YU70394A - Antagonisti receptora nadražujućih amino kiselina i postupak za njihovo dobijanje - Google Patents

Antagonisti receptora nadražujućih amino kiselina i postupak za njihovo dobijanje

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Publication number
YU70394A
YU70394A YU70394A YU70394A YU70394A YU 70394 A YU70394 A YU 70394A YU 70394 A YU70394 A YU 70394A YU 70394 A YU70394 A YU 70394A YU 70394 A YU70394 A YU 70394A
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YU
Yugoslavia
Prior art keywords
glutamic acid
phenoxy
amino acid
naphthyloxy
antagonists
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Application number
YU70394A
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English (en)
Inventor
L.J. Heinz
Lunh W.H. Walker
D.D. Schdepp
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Elly Lilly And Co. Lilly Corporate Center Indianapolis
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Publication date
Application filed by Elly Lilly And Co. Lilly Corporate Center Indianapolis filed Critical Elly Lilly And Co. Lilly Corporate Center Indianapolis
Publication of YU70394A publication Critical patent/YU70394A/sh

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    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Neurology (AREA)
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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
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Abstract

Ovaj pronalazak opisuje nova jedinjenja koja utiču na receptore nadražujućih amino kiselina i korisna su u lečenju neuroloških poremećaja. Ova nova jedinjenja imaju formulu a najpogodnija među njima su 4-(4-metilfenoksi)glutaminska kiselina, 4-(4-(6-fenilheksil)fenoksi)glutaminska kiselina, 4-(4-(3-fehuprop-2-eneil)fenoksi)glutarninska kiselina, 4-(2-naf-tiloksi) glutaminska kiselina, 4-(6-bromo-2-naftilok-si)glutaminska kiselina, 4-(4-(2-(4-nitrofenil)etenil)fenoksi glutaminska kiselina, 4-(2-fluorenoksi)glutaminska kiselina,4-(2-dibenzofuranoksi)glutaminska kiselina, 4-(5,6,7,8-teu"aMdro-2-dibenzofuranoksi)glutaminska kiselina, (2S.4S)-4-(6-brom-2-naftiloksi) glutaminska kiselina i (2S, 4S)-4-(4-(6-fenilheksil)fenoksi glutaminska kiselina. Ovaj ponalazak takođe opisuje sintetske metode za dobijanje tih novih jedinВ­enja.
YU70394A 1993-12-03 1994-12-02 Antagonisti receptora nadražujućih amino kiselina i postupak za njihovo dobijanje YU70394A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16183093A 1993-12-03 1993-12-03
US08/322,632 US5576323A (en) 1993-12-03 1994-10-13 Excitatory amino acid receptor antagonists

Publications (1)

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YU70394A true YU70394A (sh) 1997-12-05

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US (2) US5576323A (sh)
EP (1) EP0658539A1 (sh)
JP (1) JPH07267908A (sh)
KR (1) KR950018015A (sh)
CN (1) CN1108240A (sh)
AU (1) AU676781B2 (sh)
BR (1) BR9404809A (sh)
CA (1) CA2136904A1 (sh)
CO (1) CO4290421A1 (sh)
CZ (1) CZ294794A3 (sh)
FI (1) FI945704A (sh)
HU (1) HUT69181A (sh)
IL (1) IL111789A0 (sh)
NO (1) NO944578L (sh)
NZ (1) NZ270009A (sh)
PE (1) PE42595A1 (sh)
PL (1) PL306038A1 (sh)
RU (1) RU94042240A (sh)
TW (1) TW287157B (sh)
YU (1) YU70394A (sh)
ZA (1) ZA949405B (sh)

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DK160941C (da) * 1988-06-28 1991-10-21 Novo Nordisk As Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar
DE69019610D1 (de) * 1989-07-06 1995-06-29 Banyu Pharma Co Ltd Cyclische Derivate des Amidinylthiocarbapenems.
GB9324872D0 (en) * 1993-12-03 1994-01-19 Univ Pasteur Pharmaceutical compounds

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NO944578L (no) 1995-06-06
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ZA949405B (en) 1996-05-28
NZ270009A (en) 1997-01-29
IL111789A0 (en) 1995-01-24
CA2136904A1 (en) 1995-06-04
US5576323A (en) 1996-11-19
RU94042240A (ru) 1996-10-10
TW287157B (sh) 1996-10-01
EP0658539A1 (en) 1995-06-21
KR950018015A (ko) 1995-07-22
HU9403469D0 (en) 1995-02-28
NO944578D0 (no) 1994-11-29
AU676781B2 (en) 1997-03-20
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HUT69181A (en) 1995-08-28
FI945704A0 (fi) 1994-12-02
CN1108240A (zh) 1995-09-13
PE42595A1 (es) 1995-12-12
CZ294794A3 (en) 1995-12-13
FI945704A (fi) 1995-06-04
AU7915194A (en) 1995-06-08

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