ES2063705B1 - INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. - Google Patents

INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.

Info

Publication number
ES2063705B1
ES2063705B1 ES9301312A ES9301312A ES2063705B1 ES 2063705 B1 ES2063705 B1 ES 2063705B1 ES 9301312 A ES9301312 A ES 9301312A ES 9301312 A ES9301312 A ES 9301312A ES 2063705 B1 ES2063705 B1 ES 2063705B1
Authority
ES
Spain
Prior art keywords
lansoprazole
synthesis
methyl
procedure
oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9301312A
Other languages
Spanish (es)
Other versions
ES2063705A1 (en
Inventor
Vidal Carlos Monserrat
Macia Xavier Serra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Salvat SA
Original Assignee
Laboratorios Salvat SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Salvat SA filed Critical Laboratorios Salvat SA
Priority to ES9301312A priority Critical patent/ES2063705B1/en
Publication of ES2063705A1 publication Critical patent/ES2063705A1/en
Application granted granted Critical
Publication of ES2063705B1 publication Critical patent/ES2063705B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

INTERMEDIO PARA LA SINTESIS DE LANSOPRAZOL Y SU PROCEDIMIENTO DE OBTENCION. PRODUCTO QUIMICO DE FORMULA (I), LLAMADO N-OXIDO DE 2-[[[1H-BENZIMIDAZOL-2-IL]TIO]METIL]-3-METIL-4-(2,2,2-TRIFLUOROETOXI)PIRIDINA, UTILIZABLE COMO INTERMEDIO PARA LA SINTESIS DEL PRINCIPIO ACTIVO FARMACEUTICO, ANTIULCEROSO Y COMERCIAL, LLAMADO LANSOPRAZOL. PROCEDIMIENTO DE PREPARACION DE (I) A PARTIR DEL N-OXIDO DE 2,3-DIMETIL-4-NITROPIRIDINA. PROCEDIMIENTO DE UTILIZACION DEL PRODUCTO (I) COMO INTERMEDIO EN LA SINTESIS DE LANSOPRAZOL CARACTERIZADO PORQUE EL GRUPO N-OXIDO DE PIRIDINA DE (I) SE REDUCE A PIRIDILO MEDIANTE TRICLORURO DE FOSFORO EN CLOROFORMO O DIMETILFORMANIDA, DANDO EL 2-[[[3-METIL-4-(2,2,2-TRIFLUOROETOXI)-2-PIRIDIL]METIL]TIO]-1H-BENZIMIDAZOL, Y PORQUE ESTE SE OXIDA A LANSOPRAZOL MEDIANTE HIDROPEROXIDO DE TER-BUTILO EN PRESENCIA DE UN COMPUESTO DE VANADIO COMO CATALIZADOR. LA INVENCION ES UTIL PARA OBTENER INDUSTRIALMENTE LANSOPRAZOL DE FORMA MAS PURA Y CON MAYOR RENDIMIENTO.INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. CHEMICAL PRODUCT OF FORMULA (I), CALLED N -OXIDE OF 2 - [[[1H-BENZIMIDAZOL-2-IL] TIO] METHYL] -3-METHYL-4- (2,2,2-TRIFLUOROETOXI) PIRIDINE, USABLE AS INTERMEDIATE FOR THE SYNTHESIS OF THE PHARMACEUTICAL, ANTI-ULCER AND COMMERCIAL ACTIVE SUBSTANCE, CALLED LANSOPRAZOLE. PREPARATION PROCEDURE FOR (I) FROM 2,3-DIMETHYL-4-NITROPYRIDINE N-OXIDE. PROCEDURE FOR USE OF THE PRODUCT (I) AS AN INTERMEDIATE IN THE SYNTHESIS OF LANSOPRAZOLE CHARACTERIZED BECAUSE THE N-OXIDE GROUP OF PIRIDINE OF (I) IS REDUCED TO PIRIDYLL BY PHOSPHORIDE TRICLORIDE [DYMETHYLPHANE 2-DIMETHYLPHORIDE] METHYL-4- (2,2,2-TRIFLUOROETOXI) -2-PIRIDIL] METHYL] THIO] -1H-BENZIMIDAZOLE, AND BECAUSE IT OXIDIZES LANSOPRAZOLE THROUGH TER-BUTYL HYDROPEROXIDE IN THE PRESENCE OF A VANADIUM COMPOUND AS A CATALYZER. THE INVENTION IS USEFUL TO OBTAIN INDUSTRIAL LANSOPRAZOLE IN A PURE WAY AND WITH HIGHER PERFORMANCE.

ES9301312A 1993-06-14 1993-06-14 INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING. Expired - Fee Related ES2063705B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301312A ES2063705B1 (en) 1993-06-14 1993-06-14 INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301312A ES2063705B1 (en) 1993-06-14 1993-06-14 INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.

Publications (2)

Publication Number Publication Date
ES2063705A1 ES2063705A1 (en) 1995-01-01
ES2063705B1 true ES2063705B1 (en) 1995-07-16

Family

ID=8282182

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301312A Expired - Fee Related ES2063705B1 (en) 1993-06-14 1993-06-14 INTERMEDIATE FOR THE SYNTHESIS OF LANSOPRAZOLE AND ITS PROCEDURE FOR OBTAINING.

Country Status (1)

Country Link
ES (1) ES2063705B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU61103A (en) * 2001-02-02 2006-05-25 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2- (2-pyridylmethyl)sulfinyl-1h-benzimidazoles
EP1467987A1 (en) * 2002-07-26 2004-10-20 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
DE60316791T2 (en) 2002-08-21 2008-07-24 Teva Pharmaceutical Industries Ltd. PROCESS FOR PURIFYING LANZOPRAZOLE
WO2004072061A1 (en) 2003-02-05 2004-08-26 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
TW200619198A (en) * 2004-12-10 2006-06-16 Ind Tech Res Inst Method for preparing 2-(2-pyridylmethylsulphinyl)benzimidazoles
EP1847538A1 (en) * 2006-04-21 2007-10-24 Dipharma Francis S.r.l. A process for the preparation of pyridine compounds
DE602007005077D1 (en) * 2006-10-30 2010-04-15 Dipharma Francis Srl Process for the preparation of Pyridinmethylsulphinylverbindungen
EP2022789A1 (en) * 2007-08-06 2009-02-11 Farmaprojects, S.A. Process for the preparation of a gastric acid secretion inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6150978A (en) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd Pyridine derivative and preparation thereof
DK171989B1 (en) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Process for the preparation of 2- (2-pyridylmethylsulfinyl) benzimidazoles
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion PROCEDURE FOR OBTAINING COMPOUNDS DERIVED FROM PIRIDINE.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. Useful intermediates for the obtaining of 2- (2-pyridinylmetilsulfinil) -1H-benzimidazoles and corresponding procedures (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
ES2063705A1 (en) 1995-01-01

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FD1A Patent lapsed

Effective date: 20070615