RO72596B - Process for preparing thiazolidinecarboxylic, thiazacarboxylic or morpholinecarboxylic acid derivatives - Google Patents

Process for preparing thiazolidinecarboxylic, thiazacarboxylic or morpholinecarboxylic acid derivatives

Info

Publication number
RO72596B
RO72596B RO92287A RO9228777A RO72596B RO 72596 B RO72596 B RO 72596B RO 92287 A RO92287 A RO 92287A RO 9228777 A RO9228777 A RO 9228777A RO 72596 B RO72596 B RO 72596B
Authority
RO
Romania
Prior art keywords
group
thiazolidinecarboxylic
thiazacarboxylic
preparing
acid derivatives
Prior art date
Application number
RO92287A
Other languages
Romanian (ro)
Other versions
RO72596A (en
Inventor
Miquel Angel Ondetti
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Publication of RO72596B publication Critical patent/RO72596B/en
Publication of RO72596A publication Critical patent/RO72596A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedeu pentru prepararea unor derivati de acid tiazolidincarboxilic, tiazancarboxilic sau morfolincarboxilic cu formula din pag.1 a descrierii, în care X reprezinta un atom de oxigen, de sulf, o grupa SO sau SO2, R reprezinta un atom de hidrogen sau o grupa acetil, R1 reprezinta un atom de hidrogen sau o grupa metil, R2 reprezinta un atom de hidrogen, o grupa metil sau etil, R3 reprezinta un atom de hidrogen, o grupa metil, mercaptometil sau acetiltiometril, m are valoarea 2 si n valoarea 1, cînd X este oxigen.A process for the preparation of a thiazolidinecarboxylic, thiazanecarboxylic or morpholinocarboxylic acid derivative of the formula ## STR2 ## in which X represents an oxygen, sulfur, SO or SO2 group, R represents a hydrogen atom or an acetyl group, R 1 represents a hydrogen atom or a methyl group, R 2 represents a hydrogen atom, a methyl or ethyl group, R 3 represents a hydrogen atom, a methyl group, mercaptomethyl group or acetyl thiomethyl group, m is 2 and n is 1 when X is oxygen.

RO7792287A 1976-12-03 1977-12-02 PROCESS FOR THE PREPARATION OF TIAZOLIDINCARBOXYLQUATASANECANCARBOXYLIC ACID OR MORFOLINCARBOXYLIC ACID DERIVATIVES RO72596A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74728176A 1976-12-03 1976-12-03
US83610777A 1977-09-23 1977-09-23

Publications (2)

Publication Number Publication Date
RO72596B true RO72596B (en) 1983-07-30
RO72596A RO72596A (en) 1983-08-03

Family

ID=27114718

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7799106A RO78013A (en) 1976-12-03 1977-12-02 PROCESS FOR THE PREPARATION OF THIAZONCARBOXYLIC OR MORPHOLINCARBOXYLIC THIAZOLIDINCARBOXYLIC ACID DEDIVES
RO7792287A RO72596A (en) 1976-12-03 1977-12-02 PROCESS FOR THE PREPARATION OF TIAZOLIDINCARBOXYLQUATASANECANCARBOXYLIC ACID OR MORFOLINCARBOXYLIC ACID DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO7799106A RO78013A (en) 1976-12-03 1977-12-02 PROCESS FOR THE PREPARATION OF THIAZONCARBOXYLIC OR MORPHOLINCARBOXYLIC THIAZOLIDINCARBOXYLIC ACID DEDIVES

Country Status (28)

Country Link
JP (1) JPS5382778A (en)
AR (1) AR220689A1 (en)
AT (1) AT363467B (en)
AU (1) AU518147B2 (en)
BG (1) BG32269A3 (en)
CA (1) CA1146940A (en)
CH (1) CH634062A5 (en)
DD (1) DD133798A5 (en)
DE (1) DE2752719C2 (en)
DK (1) DK152494C (en)
EG (1) EG13037A (en)
ES (1) ES464555A1 (en)
FI (1) FI67378C (en)
FR (1) FR2372817A1 (en)
GB (1) GB1578940A (en)
GR (1) GR72453B (en)
HK (1) HK55881A (en)
IE (1) IE46169B1 (en)
IL (1) IL53352A0 (en)
IN (1) IN146945B (en)
IT (1) IT1092179B (en)
NL (3) NL171055C (en)
NO (1) NO148416C (en)
NZ (1) NZ185800A (en)
PT (1) PT67352B (en)
RO (2) RO78013A (en)
SE (1) SE441267B (en)
YU (1) YU41823B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1105731B (en) * 1977-06-29 1985-11-04 Yoshitomi Pharmaceutical THIAZOLIDINE COMPOUNDS
JPS5455565A (en) * 1977-10-06 1979-05-02 Santen Pharmaceut Co Ltd Novel thiazolidine derivative
JPS557255A (en) * 1978-07-03 1980-01-19 Santen Pharmaceut Co Ltd Thiazolidine derivative
US4430344A (en) * 1978-04-08 1984-02-07 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
GR73585B (en) * 1978-09-11 1984-03-26 Univ Miami
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
JPS5829950B2 (en) * 1978-10-05 1983-06-25 ウェルファイド株式会社 Cyclic iminocarboxylic acid derivatives and their salts
JPS5562060A (en) * 1978-10-31 1980-05-10 Santen Pharmaceut Co Ltd Sulfur-containing compound
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
JPS565415A (en) * 1979-06-26 1981-01-20 Santen Pharmaceut Co Ltd Ester-type hypotensor
JPS55124757A (en) * 1979-03-17 1980-09-26 Santen Pharmaceut Co Ltd Sulfur-containing compound
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
DE3152643A1 (en) * 1980-12-29 1982-12-16 Santen Pharmaceutical Co Ltd HETEROCYCLIC 5-MEMBERED RING COMPOUNDS
JPH0662529B2 (en) * 1984-07-13 1994-08-17 三共株式会社 Amino acid derivative
AU584668B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel heterocyclic amides useful as anti-inflammatory and anti-allergy agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446100C3 (en) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkanecarboxamides of thiazolidinecarboxylic acids, process for their preparation and pharmaceuticals
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
ATA857677A (en) 1981-01-15
FI67378B (en) 1984-11-30
DD133798A5 (en) 1979-01-24
NZ185800A (en) 1980-04-28
FI67378C (en) 1985-03-11
GB1578940A (en) 1980-11-12
DK152494C (en) 1988-07-25
NL8201145A (en) 1982-07-01
NL8201146A (en) 1982-07-01
DK538277A (en) 1978-06-04
NO148416C (en) 1983-10-12
RO72596A (en) 1983-08-03
AR220689A1 (en) 1980-11-28
FR2372817A1 (en) 1978-06-30
DK152494B (en) 1988-03-07
AT363467B (en) 1981-08-10
DE2752719C2 (en) 1982-03-25
AU3037977A (en) 1979-05-17
IT1092179B (en) 1985-07-06
FR2372817B1 (en) 1981-06-19
JPS5382778A (en) 1978-07-21
IE46169B1 (en) 1983-03-09
CA1146940A (en) 1983-05-24
IE46169L (en) 1978-06-03
NO774126L (en) 1978-06-06
GR72453B (en) 1983-11-09
SE441267B (en) 1985-09-23
JPS618834B2 (en) 1986-03-18
NO148416B (en) 1983-06-27
EG13037A (en) 1980-12-31
YU41823B (en) 1988-02-29
NL7713274A (en) 1978-06-06
PT67352A (en) 1978-01-01
ES464555A1 (en) 1978-09-01
IN146945B (en) 1979-10-20
YU283777A (en) 1983-01-21
IL53352A0 (en) 1978-01-31
SE7713722L (en) 1978-06-04
BG32269A3 (en) 1982-06-15
AU518147B2 (en) 1981-09-17
DE2752719A1 (en) 1978-06-08
NL171055C (en) 1983-02-01
RO78013A (en) 1981-12-25
CH634062A5 (en) 1983-01-14
HK55881A (en) 1981-11-20
FI773640A (en) 1978-06-04
PT67352B (en) 1979-05-15

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