YU56390A - Diazepin derivati - Google Patents

Diazepin derivati

Info

Publication number
YU56390A
YU56390A YU56390A YU56390A YU56390A YU 56390 A YU56390 A YU 56390A YU 56390 A YU56390 A YU 56390A YU 56390 A YU56390 A YU 56390A YU 56390 A YU56390 A YU 56390A
Authority
YU
Yugoslavia
Prior art keywords
optionally substituted
ring
optionally
chem
alkyl
Prior art date
Application number
YU56390A
Other languages
English (en)
Other versions
YU47344B (sh
Inventor
K. Cooper
M.J. Fray
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898906813A external-priority patent/GB8906813D0/en
Priority claimed from GB898926246A external-priority patent/GB8926246D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU56390A publication Critical patent/YU56390A/sh
Publication of YU47344B publication Critical patent/YU47344B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

DIAZEPIN DERIVATI.Opisani su antagonisti faktora aglomeracije krvnih pločica formule (I), (II) ili (III): gde A je opciono supstituisan benzen, piridin, naftalen, hinolin, tiofen, benzotiofen, pirazol ili izotiazol, X je O, S ili NH Y je 1,4 fenilen ili grupa formule R1 je H ili opciono supstituisan C1-C4 alkil, R2 i R3 su H ili C1-C4 alkil, B je opciono supstituisan kondenzovan 5- ili 6-člani prsten koji sadrži azotove atome, Het je opciono supstituisan 5-člani heterociklični prsten koji sadrži azot ili piridinski prsten, prsten koji je opciono kondenzovan za benzen ili heterociklični prsten koji sadrži azot i postupak za njihovo dobijanje.
YU56390A 1989-03-23 1990-03-22 Diazepin derivati i postupak za njihovo dobijanje YU47344B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898906813A GB8906813D0 (en) 1989-03-23 1989-03-23 Therapeutic agents
GB898926246A GB8926246D0 (en) 1989-11-21 1989-11-21 Therapeutic agents

Publications (2)

Publication Number Publication Date
YU56390A true YU56390A (sh) 1992-12-21
YU47344B YU47344B (sh) 1995-01-31

Family

ID=26295132

Family Applications (1)

Application Number Title Priority Date Filing Date
YU56390A YU47344B (sh) 1989-03-23 1990-03-22 Diazepin derivati i postupak za njihovo dobijanje

Country Status (21)

Country Link
US (1) US5008263A (sh)
EP (1) EP0389189B1 (sh)
JP (1) JPH0684371B2 (sh)
KR (1) KR920003981B1 (sh)
CN (1) CN1045783A (sh)
AT (1) ATE105839T1 (sh)
AU (1) AU627286B2 (sh)
CA (1) CA2012666C (sh)
DE (1) DE69008906T2 (sh)
DK (1) DK0389189T3 (sh)
ES (1) ES2052172T3 (sh)
FI (1) FI98463C (sh)
HU (1) HUT61006A (sh)
IE (1) IE62857B1 (sh)
IL (1) IL93776A (sh)
MY (1) MY106322A (sh)
NO (1) NO175151C (sh)
NZ (1) NZ233047A (sh)
PH (1) PH27513A (sh)
PT (1) PT93526B (sh)
YU (1) YU47344B (sh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9010404D0 (en) * 1990-05-09 1990-06-27 Pfizer Ltd Therapeutic agents
GB9015524D0 (en) * 1990-07-13 1990-08-29 Pfizer Ltd Therapeutic agents
GB9019409D0 (en) * 1990-09-05 1990-10-17 Pfizer Ltd Therapeutic agents
GB9019833D0 (en) * 1990-09-11 1990-10-24 Pfizer Ltd Therapeutic agents
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
PT100631B (pt) * 1991-06-28 1999-06-30 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem
IL108524A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Imidazodiazepine analogs
US5500439A (en) * 1993-12-09 1996-03-19 Alteon Inc. Aminopyrazoles
MA23420A1 (fr) * 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
WO1995029900A1 (en) * 1994-04-29 1995-11-09 Takeda Chemical Industries, Ltd. CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
FR2733749B1 (fr) 1995-05-05 1997-06-13 Oreal Compositions pour la teinture des fibres keratiniques contenant des diamino pyrazoles, procede de teinture, nouveaux diamino pyrazoles et leur procede de preparation
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
ATE374188T1 (de) * 1995-08-15 2007-10-15 Bayer Cropscience Ag Pestizide indazol-derivate
US6458823B1 (en) 1998-06-08 2002-10-01 Wyeth Diaminopyrazoles
US6172222B1 (en) 1998-06-08 2001-01-09 American Home Products Corporation Diaminopyrazoles
US6949542B2 (en) * 2002-02-06 2005-09-27 Hoffman-La Roche Inc. Dihydro-benzo[b][1,4]diazepin-2-one derivatives
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
TW201307347A (zh) 2010-11-01 2013-02-16 Arqule Inc 經取代苯並－咪唑並－吡啶並－二氮呯化合物
KR101675984B1 (ko) * 2015-02-23 2016-11-14 한양대학교 에리카산학협력단 티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물
CN105153195B (zh) * 2015-09-01 2017-09-26 汤文建 一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527689B2 (en) * 1974-09-11 1983-03-17 F. Hoffmann-La Roche & Co. Imidazodiazepine derivatives
DK476885D0 (da) * 1985-10-17 1985-10-17 Ferrosan As Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
ES2037013T3 (es) * 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.

Also Published As

Publication number Publication date
YU47344B (sh) 1995-01-31
CA2012666C (en) 1997-01-28
DE69008906T2 (de) 1994-08-25
EP0389189B1 (en) 1994-05-18
IL93776A (en) 1994-10-21
DE69008906D1 (de) 1994-06-23
US5008263A (en) 1991-04-16
HU901794D0 (en) 1990-06-28
DK0389189T3 (da) 1994-06-20
EP0389189A2 (en) 1990-09-26
IE901055L (en) 1990-09-23
PH27513A (en) 1993-08-18
PT93526B (pt) 1996-08-30
NO175151B (no) 1994-05-30
ES2052172T3 (es) 1994-07-01
KR920003981B1 (ko) 1992-05-21
FI98463C (fi) 1997-06-25
IL93776A0 (en) 1990-12-23
NO175151C (no) 1994-09-07
FI98463B (fi) 1997-03-14
MY106322A (en) 1995-05-30
CA2012666A1 (en) 1990-09-23
NZ233047A (en) 1992-06-25
NO901329L (no) 1990-09-24
EP0389189A3 (en) 1991-08-21
KR900014387A (ko) 1990-10-23
AU5214890A (en) 1990-11-01
FI901441A0 (fi) 1990-03-22
JPH0684371B2 (ja) 1994-10-26
AU627286B2 (en) 1992-08-20
ATE105839T1 (de) 1994-06-15
IE62857B1 (en) 1995-03-08
PT93526A (pt) 1990-11-07
JPH0314577A (ja) 1991-01-23
HUT61006A (en) 1992-11-30
NO901329D0 (no) 1990-03-22
CN1045783A (zh) 1990-10-03

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