BR9915004A - Benzoilpiridazinas - Google Patents
BenzoilpiridazinasInfo
- Publication number
- BR9915004A BR9915004A BR9915004-2A BR9915004A BR9915004A BR 9915004 A BR9915004 A BR 9915004A BR 9915004 A BR9915004 A BR 9915004A BR 9915004 A BR9915004 A BR 9915004A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- benzoylpyridazines
- benzoilpyridazines
- phosphorodiesterase
- cachexia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
Abstract
Patente de Invenção: "BENZOILPIRIDAZINAS". A invençãorefere-se a derivados de benzoil piridazina de fórmula I onde R^ 1^,R^ 2^, R^ 3^ e Q têm o significado definido na reivindicação 1.Tais derivados têm um efeito inibidor de fosforodiesterase IV epodem ser usados em tratamento de osteoporose, tumores,caquexia, arteriosclerose, artrite reumatóide, esclerose múltipla,diabetes mellitus, processos inflamatórios, alergias, asma, doençasauto-imune e AIDS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19850701A DE19850701A1 (de) | 1998-11-04 | 1998-11-04 | Benzoylpyridazine |
PCT/EP1999/008047 WO2000026201A1 (de) | 1998-11-04 | 1999-10-23 | Benzoylpyridazine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915004A true BR9915004A (pt) | 2001-11-13 |
Family
ID=7886577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915004-2A BR9915004A (pt) | 1998-11-04 | 1999-10-23 | Benzoilpiridazinas |
Country Status (24)
Country | Link |
---|---|
US (1) | US6376493B1 (pt) |
EP (1) | EP1124809B1 (pt) |
JP (1) | JP4354652B2 (pt) |
KR (1) | KR20010075636A (pt) |
CN (1) | CN1142153C (pt) |
AR (1) | AR021068A1 (pt) |
AT (1) | ATE262513T1 (pt) |
AU (1) | AU759328B2 (pt) |
BR (1) | BR9915004A (pt) |
CA (1) | CA2349232A1 (pt) |
CZ (1) | CZ20011551A3 (pt) |
DE (2) | DE19850701A1 (pt) |
DK (1) | DK1124809T3 (pt) |
ES (1) | ES2214891T3 (pt) |
HU (1) | HUP0104033A3 (pt) |
ID (1) | ID28816A (pt) |
NO (1) | NO20012188L (pt) |
PL (1) | PL346909A1 (pt) |
PT (1) | PT1124809E (pt) |
SI (1) | SI1124809T1 (pt) |
SK (1) | SK5782001A3 (pt) |
TW (1) | TW458970B (pt) |
WO (1) | WO2000026201A1 (pt) |
ZA (1) | ZA200104541B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19915364A1 (de) * | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Verwendung von Arylalkanoylpyridazinen |
DE10064997A1 (de) * | 2000-12-23 | 2002-06-27 | Merck Patent Gmbh | Benzoylpyridazine |
US20050070529A1 (en) * | 2001-02-12 | 2005-03-31 | Merk Pantent Gmbh | Use of type 4 phosphodiesterase inhibitors in myocardial diseases |
ES2268157T3 (es) * | 2001-11-05 | 2007-03-16 | Merck Patent Gmbh | Hidrazono-malonitrilos. |
KR100866286B1 (ko) * | 2001-11-29 | 2008-10-31 | 씨제이제일제당 (주) | 신규한 카테콜 히드라지드 유도체 및 그의 제조방법 |
KR100508156B1 (ko) * | 2002-11-29 | 2005-08-17 | 씨제이 주식회사 | 신규한 캐테콜 히드라자이드 유도체 |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
CN113264899B (zh) * | 2021-04-09 | 2022-06-14 | 台州学院 | 一种1,3,5-噁二嗪类化合物及其制备和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2139307A1 (en) | 1992-07-01 | 1994-01-20 | Donald W. Combs | 1-arylsulphonyl, arylcarbonyl and 1-arylphosphonyl-3-phenyl-1,4,5,6-tetrahydropyridazines |
DE19514568A1 (de) | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
-
1998
- 1998-11-04 DE DE19850701A patent/DE19850701A1/de not_active Withdrawn
-
1999
- 1999-10-23 PL PL99346909A patent/PL346909A1/xx unknown
- 1999-10-23 JP JP2000579590A patent/JP4354652B2/ja not_active Expired - Fee Related
- 1999-10-23 DK DK99950775T patent/DK1124809T3/da active
- 1999-10-23 PT PT99950775T patent/PT1124809E/pt unknown
- 1999-10-23 WO PCT/EP1999/008047 patent/WO2000026201A1/de not_active Application Discontinuation
- 1999-10-23 CA CA002349232A patent/CA2349232A1/en not_active Abandoned
- 1999-10-23 BR BR9915004-2A patent/BR9915004A/pt not_active IP Right Cessation
- 1999-10-23 KR KR1020017004759A patent/KR20010075636A/ko not_active Application Discontinuation
- 1999-10-23 ES ES99950775T patent/ES2214891T3/es not_active Expired - Lifetime
- 1999-10-23 CZ CZ20011551A patent/CZ20011551A3/cs unknown
- 1999-10-23 HU HU0104033A patent/HUP0104033A3/hu unknown
- 1999-10-23 SI SI9930542T patent/SI1124809T1/xx unknown
- 1999-10-23 CN CNB998127469A patent/CN1142153C/zh not_active Expired - Fee Related
- 1999-10-23 US US09/830,957 patent/US6376493B1/en not_active Expired - Fee Related
- 1999-10-23 DE DE59908968T patent/DE59908968D1/de not_active Expired - Lifetime
- 1999-10-23 AU AU63423/99A patent/AU759328B2/en not_active Ceased
- 1999-10-23 ID IDW00200101082A patent/ID28816A/id unknown
- 1999-10-23 SK SK578-2001A patent/SK5782001A3/sk unknown
- 1999-10-23 AT AT99950775T patent/ATE262513T1/de not_active IP Right Cessation
- 1999-10-23 EP EP99950775A patent/EP1124809B1/de not_active Expired - Lifetime
- 1999-10-29 TW TW088118837A patent/TW458970B/zh not_active IP Right Cessation
- 1999-11-03 AR ARP990105552A patent/AR021068A1/es not_active Application Discontinuation
-
2001
- 2001-05-03 NO NO20012188A patent/NO20012188L/no not_active Application Discontinuation
- 2001-06-01 ZA ZA200104541A patent/ZA200104541B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE59908968D1 (de) | 2004-04-29 |
CZ20011551A3 (cs) | 2001-08-15 |
HUP0104033A2 (hu) | 2002-05-29 |
AR021068A1 (es) | 2002-06-12 |
JP4354652B2 (ja) | 2009-10-28 |
EP1124809B1 (de) | 2004-03-24 |
SK5782001A3 (en) | 2001-11-06 |
ZA200104541B (en) | 2002-09-02 |
CN1142153C (zh) | 2004-03-17 |
KR20010075636A (ko) | 2001-08-09 |
ID28816A (id) | 2001-07-05 |
WO2000026201A1 (de) | 2000-05-11 |
PT1124809E (pt) | 2004-07-30 |
NO20012188D0 (no) | 2001-05-03 |
NO20012188L (no) | 2001-05-03 |
PL346909A1 (en) | 2002-03-11 |
US6376493B1 (en) | 2002-04-23 |
CN1324350A (zh) | 2001-11-28 |
DE19850701A1 (de) | 2000-05-11 |
TW458970B (en) | 2001-10-11 |
SI1124809T1 (en) | 2004-06-30 |
CA2349232A1 (en) | 2000-05-11 |
ATE262513T1 (de) | 2004-04-15 |
AU759328B2 (en) | 2003-04-10 |
AU6342399A (en) | 2000-05-22 |
JP2002528536A (ja) | 2002-09-03 |
HUP0104033A3 (en) | 2002-08-28 |
DK1124809T3 (da) | 2004-07-19 |
ES2214891T3 (es) | 2004-09-16 |
EP1124809A1 (de) | 2001-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |