ES2063705B1 - INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. - Google Patents
INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.Info
- Publication number
- ES2063705B1 ES2063705B1 ES9301312A ES9301312A ES2063705B1 ES 2063705 B1 ES2063705 B1 ES 2063705B1 ES 9301312 A ES9301312 A ES 9301312A ES 9301312 A ES9301312 A ES 9301312A ES 2063705 B1 ES2063705 B1 ES 2063705B1
- Authority
- ES
- Spain
- Prior art keywords
- lansoprazole
- synthesis
- methyl
- procedure
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
INTERMEDIO PARA LA SINTESIS DE LANSOPRAZOL Y SU PROCEDIMIENTO DE OBTENCION. PRODUCTO QUIMICO DE FORMULA (I), LLAMADO N-OXIDO DE 2-[[[1H-BENZIMIDAZOL-2-IL]TIO]METIL]-3-METIL-4-(2,2,2-TRIFLUOROETOXI)PIRIDINA, UTILIZABLE COMO INTERMEDIO PARA LA SINTESIS DEL PRINCIPIO ACTIVO FARMACEUTICO, ANTIULCEROSO Y COMERCIAL, LLAMADO LANSOPRAZOL. PROCEDIMIENTO DE PREPARACION DE (I) A PARTIR DEL N-OXIDO DE 2,3-DIMETIL-4-NITROPIRIDINA. PROCEDIMIENTO DE UTILIZACION DEL PRODUCTO (I) COMO INTERMEDIO EN LA SINTESIS DE LANSOPRAZOL CARACTERIZADO PORQUE EL GRUPO N-OXIDO DE PIRIDINA DE (I) SE REDUCE A PIRIDILO MEDIANTE TRICLORURO DE FOSFORO EN CLOROFORMO O DIMETILFORMANIDA, DANDO EL 2-[[[3-METIL-4-(2,2,2-TRIFLUOROETOXI)-2-PIRIDIL]METIL]TIO]-1H-BENZIMIDAZOL, Y PORQUE ESTE SE OXIDA A LANSOPRAZOL MEDIANTE HIDROPEROXIDO DE TER-BUTILO EN PRESENCIA DE UN COMPUESTO DE VANADIO COMO CATALIZADOR. LA INVENCION ES UTIL PARA OBTENER INDUSTRIALMENTE LANSOPRAZOL DE FORMA MAS PURA Y CON MAYOR RENDIMIENTO.INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. CHEMICAL PRODUCT OF FORMULA (I), CALLED N -OXIDE OF 2 - [[[1H-BENZIMIDAZOL-2-IL] TIO] METHYL] -3-METHYL-4- (2,2,2-TRIFLUOROETOXI) PIRIDINE, USABLE AS INTERMEDIATE FOR THE SYNTHESIS OF THE PHARMACEUTICAL, ANTI-ULCER AND COMMERCIAL ACTIVE SUBSTANCE, CALLED LANSOPRAZOLE. PREPARATION PROCEDURE FOR (I) FROM 2,3-DIMETHYL-4-NITROPYRIDINE N-OXIDE. PROCEDURE FOR USE OF THE PRODUCT (I) AS AN INTERMEDIATE IN THE SYNTHESIS OF LANSOPRAZOLE CHARACTERIZED BECAUSE THE N-OXIDE GROUP OF PIRIDINE OF (I) IS REDUCED TO PIRIDYLL BY PHOSPHORIDE TRICLORIDE [DYMETHYLPHANE 2-DIMETHYLPHORIDE] METHYL-4- (2,2,2-TRIFLUOROETOXI) -2-PIRIDIL] METHYL] THIO] -1H-BENZIMIDAZOLE, AND BECAUSE IT OXIDIZES LANSOPRAZOLE THROUGH TER-BUTYL HYDROPEROXIDE IN THE PRESENCE OF A VANADIUM COMPOUND AS A CATALYZER. THE INVENTION IS USEFUL TO OBTAIN INDUSTRIAL LANSOPRAZOLE IN A PURE WAY AND WITH HIGHER PERFORMANCE.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301312A ES2063705B1 (en) | 1993-06-14 | 1993-06-14 | INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9301312A ES2063705B1 (en) | 1993-06-14 | 1993-06-14 | INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2063705A1 ES2063705A1 (en) | 1995-01-01 |
ES2063705B1 true ES2063705B1 (en) | 1995-07-16 |
Family
ID=8282182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9301312A Expired - Fee Related ES2063705B1 (en) | 1993-06-14 | 1993-06-14 | INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2063705B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2343935A1 (en) * | 2008-12-29 | 2010-08-12 | Laboratorios Viñas S.A. | Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU61103A (en) * | 2001-02-02 | 2006-05-25 | Teva Pharmaceutical Industries Ltd. | Processes for the production of substituted 2- (2-pyridylmethyl)sulfinyl-1h-benzimidazoles |
EP1467987A1 (en) * | 2002-07-26 | 2004-10-20 | Teva Pharmaceutical Industries Ltd. | Preparation of lansoprazole and related compounds |
DE60316791T2 (en) | 2002-08-21 | 2008-07-24 | Teva Pharmaceutical Industries Ltd. | PROCESS FOR PURIFYING LANZOPRAZOLE |
WO2004072061A1 (en) | 2003-02-05 | 2004-08-26 | Teva Pharmaceutical Industries Ltd. | Method of stabilizing lansoprazole |
TW200619198A (en) * | 2004-12-10 | 2006-06-16 | Ind Tech Res Inst | Method for preparing 2-(2-pyridylmethylsulphinyl)benzimidazoles |
EP1847538A1 (en) * | 2006-04-21 | 2007-10-24 | Dipharma Francis S.r.l. | A process for the preparation of pyridine compounds |
DE602007005077D1 (en) * | 2006-10-30 | 2010-04-15 | Dipharma Francis Srl | Process for the preparation of Pyridinmethylsulphinylverbindungen |
EP2022789A1 (en) * | 2007-08-06 | 2009-02-11 | Farmaprojects, S.A. | Process for the preparation of a gastric acid secretion inhibitor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6150978A (en) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | Pyridine derivative and preparation thereof |
DK171989B1 (en) * | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Process for the preparation of 2- (2-pyridylmethylsulfinyl) benzimidazoles |
ES2023609A6 (en) * | 1990-11-29 | 1992-01-16 | Inke Sa | Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole |
ES2036948B1 (en) * | 1991-11-21 | 1994-09-01 | Genesis Para La Investigacion | PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE. |
-
1993
- 1993-06-14 ES ES9301312A patent/ES2063705B1/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2343935A1 (en) * | 2008-12-29 | 2010-08-12 | Laboratorios Viñas S.A. | Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding) |
Also Published As
Publication number | Publication date |
---|---|
ES2063705A1 (en) | 1995-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070615 |