ZA200007169B - Pharmaceutical composition containing GABA analogs and an antiviral agent to treat shingles. - Google Patents
Pharmaceutical composition containing GABA analogs and an antiviral agent to treat shingles. Download PDFInfo
- Publication number
- ZA200007169B ZA200007169B ZA200007169A ZA200007169A ZA200007169B ZA 200007169 B ZA200007169 B ZA 200007169B ZA 200007169 A ZA200007169 A ZA 200007169A ZA 200007169 A ZA200007169 A ZA 200007169A ZA 200007169 B ZA200007169 B ZA 200007169B
- Authority
- ZA
- South Africa
- Prior art keywords
- formula
- gabapentin
- hydrogen
- composition
- gaba analog
- Prior art date
Links
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title claims abstract description 26
- 239000003443 antiviral agent Substances 0.000 title claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 238000000034 method Methods 0.000 claims abstract description 21
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 34
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 19
- 229960002870 gabapentin Drugs 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims description 10
- 229960001233 pregabalin Drugs 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 150000002431 hydrogen Chemical group 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
- 229960004396 famciclovir Drugs 0.000 claims description 2
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 2
- 206010040744 Sinus headache Diseases 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 1
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract description 4
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract description 2
- 235000013922 glutamic acid Nutrition 0.000 abstract description 2
- 239000004220 glutamic acid Substances 0.000 abstract description 2
- 208000002193 Pain Diseases 0.000 description 12
- 208000007514 Herpes zoster Diseases 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- -1 GABA analogs compounds Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- AYXYPKUFHZROOJ-UHFFFAOYSA-N 3-(azaniumylmethyl)-5-methylhexanoate Chemical compound CC(C)CC(CN)CC(O)=O AYXYPKUFHZROOJ-UHFFFAOYSA-N 0.000 description 1
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- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
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- 206010037764 Radiation myelopathy Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
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- 150000003840 hydrochlorides Chemical class 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9217198P | 1998-07-09 | 1998-07-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200007169B true ZA200007169B (en) | 2002-03-04 |
Family
ID=22231986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200007169A ZA200007169B (en) | 1998-07-09 | 2000-12-04 | Pharmaceutical composition containing GABA analogs and an antiviral agent to treat shingles. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1093366B1 (de) |
| JP (1) | JP2002520300A (de) |
| KR (1) | KR20010071776A (de) |
| AT (1) | ATE279188T1 (de) |
| AU (1) | AU765246B2 (de) |
| CA (1) | CA2332929C (de) |
| DE (1) | DE69921137T2 (de) |
| DK (1) | DK1093366T3 (de) |
| ES (1) | ES2230863T3 (de) |
| ID (1) | ID27395A (de) |
| NO (1) | NO20010116D0 (de) |
| NZ (2) | NZ508489A (de) |
| PL (1) | PL345337A1 (de) |
| PT (1) | PT1093366E (de) |
| SI (1) | SI1093366T1 (de) |
| WO (1) | WO2000002592A1 (de) |
| ZA (1) | ZA200007169B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002541215A (ja) | 1999-04-09 | 2002-12-03 | ユーロ−セルティック エス． ア． | ナトリウムチャネル遮断薬組成物およびその使用 |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| NZ531586A (en) | 2001-09-03 | 2005-09-30 | Newron Pharm Spa | Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use |
| RS54522B1 (en) | 2005-12-22 | 2016-06-30 | Newron Pharmaceuticals S.P.A. | 2-Phenylethylamino Derivatives as Modulators of Calcium and (or Sodium) Channels |
| MX2007006093A (es) * | 2007-05-21 | 2009-02-25 | World Trade Imp Export Wtie Ag | Composicion farmaceutica que comprende la combinacion de un agente anticonvulsivo y un agente antiviral. |
| KR20160095358A (ko) | 2015-02-03 | 2016-08-11 | 고려대학교 산학협력단 | 우고닌 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 헤르페스 바이러스 감염 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111138A (en) * | 1993-10-05 | 1997-04-15 | Smithkline Beecham Plc | Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia |
| GB9321394D0 (en) * | 1993-10-16 | 1993-12-08 | Smihtkline Beecham P L C | Pharmaceuticals |
| NZ331142A (en) * | 1996-03-14 | 2001-04-27 | Warner Lambert Co | Bridged cyclic amino acids as pharmaceutical agents |
| BR9710536A (pt) * | 1996-07-24 | 1999-08-17 | Warner Lambert Co | Isobutilgaba e seus derivados para o tratamento da dor |
-
1999
- 1999-06-18 SI SI9930696T patent/SI1093366T1/xx unknown
- 1999-06-18 ES ES99930482T patent/ES2230863T3/es not_active Expired - Lifetime
- 1999-06-18 JP JP2000558851A patent/JP2002520300A/ja not_active Withdrawn
- 1999-06-18 AU AU47016/99A patent/AU765246B2/en not_active Ceased
- 1999-06-18 KR KR1020017000253A patent/KR20010071776A/ko not_active Application Discontinuation
- 1999-06-18 PT PT99930482T patent/PT1093366E/pt unknown
- 1999-06-18 DE DE69921137T patent/DE69921137T2/de not_active Expired - Fee Related
- 1999-06-18 CA CA002332929A patent/CA2332929C/en not_active Expired - Fee Related
- 1999-06-18 NZ NZ508489A patent/NZ508489A/en unknown
- 1999-06-18 WO PCT/US1999/013947 patent/WO2000002592A1/en not_active Application Discontinuation
- 1999-06-18 ID IDW20010053A patent/ID27395A/id unknown
- 1999-06-18 DK DK99930482T patent/DK1093366T3/da active
- 1999-06-18 AT AT99930482T patent/ATE279188T1/de not_active IP Right Cessation
- 1999-06-18 NZ NZ525623A patent/NZ525623A/en not_active Application Discontinuation
- 1999-06-18 EP EP99930482A patent/EP1093366B1/de not_active Expired - Lifetime
- 1999-06-18 PL PL99345337A patent/PL345337A1/xx not_active IP Right Cessation
-
2000
- 2000-12-04 ZA ZA200007169A patent/ZA200007169B/en unknown
-
2001
- 2001-01-08 NO NO20010116A patent/NO20010116D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4701699A (en) | 2000-02-01 |
| AU765246B2 (en) | 2003-09-11 |
| WO2000002592A1 (en) | 2000-01-20 |
| ES2230863T3 (es) | 2005-05-01 |
| PL345337A1 (en) | 2001-12-17 |
| KR20010071776A (ko) | 2001-07-31 |
| NZ508489A (en) | 2004-06-25 |
| ID27395A (id) | 2001-04-05 |
| PT1093366E (pt) | 2005-02-28 |
| NO20010116L (no) | 2001-01-08 |
| SI1093366T1 (en) | 2005-02-28 |
| EP1093366A1 (de) | 2001-04-25 |
| DE69921137D1 (de) | 2004-11-18 |
| DK1093366T3 (da) | 2004-12-06 |
| CA2332929A1 (en) | 2000-01-20 |
| EP1093366B1 (de) | 2004-10-13 |
| DE69921137T2 (de) | 2006-02-02 |
| NZ525623A (en) | 2005-08-26 |
| ATE279188T1 (de) | 2004-10-15 |
| CA2332929C (en) | 2005-05-31 |
| NO20010116D0 (no) | 2001-01-08 |
| JP2002520300A (ja) | 2002-07-09 |
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