ES2105953B1 - IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. - Google Patents
IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.Info
- Publication number
- ES2105953B1 ES2105953B1 ES9402419A ES9402419A ES2105953B1 ES 2105953 B1 ES2105953 B1 ES 2105953B1 ES 9402419 A ES9402419 A ES 9402419A ES 9402419 A ES9402419 A ES 9402419A ES 2105953 B1 ES2105953 B1 ES 2105953B1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- procedure
- piridine
- obtaining
- invention patent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
PERFECCIONAMIENTO EN EL OBJETO DE LA PATENTE DE INVENCION 9102594 POR "PROCEDIMIENTO DE OBTENCION DE COMPUESTOS DERIVADOS DE PIRIDINA" DE FORMULA I, DONDE X ES UN TRIRADICAL CH O N, R1 H O UN ALCOXI, R2 Y R3 H, ME O METOXI, Y R4 2, 2, 2-TRIFLUOROETIL, ETIL, ISOPROPIL, ME O 3-METOXIPROPILO (CON EXCEPCIONES); Y R2, R3 Y R4 ME; LAS ETAPAS DEL PROCEDIMIENTO SON: A) UNA CLORACION ALILICA DE UN ME DEL COMPUESTO IV RESULTANDO EL COMPUESTO V; B) DESOXIGENACION DEL COMPUESTO DE FORMULA V, OBTENIENDO EL COMPUESTO VI; C) SUSTITUCION NUCLEOFILA DEL RADICAL -CL DE UN ME DEL COMPUESTO VI POR -SR5, OBTENIENDO EL COMPUESTO VIII; Y D) SUSTITUCION NUCLEOFILA DEL GRUPO Z DEL COMPUESTO VIII POR -OR4, CUYO TRATAMIENTO CON UN ACIDO RINDE EL CARBOXILATO IX CUYA OXIDACION PROPORCIONA EL COMPUESTO I; ESTA OXIDACION TIENE LUGAR EN ETANOL POR ADICION DE UNA BASE ALCALINA HASTA PH NEUTRO BASICO Y DE H2O2 EN PRESENCIA DE UN CATALIZADOR.IMPROVEMENT IN THE OBJECT OF THE INVENTION PATENT 9102594 FOR "PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE" OF FORMULA I, WHERE X IS A TRIRADICAL CH ON, R1 HO AN ALCOXI, R2 AND R3 H, ME OR METOXI, AND R4 2 , 2, 2-TRIFLUOROETIL, ETIL, ISOPROPIL, ME OR 3-METOXIPROPILO (WITH EXCEPTIONS); Y R2, R3 Y R4 ME; THE STAGES OF THE PROCEDURE ARE: A) AN ALILIC CHLORINATION OF A ME OF COMPOUND IV RESULTING IN COMPOUND V; B) DEOXYGENATION OF THE COMPOUND OF FORMULA V, OBTAINING COMPOUND VI; C) NUCLEOPHILAL SUBSTITUTION OF THE RADICAL -CL OF A ME OF COMPOUND VI BY -SR5, OBTAINING COMPOUND VIII; AND D) NUCLEOPHYLAL SUBSTITUTION OF GROUP Z OF COMPOUND VIII BY -OR4, WHOSE TREATMENT WITH AN ACID PERFORMING CARBOXYLATE IX WHOSE OXIDATION PROVIDES COMPOUND I; THIS OXIDATION TAKES PLACE IN ETHANOL BY THE ADDITION OF AN ALKALINE BASE UP TO BASIC NEUTRAL PH AND OF H2O2 IN THE PRESENCE OF A CATALYST.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9102594A ES2036948B1 (en) | 1991-11-21 | 1991-11-21 | PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105953A1 ES2105953A1 (en) | 1997-10-16 |
ES2105953B1 true ES2105953B1 (en) | 1998-07-01 |
Family
ID=8274245
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9102594A Expired - Fee Related ES2036948B1 (en) | 1991-11-21 | 1991-11-21 | PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
ES9300064A Expired - Fee Related ES2066701B1 (en) | 1991-11-21 | 1993-01-15 | IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
ES9300935A Expired - Fee Related ES2067407B1 (en) | 1991-11-21 | 1993-05-04 | IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES. |
ES9402419A Expired - Fee Related ES2105953B1 (en) | 1991-11-21 | 1994-11-24 | IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9102594A Expired - Fee Related ES2036948B1 (en) | 1991-11-21 | 1991-11-21 | PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
ES9300064A Expired - Fee Related ES2066701B1 (en) | 1991-11-21 | 1993-01-15 | IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
ES9300935A Expired - Fee Related ES2067407B1 (en) | 1991-11-21 | 1993-05-04 | IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES. |
Country Status (4)
Country | Link |
---|---|
ES (4) | ES2036948B1 (en) |
HR (1) | HRP921309A2 (en) |
SI (1) | SI9200336A (en) |
YU (1) | YU99792A (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2060541B1 (en) * | 1993-02-26 | 1995-11-16 | Vinas Lab | NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME. |
ES2063705B1 (en) * | 1993-06-14 | 1995-07-16 | S A L V A T Lab Sa | INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. |
ES2166269B1 (en) * | 1999-07-14 | 2003-04-01 | Sint Quimica Sa | NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL. |
ES2163372B1 (en) * | 2000-03-13 | 2003-05-01 | Esteve Quimica Sa | OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP. |
ES2171116B1 (en) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | PROCEDURE FOR OBTAINING DERIVATIVES OF (((PIRIDIL REPLACED) METAL) UNCLE) BENCIMIDAZOL. |
ES2187248B1 (en) * | 2000-08-25 | 2004-01-16 | Sint Quimica Sa | NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL. |
TWI270542B (en) * | 2002-02-07 | 2007-01-11 | Sumitomo Chemical Co | Method for preparing sulfone or sulfoxide compound |
ATE375338T1 (en) | 2002-08-21 | 2007-10-15 | Teva Pharma | METHOD FOR THE PURIFICATION OF LANZOPRAZOLE |
PT1465890E (en) | 2002-11-18 | 2007-05-31 | Teva Pharma | Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol |
EP1485373A1 (en) | 2003-02-05 | 2004-12-15 | Teva Pharmaceutical Industries Limited | Method of stabilizing lansoprazole |
US7601737B2 (en) | 2005-07-26 | 2009-10-13 | Nycomed Gmbh | Isotopically substituted proton pump inhibitors |
WO2009066309A2 (en) * | 2007-07-12 | 2009-05-28 | Cadila Healthcare Limited | Process for preparation of omeprazole |
WO2009010937A1 (en) | 2007-07-17 | 2009-01-22 | Ranbaxy Laboratories Limited | Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate |
ES2363075B1 (en) * | 2009-12-23 | 2012-03-27 | Laboratorios Viñas S.A. | Procedure for obtaining 4-chloro-2-chloromethyl-3-methylpyridine |
CN102267979A (en) * | 2011-06-15 | 2011-12-07 | 扬州天和药业有限公司 | Method for preparing lansoprazole |
CN110317164B (en) * | 2019-07-06 | 2022-08-19 | 抚州三和医药化工有限公司 | Preparation method of omeprazole intermediate |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8204879D0 (en) * | 1982-08-26 | 1982-08-26 | Haessle Ab | NOVEL CHEMICAL INTERMEDIATES |
JPS6150978A (en) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | Pyridine derivative and preparation thereof |
ES8604202A1 (en) * | 1985-06-01 | 1986-01-16 | Rubio Lab | Prepn. of benzimidazole deriv. for treating gastric ulcers |
FI864138A (en) * | 1985-10-16 | 1987-04-17 | Fisons Plc | HETEROCYCLISKA BLANDNINGAR. |
JPS62209062A (en) * | 1986-03-10 | 1987-09-14 | Yamanouchi Pharmaceut Co Ltd | 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound |
ES2023609A6 (en) * | 1990-11-29 | 1992-01-16 | Inke Sa | Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole |
ES2024357A6 (en) * | 1990-12-05 | 1992-02-16 | Genesis Para La Investigacion | Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate |
-
1991
- 1991-11-21 ES ES9102594A patent/ES2036948B1/en not_active Expired - Fee Related
-
1992
- 1992-11-19 YU YU99792A patent/YU99792A/en unknown
- 1992-11-20 SI SI9200336A patent/SI9200336A/en unknown
- 1992-11-20 HR HRP921309 patent/HRP921309A2/en not_active Application Discontinuation
-
1993
- 1993-01-15 ES ES9300064A patent/ES2066701B1/en not_active Expired - Fee Related
- 1993-05-04 ES ES9300935A patent/ES2067407B1/en not_active Expired - Fee Related
-
1994
- 1994-11-24 ES ES9402419A patent/ES2105953B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2066701B1 (en) | 1995-12-01 |
SI9200336A (en) | 1993-06-30 |
HRP921309A2 (en) | 1995-02-28 |
ES2036948B1 (en) | 1994-09-01 |
YU99792A (en) | 1995-10-03 |
ES2067407A1 (en) | 1995-03-16 |
ES2066701A1 (en) | 1995-03-01 |
ES2036948A1 (en) | 1993-06-01 |
ES2105953A1 (en) | 1997-10-16 |
ES2067407B1 (en) | 1996-04-16 |
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