ZA200105352B - Expression and export of anti-obesity proteins as Fc fusion proteins. - Google Patents
Expression and export of anti-obesity proteins as Fc fusion proteins. Download PDFInfo
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- ZA200105352B ZA200105352B ZA200105352A ZA200105352A ZA200105352B ZA 200105352 B ZA200105352 B ZA 200105352B ZA 200105352 A ZA200105352 A ZA 200105352A ZA 200105352 A ZA200105352 A ZA 200105352A ZA 200105352 B ZA200105352 B ZA 200105352B
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- leptin
- immunoglobulin
- protein
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- fusion protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| AU (1) | AU778939B2 (id) |
| BR (1) | BR0007414A (id) |
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| ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| ATE329622T1 (de) * | 1998-04-15 | 2006-07-15 | Lexigen Pharm Corp | Steigerung der antikörper-zytokin- fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) * | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| ATE336514T1 (de) * | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
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| US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5541087A (en) * | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| WO1996031526A1 (en) * | 1995-04-06 | 1996-10-10 | Amylin Pharmaceuticals, Inc. | Anti-obesity agents |
| GB9511935D0 (en) * | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
-
2000
- 2000-01-07 BR BR0007414-4A patent/BR0007414A/pt not_active IP Right Cessation
- 2000-01-07 WO PCT/US2000/000352 patent/WO2000040615A2/en not_active Application Discontinuation
- 2000-01-07 SK SK943-2001A patent/SK9432001A3/sk unknown
- 2000-01-07 ID IDW00200101488A patent/ID30327A/id unknown
- 2000-01-07 MX MXPA01006922A patent/MXPA01006922A/es unknown
- 2000-01-07 HU HU0105090A patent/HUP0105090A2/hu unknown
- 2000-01-07 JP JP2000592323A patent/JP2002534962A/ja not_active Withdrawn
- 2000-01-07 CA CA002356401A patent/CA2356401A1/en not_active Abandoned
- 2000-01-07 CZ CZ20012406A patent/CZ20012406A3/cs unknown
- 2000-01-07 AU AU26025/00A patent/AU778939B2/en not_active Ceased
- 2000-01-07 EP EP00904239A patent/EP1141013A2/en not_active Withdrawn
- 2000-01-07 CN CN00804274A patent/CN1341121A/zh active Pending
- 2000-01-07 KR KR1020017008580A patent/KR20020007287A/ko not_active Application Discontinuation
-
2001
- 2001-06-28 ZA ZA200105352A patent/ZA200105352B/en unknown
- 2001-07-06 NO NO20013371A patent/NO20013371L/no not_active Application Discontinuation
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2003
- 2003-04-18 US US10/419,058 patent/US20040053366A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2602500A (en) | 2000-07-24 |
| WO2000040615A3 (en) | 2000-11-23 |
| KR20020007287A (ko) | 2002-01-26 |
| BR0007414A (pt) | 2001-10-16 |
| JP2002534962A (ja) | 2002-10-22 |
| CZ20012406A3 (cs) | 2002-03-13 |
| NO20013371D0 (no) | 2001-07-06 |
| HUP0105090A2 (hu) | 2002-04-29 |
| ID30327A (id) | 2001-11-22 |
| EP1141013A2 (en) | 2001-10-10 |
| CN1341121A (zh) | 2002-03-20 |
| MXPA01006922A (es) | 2002-04-24 |
| WO2000040615A2 (en) | 2000-07-13 |
| NO20013371L (no) | 2001-09-04 |
| SK9432001A3 (en) | 2003-02-04 |
| AU778939B2 (en) | 2004-12-23 |
| CA2356401A1 (en) | 2000-07-13 |
| US20040053366A1 (en) | 2004-03-18 |
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