YU64202A - Postupak za pripremanje klaritromicina i intermedijera klaritromicina, klaritromicina u osnovi bez oksima i farmaceutskog preparata koji ga sadrži - Google Patents
Postupak za pripremanje klaritromicina i intermedijera klaritromicina, klaritromicina u osnovi bez oksima i farmaceutskog preparata koji ga sadržiInfo
- Publication number
- YU64202A YU64202A YU64202A YUP64202A YU64202A YU 64202 A YU64202 A YU 64202A YU 64202 A YU64202 A YU 64202A YU P64202 A YUP64202 A YU P64202A YU 64202 A YU64202 A YU 64202A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- clarithromycin
- oxime
- processes
- protected silylated
- preparing
- Prior art date
Links
- 229960002626 clarithromycin Drugs 0.000 title abstract 7
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- MWBJRTBANFUBOX-UHFFFAOYSA-N 6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-10-hydroxyimino-4-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one Chemical compound CC1C(OC2C(C(CC(C)O2)N(C)C)O)C(C)(OC)CC(C)C(=NO)C(C)C(O)C(O)(C)C(CC)OC(=O)C(C)C1OC1CC(C)(OC)C(O)C(C)O1 MWBJRTBANFUBOX-UHFFFAOYSA-N 0.000 abstract 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- -1 silyl oxime Chemical class 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18588800P | 2000-02-29 | 2000-02-29 | |
| US18912000P | 2000-03-14 | 2000-03-14 | |
| US21323900P | 2000-06-22 | 2000-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU64202A true YU64202A (sh) | 2005-03-15 |
Family
ID=27392028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU64202A YU64202A (sh) | 2000-02-29 | 2000-12-15 | Postupak za pripremanje klaritromicina i intermedijera klaritromicina, klaritromicina u osnovi bez oksima i farmaceutskog preparata koji ga sadrži |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6617436B2 (enExample) |
| EP (1) | EP1313486A1 (enExample) |
| JP (1) | JP2004509062A (enExample) |
| KR (1) | KR20030047873A (enExample) |
| AU (2) | AU2001225787C1 (enExample) |
| CA (1) | CA2401571A1 (enExample) |
| CZ (1) | CZ20023167A3 (enExample) |
| HR (1) | HRP20020709A2 (enExample) |
| HU (1) | HUP0302466A2 (enExample) |
| IL (1) | IL151496A0 (enExample) |
| IS (1) | IS6531A (enExample) |
| PL (1) | PL366021A1 (enExample) |
| SK (1) | SK13722002A3 (enExample) |
| WO (1) | WO2001064224A1 (enExample) |
| YU (1) | YU64202A (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217951C (zh) * | 1999-12-16 | 2005-09-07 | 特瓦制药工业有限公司 | 克拉霉素多晶型物的制备方法和新的多晶型物iv |
| AU2001222619C1 (en) * | 2000-01-11 | 2006-01-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin polymorphs |
| US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| US6544555B2 (en) | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| YU64202A (sh) * | 2000-02-29 | 2005-03-15 | Teva Pharmaceutical Industries Ltd. | Postupak za pripremanje klaritromicina i intermedijera klaritromicina, klaritromicina u osnovi bez oksima i farmaceutskog preparata koji ga sadrži |
| MXPA02009587A (es) * | 2000-03-28 | 2003-05-14 | Biochemie Gmbh | Particulas granuladas con sabor enmascarado. |
| US6541014B2 (en) | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US20020068078A1 (en) | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| JP2006528190A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| JP2006528185A (ja) | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
| CA2533178C (en) | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| WO2005016311A1 (en) | 2003-08-11 | 2005-02-24 | Advancis Pharmaceutical Corporation | Robust pellet |
| AU2004264356B2 (en) | 2003-08-12 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US8246996B2 (en) * | 2003-08-29 | 2012-08-21 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| US8460710B2 (en) | 2003-09-15 | 2013-06-11 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
| US8715727B2 (en) | 2004-07-02 | 2014-05-06 | Shionogi Inc. | Tablet for pulsed delivery |
| WO2007008537A2 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International, Limited | Nanoparticulate clarithromycin formulations |
| US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
| US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
| US8299052B2 (en) | 2006-05-05 | 2012-10-30 | Shionogi Inc. | Pharmaceutical compositions and methods for improved bacterial eradication |
| WO2009023191A2 (en) * | 2007-08-09 | 2009-02-19 | Teva Pharmaceutical Industries Ltd. | An improved process for the preparation of clarithromycin |
| CN102417532A (zh) * | 2011-12-20 | 2012-04-18 | 浙江国邦药业有限公司 | 一种泰利霉素关键中间体5-德胺糖基-6-o-甲基红霉素的合成方法 |
| CN102718821B (zh) * | 2012-06-27 | 2014-12-03 | 浙江国邦药业有限公司 | 一种克拉霉素合成过程中甲基化反应以及甲基化试剂的回收套用方法 |
| CN103880901A (zh) * | 2012-12-23 | 2014-06-25 | 菏泽市方明制药有限公司 | 一种克拉霉素中间甲化物的制备方法 |
| CN106905204B (zh) * | 2017-02-24 | 2018-07-20 | 杭州新桂实业有限公司 | 一种克拉霉素合成过程中甲基化反应溶剂的回收套用方法 |
| CN108117573A (zh) * | 2017-12-26 | 2018-06-05 | 宁夏启元药业有限公司 | 4"-o-（三甲基硅）红霉素a 9-o-（1-乙氧基-1-甲基乙基）肟的合成方法 |
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| US5719272A (en) | 1996-04-02 | 1998-02-17 | Abbott Laboratories | 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives |
| US5808017A (en) | 1996-04-10 | 1998-09-15 | Abbott Laboratories | Process for preparing erythromycin A oxime |
| AUPN969796A0 (en) * | 1996-05-07 | 1996-05-30 | F.H. Faulding & Co. Limited | Taste masked liquid suspensions |
| IL127833A (en) | 1996-07-29 | 2004-06-20 | Abbott Lab | Preparation of the crystalline form II of clarithromycin |
| US5844105A (en) | 1996-07-29 | 1998-12-01 | Abbott Laboratories | Preparation of crystal form II of clarithromycin |
| US5858986A (en) | 1996-07-29 | 1999-01-12 | Abbott Laboratories | Crystal form I of clarithromycin |
| US5972389A (en) * | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| US5945405A (en) | 1997-01-17 | 1999-08-31 | Abbott Laboratories | Crystal form O of clarithromycin |
| US5864023A (en) | 1997-02-13 | 1999-01-26 | Abbott Laboratories | 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives |
| US6010718A (en) * | 1997-04-11 | 2000-01-04 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
| US6551616B1 (en) * | 1997-04-11 | 2003-04-22 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
| US20050064033A1 (en) * | 1997-04-11 | 2005-03-24 | Notario Gerard F. | Extended release formulations of erythromycin derivatives |
| PT998271E (pt) * | 1997-06-06 | 2005-10-31 | Depomed Inc | Formas de dosagem oral de farmacos com retencao gastrica para a libertacao controlada de farmacos altamente soluveis |
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| US5929219A (en) * | 1997-09-10 | 1999-07-27 | Abbott Laboratories | 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same |
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| KR100377159B1 (ko) * | 1998-09-09 | 2003-08-19 | 한미약품공업 주식회사 | 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법 |
| CA2282066C (en) * | 1999-06-29 | 2010-09-07 | Smithkline Beecham Corporation | Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria |
| DE19950781A1 (de) * | 1999-10-21 | 2001-04-26 | Knoll Ag | Mehrteiliges Etikett für Durchdrückpackungen, seine Herstellung und Verwendung |
| KR100322313B1 (ko) * | 1999-10-21 | 2002-02-06 | 민경윤 | 클라리스로마이신 결정형 2의 제조방법 및 이에 사용되는 클라리스로마이신 포르메이트 |
| KR100336447B1 (ko) * | 1999-11-24 | 2002-05-15 | 민경윤 | 클라리스로마이신의 개선된 제조방법 |
| CN1217951C (zh) * | 1999-12-16 | 2005-09-07 | 特瓦制药工业有限公司 | 克拉霉素多晶型物的制备方法和新的多晶型物iv |
| AU2001222619C1 (en) * | 2000-01-11 | 2006-01-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin polymorphs |
| YU64202A (sh) * | 2000-02-29 | 2005-03-15 | Teva Pharmaceutical Industries Ltd. | Postupak za pripremanje klaritromicina i intermedijera klaritromicina, klaritromicina u osnovi bez oksima i farmaceutskog preparata koji ga sadrži |
| HUP0300418A3 (en) * | 2000-03-15 | 2003-09-29 | Hanmi Pharm Co Ltd Hwaseong Gu | Method of preparing clarithromycin of form ii crystals |
| US6488962B1 (en) * | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| IN192748B (enExample) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
| ES2195727B1 (es) * | 2001-07-05 | 2005-03-01 | Ercros Industrial, S.A. | Un procedimiento para la obtencion de claritromicina. |
| WO2003017981A1 (en) * | 2001-08-29 | 2003-03-06 | Ranbaxy Laboratories Limited | Controlled release formulation of clarithromycin or tinidazol |
| US20050163857A1 (en) * | 2002-04-03 | 2005-07-28 | Ashok Rampal | Clarithromycin formulations having improved bioavailability |
| AU2003245504A1 (en) * | 2002-06-14 | 2003-12-31 | Andrx Corporation | Pharmaceutical compositions for drugs having ph-dependentsolubility |
| US7063862B2 (en) * | 2003-06-03 | 2006-06-20 | Biokey, Inc. | Pharmaceutical composition and method for treating |
| US20050053658A1 (en) * | 2003-09-09 | 2005-03-10 | Venkatesh Gopi M. | Extended release systems for macrolide antibiotics |
-
2000
- 2000-12-15 YU YU64202A patent/YU64202A/sh unknown
- 2000-12-15 US US09/736,447 patent/US6617436B2/en not_active Expired - Fee Related
- 2000-12-15 WO PCT/US2000/033843 patent/WO2001064224A1/en not_active Ceased
- 2000-12-15 CZ CZ20023167A patent/CZ20023167A3/cs unknown
- 2000-12-15 IL IL15149600A patent/IL151496A0/xx unknown
- 2000-12-15 AU AU2001225787A patent/AU2001225787C1/en not_active Ceased
- 2000-12-15 HR HRP20020709 patent/HRP20020709A2/hr not_active Application Discontinuation
- 2000-12-15 KR KR1020027011330A patent/KR20030047873A/ko not_active Ceased
- 2000-12-15 HU HU0302466A patent/HUP0302466A2/hu unknown
- 2000-12-15 JP JP2001563121A patent/JP2004509062A/ja not_active Withdrawn
- 2000-12-15 AU AU2578701A patent/AU2578701A/xx active Pending
- 2000-12-15 PL PL00366021A patent/PL366021A1/xx not_active Application Discontinuation
- 2000-12-15 CA CA002401571A patent/CA2401571A1/en not_active Abandoned
- 2000-12-15 EP EP00989252A patent/EP1313486A1/en not_active Withdrawn
- 2000-12-15 SK SK1372-2002A patent/SK13722002A3/sk not_active Application Discontinuation
-
2002
- 2002-08-28 IS IS6531A patent/IS6531A/is unknown
-
2003
- 2003-05-09 US US10/435,141 patent/US7101858B2/en not_active Expired - Fee Related
-
2006
- 2006-05-11 US US11/432,983 patent/US20060205683A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0302466A2 (hu) | 2003-11-28 |
| SK13722002A3 (sk) | 2003-08-05 |
| JP2004509062A (ja) | 2004-03-25 |
| CA2401571A1 (en) | 2001-09-07 |
| AU2001225787C1 (en) | 2006-09-21 |
| AU2001225787B2 (en) | 2005-12-08 |
| US20060205683A1 (en) | 2006-09-14 |
| AU2578701A (en) | 2001-09-12 |
| EP1313486A1 (en) | 2003-05-28 |
| IL151496A0 (en) | 2003-04-10 |
| CZ20023167A3 (cs) | 2003-10-15 |
| US20030216556A1 (en) | 2003-11-20 |
| US6617436B2 (en) | 2003-09-09 |
| US20010037015A1 (en) | 2001-11-01 |
| IS6531A (is) | 2002-08-28 |
| KR20030047873A (ko) | 2003-06-18 |
| HRP20020709A2 (en) | 2004-12-31 |
| PL366021A1 (en) | 2005-01-24 |
| US7101858B2 (en) | 2006-09-05 |
| WO2001064224A1 (en) | 2001-09-07 |
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