YU48849B - Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje - Google Patents

Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje

Info

Publication number
YU48849B
YU48849B YU9892A YU9892A YU48849B YU 48849 B YU48849 B YU 48849B YU 9892 A YU9892 A YU 9892A YU 9892 A YU9892 A YU 9892A YU 48849 B YU48849 B YU 48849B
Authority
YU
Yugoslavia
Prior art keywords
group
imidazo
alkyl
substituted
carbon atoms
Prior art date
Application number
YU9892A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU9892A (sh
Inventor
Norbert Hauel
Narr Dipl. Hem. Dr. Berthold
Ries dipl. hem. Dr. Uwe
van Meel farmac. Dr. Jacques
Wienen Dipl. Biol. Dr. Wolfgang
Entzeroth Dipl. Hem. Dr. Michael
Original Assignee
Dr. Karl Thomae Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Karl Thomae Gmbh. filed Critical Dr. Karl Thomae Gmbh.
Priority to SI9210098A priority Critical patent/SI9210098B/sl
Priority to EP19920119261 priority patent/EP0543263A3/de
Priority to HRP-98/92 priority patent/HRP940752B1/xx
Publication of YU9892A publication Critical patent/YU9892A/sh
Publication of YU48849B publication Critical patent/YU48849B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Benzimidazoli opšte formule u kojoj označavaju R1 atom fluora, hlora ili broma, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu, R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom, supstituisanu 5-, 6- ili 7-članu alkilenimino ili alkenilenimino grupu u kojoj je metilen grupa zamenjena sa karbonil ili sulfonil grupom, u datom slučaju, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, pri čemu supstituenti mogu biti isti ili različiti, u datom slučaju, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, pri čemu fenil jezgro jedne od prethodno pomenutih benzimidazol grupa može dodatno da bude supstituisano sa atomom fluora, metil ili trifluormetil grupom, imidazo[2,1-b]tiazol-6-il, imidazo[1,2-a]piridin-2-il, 5,6,7,8-tetrahidro-imidazo[1,2-a]-piridin-2-il, imidazo[1,2-a]pirimidin-2-il, imidazo[4,5-b]piridin-2-il, imidazo[4,5-c]-piridin-2-il, imidazo[1,2-c]pirimidin-2-il, imidazo[1,2-a]pirazin-2-il, imidazo[1,2-b]piridazin-2-il, purin-8-il, imidazo[4,5-b]pirazin-2-il, imidazo-[4,5-c]piridazin-2-il ili imidazo-[4,5-d]piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom supstituisanu, preko atoma ugljenika vezanu imidazolil, koja dodatno može da bude supstituisana u ugljenikovom kosturu sa alkil grupom, R3, alkil grupu sa 1 do 5 atoma ugqenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, a R4, karboksi ili 1H-tetrazolil grupu, i njihove soli sa neorganskim ili organskim kiselinama ili bazama,pri čemu, ukoliko ništa drugačije nije navedeno, prethodno pomenuti alkil deo uvek može da sadrži 1 do 3 atoma ugljenika, a takođe i prethodno pomenuti cikloalkil deo uvek može da sadrži 3 do 7 atoma ugljenika. - Prijava sadrži još 1 nezavisan i 5 zavisnih zahteva.
YU9892A 1991-02-06 1992-01-30 Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje YU48849B (sh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI9210098A SI9210098B (sl) 1991-02-06 1992-01-30 Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
EP19920119261 EP0543263A3 (en) 1991-11-16 1992-11-11 Benziimidazoles, pharmaceuticals containing them and process for their preparation
HRP-98/92 HRP940752B1 (en) 1991-02-06 1994-10-25 Benzimidazol, medicaments containing them and process for their preparation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4103492A DE4103492A1 (de) 1991-02-06 1991-02-06 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4117121A DE4117121A1 (de) 1991-02-06 1991-05-25 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4137812A DE4137812A1 (de) 1991-02-06 1991-11-16 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
YU9892A YU9892A (sh) 1999-03-04
YU48849B true YU48849B (sh) 2002-06-19

Family

ID=6424446

Family Applications (1)

Application Number Title Priority Date Filing Date
YU9892A YU48849B (sh) 1991-02-06 1992-01-30 Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje

Country Status (9)

Country Link
KR (1) KR100218820B1 (xx)
BR (1) BR1100667A (xx)
DE (4) DE4103492A1 (xx)
EE (1) EE03085B1 (xx)
NO (1) NO1999024I1 (xx)
TW (1) TW208015B (xx)
UA (1) UA35555C2 (xx)
YU (1) YU48849B (xx)
ZA (1) ZA92816B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
CN113307775B (zh) * 2021-04-16 2022-04-22 河北戴桥医药科技有限公司 一种替米沙坦的制备方法

Also Published As

Publication number Publication date
KR100218820B1 (ko) 1999-09-01
DE122011000013I1 (de) 2011-12-01
NO1999024I1 (no) 1999-11-30
DE4117121A1 (de) 1992-12-17
BR1100667A (pt) 2000-06-13
DE4103492A1 (de) 1992-10-08
EE03085B1 (et) 1998-04-15
DE4137812A1 (de) 1993-05-19
ZA92816B (en) 1993-07-05
TW208015B (xx) 1993-06-21
KR920016431A (ko) 1992-09-24
YU9892A (sh) 1999-03-04
UA35555C2 (uk) 2001-04-16

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