ZA200108051B - C7 carbonate substituted taxanes as antitumor agents. - Google Patents
C7 carbonate substituted taxanes as antitumor agents.Info
- Publication number
- ZA200108051B ZA200108051B ZA200108051A ZA200108051A ZA200108051B ZA 200108051 B ZA200108051 B ZA 200108051B ZA 200108051 A ZA200108051 A ZA 200108051A ZA 200108051 A ZA200108051 A ZA 200108051A ZA 200108051 B ZA200108051 B ZA 200108051B
- Authority
- ZA
- South Africa
- Prior art keywords
- antitumor agents
- carbonate substituted
- substituted taxanes
- taxanes
- carbonate
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000005587 carbonate group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17967100P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200108051B true ZA200108051B (en) | 2003-12-01 |
Family
ID=22657501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108051A ZA200108051B (en) | 2000-02-02 | 2001-10-01 | C7 carbonate substituted taxanes as antitumor agents. |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6780879B2 (hu) |
| EP (1) | EP1165552A1 (hu) |
| JP (1) | JP2003522170A (hu) |
| KR (1) | KR20010112395A (hu) |
| CN (1) | CN1362958A (hu) |
| AU (1) | AU776122B2 (hu) |
| BG (1) | BG64890B1 (hu) |
| BR (1) | BR0104351A (hu) |
| CA (1) | CA2368540A1 (hu) |
| CZ (1) | CZ20013429A3 (hu) |
| GE (1) | GEP20043226B (hu) |
| HK (1) | HK1047934A1 (hu) |
| HU (1) | HUP0200756A3 (hu) |
| IL (1) | IL145637A0 (hu) |
| MX (1) | MXPA01009906A (hu) |
| NO (1) | NO20014755L (hu) |
| NZ (1) | NZ514380A (hu) |
| PL (1) | PL350315A1 (hu) |
| RO (1) | RO121271B1 (hu) |
| RU (1) | RU2265019C2 (hu) |
| SK (1) | SK13702001A3 (hu) |
| TR (1) | TR200102857T1 (hu) |
| UA (1) | UA74331C2 (hu) |
| WO (1) | WO2001057030A1 (hu) |
| ZA (1) | ZA200108051B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010112395A (ko) * | 2000-02-02 | 2001-12-20 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 항종양제로서의 ｃ７ 카르보네이트 치환된 탁산 |
| US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
| PE20050693A1 (es) * | 2004-02-13 | 2005-09-27 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| US20060189679A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
| JP2011517455A (ja) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| ES2230790T3 (es) | 1992-01-15 | 2005-05-01 | E.R. SQUIBB & SONS, INC. | Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos. |
| FR2687150B1 (fr) | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5698712A (en) | 1992-03-06 | 1997-12-16 | Indena S.P.A. | Baccatine III derivatives |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5319112A (en) | 1992-08-18 | 1994-06-07 | Virgnia Tech Intellectual Properties, Inc. | Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol |
| US5470866A (en) | 1992-08-18 | 1995-11-28 | Virginia Polytechnic Institute And State University | Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol |
| IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them |
| CA2111527C (en) | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| DE69433297T2 (de) * | 1993-02-05 | 2004-10-21 | Bryn Mawr College Bryn Mawr | Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| US5475011A (en) | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| EP0703909B1 (en) | 1993-06-11 | 2000-04-26 | PHARMACIA & UPJOHN COMPANY | Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| US5622986A (en) * | 1993-10-20 | 1997-04-22 | Enzon, Inc. | 2'-and/or 7-substituted taxanes |
| US5824701A (en) * | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
| FR2711369B1 (fr) | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
| AU4133096A (en) | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
| US5801191A (en) * | 1995-06-01 | 1998-09-01 | Biophysica Foundation | Taxoids |
| TW354293B (en) | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| CA2231837A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| IL126856A0 (en) | 1996-05-06 | 1999-09-22 | Univ Florida State | 1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| PL350028A1 (en) * | 2000-02-02 | 2002-10-21 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents |
| US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| KR20010112395A (ko) * | 2000-02-02 | 2001-12-20 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 항종양제로서의 ｃ７ 카르보네이트 치환된 탁산 |
| JP2003521545A (ja) * | 2000-02-02 | 2003-07-15 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 改良された溶解性を有するタキサン製剤 |
| IL145635A0 (en) | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | Taxane formulations having improved solubility |
-
2001
- 2001-02-02 KR KR1020017012603A patent/KR20010112395A/ko active IP Right Grant
- 2001-02-02 JP JP2001557862A patent/JP2003522170A/ja active Pending
- 2001-02-02 RU RU2001129502/04A patent/RU2265019C2/ru not_active IP Right Cessation
- 2001-02-02 GE GEAP20016128A patent/GEP20043226B/en unknown
- 2001-02-02 EP EP01906952A patent/EP1165552A1/en not_active Withdrawn
- 2001-02-02 CN CN01800313A patent/CN1362958A/zh active Pending
- 2001-02-02 AU AU34793/01A patent/AU776122B2/en not_active Ceased
- 2001-02-02 CA CA002368540A patent/CA2368540A1/en not_active Withdrawn
- 2001-02-02 HU HU0200756A patent/HUP0200756A3/hu unknown
- 2001-02-02 WO PCT/US2001/003554 patent/WO2001057030A1/en active IP Right Grant
- 2001-02-02 PL PL01350315A patent/PL350315A1/xx not_active Application Discontinuation
- 2001-02-02 BR BR0104351-0A patent/BR0104351A/pt not_active IP Right Cessation
- 2001-02-02 US US09/776,137 patent/US6780879B2/en not_active Expired - Fee Related
- 2001-02-02 IL IL14563701A patent/IL145637A0/xx unknown
- 2001-02-02 RO ROA200101084A patent/RO121271B1/ro unknown
- 2001-02-02 SK SK1370-2001A patent/SK13702001A3/sk unknown
- 2001-02-02 UA UA2001106732A patent/UA74331C2/uk unknown
- 2001-02-02 CZ CZ20013429A patent/CZ20013429A3/cs unknown
- 2001-02-02 TR TR2001/02857T patent/TR200102857T1/xx unknown
- 2001-02-02 MX MXPA01009906A patent/MXPA01009906A/es active IP Right Grant
- 2001-02-02 NZ NZ514380A patent/NZ514380A/en unknown
- 2001-10-01 ZA ZA200108051A patent/ZA200108051B/xx unknown
- 2001-10-01 NO NO20014755A patent/NO20014755L/no not_active Application Discontinuation
- 2001-10-01 BG BG105966A patent/BG64890B1/bg unknown
-
2003
- 2003-01-07 HK HK03100166.5A patent/HK1047934A1/zh unknown
- 2003-12-22 US US10/743,581 patent/US6992104B2/en not_active Expired - Fee Related
-
2005
- 2005-03-17 US US11/082,380 patent/US7226944B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040138267A1 (en) | 2004-07-15 |
| PL350315A1 (en) | 2002-12-02 |
| BG64890B1 (bg) | 2006-08-31 |
| US20050165051A1 (en) | 2005-07-28 |
| EP1165552A1 (en) | 2002-01-02 |
| MXPA01009906A (es) | 2003-07-28 |
| US20020065304A1 (en) | 2002-05-30 |
| US7226944B2 (en) | 2007-06-05 |
| CZ20013429A3 (cs) | 2002-04-17 |
| JP2003522170A (ja) | 2003-07-22 |
| HK1047934A1 (zh) | 2003-03-14 |
| BR0104351A (pt) | 2002-01-02 |
| NO20014755D0 (no) | 2001-10-01 |
| AU3479301A (en) | 2001-08-14 |
| HUP0200756A2 (hu) | 2002-07-29 |
| WO2001057030A1 (en) | 2001-08-09 |
| CA2368540A1 (en) | 2001-08-09 |
| US6992104B2 (en) | 2006-01-31 |
| KR20010112395A (ko) | 2001-12-20 |
| RO121271B1 (ro) | 2007-02-28 |
| IL145637A0 (en) | 2002-06-30 |
| HUP0200756A3 (en) | 2005-02-28 |
| TR200102857T1 (tr) | 2002-06-21 |
| NO20014755L (no) | 2001-11-29 |
| RU2265019C2 (ru) | 2005-11-27 |
| US6780879B2 (en) | 2004-08-24 |
| SK13702001A3 (sk) | 2002-06-04 |
| NZ514380A (en) | 2005-03-24 |
| UA74331C2 (uk) | 2005-12-15 |
| BG105966A (en) | 2002-07-31 |
| AU776122B2 (en) | 2004-08-26 |
| GEP20043226B (en) | 2004-04-26 |
| CN1362958A (zh) | 2002-08-07 |
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