ZA200108015B - Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases. - Google Patents

Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases.

Info

Publication number
ZA200108015B
ZA200108015B ZA200108015A ZA200108015A ZA200108015B ZA 200108015 B ZA200108015 B ZA 200108015B ZA 200108015 A ZA200108015 A ZA 200108015A ZA 200108015 A ZA200108015 A ZA 200108015A ZA 200108015 B ZA200108015 B ZA 200108015B
Authority
ZA
South Africa
Prior art keywords
naphthyridine
cyano
inhibitors
substituted
tyrosine kinases
Prior art date
Application number
ZA200108015A
Other languages
English (en)
Inventor
Allan Wissner
Ayako Yamashita
Philip Ross Hamann
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ZA200108015B publication Critical patent/ZA200108015B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200108015A 1999-04-21 2001-09-28 Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases. ZA200108015B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29550799A 1999-04-21 1999-04-21

Publications (1)

Publication Number Publication Date
ZA200108015B true ZA200108015B (en) 2003-03-26

Family

ID=23138006

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200108015A ZA200108015B (en) 1999-04-21 2001-09-28 Substituted 3-cyano-[1.7], [1.5], and [1.8]-naphthyridine inhibitors of tyrosine kinases.

Country Status (23)

Country Link
EP (1) EP1171440B1 (pt)
JP (1) JP2002543198A (pt)
KR (1) KR20020002433A (pt)
CN (1) CN100408576C (pt)
AR (1) AR029880A1 (pt)
AT (1) ATE264328T1 (pt)
AU (1) AU776962B2 (pt)
BR (1) BR0009870A (pt)
CA (1) CA2365212A1 (pt)
CZ (1) CZ20013660A3 (pt)
DE (1) DE60009888T2 (pt)
DK (1) DK1171440T3 (pt)
ES (1) ES2216884T3 (pt)
HK (1) HK1040077B (pt)
HU (1) HUP0200816A3 (pt)
IL (1) IL145870A0 (pt)
NO (1) NO20015062D0 (pt)
NZ (1) NZ514576A (pt)
PL (1) PL350920A1 (pt)
PT (1) PT1171440E (pt)
RU (1) RU2001131356A (pt)
WO (1) WO2000066583A1 (pt)
ZA (1) ZA200108015B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276519B2 (en) * 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CN101223170A (zh) * 2005-05-18 2008-07-16 惠氏公司 Tpl2激酶的4,6-二氨基-[1,7]萘啶-3-甲腈抑制剂以及其制备和使用方法
JP5131990B2 (ja) 2006-01-31 2013-01-30 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害剤およびその使用方法
ES2301380B1 (es) * 2006-08-09 2009-06-08 Laboratorios Almirall S.A. Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) * 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
CA2765823A1 (en) * 2009-06-25 2010-12-29 Amgen Inc. Tricyclic heterocyclic compounds as mediators of p13k activity
EP2332939A1 (en) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
CA2816957A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN102675311A (zh) * 2011-06-14 2012-09-19 苏春华 一种氟代丙烯酰胺的衍生物
CA2863132A1 (en) 2012-01-30 2013-08-08 F. Hoffmann-La Roche Ag Isoquinoline and naphthyridine derivatives
UY35772A (es) 2013-10-14 2015-05-29 Bayer Cropscience Ag Nuevos compuestos plaguicidas
SG11201805286RA (en) 2015-12-24 2018-07-30 Kyowa Hakko Kirin Co Ltd α,β-UNSATURATED AMIDE COMPOUND
CN107556309B (zh) * 2017-09-11 2020-12-01 浙江永宁药业股份有限公司 多取代四氢萘啶类化合物的药物用途及其制备方法
CN108299429B (zh) * 2018-04-09 2021-10-08 中南大学 一类八氢苯并萘啶化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
ATE300521T1 (de) * 1996-09-25 2005-08-15 Astrazeneca Ab Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives

Also Published As

Publication number Publication date
HK1040077A1 (en) 2002-05-24
AU4463900A (en) 2000-11-17
HK1040077B (zh) 2004-09-10
EP1171440A1 (en) 2002-01-16
CZ20013660A3 (cs) 2002-01-16
PL350920A1 (en) 2003-02-10
AU776962B2 (en) 2004-09-30
NZ514576A (en) 2004-02-27
IL145870A0 (en) 2002-07-25
DE60009888D1 (de) 2004-05-19
ATE264328T1 (de) 2004-04-15
EP1171440B1 (en) 2004-04-14
DE60009888T2 (de) 2005-04-21
JP2002543198A (ja) 2002-12-17
CA2365212A1 (en) 2000-11-09
HUP0200816A2 (en) 2002-08-28
CN1347416A (zh) 2002-05-01
KR20020002433A (ko) 2002-01-09
NO20015062L (no) 2001-10-18
PT1171440E (pt) 2004-07-30
CN100408576C (zh) 2008-08-06
AR029880A1 (es) 2003-07-23
NO20015062D0 (no) 2001-10-18
ES2216884T3 (es) 2004-11-01
DK1171440T3 (da) 2004-08-02
RU2001131356A (ru) 2003-06-27
HUP0200816A3 (en) 2003-06-30
WO2000066583A1 (en) 2000-11-09
BR0009870A (pt) 2002-01-08

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