YU60496A - Novi 16,17-seko-,16-keto-i 16-oksimino-17- supstituisani steroidi estratrienske i androstenske serije sa biološkom aktivnošću - Google Patents

Novi 16,17-seko-,16-keto-i 16-oksimino-17- supstituisani steroidi estratrienske i androstenske serije sa biološkom aktivnošću

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Publication number
YU60496A
YU60496A YU60496A YU60496A YU60496A YU 60496 A YU60496 A YU 60496A YU 60496 A YU60496 A YU 60496A YU 60496 A YU60496 A YU 60496A YU 60496 A YU60496 A YU 60496A
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YU
Yugoslavia
Prior art keywords
substituted
oximino
keto
group
benzyl
Prior art date
Application number
YU60496A
Other languages
English (en)
Inventor
Ljubica Medić-Mijaičević
Vjera PEJANOVIĆ
Dušan Miljković
Katarina Penov Gaši
Julijana Petrović
Evgenija Đurendić
Radmila Kovačević
Slobodanka Stanković
Original Assignee
Galenika A.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galenika A.D. filed Critical Galenika A.D.
Priority to YUP-604/96A priority Critical patent/RS49568B/sr
Publication of YU60496A publication Critical patent/YU60496A/sh
Publication of RS49568B publication Critical patent/RS49568B/sr

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Abstract

Pronalazak se odnosi na sintezu novih, biološki aktivnih 16,17-seko-, 16-keto- i 16-oksimino-17-supstituisanih steroida estronske i androstenske serije. Prema pronalasku se na 17-keto grupu odgovarajućih 17-keto-16-oksima vrši adicija RLi ili RMgJ, gde R predstavlja alkil sa 1-4 ugljenikova atoma, fenil, benzil ili pikolil ostatak, u tetrahidrofuranu. Dobijeni 16-oksimino-17-supstituisani estra-1,3,5(10)-trienski i 16-oksimino-17-supstituisani-5-androstenski derivati opšte formule II se ili dalje koriste kao intermedijeri u postupku ili kao nova biološki aktivna jedinjenja. Za dobijanje 16,17-seko-17-supstituisanih derivata, u obe serije, se derivati kod kojih je R1 oksimino grupa, podvrgavaju Beckman-ovoj fragmentaciji, pod dejstvom p-toluol sulfonilhlorida u piridinu, dok se 16-keto-17-supstituisani derviati, u obe serije, dobijaju samo kada je R benzil ili metil ostatak, hidrolizom 16-oksimino grupe u odgovarajuću keto grupu, delovanjem kiselim vodenim titantrihloridom, uz simultanu migraciju benzil, odnosno, metil grupe sa 17 α na 17 Гџ poziciju.
YUP-604/96A 1996-11-14 1996-11-14 Supstituisani 16,17-sekosteroidi estratrienske i androstenske serije sa biološkom aktivnošću RS49568B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YUP-604/96A RS49568B (sr) 1996-11-14 1996-11-14 Supstituisani 16,17-sekosteroidi estratrienske i androstenske serije sa biološkom aktivnošću

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YUP-604/96A RS49568B (sr) 1996-11-14 1996-11-14 Supstituisani 16,17-sekosteroidi estratrienske i androstenske serije sa biološkom aktivnošću

Publications (2)

Publication Number Publication Date
YU60496A true YU60496A (sh) 1998-12-23
RS49568B RS49568B (sr) 2007-04-10

Family

ID=47602012

Country Status (1)

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RS (1) RS49568B (sh)

Also Published As

Publication number Publication date
RS49568B (sr) 2007-04-10

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