ZA200100936B - Pharmaceuticals compositions comprising ibuprofen and domperidone. - Google Patents
Pharmaceuticals compositions comprising ibuprofen and domperidone. Download PDFInfo
- Publication number
- ZA200100936B ZA200100936B ZA200100936A ZA200100936A ZA200100936B ZA 200100936 B ZA200100936 B ZA 200100936B ZA 200100936 A ZA200100936 A ZA 200100936A ZA 200100936 A ZA200100936 A ZA 200100936A ZA 200100936 B ZA200100936 B ZA 200100936B
- Authority
- ZA
- South Africa
- Prior art keywords
- ibuprofen
- medicament
- carrier material
- weight
- domperidone
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 91
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title claims description 82
- 229960001680 ibuprofen Drugs 0.000 title claims description 69
- 239000003814 drug Substances 0.000 title claims description 60
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 title claims description 46
- 229960001253 domperidone Drugs 0.000 title claims description 46
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- 229940069328 povidone Drugs 0.000 claims description 21
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- 235000010413 sodium alginate Nutrition 0.000 description 1
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- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- WZWGGYFEOBVNLA-UHFFFAOYSA-N sodium;dihydrate Chemical compound O.O.[Na] WZWGGYFEOBVNLA-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816899.0A GB9816899D0 (en) | 1998-08-05 | 1998-08-05 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200100936B true ZA200100936B (en) | 2003-07-02 |
Family
ID=10836640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200100936A ZA200100936B (en) | 1998-08-05 | 2001-02-02 | Pharmaceuticals compositions comprising ibuprofen and domperidone. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6991806B1 (de) |
| EP (1) | EP1100472B1 (de) |
| JP (1) | JP2002522377A (de) |
| KR (1) | KR20010072269A (de) |
| CN (1) | CN1321084A (de) |
| AT (1) | ATE237316T1 (de) |
| AU (1) | AU755835B2 (de) |
| BG (1) | BG105303A (de) |
| BR (1) | BR9912706A (de) |
| CA (1) | CA2339193C (de) |
| DE (1) | DE69906982T2 (de) |
| ES (1) | ES2197676T3 (de) |
| GB (1) | GB9816899D0 (de) |
| HU (1) | HUP0103421A3 (de) |
| IL (1) | IL141055A0 (de) |
| MX (1) | MXPA01001120A (de) |
| NO (1) | NO20010537L (de) |
| NZ (1) | NZ509806A (de) |
| PL (1) | PL345811A1 (de) |
| SK (1) | SK1752001A3 (de) |
| TR (1) | TR200100611T2 (de) |
| WO (1) | WO2000007570A1 (de) |
| ZA (1) | ZA200100936B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9816899D0 (en) * | 1998-08-05 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
| US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
| ES2291749T5 (es) * | 2002-12-20 | 2011-07-21 | F. Hoffmann-La Roche Ag | Formulación de altas dosis de ibandronato. |
| DK1660104T3 (da) * | 2003-08-26 | 2010-06-21 | Shire Holdings Ag | Farmaceutisk formulering indeholdende lanthanforbindelser |
| JP4575654B2 (ja) * | 2003-09-05 | 2010-11-04 | エスエス製薬株式会社 | 溶解性と流動性を改善した医薬組成物 |
| US20050065172A1 (en) * | 2003-09-23 | 2005-03-24 | Shah Indukumar G. | Solid dosage form comprising caffeine |
| ES2244324B1 (es) * | 2004-03-25 | 2006-11-16 | Ferrer Internacional, S.A. | Composiciones diureticas de liberacion prolongada. |
| JP3996626B2 (ja) * | 2004-06-22 | 2007-10-24 | 塩野義製薬株式会社 | 口腔内速崩壊錠 |
| US20070077297A1 (en) | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| US20060068009A1 (en) * | 2004-09-30 | 2006-03-30 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| EP1905428A1 (de) * | 2006-09-26 | 2008-04-02 | Losan Pharma GmbH | Ibuprofen-Brausezubereitung mit hoher Lösungsgeschwindigkeit und Verfahren zu deren Herstellung |
| FR2909877B1 (fr) * | 2006-12-13 | 2009-07-10 | Galenix Dev Soc Par Actions Si | Composition pharmaceutique contenat de la 5-chloro-1-[1-[3- (2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl] piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one et son procede de preparation |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2292M (fr) | 1962-06-27 | 1964-01-27 | Sandoz Sa | Médicament a base d'une combinaison de dihydro-ergotamine, de caféine et d'une hydantoine. |
| US4985459A (en) | 1984-02-08 | 1991-01-15 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same |
| EP0327040A3 (de) | 1988-02-05 | 1990-11-28 | Predrag Dr.Sc. Sikiric | Verwendung von Dopamin und/oder von Dopamin-Agonisten zur Herstellung eines Arzneimittels für die Behandlung des Verdauungstrakts |
| US5053429A (en) | 1988-04-08 | 1991-10-01 | The Lithox Corporation, Inc. | Treating inflammatory pain with methionine |
| GB8816187D0 (en) | 1988-07-07 | 1988-08-10 | Glaxo Group Ltd | Medicaments |
| CA2020018A1 (en) | 1990-06-27 | 1991-12-28 | Don L. Simmons | Method and composition for treating the migraine complex |
| US5215758A (en) | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
| MX9300110A (es) | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
| IT1264020B (it) | 1993-01-28 | 1996-09-09 | Recordati Chem Pharm | Procedimento per la preparazione di microgranuli idonei alla sospensione in liquidi |
| TW466119B (en) | 1994-02-28 | 2001-12-01 | Janssen Pharmaceutica Nv | Film coated tablet of paracetamol and domperidone |
| GB2313309B (en) | 1996-05-24 | 2000-01-26 | Ninh Thuy On | Pharmaceutical compositions comprising a nonsteroidal anti-inflammatory drug and domperidone in the treatment of migraine |
| GB9710767D0 (en) * | 1996-06-26 | 1997-07-23 | On Ninh | Analgesic and anti-inflamatory compositions comprising domperidone and methods of using same |
| US5891885A (en) | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| GB9702392D0 (en) * | 1997-02-06 | 1997-03-26 | Boots Co Plc | Therapeutic agents |
| GB9810092D0 (en) | 1998-05-11 | 1998-07-08 | Merck Sharp & Dohme | Therapeutic agents |
| GB9816899D0 (en) * | 1998-08-05 | 1998-09-30 | Boots Co Plc | Therapeutic agents |
| GB9822333D0 (en) | 1998-10-13 | 1998-12-09 | Merck Sharp & Dohme | Pharmaceutical formulation |
-
1998
- 1998-08-05 GB GBGB9816899.0A patent/GB9816899D0/en not_active Ceased
-
1999
- 1999-08-04 AT AT99948741T patent/ATE237316T1/de not_active IP Right Cessation
- 1999-08-04 KR KR1020017001539A patent/KR20010072269A/ko not_active Application Discontinuation
- 1999-08-04 MX MXPA01001120A patent/MXPA01001120A/es unknown
- 1999-08-04 HU HU0103421A patent/HUP0103421A3/hu unknown
- 1999-08-04 CA CA002339193A patent/CA2339193C/en not_active Expired - Fee Related
- 1999-08-04 ES ES99948741T patent/ES2197676T3/es not_active Expired - Lifetime
- 1999-08-04 AU AU61904/99A patent/AU755835B2/en not_active Ceased
- 1999-08-04 US US09/774,171 patent/US6991806B1/en not_active Expired - Fee Related
- 1999-08-04 DE DE69906982T patent/DE69906982T2/de not_active Expired - Lifetime
- 1999-08-04 TR TR2001/00611T patent/TR200100611T2/xx unknown
- 1999-08-04 JP JP2000563256A patent/JP2002522377A/ja active Pending
- 1999-08-04 CN CN99811670A patent/CN1321084A/zh active Pending
- 1999-08-04 NZ NZ509806A patent/NZ509806A/xx unknown
- 1999-08-04 IL IL14105599A patent/IL141055A0/xx unknown
- 1999-08-04 WO PCT/EP1999/005753 patent/WO2000007570A1/en not_active Application Discontinuation
- 1999-08-04 PL PL99345811A patent/PL345811A1/xx not_active Application Discontinuation
- 1999-08-04 BR BR9912706-7A patent/BR9912706A/pt not_active IP Right Cessation
- 1999-08-04 EP EP99948741A patent/EP1100472B1/de not_active Expired - Lifetime
- 1999-08-04 SK SK175-2001A patent/SK1752001A3/sk unknown
-
2001
- 2001-01-31 NO NO20010537A patent/NO20010537L/no not_active Application Discontinuation
- 2001-02-02 ZA ZA200100936A patent/ZA200100936B/en unknown
- 2001-03-01 BG BG105303A patent/BG105303A/xx unknown
-
2005
- 2005-09-22 US US11/232,038 patent/US20060013872A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TR200100611T2 (tr) | 2001-10-22 |
| NO20010537L (no) | 2001-03-14 |
| EP1100472B1 (de) | 2003-04-16 |
| US6991806B1 (en) | 2006-01-31 |
| JP2002522377A (ja) | 2002-07-23 |
| MXPA01001120A (es) | 2002-04-24 |
| NZ509806A (en) | 2003-04-29 |
| NO20010537D0 (no) | 2001-01-31 |
| BR9912706A (pt) | 2002-01-29 |
| WO2000007570A1 (en) | 2000-02-17 |
| HUP0103421A2 (hu) | 2002-02-28 |
| HUP0103421A3 (en) | 2003-01-28 |
| BG105303A (en) | 2001-11-30 |
| GB9816899D0 (en) | 1998-09-30 |
| CN1321084A (zh) | 2001-11-07 |
| ES2197676T3 (es) | 2004-01-01 |
| PL345811A1 (en) | 2002-01-14 |
| ATE237316T1 (de) | 2003-05-15 |
| US20060013872A1 (en) | 2006-01-19 |
| DE69906982D1 (de) | 2003-05-22 |
| AU6190499A (en) | 2000-02-28 |
| DE69906982T2 (de) | 2004-03-04 |
| EP1100472A1 (de) | 2001-05-23 |
| IL141055A0 (en) | 2002-02-10 |
| CA2339193C (en) | 2009-01-20 |
| AU755835B2 (en) | 2002-12-19 |
| CA2339193A1 (en) | 2000-02-17 |
| KR20010072269A (ko) | 2001-07-31 |
| SK1752001A3 (en) | 2001-08-06 |
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