ES2105953B1 - IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. - Google Patents

IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Info

Publication number
ES2105953B1
ES2105953B1 ES9402419A ES9402419A ES2105953B1 ES 2105953 B1 ES2105953 B1 ES 2105953B1 ES 9402419 A ES9402419 A ES 9402419A ES 9402419 A ES9402419 A ES 9402419A ES 2105953 B1 ES2105953 B1 ES 2105953B1
Authority
ES
Spain
Prior art keywords
compound
procedure
piridine
obtaining
invention patent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9402419A
Other languages
Spanish (es)
Other versions
ES2105953A1 (en
Inventor
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro Genesis para la Investigacion SL
Original Assignee
Centro Genesis para la Investigacion SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Genesis para la Investigacion SL filed Critical Centro Genesis para la Investigacion SL
Publication of ES2105953A1 publication Critical patent/ES2105953A1/en
Application granted granted Critical
Publication of ES2105953B1 publication Critical patent/ES2105953B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PERFECCIONAMIENTO EN EL OBJETO DE LA PATENTE DE INVENCION 9102594 POR "PROCEDIMIENTO DE OBTENCION DE COMPUESTOS DERIVADOS DE PIRIDINA" DE FORMULA I, DONDE X ES UN TRIRADICAL CH O N, R1 H O UN ALCOXI, R2 Y R3 H, ME O METOXI, Y R4 2, 2, 2-TRIFLUOROETIL, ETIL, ISOPROPIL, ME O 3-METOXIPROPILO (CON EXCEPCIONES); Y R2, R3 Y R4 ME; LAS ETAPAS DEL PROCEDIMIENTO SON: A) UNA CLORACION ALILICA DE UN ME DEL COMPUESTO IV RESULTANDO EL COMPUESTO V; B) DESOXIGENACION DEL COMPUESTO DE FORMULA V, OBTENIENDO EL COMPUESTO VI; C) SUSTITUCION NUCLEOFILA DEL RADICAL -CL DE UN ME DEL COMPUESTO VI POR -SR5, OBTENIENDO EL COMPUESTO VIII; Y D) SUSTITUCION NUCLEOFILA DEL GRUPO Z DEL COMPUESTO VIII POR -OR4, CUYO TRATAMIENTO CON UN ACIDO RINDE EL CARBOXILATO IX CUYA OXIDACION PROPORCIONA EL COMPUESTO I; ESTA OXIDACION TIENE LUGAR EN ETANOL POR ADICION DE UNA BASE ALCALINA HASTA PH NEUTRO BASICO Y DE H2O2 EN PRESENCIA DE UN CATALIZADOR.IMPROVEMENT IN THE OBJECT OF THE INVENTION PATENT 9102594 FOR "PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE" OF FORMULA I, WHERE X IS A TRIRADICAL CH ON, R1 HO AN ALCOXI, R2 AND R3 H, ME OR METOXI, AND R4 2 , 2, 2-TRIFLUOROETIL, ETIL, ISOPROPIL, ME OR 3-METOXIPROPILO (WITH EXCEPTIONS); Y R2, R3 Y R4 ME; THE STAGES OF THE PROCEDURE ARE: A) AN ALILIC CHLORINATION OF A ME OF COMPOUND IV RESULTING IN COMPOUND V; B) DEOXYGENATION OF THE COMPOUND OF FORMULA V, OBTAINING COMPOUND VI; C) NUCLEOPHILAL SUBSTITUTION OF THE RADICAL -CL OF A ME OF COMPOUND VI BY -SR5, OBTAINING COMPOUND VIII; AND D) NUCLEOPHYLAL SUBSTITUTION OF GROUP Z OF COMPOUND VIII BY -OR4, WHOSE TREATMENT WITH AN ACID PERFORMING CARBOXYLATE IX WHOSE OXIDATION PROVIDES COMPOUND I; THIS OXIDATION TAKES PLACE IN ETHANOL BY THE ADDITION OF AN ALKALINE BASE UP TO BASIC NEUTRAL PH AND OF H2O2 IN THE PRESENCE OF A CATALYST.

ES9402419A 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. Expired - Fee Related ES2105953B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102594A ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Publications (2)

Publication Number Publication Date
ES2105953A1 ES2105953A1 (en) 1997-10-16
ES2105953B1 true ES2105953B1 (en) 1998-07-01

Family

ID=8274245

Family Applications (4)

Application Number Title Priority Date Filing Date
ES9102594A Expired - Fee Related ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A Expired - Fee Related ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.
ES9402419A Expired - Fee Related ES2105953B1 (en) 1991-11-21 1994-11-24 IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES9102594A Expired - Fee Related ES2036948B1 (en) 1991-11-21 1991-11-21 PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300064A Expired - Fee Related ES2066701B1 (en) 1991-11-21 1993-01-15 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.
ES9300935A Expired - Fee Related ES2067407B1 (en) 1991-11-21 1993-05-04 IMPROVEMENTS IN THE PURPOSE OF PATENT 9102594 BY PROCEDURE FOR OBTAINING PIRIDINE DERIVATIVES.

Country Status (4)

Country Link
ES (4) ES2036948B1 (en)
HR (1) HRP921309A2 (en)
SI (1) SI9200336A (en)
YU (1) YU99792A (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060541B1 (en) * 1993-02-26 1995-11-16 Vinas Lab NEW PROCEDURE FOR THE SYNTHESIS OF A DERIVATIVE OF 2- (2-PIRIDILMETILSUFINIL) BENCIMIDAZOLE, AND NEW INTERMEDIATE PRODUCTS OBTAINED WITH THE SAME.
ES2063705B1 (en) * 1993-06-14 1995-07-16 S A L V A T Lab Sa INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa OXIDATION PROCEDURE OF A SULFOXIDE TIOETER GROUP.
ES2171116B1 (en) * 2000-04-14 2003-08-01 Esteve Quimica Sa PROCEDURE FOR OBTAINING DERIVATIVES OF (((PIRIDIL REPLACED) METAL) UNCLE) BENCIMIDAZOL.
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
TWI270542B (en) * 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
ATE375338T1 (en) 2002-08-21 2007-10-15 Teva Pharma METHOD FOR THE PURIFICATION OF LANZOPRAZOLE
PT1465890E (en) 2002-11-18 2007-05-31 Teva Pharma Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
EP1485373A1 (en) 2003-02-05 2004-12-15 Teva Pharmaceutical Industries Limited Method of stabilizing lansoprazole
US7601737B2 (en) 2005-07-26 2009-10-13 Nycomed Gmbh Isotopically substituted proton pump inhibitors
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
WO2009010937A1 (en) 2007-07-17 2009-01-22 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
ES2363075B1 (en) * 2009-12-23 2012-03-27 Laboratorios Viñas S.A. Procedure for obtaining 4-chloro-2-chloromethyl-3-methylpyridine
CN102267979A (en) * 2011-06-15 2011-12-07 扬州天和药业有限公司 Method for preparing lansoprazole
CN110317164B (en) * 2019-07-06 2022-08-19 抚州三和医药化工有限公司 Preparation method of omeprazole intermediate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204879D0 (en) * 1982-08-26 1982-08-26 Haessle Ab NOVEL CHEMICAL INTERMEDIATES
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
ES8604202A1 (en) * 1985-06-01 1986-01-16 Rubio Lab Prepn. of benzimidazole deriv. for treating gastric ulcers
FI864138A (en) * 1985-10-16 1987-04-17 Fisons Plc HETEROCYCLISKA BLANDNINGAR.
JPS62209062A (en) * 1986-03-10 1987-09-14 Yamanouchi Pharmaceut Co Ltd 2-pyridylmethylthio-or 2-pyridylmethylsulfinyl-substituted condensed ring compound
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2024357A6 (en) * 1990-12-05 1992-02-16 Genesis Para La Investigacion Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate

Also Published As

Publication number Publication date
ES2066701B1 (en) 1995-12-01
SI9200336A (en) 1993-06-30
HRP921309A2 (en) 1995-02-28
ES2036948B1 (en) 1994-09-01
YU99792A (en) 1995-10-03
ES2067407A1 (en) 1995-03-16
ES2066701A1 (en) 1995-03-01
ES2036948A1 (en) 1993-06-01
ES2105953A1 (en) 1997-10-16
ES2067407B1 (en) 1996-04-16

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