YU65800A - Novi derivati oktahidro-6,10-diokso-6h-piridazino(1,2-a) (1,2)diazepin-1-karboksilne kiseline, njihov postupak dobijanja i njihova primena za dobijanje terapeutski aktivnih jedinjenja - Google Patents

Novi derivati oktahidro-6,10-diokso-6h-piridazino(1,2-a) (1,2)diazepin-1-karboksilne kiseline, njihov postupak dobijanja i njihova primena za dobijanje terapeutski aktivnih jedinjenja

Info

Publication number
YU65800A
YU65800A YU65800A YU65800A YU65800A YU 65800 A YU65800 A YU 65800A YU 65800 A YU65800 A YU 65800A YU 65800 A YU65800 A YU 65800A YU 65800 A YU65800 A YU 65800A
Authority
YU
Yugoslavia
Prior art keywords
pyridazino
diazepin
dioxo
preparation
carboxylic acid
Prior art date
Application number
YU65800A
Other languages
English (en)
Inventor
Colette Colladant
Veronique Crocq
John Patrick Larkin
Patrick Roussel
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of YU65800A publication Critical patent/YU65800A/sh
Publication of RS50423B publication Critical patent/RS50423B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Pronalazak se odnsi na jedinjenja formule (I) u SR konfiguraciji ili u obliku SR +SS smeše, gde R je atom vodonika ili alkil ili aralkil radikal koji sadrži do 18 atoma ugljenika, gde je funkcija amina slobodna ili zaštićena. Jedinjenja se mogu koristiti za dobijanje aktivnih sastojaka za lekove.[The invention concerns compounds of formula (I) in SR configuration or in the form of a SR + SS mixture, wherein R represents a hydrogen atom, an alkyl or aralkyl radical containing up to 18 carbon atoms, the amine function being free or protected. The compounds can be used for preparing active principles for medicines.
YUP-658/00A 1998-04-27 1999-04-26 Novi derivati oktahidro-6,10-diokso-6h-piridazino(1,2-a) (1,2) diazepin-1-karboksilne kiseline, njihov postupak dobijanja i njihova primena za dobijanje farmaceutski aktivnih jedinjenja RS50423B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9805243A FR2777889B1 (fr) 1998-04-27 1998-04-27 Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs

Publications (2)

Publication Number Publication Date
YU65800A true YU65800A (sh) 2003-01-31
RS50423B RS50423B (sr) 2009-12-31

Family

ID=9525705

Country Status (38)

Country Link
US (3) US6548664B1 (sh)
EP (1) EP1073673B1 (sh)
JP (2) JP4332298B2 (sh)
KR (1) KR100561582B1 (sh)
CN (1) CN1167711C (sh)
AP (1) AP1518A (sh)
AR (1) AR016466A1 (sh)
AU (1) AU755286B2 (sh)
BG (1) BG65282B1 (sh)
BR (1) BR9910020A (sh)
CA (1) CA2330492C (sh)
CU (1) CU23155A3 (sh)
CY (1) CY1107599T1 (sh)
DE (1) DE69934790T2 (sh)
DK (1) DK1073673T3 (sh)
EA (1) EA003280B1 (sh)
EE (1) EE04682B1 (sh)
ES (1) ES2279617T3 (sh)
FR (1) FR2777889B1 (sh)
GE (1) GEP20033119B (sh)
HK (1) HK1039131A1 (sh)
HR (1) HRP20000733B1 (sh)
HU (1) HU230060B1 (sh)
ID (1) ID26292A (sh)
IL (3) IL139102A0 (sh)
ME (2) MEP40808A (sh)
NO (1) NO328864B1 (sh)
NZ (1) NZ507618A (sh)
PL (1) PL203762B1 (sh)
PT (1) PT1073673E (sh)
RS (1) RS50423B (sh)
SI (1) SI1073673T1 (sh)
SK (1) SK288050B6 (sh)
TR (1) TR200003142T2 (sh)
TW (1) TWI249537B (sh)
UA (1) UA71913C2 (sh)
WO (1) WO1999055724A1 (sh)
ZA (1) ZA200006081B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177565B1 (en) 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6201118B1 (en) 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
FR2853901B1 (fr) * 2003-04-16 2005-06-17 Isochem Sa Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) * 2003-06-26 2005-03-31 Honeywell Specialty Chemicals Seelze Gmbh Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril
JP7102199B2 (ja) 2018-04-11 2022-07-19 キヤノン株式会社 駆動装置、像ぶれ補正装置及び撮像装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6201118B1 (en) * 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor

Also Published As

Publication number Publication date
SK16002000A3 (sk) 2001-09-11
CN1167711C (zh) 2004-09-22
CA2330492A1 (fr) 1999-11-04
AR016466A1 (es) 2001-07-04
HUP0102447A2 (hu) 2001-11-28
AU755286B2 (en) 2002-12-05
BG65282B1 (bg) 2007-11-30
HRP20000733A2 (en) 2001-02-28
US6548664B1 (en) 2003-04-15
UA71913C2 (uk) 2005-01-17
ZA200006081B (en) 2001-10-29
TWI249537B (en) 2006-02-21
EA003280B1 (ru) 2003-04-24
JP2002513030A (ja) 2002-05-08
CN1306539A (zh) 2001-08-01
KR20010043033A (ko) 2001-05-25
KR100561582B1 (ko) 2006-03-20
NZ507618A (en) 2003-07-25
BR9910020A (pt) 2001-01-09
JP2009155343A (ja) 2009-07-16
NO328864B1 (no) 2010-05-31
AP2000001973A0 (en) 2000-12-31
EE200000619A (et) 2002-06-17
GEP20033119B (en) 2003-11-25
JP5101558B2 (ja) 2012-12-19
PT1073673E (pt) 2007-03-30
HRP20000733B1 (en) 2009-06-30
IL190120A (en) 2011-10-31
ID26292A (id) 2000-12-14
EP1073673A1 (fr) 2001-02-07
DE69934790D1 (de) 2007-02-22
NO20005391L (no) 2000-12-19
DE69934790T2 (de) 2007-10-31
MEP40808A (en) 2011-02-10
US20020128473A1 (en) 2002-09-12
IL139102A0 (en) 2001-11-25
FR2777889A1 (fr) 1999-10-29
CA2330492C (fr) 2012-03-13
EP1073673B1 (fr) 2007-01-10
SI1073673T1 (sl) 2007-04-30
PL343720A1 (en) 2001-09-10
EE04682B1 (et) 2006-08-15
TR200003142T2 (tr) 2001-03-21
EA200001107A1 (ru) 2001-04-23
IL139102A (en) 2008-06-05
WO1999055724A1 (fr) 1999-11-04
ME00300B (me) 2011-05-10
AP1518A (en) 2005-12-12
US20030130269A1 (en) 2003-07-10
AU3427499A (en) 1999-11-16
PL203762B1 (pl) 2009-11-30
HK1039131A1 (en) 2002-04-12
ES2279617T3 (es) 2007-08-16
FR2777889B1 (fr) 2004-07-09
HU230060B1 (hu) 2015-06-29
HUP0102447A3 (en) 2003-05-28
DK1073673T3 (da) 2007-05-07
CU23155A3 (es) 2006-07-18
US6570012B2 (en) 2003-05-27
JP4332298B2 (ja) 2009-09-16
CY1107599T1 (el) 2013-03-13
RS50423B (sr) 2009-12-31
BG104891A (en) 2001-10-31
IL190120A0 (en) 2008-08-07
NO20005391D0 (no) 2000-10-26
SK288050B6 (sk) 2013-03-01

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