ZA200104541B - Benzoylpyridazines. - Google Patents
Benzoylpyridazines. Download PDFInfo
- Publication number
- ZA200104541B ZA200104541B ZA200104541A ZA200104541A ZA200104541B ZA 200104541 B ZA200104541 B ZA 200104541B ZA 200104541 A ZA200104541 A ZA 200104541A ZA 200104541 A ZA200104541 A ZA 200104541A ZA 200104541 B ZA200104541 B ZA 200104541B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- compound
- physiologically acceptable
- phenyl
- compounds
- Prior art date
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- VDWSVBMVZLRATD-UHFFFAOYSA-N phenyl(pyridazin-3-yl)methanone Chemical class C=1C=CN=NC=1C(=O)C1=CC=CC=C1 VDWSVBMVZLRATD-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 61
- -1 R® is A Chemical group 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 9
- 229910052794 bromium Inorganic materials 0.000 claims description 9
- 229910052801 chlorine Inorganic materials 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
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- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims description 3
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- 125000003342 alkenyl group Chemical group 0.000 claims description 3
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
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- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- SUOLFDICCAMABO-UHFFFAOYSA-N [4-[6-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-1H-pyridazine-2-carbonyl]-2-piperidin-4-ylphenyl]-methylcarbamic acid Chemical compound C1=C(OC)C(OCC)=CC(C2NN(C=CC2)C(=O)C=2C=C(C(N(C)C(O)=O)=CC=2)C2CCNCC2)=C1 SUOLFDICCAMABO-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 description 17
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Classifications
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19850701A DE19850701A1 (de) | 1998-11-04 | 1998-11-04 | Benzoylpyridazine |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200104541B true ZA200104541B (en) | 2002-09-02 |
Family
ID=7886577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200104541A ZA200104541B (en) | 1998-11-04 | 2001-06-01 | Benzoylpyridazines. |
Country Status (24)
Country | Link |
---|---|
US (1) | US6376493B1 (xx) |
EP (1) | EP1124809B1 (xx) |
JP (1) | JP4354652B2 (xx) |
KR (1) | KR20010075636A (xx) |
CN (1) | CN1142153C (xx) |
AR (1) | AR021068A1 (xx) |
AT (1) | ATE262513T1 (xx) |
AU (1) | AU759328B2 (xx) |
BR (1) | BR9915004A (xx) |
CA (1) | CA2349232A1 (xx) |
CZ (1) | CZ20011551A3 (xx) |
DE (2) | DE19850701A1 (xx) |
DK (1) | DK1124809T3 (xx) |
ES (1) | ES2214891T3 (xx) |
HU (1) | HUP0104033A3 (xx) |
ID (1) | ID28816A (xx) |
NO (1) | NO20012188D0 (xx) |
PL (1) | PL346909A1 (xx) |
PT (1) | PT1124809E (xx) |
SI (1) | SI1124809T1 (xx) |
SK (1) | SK5782001A3 (xx) |
TW (1) | TW458970B (xx) |
WO (1) | WO2000026201A1 (xx) |
ZA (1) | ZA200104541B (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
DE10064997A1 (de) * | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
CA2437932A1 (en) * | 2001-02-12 | 2002-09-19 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Use of type 4 phosphodiesterase inhibitors in myocardial diseases |
HUP0401747A3 (en) * | 2001-11-05 | 2005-06-28 | Merck Patent Gmbh | Piridazine derivatives of hydrazono-malonitriles, their use, process for preparation of the compounds and pharmaceutical compositions containing the compounds |
KR100866286B1 (ko) * | 2001-11-29 | 2008-10-31 | 씨제이제일제당 (주) | 신규한 카테콜 히드라지드 유도체 및 그의 제조방법 |
KR100508156B1 (ko) * | 2002-11-29 | 2005-08-17 | 씨제이 주식회사 | 신규한 캐테콜 히드라자이드 유도체 |
CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
CN113264899B (zh) * | 2021-04-09 | 2022-06-14 | 台州学院 | 一种1,3,5-噁二嗪类化合物及其制备和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU668206B2 (en) * | 1992-07-01 | 1996-04-26 | Ortho Pharmaceutical Corporation | 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines |
DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
-
1998
- 1998-11-04 DE DE19850701A patent/DE19850701A1/de not_active Withdrawn
-
1999
- 1999-10-23 US US09/830,957 patent/US6376493B1/en not_active Expired - Fee Related
- 1999-10-23 KR KR1020017004759A patent/KR20010075636A/ko not_active Application Discontinuation
- 1999-10-23 JP JP2000579590A patent/JP4354652B2/ja not_active Expired - Fee Related
- 1999-10-23 AT AT99950775T patent/ATE262513T1/de not_active IP Right Cessation
- 1999-10-23 EP EP99950775A patent/EP1124809B1/de not_active Expired - Lifetime
- 1999-10-23 HU HU0104033A patent/HUP0104033A3/hu unknown
- 1999-10-23 DE DE59908968T patent/DE59908968D1/de not_active Expired - Lifetime
- 1999-10-23 DK DK99950775T patent/DK1124809T3/da active
- 1999-10-23 WO PCT/EP1999/008047 patent/WO2000026201A1/de not_active Application Discontinuation
- 1999-10-23 PT PT99950775T patent/PT1124809E/pt unknown
- 1999-10-23 BR BR9915004-2A patent/BR9915004A/pt not_active IP Right Cessation
- 1999-10-23 ES ES99950775T patent/ES2214891T3/es not_active Expired - Lifetime
- 1999-10-23 SI SI9930542T patent/SI1124809T1/xx unknown
- 1999-10-23 ID IDW00200101082A patent/ID28816A/id unknown
- 1999-10-23 CN CNB998127469A patent/CN1142153C/zh not_active Expired - Fee Related
- 1999-10-23 CA CA002349232A patent/CA2349232A1/en not_active Abandoned
- 1999-10-23 SK SK578-2001A patent/SK5782001A3/sk unknown
- 1999-10-23 CZ CZ20011551A patent/CZ20011551A3/cs unknown
- 1999-10-23 PL PL99346909A patent/PL346909A1/xx unknown
- 1999-10-23 AU AU63423/99A patent/AU759328B2/en not_active Ceased
- 1999-10-29 TW TW088118837A patent/TW458970B/zh not_active IP Right Cessation
- 1999-11-03 AR ARP990105552A patent/AR021068A1/es not_active Application Discontinuation
-
2001
- 2001-05-03 NO NO20012188A patent/NO20012188D0/no not_active Application Discontinuation
- 2001-06-01 ZA ZA200104541A patent/ZA200104541B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0104033A2 (hu) | 2002-05-29 |
CN1142153C (zh) | 2004-03-17 |
HUP0104033A3 (en) | 2002-08-28 |
JP2002528536A (ja) | 2002-09-03 |
SK5782001A3 (en) | 2001-11-06 |
DE19850701A1 (de) | 2000-05-11 |
AU6342399A (en) | 2000-05-22 |
AU759328B2 (en) | 2003-04-10 |
JP4354652B2 (ja) | 2009-10-28 |
NO20012188L (no) | 2001-05-03 |
EP1124809A1 (de) | 2001-08-22 |
WO2000026201A1 (de) | 2000-05-11 |
AR021068A1 (es) | 2002-06-12 |
CA2349232A1 (en) | 2000-05-11 |
DE59908968D1 (de) | 2004-04-29 |
TW458970B (en) | 2001-10-11 |
PT1124809E (pt) | 2004-07-30 |
ATE262513T1 (de) | 2004-04-15 |
EP1124809B1 (de) | 2004-03-24 |
BR9915004A (pt) | 2001-11-13 |
CN1324350A (zh) | 2001-11-28 |
NO20012188D0 (no) | 2001-05-03 |
CZ20011551A3 (cs) | 2001-08-15 |
ID28816A (id) | 2001-07-05 |
US6376493B1 (en) | 2002-04-23 |
KR20010075636A (ko) | 2001-08-09 |
DK1124809T3 (da) | 2004-07-19 |
ES2214891T3 (es) | 2004-09-16 |
PL346909A1 (en) | 2002-03-11 |
SI1124809T1 (en) | 2004-06-30 |
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