ES2060541B1 - New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith. - Google Patents

New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith.

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Publication number
ES2060541B1
ES2060541B1 ES9300384A ES9300384A ES2060541B1 ES 2060541 B1 ES2060541 B1 ES 2060541B1 ES 9300384 A ES9300384 A ES 9300384A ES 9300384 A ES9300384 A ES 9300384A ES 2060541 B1 ES2060541 B1 ES 2060541B1
Authority
ES
Spain
Prior art keywords
methyl
benzimidazole
new
piridilmetilsufinil
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9300384A
Other languages
Spanish (es)
Other versions
ES2060541A1 (en
Inventor
Vinas Antonio Buxade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Vinas SA
Original Assignee
Laboratorios Vinas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vinas SA filed Critical Laboratorios Vinas SA
Priority to ES9300384A priority Critical patent/ES2060541B1/en
Publication of ES2060541A1 publication Critical patent/ES2060541A1/en
Application granted granted Critical
Publication of ES2060541B1 publication Critical patent/ES2060541B1/en
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Abstract

EL METODO, DE ACUERDO CON LA INVENCI6N, ES UN PROCESO MULTI-PASO (ESQUEMA I) PARA PREPARAR 2-(((3-METIL-4-(2,2,2- TRIFLUOROETOXI)-2-PIRIDIL)METIL)SULFINIL)-1H-BENZIMIDAZOL QUE COMPRENDE LOS PASOS SIGUIENTES: PASO A): SUSTITUCION NUCLEOFILA DEL GRUPO Z DEL 2- (((3-METIL-4-Z-2-PIRIDIL)METIL)SULFINIL)-1H-BENCIMIDAZOL POR 2,2,2-TRIFLUOROETANOL; METHOD, ACCORDING TO INVENCI6N, is a multi-STEP (SCHEME I) Process for preparing 2 - (((3-methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl) methyl) sulfinyl) -1H-benzimidazole which comprises the following steps: STEP A): nucleophilic Substitution GROUP Z-2- (((3-methyl-4-Z-2-pyridyl) methyl) sulfinyl) -1H-benzimidazole 2.2, 2-trifluoroethanol; PASO B): OBTENCI6N DEL 2-(((3-METIL-4-Z-2-PIRIDIL)ME- TIL)SULFINIL)-LH-BENCIMIDAZOL POR OXIDACI6N DEL 2-(((3- METIL-4-Z-2-PIRIDIL)METIL)TIO)-LH-BENCIMIDAZOL; STEP B): OBTENCI6N OF 2 - (((3-methyl-4-Z-2-pyridyl) methyl) sulfinyl) -LH-benzimidazole OXIDACI6N OF 2 - (((3-methyl-4-Z-2 pyridyl) methyl) thio) -LH-benzimidazole; PASO C): PREPARACI6N DEL 2-(((3-METIL-4-Z-2-PIRI- DIL)METIL)TIO)-1H-BENCIMIDAZOL A PARTIR DE N-6XIDO DE 2,3- DIMETIL-4-NITROPIRIDINA. STEP C): PREPARACI6N OF 2 - (((3-methyl-4-Z-2-PIRI- DIL) methyl) thio) -1H-benzimidazole FROM N-6XIDO of 2,3- dimethyl-4-nitropyridine.
ES9300384A 1993-02-26 1993-02-26 New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith. Expired - Fee Related ES2060541B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9300384A ES2060541B1 (en) 1993-02-26 1993-02-26 New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9300384A ES2060541B1 (en) 1993-02-26 1993-02-26 New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith.

Publications (2)

Publication Number Publication Date
ES2060541A1 ES2060541A1 (en) 1994-11-16
ES2060541B1 true ES2060541B1 (en) 1995-11-16

Family

ID=8280919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9300384A Expired - Fee Related ES2060541B1 (en) 1993-02-26 1993-02-26 New process for the synthesis of a 2- (2-piridilmetilsufinil) benzimidazole, and new intermediate products obtained therewith.

Country Status (1)

Country Link
ES (1) ES2060541B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. useful for obtaining 2- (2-pyridinylmethylsulphinyl) -1H-benzimidazoles and intermediates corresponding procedures.
ES2363075A1 (en) * 2009-12-23 2011-07-20 Laboratorios Viñas S.A. Process to obtain 4-chloromethyl-3-methylpyridine.

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa New procedure for obtaining derivatives of 2- (2-pyridinylmethylsulphinyl) -1H-benzimidazole.
ES2163372B1 (en) * 2000-03-13 2003-05-01 Esteve Quimica Sa Oxidation process of a thioether group to a sulfoxide.
ES2187248B1 (en) * 2000-08-25 2004-01-16 Sint Quimica Sa New procedure for obtaining derivatives of 2- (2-pyridinylmethylsulphinyl) -1H-benzimidazole.
ES2185459B1 (en) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa Procedure for obtaining pantoprazole and intermediates therefor.
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
AU2003288703A1 (en) * 2003-12-05 2005-06-24 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
ES2264362B1 (en) * 2004-12-22 2007-11-01 Laboratorios Viñas S.A. "Procedure for obtaining derivatives of 2- (2-piridinilmetilsufinil-1h-benzimidazoles".
EP2181106A1 (en) 2007-07-17 2010-05-05 Ranbaxy Laboratories Limited Process for the preparation op pantoprazole sodium and pantoprazole sodium sesquihydrate
IT1391776B1 (en) 2008-11-18 2012-01-27 Dipharma Francis Srl Process for the preparation of dexlansoprazole
IT1395118B1 (en) 2009-07-29 2012-09-05 Dipharma Francis Srl Process for the preparation of crystalline dexlansoprazole
JP6377334B2 (en) * 2013-10-25 2018-08-22 東洋鋼鈑株式会社 Nonlinear optical dyes, photorefractive material composition, photorefractive substrate and the holographic recording medium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204879D0 (en) * 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
JPH0244473B2 (en) * 1984-08-16 1990-10-04 Takeda Chemical Industries Ltd Pirijinjudotaioyobisonoseizoho
DK171989B1 (en) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd A process for the preparation of 2- (2-pyridylmethylsulfinyl) -benzimidazoles
ES2023609A6 (en) * 1990-11-29 1992-01-16 Inke Sa Process for obtaining 2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulphinyl]-1H- benzimidazole
ES2036948B1 (en) * 1991-11-21 1994-09-01 Genesis Para La Investigacion Process for obtaining compounds derived from pyridine.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2343935A1 (en) * 2008-12-29 2010-08-12 Laboratorios Viñas S.A. useful for obtaining 2- (2-pyridinylmethylsulphinyl) -1H-benzimidazoles and intermediates corresponding procedures.
ES2363075A1 (en) * 2009-12-23 2011-07-20 Laboratorios Viñas S.A. Process to obtain 4-chloromethyl-3-methylpyridine.

Also Published As

Publication number Publication date
ES2060541A1 (en) 1994-11-16

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