ES2067407A1 - Procedure for obtaining compounds derived from pyridine. - Google Patents

Procedure for obtaining compounds derived from pyridine.

Info

Publication number
ES2067407A1
ES2067407A1 ES09300935A ES9300935A ES2067407A1 ES 2067407 A1 ES2067407 A1 ES 2067407A1 ES 09300935 A ES09300935 A ES 09300935A ES 9300935 A ES9300935 A ES 9300935A ES 2067407 A1 ES2067407 A1 ES 2067407A1
Authority
ES
Spain
Prior art keywords
procedure
pyridine
compounds derived
obtaining compounds
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300935A
Other languages
Spanish (es)
Other versions
ES2067407B1 (en
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Genesis para la Investigacion SL
Original Assignee
Centro Genesis para la Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Publication of ES2067407A1 publication Critical patent/ES2067407A1/en
Application granted granted Critical
Publication of ES2067407B1 publication Critical patent/ES2067407B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for obtaining compounds derived from pyridine with formula I, where X is N or CH triradical, R<1> is a hydrogen, methoxy, difluoromethoxy 2,2,2-trifluoroethoxy, isopropyloxy, 2-methylpropyloxy or cyclopropylmethyloxy radical, R<2> and R<3> are independently a hydrogen, methyl or methoxy radical, and R<4> is a 2,2,2-trifluoroethyl, ethyl, isopropyl, methyl or 3-methoxypropile radical, excepting the case in which simultaneously: X is -CH=, R<1> is MeO-, and R<2>, R<3> and R<4> are Me the procedure consists of at least 7 steps, the first being the N-oxidation of a methylpiridine with H2O2 and a catalyst, and the last an S-oxidation of a thioether with a peracid or with H2O2, a base and a catalyst.
ES9300935A 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES. Expired - Fee Related ES2067407B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102594A ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Publications (2)

Publication Number Publication Date
ES2067407A1 true ES2067407A1 (en) 1995-03-16
ES2067407B1 ES2067407B1 (en) 1996-04-16

Family

ID=8274245

Family Applications (4)

Application Number Title Priority Date Filing Date
ES9102594A Expired - Fee Related ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A Expired - Fee Related ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.
ES9402419A Expired - Fee Related ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES9102594A Expired - Fee Related ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES9402419A Expired - Fee Related ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Country Status (4)

Country Link
ES (4) ES2036948B1 (en)
HR (1) HRP921309A2 (en)
SI (1) SI9200336A (en)
YU (1) YU99792A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110317164A (en) * 2019-07-06 2019-10-11 抚州三和医药化工有限公司 A kind of preparation method of intermediate of omeprazole

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541B1 (en) * 1993-02-26 1995-11-16 Vinas Lab NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.
ES2063705B1 (en) * 1993-06-14 1995-07-16 S A L V A T Lab Sa INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP.
ES2171116B1 (en) * 2000-04-14 2003-08-01 Esteve Quimica Sa PROCEDURE FOR OBTAINING DERIVATIVES OF (((PIRIDIL REPLACED) METAL) UNCLE) BENCIMIDAZOL.
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
TWI270542B (en) * 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
ATE375338T1 (en) 2002-08-21 2007-10-15 Teva Pharma METHOD FOR THE PURIFICATION OF LANZOPRAZOLE
PT1465890E (en) 2002-11-18 2007-05-31 Teva Pharma Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
EP1485373A1 (en) 2003-02-05 2004-12-15 Teva Pharmaceutical Industries Limited Method of stabilizing lansoprazole
US7601737B2 (en) 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
ES2363075B1 (en) * 2009-12-23 2012-03-27 Laboratorios Viñas S.A. Procedure for obtaining 4-chloro-2-chloromethyl-3-methylpyridine
CN102267979A (en) * 2011-06-15 2011-12-07 扬州天和药业有限公司 Method for preparing lansoprazole

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8404993A1 (en) * 1982-08-26 1984-05-16 Haessle Ab Intermediates for the preparation of omeprazole.
JPS62209062A (en) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound
ES2024357A6 (en) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
ES8604202A1 (en) * 1985-06-01 1986-01-16 Rubio Lab Prepn. of benzimidazole deriv. for treating gastric ulcers
FI864138A (en) * 1985-10-16 1987-04-17 Fisons Plc HETEROCYCLISKA BLANDNINGAR.
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8404993A1 (en) * 1982-08-26 1984-05-16 Haessle Ab Intermediates for the preparation of omeprazole.
JPS62209062A (en) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound
ES2024357A6 (en) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, Vol. 12, n‘ 70 (C-479)(2917), 4 Marzo 1988 & JP-A-62209062 (YAMANOUCHI PHARMACEUT. CO. LTD.) 14-9-1987 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110317164A (en) * 2019-07-06 2019-10-11 抚州三和医药化工有限公司 A kind of preparation method of intermediate of omeprazole
CN110317164B (en) * 2019-07-06 2022-08-19 抚州三和医药化工有限公司 Preparation method of omeprazole intermediate

Also Published As

Publication number Publication date
ES2066701B1 (en) 1995-12-01
ES2105953B1 (en) 1998-07-01
SI9200336A (en) 1993-06-30
HRP921309A2 (en) 1995-02-28
ES2036948B1 (en) 1994-09-01
YU99792A (en) 1995-10-03
ES2066701A1 (en) 1995-03-01
ES2036948A1 (en) 1993-06-01
ES2105953A1 (en) 1997-10-16
ES2067407B1 (en) 1996-04-16

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Effective date: 20190611