435A1 (en) | 2001-06-26 | 2003-07-24 | Gulzar Ahmed | N-heterocyclic inhibitors of TNF-alpha expression |
| US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
| US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
| ATE407678T1 (de) | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| WO2003062246A1 (en) * | 2002-01-22 | 2003-07-31 | Warner-Lambert Company Llc | 2-thia-1,6,8-triaza-naphtalene-2,2-dioxides as cdk inhibitors |
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| BR0316680A (pt) | 2002-11-28 | 2005-10-18 | Schering Ag | Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos |
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| NZ555474A (en) * | 2004-12-17 | 2010-10-29 | Astrazeneca Ab | 4-(4-(imidazol-4-yl) pyrimidin-2-ylamino) benzamides as CDK inhibitors |
| MX2008001428A (es) * | 2005-07-30 | 2008-04-04 | Astrazeneca Ab | Compuestos de imidazolil-pirimidina para uso en el tratamiento de trastornos proliferativos. |
| WO2007036732A1 (en) | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
| US7713987B2 (en) | 2005-12-06 | 2010-05-11 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2,4-diamines and their uses |
| PE20120006A1 (es) * | 2006-05-15 | 2012-02-02 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| BRPI0821209A2 (pt) | 2007-12-19 | 2019-09-24 | Amgen Inc | composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor. |
| US8389533B2 (en) | 2008-04-07 | 2013-03-05 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| CN103703000B (zh) | 2011-03-23 | 2015-11-25 | 安姆根有限公司 | Cdk4/6和flt3的稠合三环双重抑制剂 |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE |
| CN111686113B (zh) * | 2019-03-15 | 2022-12-30 | 北京大学 | Sonic Hedgehog抑制剂及应用 |
| CN112110863A (zh) * | 2020-08-27 | 2020-12-22 | 中山大学 | 一种磺酰氟类化合物、其制备方法以及通过其制备磺酰胺类化合物的方法 |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| WO2026024674A1 (en) | 2024-07-22 | 2026-01-29 | Genesis Therapeutics, Inc. | Methods of treating skp2-associated cancers |
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| US4659363A (en) | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
| US4946956A (en) | 1988-09-21 | 1990-08-07 | Uniroyal Chemical Company, Inc. | Arylenediamine substituted pyrimidines |
| HU206337B (en) | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
| US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| GB9012592D0 (en) | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
| US5409930A (en) | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (https=) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| WO1994007890A1 (fr) | 1992-10-05 | 1994-04-14 | Ube Industries, Ltd. | Compose pyrimidine |
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-
2000
- 2000-03-28 GB GBGB0007371.8A patent/GB0007371D0/en not_active Ceased
-
2001
- 2001-03-23 DK DK01914026T patent/DK1268445T3/da active
- 2001-03-23 WO PCT/GB2001/001264 patent/WO2001072717A1/en not_active Ceased
- 2001-03-23 NZ NZ521032A patent/NZ521032A/en unknown
- 2001-03-23 EP EP01914026A patent/EP1268445B1/en not_active Expired - Lifetime
- 2001-03-23 AU AU3941401A patent/AU3941401A/xx active Pending
- 2001-03-23 KR KR1020027012916A patent/KR100802367B1/ko not_active Expired - Fee Related
- 2001-03-23 DE DE60113080T patent/DE60113080T2/de not_active Expired - Fee Related
- 2001-03-23 US US10/239,790 patent/US6906065B2/en not_active Expired - Fee Related
- 2001-03-23 PT PT01914026T patent/PT1268445E/pt unknown
- 2001-03-23 CA CA002399864A patent/CA2399864A1/en not_active Abandoned
- 2001-03-23 AT AT01914026T patent/ATE303366T1/de not_active IP Right Cessation
- 2001-03-23 JP JP2001570630A patent/JP2003528861A/ja active Pending
- 2001-03-23 IL IL15139201A patent/IL151392A0/xx active IP Right Grant
- 2001-03-23 CN CNB018071570A patent/CN1231471C/zh not_active Expired - Fee Related
- 2001-03-23 AU AU2001239414A patent/AU2001239414B2/en not_active Ceased
- 2001-03-23 MX MXPA02009255A patent/MXPA02009255A/es active IP Right Grant
- 2001-03-23 ES ES01914026T patent/ES2247078T3/es not_active Expired - Lifetime
- 2001-03-23 BR BR0109577-3A patent/BR0109577A/pt not_active Application Discontinuation
- 2001-03-27 MY MYPI20011414A patent/MY124527A/en unknown
-
2002
- 2002-08-21 IL IL151392A patent/IL151392A/en not_active IP Right Cessation
- 2002-08-29 ZA ZA200206957A patent/ZA200206957B/en unknown
- 2002-09-27 NO NO20024644A patent/NO324228B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2399864A1 (en) | 2001-10-04 |
| BR0109577A (pt) | 2003-01-28 |
| KR20020083532A (ko) | 2002-11-02 |
| GB0007371D0 (en) | 2000-05-17 |
| EP1268445A1 (en) | 2003-01-02 |
| JP2003528861A (ja) | 2003-09-30 |
| KR100802367B1 (ko) | 2008-02-13 |
| ES2247078T3 (es) | 2006-03-01 |
| ATE303366T1 (de) | 2005-09-15 |
| IL151392A0 (en) | 2003-04-10 |
| US6906065B2 (en) | 2005-06-14 |
| WO2001072717A1 (en) | 2001-10-04 |
| MY124527A (en) | 2006-06-30 |
| DK1268445T3 (da) | 2005-11-07 |
| AU3941401A (en) | 2001-10-08 |
| DE60113080D1 (de) | 2005-10-06 |
| US20030087923A1 (en) | 2003-05-08 |
| EP1268445B1 (en) | 2005-08-31 |
| DE60113080T2 (de) | 2006-05-18 |
| CN1231471C (zh) | 2005-12-14 |
| NO324228B1 (no) | 2007-09-10 |
| NO20024644L (no) | 2002-11-27 |
| NO20024644D0 (no) | 2002-09-27 |
| PT1268445E (pt) | 2005-11-30 |
| AU2001239414B2 (en) | 2004-09-02 |
| IL151392A (en) | 2007-06-17 |
| NZ521032A (en) | 2004-05-28 |
| MXPA02009255A (es) | 2003-03-12 |
| CN1419548A (zh) | 2003-05-21 |
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