IE46169L - Thiazolidine, thiazine and morpholine carboxylic acids and¹esters - Google Patents

Thiazolidine, thiazine and morpholine carboxylic acids and¹esters

Info

Publication number
IE46169L
IE46169L IE772397A IE239777A IE46169L IE 46169 L IE46169 L IE 46169L IE 772397 A IE772397 A IE 772397A IE 239777 A IE239777 A IE 239777A IE 46169 L IE46169 L IE 46169L
Authority
IE
Ireland
Prior art keywords
and1esters
thiazine
thiazolidine
carboxylic acids
formula
Prior art date
Application number
IE772397A
Other versions
IE46169B1 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IE46169L publication Critical patent/IE46169L/en
Publication of IE46169B1 publication Critical patent/IE46169B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Abstract

The novel compounds of the general formula I, and their salts, are suitable for alleviating or eliminating angiotensin-induced hypertension. These compounds are prepared by acylating a compound of the formula II with a compound of the formula III. The symbols which are used in the formulae are defined in the claims. The compounds of the formula I in which R4 is a hydrogen atom can be oxidised to the corresponding disulphides. <IMAGE> [GB1578940A]
IE2397/77A 1976-12-03 1977-11-25 Thiazolidine, thiazane and morpholine carboxylic acids and esters IE46169B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74728176A 1976-12-03 1976-12-03
US83610777A 1977-09-23 1977-09-23

Publications (2)

Publication Number Publication Date
IE46169L true IE46169L (en) 1978-06-03
IE46169B1 IE46169B1 (en) 1983-03-09

Family

ID=27114718

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2397/77A IE46169B1 (en) 1976-12-03 1977-11-25 Thiazolidine, thiazane and morpholine carboxylic acids and esters

Country Status (28)

Country Link
JP (1) JPS5382778A (en)
AR (1) AR220689A1 (en)
AT (1) AT363467B (en)
AU (1) AU518147B2 (en)
BG (1) BG32269A3 (en)
CA (1) CA1146940A (en)
CH (1) CH634062A5 (en)
DD (1) DD133798A5 (en)
DE (1) DE2752719C2 (en)
DK (1) DK152494C (en)
EG (1) EG13037A (en)
ES (1) ES464555A1 (en)
FI (1) FI67378C (en)
FR (1) FR2372817A1 (en)
GB (1) GB1578940A (en)
GR (1) GR72453B (en)
HK (1) HK55881A (en)
IE (1) IE46169B1 (en)
IL (1) IL53352A0 (en)
IN (1) IN146945B (en)
IT (1) IT1092179B (en)
NL (3) NL171055C (en)
NO (1) NO148416C (en)
NZ (1) NZ185800A (en)
PT (1) PT67352B (en)
RO (2) RO72596A (en)
SE (1) SE441267B (en)
YU (1) YU41823B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2395998A1 (en) * 1977-06-29 1979-01-26 Yoshitomi Pharmaceutical NEW THIAZOLIDINE DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF HYPERTENSION
JPS5455565A (en) * 1977-10-06 1979-05-02 Santen Pharmaceut Co Ltd Novel thiazolidine derivative
JPS557255A (en) * 1978-07-03 1980-01-19 Santen Pharmaceut Co Ltd Thiazolidine derivative
AU528115B2 (en) * 1978-04-08 1983-04-14 Santen Pharmaceutical Co. Ltd. Antihypertensive 4-thiazolidine/carboxylic acids
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
GR73585B (en) * 1978-09-11 1984-03-26 Univ Miami
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
JPS5829950B2 (en) * 1978-10-05 1983-06-25 ウェルファイド株式会社 Cyclic iminocarboxylic acid derivatives and their salts
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
JPS5562060A (en) * 1978-10-31 1980-05-10 Santen Pharmaceut Co Ltd Sulfur-containing compound
JPS55124757A (en) * 1979-03-17 1980-09-26 Santen Pharmaceut Co Ltd Sulfur-containing compound
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
JPS565415A (en) * 1979-06-26 1981-01-20 Santen Pharmaceut Co Ltd Ester-type hypotensor
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
DE3152643A1 (en) * 1980-12-29 1982-12-16 Santen Pharmaceutical Co Ltd HETEROCYCLIC 5-MEMBERED RING COMPOUNDS
JPH0662529B2 (en) * 1984-07-13 1994-08-17 三共株式会社 Amino acid derivative
CA1277663C (en) * 1985-02-04 1990-12-11 Richard A. Mueller Heterocyclic amides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446100C3 (en) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkanecarboxamides of thiazolidinecarboxylic acids, process for their preparation and pharmaceuticals
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Also Published As

Publication number Publication date
CA1146940A (en) 1983-05-24
AU3037977A (en) 1979-05-17
NL8201145A (en) 1982-07-01
JPS5382778A (en) 1978-07-21
NO148416B (en) 1983-06-27
NZ185800A (en) 1980-04-28
DK152494C (en) 1988-07-25
ATA857677A (en) 1981-01-15
DE2752719A1 (en) 1978-06-08
BG32269A3 (en) 1982-06-15
FI67378B (en) 1984-11-30
NL171055C (en) 1983-02-01
GR72453B (en) 1983-11-09
IL53352A0 (en) 1978-01-31
YU283777A (en) 1983-01-21
ES464555A1 (en) 1978-09-01
JPS618834B2 (en) 1986-03-18
PT67352B (en) 1979-05-15
FI773640A (en) 1978-06-04
DD133798A5 (en) 1979-01-24
RO72596B (en) 1983-07-30
NO148416C (en) 1983-10-12
HK55881A (en) 1981-11-20
NL7713274A (en) 1978-06-06
CH634062A5 (en) 1983-01-14
FR2372817B1 (en) 1981-06-19
PT67352A (en) 1978-01-01
NO774126L (en) 1978-06-06
EG13037A (en) 1980-12-31
IT1092179B (en) 1985-07-06
IE46169B1 (en) 1983-03-09
DK538277A (en) 1978-06-04
AT363467B (en) 1981-08-10
AU518147B2 (en) 1981-09-17
RO78013A (en) 1981-12-25
SE7713722L (en) 1978-06-04
SE441267B (en) 1985-09-23
FI67378C (en) 1985-03-11
FR2372817A1 (en) 1978-06-30
DK152494B (en) 1988-03-07
GB1578940A (en) 1980-11-12
RO72596A (en) 1983-08-03
AR220689A1 (en) 1980-11-28
YU41823B (en) 1988-02-29
NL8201146A (en) 1982-07-01
DE2752719C2 (en) 1982-03-25
IN146945B (en) 1979-10-20

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Legal Events

Date Code Title Description
MK9A Patent expired