YU99792A - PROCEDURE FOR OBTAINING PYRIDINE DERIVATIVES - Google Patents

PROCEDURE FOR OBTAINING PYRIDINE DERIVATIVES

Info

Publication number
YU99792A
YU99792A YU99792A YU99792A YU99792A YU 99792 A YU99792 A YU 99792A YU 99792 A YU99792 A YU 99792A YU 99792 A YU99792 A YU 99792A YU 99792 A YU99792 A YU 99792A
Authority
YU
Yugoslavia
Prior art keywords
pyridine derivatives
methyl
radical
procedure
hydrogen
Prior art date
Application number
YU99792A
Other languages
Serbo-Croatian (sh)
Inventor
A. Palomo Coll
Original Assignee
Centro Genesis Para La Investigacion S.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis Para La Investigacion S.L. filed Critical Centro Genesis Para La Investigacion S.L.
Publication of YU99792A publication Critical patent/YU99792A/en

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA PIRIDINA, postupak za dobijanje derivata piridina formule 1, gde je X CH ili N triradikal, R1 je vodonik, metoksi, difluorometoksi 2, 2,2-tri-fluoroetoksi, izopropiloksi, 2-metilpropiloksi ili ciklopropilmetoksi radikal, R2 i R3 su nezavisno vodonik, metil ili metoksi radikal, a R4 je 2,2,2-trifluoroetil, etil, izopropil, metil ili 3-metoksipropil radikal, osim gde je u isto vreme X -CH=, R1 je MeO-; a R2, R3 i R4 su Me; postupak obuhvata minimum od 7 stupnjeva, od kojih je prvi N -oksidacija metil piridina sa vodonik peroksidom i katalizatorom, a poslednji je S - oksidacija tioetra sa per - kiselinom ili sa vodonik peroksidom, bazom i katalizatorom.A process for the preparation of pyridine derivatives, a process for the preparation of pyridine derivatives of formula 1, wherein X is CH or N triradical, R 1 is hydrogen, methoxy, difluoromethoxy 2, 2,2-trifluoroethoxy, isopropyloxy, 2-methylpropyloxy or cyclopropylmethoxy radical, R2 R3 is independently hydrogen, methyl or methoxy radical, and R4 is 2,2,2-trifluoroethyl, ethyl, isopropyl, methyl or 3-methoxypropyl radical, except where at the same time X is -CH =, R1 is MeO-; and R2, R3 and R4 are Me; the procedure involves a minimum of 7 steps, the first being N -oxidation of methyl pyridine with hydrogen peroxide and catalyst and the last one is S - oxidation of thioether with per-acid or with hydrogen peroxide, base and catalyst.

YU99792A 1991-11-21 1992-11-19 PROCEDURE FOR OBTAINING PYRIDINE DERIVATIVES YU99792A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102594A ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Publications (1)

Publication Number Publication Date
YU99792A true YU99792A (en) 1995-10-03

Family

ID=8274245

Family Applications (1)

Application Number Title Priority Date Filing Date
YU99792A YU99792A (en) 1991-11-21 1992-11-19 PROCEDURE FOR OBTAINING PYRIDINE DERIVATIVES

Country Status (4)

Country Link
ES (4) ES2036948B1 (en)
HR (1) HRP921309A2 (en)
SI (1) SI9200336A (en)
YU (1) YU99792A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541B1 (en) * 1993-02-26 1995-11-16 Vinas Lab NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.
ES2063705B1 (en) * 1993-06-14 1995-07-16 S A L V A T Lab Sa INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP.
ES2171116B1 (en) * 2000-04-14 2003-08-01 Esteve Quimica Sa PROCEDURE FOR OBTAINING DERIVATIVES OF (((PIRIDIL REPLACED) METAL) UNCLE) BENCIMIDAZOL.
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
AU2003258335A1 (en) 2002-08-21 2004-03-11 Teva Pharmaceutical Industries Ltd. A method for the purification of lansoprazole
US7683080B2 (en) 2002-11-18 2010-03-23 Teva Pharmaceutical Industries Ltd. Stable iansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
CA2515130A1 (en) 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
US7601737B2 (en) 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
ES2363075B1 (en) * 2009-12-23 2012-03-27 Laboratorios Viñas S.A. Procedure for obtaining 4-chloro-2-chloromethyl-3-methylpyridine
CN102267979A (en) * 2011-06-15 2011-12-07 扬州天和药业有限公司 Method for preparing lansoprazole
CN110317164B (en) * 2019-07-06 2022-08-19 抚州三和医药化工有限公司 Preparation method of omeprazole intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204879D0 (en) * 1982-08-26 1982-08-26 Haessle Ab NOVEL CHEMICAL INTERMEDIATES
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
ES8604202A1 (en) * 1985-06-01 1986-01-16 Rubio Lab Prepn. of benzimidazole deriv. for treating gastric ulcers
FI864138A (en) * 1985-10-16 1987-04-17 Fisons Plc HETEROCYCLISKA BLANDNINGAR.
JPS62209062A (en) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2024357A6 (en) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Also Published As

Publication number Publication date
SI9200336A (en) 1993-06-30
ES2066701A1 (en) 1995-03-01
ES2036948A1 (en) 1993-06-01
ES2067407A1 (en) 1995-03-16
HRP921309A2 (en) 1995-02-28
ES2105953B1 (en) 1998-07-01
ES2036948B1 (en) 1994-09-01
ES2066701B1 (en) 1995-12-01
ES2067407B1 (en) 1996-04-16
ES2105953A1 (en) 1997-10-16

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