ES2023609A6 - Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole - Google Patents
Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazoleInfo
- Publication number
- ES2023609A6 ES2023609A6 ES9003047A ES9003047A ES2023609A6 ES 2023609 A6 ES2023609 A6 ES 2023609A6 ES 9003047 A ES9003047 A ES 9003047A ES 9003047 A ES9003047 A ES 9003047A ES 2023609 A6 ES2023609 A6 ES 2023609A6
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- sulphinyl
- pyridinyl
- benzimidazole
- trifluoroethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole. Comprises replacing the salient group in the 4 position of the pyridine in substituted 2-[[(3-methyl-2- pyridinyl)methyl]sulphinyl]-1H-benzimidazole derivatives by 2,2,2-trifluoroethanol in order to obtain the desired product which is isolated from the reaction mixture by conventional means. The product obtained has useful therapeutic properties deriving from its activities as an inhibitor of the secretion of gastric acid and its antiulcer activity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003047A ES2023609A6 (en) | 1990-11-29 | 1990-11-29 | Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9003047A ES2023609A6 (en) | 1990-11-29 | 1990-11-29 | Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2023609A6 true ES2023609A6 (en) | 1992-01-16 |
Family
ID=8269833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9003047A Expired - Fee Related ES2023609A6 (en) | 1990-11-29 | 1990-11-29 | Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2023609A6 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2036948A1 (en) * | 1991-11-21 | 1993-06-01 | Genesis Para La Investigacion | Procedure for obtaining compounds derived from pyridine. |
ES2037609A1 (en) * | 1991-12-02 | 1993-06-16 | Techquin Etablissment | 1H-benzimidazole deriv. prepn. |
ES2037608A1 (en) * | 1991-12-02 | 1993-06-16 | Techquin Etablissment | 2(((3-Methyl-New 1H-benzimidazole deriv. prepn. |
ES2058027A1 (en) * | 1991-11-21 | 1994-10-16 | Genesis Para La Investigacion | Improvements in the object of Patent 9102594 for Procedure for obtaining compounds derived from pyridine |
ES2060541A1 (en) * | 1993-02-26 | 1994-11-16 | Vinas Lab | New procedure for the synthesis of a derivative of 2-(2- pyridylmethylsulphinyl)benzimidazole, and new intermediate products obtained therewith |
ES2063705A1 (en) * | 1993-06-14 | 1995-01-01 | S A L V A T Lab Sa | Intermediate for the synthesis of lansoprazole and procedure for obtaining it |
WO2001004109A1 (en) * | 1999-07-14 | 2001-01-18 | Quimica Sintetica, S.A. | Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles |
ES2187248A1 (en) * | 2000-08-25 | 2003-05-16 | Sint Quimica Sa | Procedure is for obtaining derivatives of 2-(2-pyridinyl methyl-sulphinyl)-benzimidazole to be used in treatment or prevention of peptic ulcers |
WO2005054228A1 (en) * | 2003-12-05 | 2005-06-16 | Hetero Drugs Limited | A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers |
ES2264362A1 (en) * | 2004-12-22 | 2006-12-16 | Laboratorios Viñas S.A. | Procedure is for obtaining derivatives of 2-(2-) pyridinil-methylsulfinil-1H-benzimidazols of general formula useful as inhibitors of acid secretion or as anti-ulcerous agents |
ITMI20082046A1 (en) * | 2008-11-18 | 2010-05-19 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF DEXLANSOPRAZOL |
US8314241B2 (en) | 2009-07-29 | 2012-11-20 | Dipharma Francis S.R.L. | Process for the preparation of crystalline dexlansoprazole |
-
1990
- 1990-11-29 ES ES9003047A patent/ES2023609A6/en not_active Expired - Fee Related
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2105953A1 (en) * | 1991-11-21 | 1997-10-16 | Genesis Para La Investigacion | Procedure for obtaining compounds derived from pyridine. |
ES2036948A1 (en) * | 1991-11-21 | 1993-06-01 | Genesis Para La Investigacion | Procedure for obtaining compounds derived from pyridine. |
ES2058027A1 (en) * | 1991-11-21 | 1994-10-16 | Genesis Para La Investigacion | Improvements in the object of Patent 9102594 for Procedure for obtaining compounds derived from pyridine |
ES2037608A1 (en) * | 1991-12-02 | 1993-06-16 | Techquin Etablissment | 2(((3-Methyl-New 1H-benzimidazole deriv. prepn. |
ES2037609A1 (en) * | 1991-12-02 | 1993-06-16 | Techquin Etablissment | 1H-benzimidazole deriv. prepn. |
ES2060541A1 (en) * | 1993-02-26 | 1994-11-16 | Vinas Lab | New procedure for the synthesis of a derivative of 2-(2- pyridylmethylsulphinyl)benzimidazole, and new intermediate products obtained therewith |
ES2063705A1 (en) * | 1993-06-14 | 1995-01-01 | S A L V A T Lab Sa | Intermediate for the synthesis of lansoprazole and procedure for obtaining it |
ES2166269A1 (en) * | 1999-07-14 | 2002-04-01 | Sint Quimica Sa | Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles |
WO2001004109A1 (en) * | 1999-07-14 | 2001-01-18 | Quimica Sintetica, S.A. | Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles |
ES2187248A1 (en) * | 2000-08-25 | 2003-05-16 | Sint Quimica Sa | Procedure is for obtaining derivatives of 2-(2-pyridinyl methyl-sulphinyl)-benzimidazole to be used in treatment or prevention of peptic ulcers |
WO2005054228A1 (en) * | 2003-12-05 | 2005-06-16 | Hetero Drugs Limited | A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers |
ES2264362A1 (en) * | 2004-12-22 | 2006-12-16 | Laboratorios Viñas S.A. | Procedure is for obtaining derivatives of 2-(2-) pyridinil-methylsulfinil-1H-benzimidazols of general formula useful as inhibitors of acid secretion or as anti-ulcerous agents |
ITMI20082046A1 (en) * | 2008-11-18 | 2010-05-19 | Dipharma Francis Srl | PROCEDURE FOR THE PREPARATION OF DEXLANSOPRAZOL |
US8198455B2 (en) | 2008-11-18 | 2012-06-12 | Dipharma Francis S.R.L. | Process for the preparation of dexlansoprazole |
US8314241B2 (en) | 2009-07-29 | 2012-11-20 | Dipharma Francis S.R.L. | Process for the preparation of crystalline dexlansoprazole |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |
Owner name: QUIMICA SINTETICA, S.A. (TITULAR DEL 50%) |
|
GC1A | Exploitation certificate registered application without search report |
Effective date: 19961025 |
|
PC1A | Transfer granted | ||
FD2A | Announcement of lapse in spain |
Effective date: 20110301 |