PT1165595E - Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486 - Google Patents

Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486

Info

Publication number
PT1165595E
PT1165595E PT00922530T PT00922530T PT1165595E PT 1165595 E PT1165595 E PT 1165595E PT 00922530 T PT00922530 T PT 00922530T PT 00922530 T PT00922530 T PT 00922530T PT 1165595 E PT1165595 E PT 1165595E
Authority
PT
Portugal
Prior art keywords
glycocorticoid
antagonist
derivatives
biliary acids
specific
Prior art date
Application number
PT00922530T
Other languages
English (en)
Inventor
Theresa Apelqvist
Jinchang Wu
Konrad F Koehler
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of PT1165595E publication Critical patent/PT1165595E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT00922530T 1999-03-27 2000-03-18 Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486 PT1165595E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9907048.4A GB9907048D0 (en) 1999-03-27 1999-03-27 Novel glucocorticoid receptor ligands for the treatment of meta bolic disorders

Publications (1)

Publication Number Publication Date
PT1165595E true PT1165595E (pt) 2003-08-29

Family

ID=10850457

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00922530T PT1165595E (pt) 1999-03-27 2000-03-18 Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486

Country Status (13)

Country Link
US (1) US6468975B1 (pt)
EP (1) EP1165595B1 (pt)
JP (1) JP2002540215A (pt)
KR (1) KR20020002486A (pt)
AT (1) ATE240346T1 (pt)
AU (1) AU758654B2 (pt)
CA (1) CA2367792A1 (pt)
DE (1) DE60002692T2 (pt)
DK (1) DK1165595T3 (pt)
ES (1) ES2197091T3 (pt)
GB (1) GB9907048D0 (pt)
PT (1) PT1165595E (pt)
WO (1) WO2000058337A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001253226B2 (en) * 2000-04-07 2006-06-08 University Of Maryland, Baltimore Bile acid containing prodrugs with enhanced bioavailability
US7141559B2 (en) 2002-06-19 2006-11-28 Karo Bio Ab Glucocorticoid receptor ligands for the treatment of metabolic disorders
ATE346082T1 (de) * 2002-06-19 2006-12-15 Karobio Ab Glucocorticoidrezeptorliganden zur behandlung von stoffwechselstörungen
CA2742964C (en) 2008-11-07 2020-07-07 University Of Sheffield Medicament and method of diagnosis
EP2771463A4 (en) 2011-10-25 2015-09-09 Isis Pharmaceuticals Inc ANTISENSE MODULATION OF GCCR EXPRESSION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441129A (en) * 1942-05-23 1948-05-11 Berczeller Arpad Bile acid derivatives of aryl sulfonamides
US4418059A (en) * 1981-07-20 1983-11-29 Montefiore Medical Center Nucleoside ester compositions
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
US5929058A (en) * 1996-12-24 1999-07-27 Zymogenetics, Inc. Treatment agents and methods for treating type II diabetes and symptoms of type II diabetes
KR20010052431A (ko) 1998-06-08 2001-06-25 오테스코그 페르 당뇨병 치료제

Also Published As

Publication number Publication date
AU4289300A (en) 2000-10-16
DK1165595T3 (da) 2003-09-15
EP1165595A1 (en) 2002-01-02
AU758654B2 (en) 2003-03-27
WO2000058337A1 (en) 2000-10-05
DE60002692D1 (de) 2003-06-18
ES2197091T3 (es) 2004-01-01
EP1165595B1 (en) 2003-05-14
US6468975B1 (en) 2002-10-22
KR20020002486A (ko) 2002-01-09
GB9907048D0 (en) 1999-05-19
JP2002540215A (ja) 2002-11-26
DE60002692T2 (de) 2004-03-25
CA2367792A1 (en) 2000-10-05
ATE240346T1 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
NO20021358D0 (no) Alkylendiamin-substituerte heterocykler
DK1200412T3 (da) Antiproliferative imidazolforbindelser
DE60204452D1 (de) Pyrazolo[1,5]pyridinderivate
AU2003301020A1 (en) Isoquinolinone derivatives and their use as therapeutic agents
TR200100238T2 (tr) Yeni sübstitüe edilmiş pirazol türevleri
ATE440087T1 (de) 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
DE69821132D1 (de) 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes
DE69926806D1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
DE69724811D1 (de) Pentafluorobenzensulfonamide und analoge
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
ATE284853T1 (de) Ureido-thiobuttersäurederivate als ppar-agonisten
ES2243579T3 (es) Derivados de pirazolopirideno.
WO2003063791A3 (en) Non-steroidal analogs of 2-methoxyestradiol
NO20002676L (no) Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
NO20020282D0 (no) Nytt difenylpiperidinderivat
BR0108088A (pt) Pirrolidinas 1,3-dissubstituìdas e 1,3,3-trissubstituìdas como ligandos receptores de histamina-3 e suas aplicações terapêuticas
UA72948C2 (uk) Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів
BRPI0409376A (pt) derivados de indeno como agentes farmacêuticos
NZ516397A (en) Aminothiazole derivatives and their use as CRF receptor ligands
BR0318521A (pt) arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
ATE397599T1 (de) Als modulatoren der chemokinrezeptoraktivität geeignete piperidinderivate
SE9902551D0 (sv) Novel compounds
PT1165595E (pt) Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486
ATE290857T1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
ATE322244T1 (de) Verwendung von polyaminosäurederivaten zur behandlung von seborrhoe und verwandten hautstörungen