YU69892A - Novi derivati analoga taksola, njihovo dobijanje i smeše koje ih sadrže - Google Patents

Novi derivati analoga taksola, njihovo dobijanje i smeše koje ih sadrže

Info

Publication number
YU69892A
YU69892A YU69892A YU69892A YU69892A YU 69892 A YU69892 A YU 69892A YU 69892 A YU69892 A YU 69892A YU 69892 A YU69892 A YU 69892A YU 69892 A YU69892 A YU 69892A
Authority
YU
Yugoslavia
Prior art keywords
radical
formula
mixtures containing
denote
denotes
Prior art date
Application number
YU69892A
Other languages
English (en)
Inventor
J.D.. Bouezat
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU69892A publication Critical patent/YU69892A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novi derivati analoga taksola opšte formule (I), njihovo dobijanje i smeše koje ih sadrže. U formuli (I): - Ar označava radikal aril, - R označava radikal opšte formule: R7O- (II) u kojoj R7 označava radikal alkil koji je u datom slučaju supstituisan, alkenil, alkinil, cikloalkil, cikloalkenil, bicikloalkil, fenil ili heterociklil, -R1 i R2, isti ili različiti, označavaju atom vodonika ili radikal opšte formule (III) u kojoj R3 i R4, isti ili različiti, označavaju atom vodonika ili radikal alkil (koji je u datom slučaju supstituisan hidroksi-, karboksi-, alkiloksikarbonil- grupom ili radikalom formule (IV) u kojoj R5 i R6, isti ili različiti, označavaju atom vodonika ili radikal alkil ili zajedno formiraju zasićen ili nezasićen heterociklus koji ima 5 ili 6 članova) ili R3 i R4 formiraju zasićen ili nezasićen heterociklus koji ima 5 ili 6 članova. Novi produkti formule (I) imaju značajne antitumorske i antileukemijske osobine.
YU69892A 1991-07-16 1992-07-15 Novi derivati analoga taksola, njihovo dobijanje i smeše koje ih sadrže YU69892A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108937A FR2679230B1 (fr) 1991-07-16 1991-07-16 Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.

Publications (1)

Publication Number Publication Date
YU69892A true YU69892A (sh) 1995-10-03

Family

ID=9415141

Family Applications (1)

Application Number Title Priority Date Filing Date
YU69892A YU69892A (sh) 1991-07-16 1992-07-15 Novi derivati analoga taksola, njihovo dobijanje i smeše koje ih sadrže

Country Status (17)

Country Link
EP (2) EP0596010A1 (sh)
JP (1) JPH06509107A (sh)
AU (1) AU2388092A (sh)
CA (1) CA2113074A1 (sh)
CZ (1) CZ9094A3 (sh)
FI (1) FI940191A (sh)
FR (1) FR2679230B1 (sh)
HU (1) HUT66600A (sh)
IE (1) IE922305A1 (sh)
MX (1) MX9204140A (sh)
NO (1) NO934723D0 (sh)
NZ (1) NZ243548A (sh)
SK (1) SK4894A3 (sh)
TW (1) TW201740B (sh)
WO (1) WO1993002065A1 (sh)
YU (1) YU69892A (sh)
ZA (1) ZA925245B (sh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69432140T2 (de) * 1993-03-05 2003-07-31 Univ Florida State Verfahren zur Herstellung von 9-Desoxotaxanen
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5547981A (en) * 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
ATE192147T1 (de) * 1993-06-11 2000-05-15 Upjohn Co Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5622986A (en) * 1993-10-20 1997-04-22 Enzon, Inc. 2'-and/or 7-substituted taxanes
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
US6545168B1 (en) 1996-05-06 2003-04-08 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
BR9710366A (pt) * 1996-07-15 1999-08-17 Yakult Honsha Kk Derivados de taxane e drogas que os contêm
GB9705903D0 (en) 1997-03-21 1997-05-07 Elliott Gillian D VP22 Proteins and uses thereof
CN1221539C (zh) * 1997-12-19 2005-10-05 株式会社益力多本社 紫杉烷衍生物
CZ20013521A3 (cs) * 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. C7 karbamoyloxy substituované taxany jako protinádorové látky
ATE401325T1 (de) 2000-02-02 2008-08-15 Univ Florida State Res Found C10-carbamoyloxysubstituierte taxane als antitumormittel
AR030188A1 (es) 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
HUP0600533A2 (en) 2001-11-30 2006-11-28 Bristol Myers Squibb Co Paclitaxel solvates
WO2005035003A2 (en) * 2003-09-22 2005-04-21 Dihedron Corporation Compositions and methods for increasing drug efficiency
JP2007527432A (ja) 2004-03-05 2007-09-27 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ７ラクチルオキシ置換タキサン
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
HU9400113D0 (en) 1994-05-30
FR2679230A1 (fr) 1993-01-22
IE922305A1 (en) 1993-01-27
EP0524093A1 (fr) 1993-01-20
NO934723L (no) 1993-12-20
HUT66600A (en) 1994-12-28
FI940191A0 (fi) 1994-01-14
NZ243548A (en) 1994-07-26
TW201740B (sh) 1993-03-11
CZ9094A3 (en) 1994-06-15
AU2388092A (en) 1993-02-23
NO934723D0 (no) 1993-12-20
ZA925245B (en) 1993-04-28
CA2113074A1 (fr) 1993-02-04
SK4894A3 (en) 1994-12-07
FR2679230B1 (fr) 1993-11-19
FI940191A (fi) 1994-01-14
EP0596010A1 (fr) 1994-05-11
JPH06509107A (ja) 1994-10-13
MX9204140A (es) 1993-01-01
WO1993002065A1 (fr) 1993-02-04

Similar Documents

Publication Publication Date Title
YU69892A (sh) Novi derivati analoga taksola, njihovo dobijanje i smeše koje ih sadrže
FI964920A0 (fi) Uudet farnesyylitransferaasin inhibiittorit, niiden valmistus ja niitä sisältävät farmaseuttiset valmisteet
ES422395A1 (es) Un procedimiento para la preparacion de cinamamidas e hi- drocinamamidas.
GB1064629A (en) Alkene derivatives
NO952264L (no) Nye taxoider, deres fremstilling og farmasöytiske preparater inneholdende taxoidene
HUT55401A (en) Process for producing platinum(ii) complexes and pharmaceutical compositions comprising such compounds as active ingredient
ES351795A1 (es) Procedimiento para la preparacion de derivados de 1,4-dihi-dropiridina.
IL90826A0 (en) 13-alkyl-11-beta-phenyl-gonane derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ES449418A1 (es) Procedimiento para la obtencion de imidazolil-o, n-acetales.
DE69230958D1 (de) Arzneizusammensetzung auf Basis von Dioxabicyclo[3.3.0]octanderivaten
NZ227042A (en) Substituted alkylamine derivatives and pharmaceutical compositions
ES426401A1 (es) Procedimiento para la obtencion de derivados de imidazol.
GB1178279A (en) Benzyl Sulfone Derivatives and Pharmaceutical Compositions containing them
AR029618A1 (es) Compuestos de amida , procedimientos para prepararlos, las composiciones farmaceuticas que los contienen y el uso de dichos compuestos para la fabricacion de medicamentos
GB1389504A (en) 2-amino-1,4-dihydropyridines their production and their medicinal use
DK0630428T3 (da) Fremgangsmåde til fremstilling af taxanderivater
GB1513948A (en) Thiazolidine derivatives and process for their manufactur
ES399808A1 (es) Procedimiento para la preparacion de nuevos n-acil-biscar- bamatos herbicidas.
ES463424A1 (es) Procedimiento de preparacion de lactamas sustituidas en n.
ES453162A1 (es) Un procedimiento para la obtencion de compuestos heteroci- clicos.
GB1412616A (en) Stabilisation of rubber products with 1,3,5-triazine derivatives
GB1136919A (en) Amines
ES472263A1 (es) Procedimiento para preparar derivados de urea
ES341324A1 (es) Un procedimiento para la preparacion de pirazinoilguanidi- nas y pirazinamidoguanidinas.
ES424436A1 (es) Procedimiento para la preparacion de 1-(1-unidayolprocedimiento para la preparacion de 1-(1-imidazolil)- iso- quinoleinas. il)-iso- quinoleinas.