ZA200006817B - Combination therapy for treatment of Bipolar Disorders. - Google Patents
Combination therapy for treatment of Bipolar Disorders. Download PDFInfo
- Publication number
- ZA200006817B ZA200006817B ZA200006817A ZA200006817A ZA200006817B ZA 200006817 B ZA200006817 B ZA 200006817B ZA 200006817 A ZA200006817 A ZA 200006817A ZA 200006817 A ZA200006817 A ZA 200006817A ZA 200006817 B ZA200006817 B ZA 200006817B
- Authority
- ZA
- South Africa
- Prior art keywords
- olanzapine
- component
- composition
- group
- substance
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 36
- 208000020925 Bipolar disease Diseases 0.000 title claims description 33
- 238000002648 combination therapy Methods 0.000 title description 2
- 229960005017 olanzapine Drugs 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 37
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 21
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims description 20
- 229960002464 fluoxetine Drugs 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 19
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 12
- 239000001961 anticonvulsive agent Substances 0.000 claims description 12
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims description 12
- 239000003693 atypical antipsychotic agent Substances 0.000 claims description 11
- 229940127236 atypical antipsychotics Drugs 0.000 claims description 11
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 10
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 9
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- 229960004431 quetiapine Drugs 0.000 claims description 8
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- 208000028683 bipolar I disease Diseases 0.000 claims description 7
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- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims description 7
- 229960000652 sertindole Drugs 0.000 claims description 7
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N sertindole Chemical compound C1=CC(F)=CC=C1N1C2=CC=C(Cl)C=C2C(C2CCN(CCN3C(NCC3)=O)CC2)=C1 GZKLJWGUPQBVJQ-UHFFFAOYSA-N 0.000 claims description 7
- 229960000607 ziprasidone Drugs 0.000 claims description 7
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims description 7
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims description 6
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- 208000020401 Depressive disease Diseases 0.000 claims description 6
- 208000025307 bipolar depression Diseases 0.000 claims description 6
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- RTHCYVBBDHJXIQ-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 0.000 description 1
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- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 1
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- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8712698P | 1998-05-29 | 1998-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200006817B true ZA200006817B (en) | 2002-02-21 |
Family
ID=22203275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200006817A ZA200006817B (en) | 1998-05-29 | 2000-11-21 | Combination therapy for treatment of Bipolar Disorders. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0966967A3 (no) |
| JP (1) | JP2002516864A (no) |
| KR (1) | KR20010043731A (no) |
| CN (1) | CN1302207A (no) |
| AU (1) | AU756468B2 (no) |
| BR (1) | BR9911068A (no) |
| CA (1) | CA2332408A1 (no) |
| CZ (1) | CZ20004280A3 (no) |
| EA (1) | EA003611B1 (no) |
| HR (1) | HRP20000798A2 (no) |
| HU (1) | HUP0102511A2 (no) |
| IL (1) | IL139591A0 (no) |
| NO (1) | NO20005884L (no) |
| NZ (1) | NZ507981A (no) |
| PL (1) | PL344304A1 (no) |
| SK (1) | SK17492000A3 (no) |
| TR (1) | TR200003525T2 (no) |
| WO (1) | WO1999062522A1 (no) |
| ZA (1) | ZA200006817B (no) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960577B2 (en) | 1998-05-22 | 2005-11-01 | Eli Lilly And Company | Combination therapy for treatment of refractory depression |
| JP2002530339A (ja) * | 1998-11-23 | 2002-09-17 | セプラコール， インク． | ２−ヒドロキシメチルオランザピン組成物及び方法 |
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| FR2851163B1 (fr) * | 2003-02-14 | 2007-04-27 | Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament | |
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| AU8072691A (en) * | 1990-06-28 | 1992-01-23 | Beecham Group Plc | Pharmaceutical preparations |
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| ZA977967B (en) * | 1996-09-23 | 1999-03-04 | Lilly Co Eli | Combination therapy for treatment of psychoses |
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1999
- 1999-05-21 EP EP99303968A patent/EP0966967A3/en not_active Withdrawn
- 1999-05-21 JP JP2000551778A patent/JP2002516864A/ja not_active Withdrawn
- 1999-05-21 SK SK1749-2000A patent/SK17492000A3/sk unknown
- 1999-05-21 CA CA002332408A patent/CA2332408A1/en not_active Abandoned
- 1999-05-21 HU HU0102511A patent/HUP0102511A2/hu unknown
- 1999-05-21 TR TR2000/03525T patent/TR200003525T2/xx unknown
- 1999-05-21 NZ NZ507981A patent/NZ507981A/en unknown
- 1999-05-21 EA EA200001244A patent/EA003611B1/ru not_active IP Right Cessation
- 1999-05-21 CN CN99806479A patent/CN1302207A/zh active Pending
- 1999-05-21 PL PL99344304A patent/PL344304A1/xx unknown
- 1999-05-21 IL IL13959199A patent/IL139591A0/xx unknown
- 1999-05-21 KR KR1020007013060A patent/KR20010043731A/ko not_active Application Discontinuation
- 1999-05-21 WO PCT/US1999/011314 patent/WO1999062522A1/en not_active Application Discontinuation
- 1999-05-21 AU AU40088/99A patent/AU756468B2/en not_active Ceased
- 1999-05-21 BR BR9911068-7A patent/BR9911068A/pt not_active IP Right Cessation
- 1999-05-21 CZ CZ20004280A patent/CZ20004280A3/cs unknown
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2000
- 2000-11-20 HR HR20000798A patent/HRP20000798A2/hr not_active Application Discontinuation
- 2000-11-21 NO NO20005884A patent/NO20005884L/no not_active Application Discontinuation
- 2000-11-21 ZA ZA200006817A patent/ZA200006817B/en unknown
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| Publication number | Publication date |
|---|---|
| WO1999062522A1 (en) | 1999-12-09 |
| SK17492000A3 (sk) | 2002-04-04 |
| HRP20000798A2 (en) | 2001-10-31 |
| NZ507981A (en) | 2003-10-31 |
| CA2332408A1 (en) | 1999-12-09 |
| AU756468B2 (en) | 2003-01-16 |
| HUP0102511A2 (hu) | 2001-11-28 |
| NO20005884D0 (no) | 2000-11-21 |
| TR200003525T2 (tr) | 2001-04-20 |
| CZ20004280A3 (cs) | 2001-09-12 |
| NO20005884L (no) | 2001-01-24 |
| PL344304A1 (en) | 2001-10-22 |
| CN1302207A (zh) | 2001-07-04 |
| EP0966967A3 (en) | 2000-05-31 |
| AU4008899A (en) | 1999-12-20 |
| KR20010043731A (ko) | 2001-05-25 |
| EA200001244A1 (ru) | 2001-06-25 |
| EA003611B1 (ru) | 2003-06-26 |
| BR9911068A (pt) | 2001-02-06 |
| EP0966967A2 (en) | 1999-12-29 |
| JP2002516864A (ja) | 2002-06-11 |
| IL139591A0 (en) | 2002-02-10 |
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