YU9892A - Benzimidazoli, njihove 1-, 3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje - Google Patents

Benzimidazoli, njihove 1-, 3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje

Info

Publication number
YU9892A
YU9892A YU9892A YU9892A YU9892A YU 9892 A YU9892 A YU 9892A YU 9892 A YU9892 A YU 9892A YU 9892 A YU9892 A YU 9892A YU 9892 A YU9892 A YU 9892A
Authority
YU
Yugoslavia
Prior art keywords
group
imidazo
alkyl
pyridin
carbon atoms
Prior art date
Application number
YU9892A
Other languages
English (en)
Other versions
YU48849B (sh
Inventor
Norbert Dr. Hauel
Berthold Dr. Narr
Uwe Dr. Ries
Jacques Dr. Van Meel
Wolfgang Dr. Wienen
Michael Dr. Entzeroth
Original Assignee
Thomae, Karl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae, Karl filed Critical Thomae, Karl
Priority to SI9210098A priority Critical patent/SI9210098B/sl
Priority to EP19920119261 priority patent/EP0543263A3/de
Priority to HRP-98/92 priority patent/HRP940752B1/xx
Publication of YU9892A publication Critical patent/YU9892A/sh
Publication of YU48849B publication Critical patent/YU48849B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Opisani su benzimidazoli, formule u kojoj označavaju R1, fluor, hlor ili brom, alkil, cikloalkil, fluormetil, difluormetil ili trifluormetil grupu; R2, u datom slučaju, sa jednom ili dve alkil grupe ili sa tetrametilen ili pentametilen grupom supstituisanu 5-, 6-ili 7-članu alkilenimino ili alkenilenimino grupu, sa alkil ili fenil grupom mono ili disupstituisanu imido grupu maleinske kiseline, u 1-položaju, sa alkil grupom, sa 1 do 6 atoma ugljenika, ili sa cikloalkil grupom supstituisanu benzimidazol-2-il ili 4,5,6,7-tetrahidro-benzimidazol-2-il grupu, imidazo(2,1-b)tiazol-6-il, imidazo(1,2-a)piridin-2-il, 5,6,7,8-tetrahidro-imidazo-(1,2-a)-piridin-2-il, imidazo(1,2-a)pirimidin-2-il, imidazo(4,5-b)piridin-2-il, imidazo-(4,5-c)-piridin-2-il, imidazo(1,2-c)pirimidin-2-il, imidazo(1,2-a)pirazin-2-il, imidazo-(1,2-b)-piridizin-2-il, purin-8-il, imidazo(4,5-b)pirazin-2-il, imidazo(4,5-c)piridazin-2-il ili imidazo(4,5-d)piridazin-2-il grupu, piridil grupu, ili u datom slučaju, u 1-položaju, sa alkil ili benzil grupom preko ugljenika vezanu imidazolil grupu; R3, alkil grupu sa 1 do 5 atoma ugljenika ili cikloalkil grupu sa 3 do 5 atoma ugljenika, R4, karboksi ili 1H-tetrazolil grupu,i njihove 1-, 3-izomerne smeše i njihove soli kao i postupci za njihovo dobijanje.Nova jedinjenja predstavljaju naročito angiotenzijske antagoniste.
YU9892A 1991-02-06 1992-01-30 Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje YU48849B (sh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SI9210098A SI9210098B (sl) 1991-02-06 1992-01-30 Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
EP19920119261 EP0543263A3 (en) 1991-11-16 1992-11-11 Benziimidazoles, pharmaceuticals containing them and process for their preparation
HRP-98/92 HRP940752B1 (en) 1991-02-06 1994-10-25 Benzimidazol, medicaments containing them and process for their preparation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4103492A DE4103492A1 (de) 1991-02-06 1991-02-06 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4117121A DE4117121A1 (de) 1991-02-06 1991-05-25 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4137812A DE4137812A1 (de) 1991-02-06 1991-11-16 Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
YU9892A true YU9892A (sh) 1999-03-04
YU48849B YU48849B (sh) 2002-06-19

Family

ID=6424446

Family Applications (1)

Application Number Title Priority Date Filing Date
YU9892A YU48849B (sh) 1991-02-06 1992-01-30 Benzimidazoli, njihove 1-,3-izomerne smeše i njihove soli kao i postupak za njihovo dobijanje

Country Status (9)

Country Link
KR (1) KR100218820B1 (sh)
BR (1) BR1100667A (sh)
DE (4) DE4103492A1 (sh)
EE (1) EE03085B1 (sh)
NO (1) NO1999024I1 (sh)
TW (1) TW208015B (sh)
UA (1) UA35555C2 (sh)
YU (1) YU48849B (sh)
ZA (1) ZA92816B (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan
CN113307775B (zh) * 2021-04-16 2022-04-22 河北戴桥医药科技有限公司 一种替米沙坦的制备方法

Also Published As

Publication number Publication date
TW208015B (sh) 1993-06-21
DE4103492A1 (de) 1992-10-08
EE03085B1 (et) 1998-04-15
KR920016431A (ko) 1992-09-24
ZA92816B (en) 1993-07-05
KR100218820B1 (ko) 1999-09-01
YU48849B (sh) 2002-06-19
UA35555C2 (uk) 2001-04-16
DE122011000013I1 (de) 2011-12-01
NO1999024I1 (no) 1999-11-30
DE4117121A1 (de) 1992-12-17
BR1100667A (pt) 2000-06-13
DE4137812A1 (de) 1993-05-19

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