ZA200200568B - Ectoparasiticidal aqueous suspension formulations of spinosyns. - Google Patents
Ectoparasiticidal aqueous suspension formulations of spinosyns. Download PDFInfo
- Publication number
- ZA200200568B ZA200200568B ZA200200568A ZA200200568A ZA200200568B ZA 200200568 B ZA200200568 B ZA 200200568B ZA 200200568 A ZA200200568 A ZA 200200568A ZA 200200568 A ZA200200568 A ZA 200200568A ZA 200200568 B ZA200200568 B ZA 200200568B
- Authority
- ZA
- South Africa
- Prior art keywords
- formulation
- spinosyn
- amount
- composition
- dispersant
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 123
- 238000009472 formulation Methods 0.000 title claims description 98
- 229930185156 spinosyn Natural products 0.000 title claims description 74
- 239000007900 aqueous suspension Substances 0.000 title claims description 22
- 230000001984 ectoparasiticidal effect Effects 0.000 title claims description 19
- 239000002270 dispersing agent Substances 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 23
- 239000000725 suspension Substances 0.000 claims description 23
- 239000004094 surface-active agent Substances 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 241001465754 Metazoa Species 0.000 claims description 12
- 239000002518 antifoaming agent Substances 0.000 claims description 12
- 239000004599 antimicrobial Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- 229920001285 xanthan gum Polymers 0.000 claims description 11
- 235000010493 xanthan gum Nutrition 0.000 claims description 11
- 239000000230 xanthan gum Substances 0.000 claims description 11
- 229940082509 xanthan gum Drugs 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 9
- -1 alkylene diol Chemical class 0.000 claims description 8
- 244000078703 ectoparasite Species 0.000 claims description 8
- 239000006083 mineral thickener Substances 0.000 claims description 8
- SRJQTHAZUNRMPR-UHFFFAOYSA-N spinosyn A Natural products CC1C(=O)C2=CC3C4CC(OC5C(C(OC)C(OC)C(C)O5)OC)CC4C=CC3C2CC(=O)OC(CC)CCCC1OC1CCC(N(C)C)C(C)O1 SRJQTHAZUNRMPR-UHFFFAOYSA-N 0.000 claims description 8
- 238000009736 wetting Methods 0.000 claims description 8
- SRJQTHAZUNRMPR-UYQKXTDMSA-N spinosyn A Chemical compound O([C@H]1CCC[C@@H](OC(=O)C[C@H]2[C@@H]3C=C[C@@H]4C[C@H](C[C@H]4[C@@H]3C=C2C(=O)[C@@H]1C)O[C@H]1[C@@H]([C@H](OC)[C@@H](OC)[C@H](C)O1)OC)CC)[C@H]1CC[C@H](N(C)C)[C@@H](C)O1 SRJQTHAZUNRMPR-UYQKXTDMSA-N 0.000 claims description 7
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 6
- 206010061217 Infestation Diseases 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000000699 topical effect Effects 0.000 claims description 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 4
- 241000282849 Ruminantia Species 0.000 claims description 4
- 230000000813 microbial effect Effects 0.000 claims description 4
- 239000004540 pour-on Substances 0.000 claims description 4
- 239000004544 spot-on Substances 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 1
- 230000008774 maternal effect Effects 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 description 15
- 239000004480 active ingredient Substances 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- JFLRKDZMHNBDQS-UCQUSYKYSA-N CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C Chemical compound CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C(=C[C@H]3[C@@H]2CC(=O)O1)C)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C.CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@H]3[C@@H]4C[C@@H](C[C@H]4C=C[C@H]3C2CC(=O)O1)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C JFLRKDZMHNBDQS-UCQUSYKYSA-N 0.000 description 9
- 239000005930 Spinosad Substances 0.000 description 9
- 229940014213 spinosad Drugs 0.000 description 9
- 239000007787 solid Substances 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 229920001983 poloxamer Polymers 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- 239000013011 aqueous formulation Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 239000002736 nonionic surfactant Substances 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241001494479 Pecora Species 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- RDECBWLKMPEKPM-UHFFFAOYSA-N spinosyn D Natural products CC1C(=O)C2=CC3C4CC(OC5C(C(OC)C(OC)C(C)O5)OC)CC4C(C)=CC3C2CC(=O)OC(CC)CCCC1OC1CCC(N(C)C)C(C)O1 RDECBWLKMPEKPM-UHFFFAOYSA-N 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000868102 Saccharopolyspora spinosa Species 0.000 description 2
- 244000300264 Spinacia oleracea Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000007798 antifreeze agent Substances 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000004495 emulsifiable concentrate Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- RDECBWLKMPEKPM-PSCJHHPTSA-N spinosyn D Chemical compound O([C@H]1CCC[C@@H](OC(=O)C[C@H]2[C@@H]3C=C(C)[C@@H]4C[C@H](C[C@H]4[C@@H]3C=C2C(=O)[C@@H]1C)O[C@H]1[C@@H]([C@H](OC)[C@@H](OC)[C@H](C)O1)OC)CC)[C@H]1CC[C@H](N(C)C)[C@@H](C)O1 RDECBWLKMPEKPM-PSCJHHPTSA-N 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000001238 wet grinding Methods 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000256113 Culicidae Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CEAGUSGLAUVBEQ-UHFFFAOYSA-N Forosamine Natural products CC1CC(N(C)C)CC(O)O1 CEAGUSGLAUVBEQ-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241000920471 Lucilia caesar Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 241000257226 Muscidae Species 0.000 description 1
- 241000257186 Phormia regina Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241001494115 Stomoxys calcitrans Species 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001346 alkyl aryl ethers Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- SZGAAHDUAFVZSS-SFYZADRCSA-N forosamine Chemical compound C[C@@H](O)[C@@H](N(C)C)CCC=O SZGAAHDUAFVZSS-SFYZADRCSA-N 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 230000001418 larval effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229910001482 mixed metal silicate Inorganic materials 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical class CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910021647 smectite Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14852799P | 1999-08-12 | 1999-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200200568B true ZA200200568B (en) | 2003-06-25 |
Family
ID=22526149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200200568A ZA200200568B (en) | 1999-08-12 | 2002-01-22 | Ectoparasiticidal aqueous suspension formulations of spinosyns. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1207757B1 (zh) |
| JP (1) | JP2003506464A (zh) |
| KR (1) | KR20020029098A (zh) |
| CN (1) | CN1306867C (zh) |
| AR (1) | AR025235A1 (zh) |
| AT (1) | ATE289478T1 (zh) |
| AU (1) | AU770879B2 (zh) |
| BR (1) | BR0013250A (zh) |
| CA (1) | CA2379331C (zh) |
| CO (1) | CO5221062A1 (zh) |
| DE (1) | DE60018289T2 (zh) |
| EA (1) | EA004251B1 (zh) |
| EG (1) | EG22674A (zh) |
| ES (1) | ES2235931T3 (zh) |
| HU (1) | HUP0202786A3 (zh) |
| IL (2) | IL147827A0 (zh) |
| MX (1) | MXPA02001504A (zh) |
| MY (1) | MY127822A (zh) |
| NO (1) | NO327737B1 (zh) |
| NZ (1) | NZ516787A (zh) |
| PE (1) | PE20010360A1 (zh) |
| PT (1) | PT1207757E (zh) |
| SV (1) | SV2002000142A (zh) |
| TW (1) | TWI221402B (zh) |
| WO (1) | WO2001011964A1 (zh) |
| ZA (1) | ZA200200568B (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6933318B1 (en) | 1999-08-12 | 2005-08-23 | Eli Lilly And Company | Topical organic ectoparasiticidal formulations |
| AUPQ441699A0 (en) | 1999-12-02 | 2000-01-06 | Eli Lilly And Company | Pour-on formulations |
| US6727228B2 (en) | 2001-04-25 | 2004-04-27 | Johnson & Johnson Consumer Companies, Inc. | Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs |
| DE10135550A1 (de) | 2001-07-20 | 2003-01-30 | Bayer Cropscience Ag | Verfahren zum Herstellen von neuen Spinosyn-Derivaten |
| ES2723779T3 (es) | 2001-09-17 | 2019-09-02 | Elanco Us Inc | Formulación para el control de piojos y garrapatas en el ganado |
| US20040197465A1 (en) | 2003-04-02 | 2004-10-07 | Clark Harry M. | Composition and method |
| US20050042362A1 (en) | 2003-04-02 | 2005-02-24 | Clark Harry M. | Pet food composition and method |
| PL1610613T3 (pl) * | 2003-04-04 | 2017-06-30 | Merial, Inc. | Miejscowe preparaty weterynaryjne przeciw robakom |
| US7579017B2 (en) * | 2003-06-18 | 2009-08-25 | Brook Chandler Murphy | Physical mode of action pesticide |
| WO2008067054A2 (en) | 2006-10-12 | 2008-06-05 | Topaz Pharmaceuticals Llc | Topical avermectin formulations and methods for elimination and prophylaxis of susceptible and treatment-resistant strains of head lice |
| JP5694944B2 (ja) * | 2008-10-29 | 2015-04-01 | トパズ ファーマシューティカルズ インコーポレイティド | エマルション系局所治療用製剤の保存方式 |
| EP2228054A1 (en) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| TW201041509A (en) | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity |
| TW201041508A (en) * | 2009-04-30 | 2010-12-01 | Dow Agrosciences Llc | Pesticide compositions exhibiting enhanced activity |
| CN102475681A (zh) * | 2010-11-23 | 2012-05-30 | 天津金耀集团有限公司 | 治疗皮肤病的分离式水混悬剂药物 |
| CN108137529A (zh) | 2015-09-03 | 2018-06-08 | 阿格里麦蒂斯有限责任公司 | 作为杀虫剂的多杀菌素衍生物 |
| US10570165B2 (en) | 2017-01-13 | 2020-02-25 | Agrimetis, Llc | Aziridine spinosyn derivatives and methods of making |
| JP7079375B2 (ja) | 2019-03-18 | 2022-06-01 | クミアイ化学工業株式会社 | 水性懸濁農薬組成物およびその散布方法 |
| CN111771882A (zh) * | 2020-07-27 | 2020-10-16 | 江西禾益化工股份有限公司 | 一种黄元胶水溶剂及其制备方法 |
| AU2022403979A1 (en) * | 2021-12-07 | 2024-07-04 | Adama Makhteshim Ltd. | Composition containing a macrolide insecticidal compound and polycationic rheology modifier |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2088212B (en) * | 1980-11-21 | 1985-12-04 | Wellcome Found | Pest control |
| ZW1682A1 (en) * | 1981-02-09 | 1983-08-31 | Aeci Ltd | Insecticidal composition |
| OA09249A (fr) * | 1988-12-19 | 1992-06-30 | Lilly Co Eli | Composés de macrolides. |
| JP4561941B2 (ja) * | 1999-08-04 | 2010-10-13 | 日産化学工業株式会社 | 懸濁組成物および散布方法 |
-
2000
- 2000-08-02 IL IL14782700A patent/IL147827A0/xx active IP Right Grant
- 2000-08-02 CA CA002379331A patent/CA2379331C/en not_active Expired - Fee Related
- 2000-08-02 EA EA200200251A patent/EA004251B1/ru not_active IP Right Cessation
- 2000-08-02 CN CNB008112347A patent/CN1306867C/zh not_active Expired - Fee Related
- 2000-08-02 JP JP2001516327A patent/JP2003506464A/ja active Pending
- 2000-08-02 MX MXPA02001504A patent/MXPA02001504A/es active IP Right Grant
- 2000-08-02 KR KR1020027001772A patent/KR20020029098A/ko not_active Application Discontinuation
- 2000-08-02 NZ NZ516787A patent/NZ516787A/en not_active IP Right Cessation
- 2000-08-02 BR BR0013250-0A patent/BR0013250A/pt not_active Application Discontinuation
- 2000-08-02 EP EP00955248A patent/EP1207757B1/en not_active Expired - Lifetime
- 2000-08-02 HU HU0202786A patent/HUP0202786A3/hu unknown
- 2000-08-02 AT AT00955248T patent/ATE289478T1/de not_active IP Right Cessation
- 2000-08-02 AU AU67477/00A patent/AU770879B2/en not_active Expired
- 2000-08-02 WO PCT/US2000/019558 patent/WO2001011964A1/en active IP Right Grant
- 2000-08-02 DE DE60018289T patent/DE60018289T2/de not_active Expired - Lifetime
- 2000-08-02 PT PT00955248T patent/PT1207757E/pt unknown
- 2000-08-02 ES ES00955248T patent/ES2235931T3/es not_active Expired - Lifetime
- 2000-08-09 CO CO00059538A patent/CO5221062A1/es active IP Right Grant
- 2000-08-09 EG EG20001041A patent/EG22674A/xx active
- 2000-08-11 SV SV2000000142A patent/SV2002000142A/es unknown
- 2000-08-11 AR ARP000104174A patent/AR025235A1/es not_active Application Discontinuation
- 2000-08-11 TW TW089116229A patent/TWI221402B/zh not_active IP Right Cessation
- 2000-08-11 PE PE2000000821A patent/PE20010360A1/es not_active Application Discontinuation
- 2000-08-11 MY MYPI20003700A patent/MY127822A/en unknown
-
2002
- 2002-01-22 ZA ZA200200568A patent/ZA200200568B/en unknown
- 2002-01-24 IL IL147827A patent/IL147827A/en not_active IP Right Cessation
- 2002-02-07 NO NO20020611A patent/NO327737B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1207757B1 (en) | Ectoparasiticidal aqueous suspension formulations of spinosyns | |
| US6927210B1 (en) | Ectoparasiticidal aqueous suspension formulations of spinosyns | |
| EP3269243B1 (en) | Preparation method for pesticide nano solid dispersion | |
| KR101760532B1 (ko) | 식물 보호 및 산업상 비-작물 분야용 아주반트/첨가제로서의 농약과 조합된 소포로리피드 및 그의 유도체의 용도 | |
| EP2104422A2 (en) | Ostwald ripening inhibition in chemical formulations | |
| EP0249770A1 (en) | Aqueous suspension concentrate compositions of pendimethalin | |
| WO2013026470A1 (en) | Aqueous suspension concentrate comprising dodecylguanidine | |
| JPS6362482B2 (zh) | ||
| AU770542B2 (en) | Topical organic ectoparasiticidal formulations | |
| CN104738066A (zh) | 一种杀菌组合物 | |
| KR100289544B1 (ko) | 농약조성물 | |
| CN102428934A (zh) | 一种含烯丙苯噻唑的新型杀菌组合物 | |
| US6933318B1 (en) | Topical organic ectoparasiticidal formulations | |
| JP4902929B2 (ja) | 工業用抗菌組成物及び抗菌方法 | |
| JP3623034B2 (ja) | 安定化された水性懸濁状除草剤組成物 | |
| CN114223664B (zh) | 含氟唑菌酰羟胺和葡萄糖酸铜的组合物及其制剂与用途 | |
| CN107711833A (zh) | 一种含辛菌胺的抗病毒组合物 | |
| NZ304965A (en) | Pesticide formulation containing beta cypermethrin and ethoxylated polyaryl phenol phosphate or sulphate as a surfactant | |
| EP4351339A1 (en) | Spinosyn pesticidal compositions | |
| CN116997256A (zh) | 新型油悬浮液浓缩物组合物 | |
| WO2023044567A1 (en) | Compositions comprising a saturated or unsaturated aliphatic acid and a non-ionic surfactant for enhancing penetration of pesticide components | |
| CN118266472A (zh) | 一种氟吡菌酰胺悬浮剂及其制备方法 | |
| CN110537549A (zh) | 杀菌剂组合物及其用途 | |
| WO2013086595A1 (pt) | Composição espessante para uso em formulações agroquímicas, uso de uma composição espessante, e, formulações agroquímicas contendo composição espessante |