ZA200206880B - Method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample, ESR-spectrometer for carrying out said method, and use of the method for diagnostic purposes and for controlling albumin-containing preparations. - Google Patents
Method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample, ESR-spectrometer for carrying out said method, and use of the method for diagnostic purposes and for controlling albumin-containing preparations. Download PDFInfo
- Publication number
- ZA200206880B ZA200206880B ZA200206880A ZA200206880A ZA200206880B ZA 200206880 B ZA200206880 B ZA 200206880B ZA 200206880 A ZA200206880 A ZA 200206880A ZA 200206880 A ZA200206880 A ZA 200206880A ZA 200206880 B ZA200206880 B ZA 200206880B
- Authority
- ZA
- South Africa
- Prior art keywords
- albumin
- esr
- spin probe
- probe
- spin
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title claims abstract description 127
- 108010088751 Albumins Proteins 0.000 title claims abstract description 127
- 238000000034 method Methods 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000001514 detection method Methods 0.000 title claims abstract description 4
- 230000036285 pathological change Effects 0.000 claims abstract description 9
- 231100000915 pathological change Toxicity 0.000 claims abstract description 9
- 238000012544 monitoring process Methods 0.000 claims abstract description 7
- 241001465754 Metazoa Species 0.000 claims abstract description 6
- 239000000523 sample Substances 0.000 claims description 201
- 229940050528 albumin Drugs 0.000 claims description 121
- 230000027455 binding Effects 0.000 claims description 116
- 238000009739 binding Methods 0.000 claims description 116
- 239000003153 chemical reaction reagent Substances 0.000 claims description 56
- 238000001362 electron spin resonance spectrum Methods 0.000 claims description 38
- 230000032258 transport Effects 0.000 claims description 37
- 230000003595 spectral effect Effects 0.000 claims description 34
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 31
- 229930195729 fatty acid Natural products 0.000 claims description 31
- 239000000194 fatty acid Substances 0.000 claims description 31
- 150000004665 fatty acids Chemical class 0.000 claims description 31
- 201000010099 disease Diseases 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
- 230000006870 function Effects 0.000 claims description 27
- 238000001228 spectrum Methods 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 210000004369 blood Anatomy 0.000 claims description 22
- 239000008280 blood Substances 0.000 claims description 22
- 102000007562 Serum Albumin Human genes 0.000 claims description 16
- 108010071390 Serum Albumin Proteins 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- 235000019441 ethanol Nutrition 0.000 claims description 15
- 238000004422 calculation algorithm Methods 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 230000035945 sensitivity Effects 0.000 claims description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000008859 change Effects 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 230000009870 specific binding Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 238000011835 investigation Methods 0.000 claims description 5
- 230000006641 stabilisation Effects 0.000 claims description 5
- 238000011105 stabilization Methods 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 230000002730 additional effect Effects 0.000 claims description 3
- 238000005094 computer simulation Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 230000000771 oncological effect Effects 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- 239000007858 starting material Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 2
- 230000014509 gene expression Effects 0.000 claims description 2
- 238000012067 mathematical method Methods 0.000 claims description 2
- 230000001955 cumulated effect Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 abstract description 22
- 238000011156 evaluation Methods 0.000 abstract description 5
- 238000003908 quality control method Methods 0.000 abstract description 5
- 238000004590 computer program Methods 0.000 abstract description 4
- 239000010836 blood and blood product Substances 0.000 abstract description 2
- 229940125691 blood product Drugs 0.000 abstract description 2
- 238000004435 EPR spectroscopy Methods 0.000 description 70
- 210000002966 serum Anatomy 0.000 description 47
- 210000002381 plasma Anatomy 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 11
- 238000004088 simulation Methods 0.000 description 11
- 201000011510 cancer Diseases 0.000 description 10
- 238000003745 diagnosis Methods 0.000 description 9
- 238000003759 clinical diagnosis Methods 0.000 description 8
- RPAZYIOIDZRJOO-UHFFFAOYSA-N 16-DOXYL-stearic acid Chemical compound OC(=O)CCCCCCCCCCCCCCC1(CC)OCC(C)(C)N1[O] RPAZYIOIDZRJOO-UHFFFAOYSA-N 0.000 description 7
- 230000001476 alcoholic effect Effects 0.000 description 6
- 238000004364 calculation method Methods 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 238000010183 spectrum analysis Methods 0.000 description 6
- 238000013019 agitation Methods 0.000 description 5
- 238000011068 loading method Methods 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 238000012106 screening analysis Methods 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000000804 electron spin resonance spectroscopy Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000007452 Plasmacytoma Diseases 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 230000002489 hematologic effect Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 230000035790 physiological processes and functions Effects 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 238000012369 In process control Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000002844 continuous effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000013399 early diagnosis Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010965 in-process control Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000003270 steroid hormone Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 125000000349 (Z)-3-carboxyprop-2-enoyl group Chemical group O=C([*])/C([H])=C([H])\C(O[H])=O 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000026097 Factitious disease Diseases 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000006035 Tryptophane Substances 0.000 description 1
- 241000270433 Varanidae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000011797 cavity material Substances 0.000 description 1
- 208000037516 chromosome inversion disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000001719 hemosorption Effects 0.000 description 1
- -1 heterocyclic hydrocarbons Chemical class 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000004124 rheumatic heart disease Diseases 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/60—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using electron paramagnetic resonance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10011163A DE10011163A1 (de) | 2000-02-28 | 2000-02-28 | Verfahren zur Diagnose und/oder Überwachung physiologischer oder pathologischer Veränderungen im menschlichen oder tierischen Körper und ESR-Spektrometer zur Durchführung des Verfahrens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206880B true ZA200206880B (en) | 2003-05-12 |
Family
ID=7633890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206880A ZA200206880B (en) | 2000-02-28 | 2002-08-28 | Method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample, ESR-spectrometer for carrying out said method, and use of the method for diagnostic purposes and for controlling albumin-containing preparations. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7166474B2 (ru) |
| EP (1) | EP1269213B1 (ru) |
| JP (1) | JP4885396B2 (ru) |
| CN (1) | CN1252489C (ru) |
| AT (1) | ATE268914T1 (ru) |
| AU (2) | AU2001240662B2 (ru) |
| CA (1) | CA2401486C (ru) |
| DE (2) | DE10011163A1 (ru) |
| DK (1) | DK1269213T3 (ru) |
| ES (1) | ES2225494T3 (ru) |
| IL (2) | IL151516A0 (ru) |
| PT (1) | PT1269213E (ru) |
| RU (1) | RU2275648C2 (ru) |
| TR (1) | TR200402253T4 (ru) |
| WO (1) | WO2001065270A2 (ru) |
| ZA (1) | ZA200206880B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2858057B1 (fr) * | 2003-07-21 | 2006-05-26 | Abx Sa | Dispositif de controle de qualite pour analyseur sanguin fonctionnant en sang total |
| DE102004013330A1 (de) * | 2004-03-17 | 2005-10-27 | Tenovis Gmbh & Co. Kg | Telekommunikationsanlage, Verbund aus Telekommunikationsanlagen, Verfahren zur Konfiguration und zum Betrieb eines solchen Verbundes sowie Software zur Indentifizierung eines Kunden und einer Anlage darin |
| US8632986B2 (en) | 2008-10-28 | 2014-01-21 | Uladzimir A. Murauski | Methods and kits for detection of toxemia |
| WO2013124325A1 (en) | 2012-02-20 | 2013-08-29 | Murauski Uladzimir A | Methods and kits for detection of active malignancy |
| US10352974B2 (en) * | 2016-06-22 | 2019-07-16 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Method and apparatus to implement frequency stabilization of a resonator |
| JP7002245B2 (ja) | 2017-08-10 | 2022-01-20 | シスメックス株式会社 | 血液分析装置、血液分析方法およびプログラム |
| CN112930568A (zh) * | 2019-04-23 | 2021-06-08 | 艾斯皮雷科技股份有限公司 | 用于定位或识别恶性肿瘤的装置和方法 |
| EP3786642A1 (en) | 2019-08-30 | 2021-03-03 | ESPIRE Technologies GmbH | Method for functional characteristics of proteins for classification of patients to be associated to a specific disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1179971A (en) * | 1967-02-08 | 1970-02-04 | Varian Mat Gmbh | Improved Arrangement for Measuring Magnet Fields. |
| DE3726051A1 (de) * | 1987-08-06 | 1989-02-16 | Bruker Analytische Messtechnik | Elektronenspinresonanz-spektrometer |
| US5530350A (en) | 1991-11-20 | 1996-06-25 | Auburn International, Inc. | Magnetic resonance analysis in real time, industrial usage mode |
| JP3281007B2 (ja) * | 1991-12-06 | 2002-05-13 | 住友特殊金属株式会社 | 電子スピン共鳴装置 |
| JP3322688B2 (ja) * | 1992-04-23 | 2002-09-09 | 住友特殊金属株式会社 | 電子スピン共鳴装置 |
| JPH0666908A (ja) * | 1992-08-13 | 1994-03-11 | Mitsubishi Electric Corp | Ｅｓｒ装置 |
| JPH06329646A (ja) * | 1993-05-20 | 1994-11-29 | Taisho Pharmaceut Co Ltd | スピンラベル化トリグリセライド化合物 |
| TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| FR2726088B1 (fr) | 1994-10-19 | 1997-01-24 | Sadis Bruker Spectrospin | Procede de reglage et d'ajustement en frequence, notamment de ponts hyperfrequences, et dispositif mettant en oeuvre un tel procede |
| JPH08313463A (ja) * | 1995-05-16 | 1996-11-29 | Yamagata Pref Gov Technopolis Zaidan | 電子スピン共鳴装置 |
| EP0973043A1 (en) * | 1998-07-13 | 2000-01-19 | Newpharm & Trading SA | Method of diagnosing malignant neoplasms based on ESR spectroscopy |
| DE19834939A1 (de) * | 1998-07-29 | 2000-02-03 | Norbert Groth | Mikrospektrometer für die ESR-Spektroskopie und Meßverfahren |
-
2000
- 2000-02-28 DE DE10011163A patent/DE10011163A1/de not_active Ceased
-
2001
- 2001-02-28 AU AU2001240662A patent/AU2001240662B2/en not_active Ceased
- 2001-02-28 RU RU2002123351/28A patent/RU2275648C2/ru not_active IP Right Cessation
- 2001-02-28 ES ES01911706T patent/ES2225494T3/es not_active Expired - Lifetime
- 2001-02-28 DK DK01911706T patent/DK1269213T3/da active
- 2001-02-28 CN CN01805754.3A patent/CN1252489C/zh not_active Expired - Fee Related
- 2001-02-28 JP JP2001563914A patent/JP4885396B2/ja not_active Expired - Fee Related
- 2001-02-28 TR TR2004/02253T patent/TR200402253T4/xx unknown
- 2001-02-28 CA CA002401486A patent/CA2401486C/en not_active Expired - Fee Related
- 2001-02-28 EP EP01911706A patent/EP1269213B1/de not_active Expired - Lifetime
- 2001-02-28 AU AU4066201A patent/AU4066201A/xx active Pending
- 2001-02-28 US US10/220,170 patent/US7166474B2/en not_active Expired - Lifetime
- 2001-02-28 PT PT01911706T patent/PT1269213E/pt unknown
- 2001-02-28 IL IL15151601A patent/IL151516A0/xx active IP Right Grant
- 2001-02-28 WO PCT/EP2001/002248 patent/WO2001065270A2/de active IP Right Grant
- 2001-02-28 DE DE50102536T patent/DE50102536D1/de not_active Expired - Lifetime
- 2001-02-28 AT AT01911706T patent/ATE268914T1/de active
-
2002
- 2002-08-28 IL IL151516A patent/IL151516A/en unknown
- 2002-08-28 ZA ZA200206880A patent/ZA200206880B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001240662B2 (en) | 2006-04-27 |
| IL151516A (en) | 2006-12-31 |
| DE50102536D1 (de) | 2004-07-15 |
| DE10011163A1 (de) | 2001-09-13 |
| CA2401486A1 (en) | 2001-09-07 |
| US20030170912A1 (en) | 2003-09-11 |
| EP1269213A2 (de) | 2003-01-02 |
| WO2001065270A3 (de) | 2002-04-04 |
| RU2002123351A (ru) | 2004-03-20 |
| CN1252489C (zh) | 2006-04-19 |
| WO2001065270A2 (de) | 2001-09-07 |
| EP1269213B1 (de) | 2004-06-09 |
| ES2225494T3 (es) | 2005-03-16 |
| TR200402253T4 (tr) | 2004-10-21 |
| DK1269213T3 (da) | 2004-10-25 |
| JP2003525456A (ja) | 2003-08-26 |
| PT1269213E (pt) | 2004-10-29 |
| AU4066201A (en) | 2001-09-12 |
| US7166474B2 (en) | 2007-01-23 |
| IL151516A0 (en) | 2003-04-10 |
| RU2275648C2 (ru) | 2006-04-27 |
| CN1418314A (zh) | 2003-05-14 |
| JP4885396B2 (ja) | 2012-02-29 |
| ATE268914T1 (de) | 2004-06-15 |
| CA2401486C (en) | 2009-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Cheng et al. | Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy | |
| ES2529040T3 (es) | Proceso para la determinación de lipoproteínas en fluidos corporales | |
| US5200345A (en) | Methods and apparatus for quantifying tissue damage, determining tissue type, monitoring neural activity, and determining hematocrit | |
| BG64326B1 (bg) | Използване на едномерен ядреномагнитен резонанс за идентифициране на лиганди с таргет биомолекули | |
| CA2401486C (en) | Method for the esr-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample, an esr spectrometer for carrying out said method, anduse of the method for diagnostic purposes and for controlling albumin-containing preparations | |
| Piotto et al. | 23 Reproducible Sample Preparation and Spectrum Acquisition Techniques for Metabolic Profiling of Human Tissues by Proton High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance | |
| Picarelli et al. | Quantitative determination of faecal fat, nitrogen and water by means of a spectrophotometric technique: near infrared reflectance analysis (NIRA). Assessment of its accuracy and reproducibility compared with chemical methods | |
| Smith et al. | Nuclear magnetic resonance spectroscopy | |
| Goldsmith et al. | NMR in cancer. XI. Application of the NMR malignancy index to human gastro‐intestinal tumors | |
| US4918021A (en) | Process for the detection of cancer | |
| JPH0643995B2 (ja) | 癌種の存在の診断装置 | |
| PT98433B (pt) | Processo para o diagnostico da presenca de cancro em seres humanos usando um ensaio de ressonancia magnetica nuclear | |
| EP0973043A1 (en) | Method of diagnosing malignant neoplasms based on ESR spectroscopy | |
| IE920029A1 (en) | Process for the detection and localization of cancer | |
| Kagimoto et al. | Nuclear magnetic resonance study of human bone marrows from patients with leukemia, anemia, and myeloma and from normal donors | |
| US20220214292A1 (en) | Portable nmr instrumentation and methods for analysis of body fluids | |
| WO2006095238A1 (en) | Assay of sebum lipid components by nuclear magnetic resonance | |
| CN117647552A (zh) | 一种猪血浆脂蛋白亚类测定方法与应用 | |
| BG113543A (bg) | Електрон парамагнитен резонанс метод за определяне нивата на серумен албумин и хипоалбуминемия при пациенти с коронавирусна инфекция (covid- 19) | |
| WO1991004706A1 (en) | Nmr apparatus and method for detecting cancer | |
| Smith et al. | Magnetic Resonance in Medicine, High Resolution Ex Vivo | |
| WO2007073227A1 (fr) | Procede et dispositif diagnostiques et procede de preparation de serum | |
| JPH04353781A (ja) | Ｎｍｒ装置を用いた乳酸濃度測定方法 |