YU47215B - PROCEDURE FOR OBTAINING HINOLINE-CARBOXYLIC ACID DERIVATIVES AND ITS INTERMEDIATE - Google Patents

PROCEDURE FOR OBTAINING HINOLINE-CARBOXYLIC ACID DERIVATIVES AND ITS INTERMEDIATE

Info

Publication number
YU47215B
YU47215B YU243789A YU243789A YU47215B YU 47215 B YU47215 B YU 47215B YU 243789 A YU243789 A YU 243789A YU 243789 A YU243789 A YU 243789A YU 47215 B YU47215 B YU 47215B
Authority
YU
Yugoslavia
Prior art keywords
general formula
salt
compound
defined above
carboxylic acid
Prior art date
Application number
YU243789A
Other languages
Serbo-Croatian (sh)
Other versions
YU243789A (en
Inventor
J. Hermecz
G. Kereszturi
L. Vasvari
A. Horvath
M. Balogh
P. Ritli
J. Sipos
A. Pajor
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Temekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Temekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Temekek Gyara Rt.
Publication of YU243789A publication Critical patent/YU243789A/en
Publication of YU47215B publication Critical patent/YU47215B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages

Abstract

Postupak za dobijanje derivata hinolin karboksilne kiseline opšte formule I gde R1 i R3 označavaju vodonik ili C1-4alkil, R2 označava C1-4alkil, R4, R5 i R6 označavaju vodonik ili halogen i njihovih farmaceutski prihvatljivih soli, naznačen time, što obuhvata reagovanje jedinjenja opšte formule II gde R označava halogen ili alifatičnu aciloksi grupu koja sadrži 2-6 atoma ugljenika ili aromatičnu aciloksi grupu koja sadrži 7 do 11 atoma ugljenika, R4, R5 i R6 imaju značenja definisana napred, sa piperazin derivatom opšte formule III gde R1, R2 i R3 imaju značenja definisana napred, ili sa njegovom solju u prisustvu organskog rastvarača i sredstva za vezivanje kiseline, i podvrgavanje tako dobivenog jedinjenja opšte formule IV gde R, R1, R2 i R3 su kao što je definisano napred hidrolizi u kiseloj ili alkalnoj sredini posle ili bez izolovanja, i ako se želi prevodjenje jedinjenja opšte formule tako dobivenog u njegovu so ili oslobadjanje iz soli. Prijava sadrži još 1 nezavisan i 9 zavisnih zahteva.A process for preparing quinoline carboxylic acid derivatives of general formula I wherein R1 and R3 are hydrogen or C1-4alkyl, R2 is C1-4alkyl, R4, R5 and R6 are hydrogen or halogen and pharmaceutically acceptable salts thereof, comprising reacting a compound of general of formula II wherein R denotes halogen or an aliphatic acyloxy group containing 2-6 carbon atoms or an aromatic acyloxy group containing 7 to 11 carbon atoms, R4, R5 and R6 have the meanings defined above, with a piperazine derivative of general formula III wherein R1, R2 and R3 has the meanings defined above, or with a salt thereof in the presence of an organic solvent and an acid scavenger, and subjecting the compound of general formula IV thus obtained wherein R, R1, R2 and R3 are as defined above by hydrolysis in an acidic or alkaline medium after or without isolation, and if it is desired to convert the compound of general formula thus obtained into its salt or release it from the salt. The application contains 1 more independent and 9 dependent requests.

YU243789A 1988-12-22 1989-12-22 PROCEDURE FOR OBTAINING HINOLINE-CARBOXYLIC ACID DERIVATIVES AND ITS INTERMEDIATE YU47215B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU886560A HU203746B (en) 1988-12-22 1988-12-22 Process for producing quinoline-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
YU243789A YU243789A (en) 1991-02-28
YU47215B true YU47215B (en) 1995-01-31

Family

ID=10971814

Family Applications (1)

Application Number Title Priority Date Filing Date
YU243789A YU47215B (en) 1988-12-22 1989-12-22 PROCEDURE FOR OBTAINING HINOLINE-CARBOXYLIC ACID DERIVATIVES AND ITS INTERMEDIATE

Country Status (11)

Country Link
JP (1) JP2825641B2 (en)
KR (1) KR0146335B1 (en)
CN (1) CN1031190C (en)
AT (1) AT397385B (en)
AU (1) AU622256B2 (en)
FR (1) FR2640974B1 (en)
GB (1) GB2245562B (en)
HU (1) HU203746B (en)
IL (1) IL92821A0 (en)
WO (1) WO1990006922A1 (en)
YU (1) YU47215B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2077490B1 (en) * 1992-11-18 1996-10-16 Marga Investigacion TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.
NZ260530A (en) * 1994-05-16 1997-06-24 Nigel Paul Maynard Organoborate complexes of divalent metal; use as timber treament agents
ES2092963B1 (en) * 1995-04-12 1997-12-16 Sint Quimica Sa PROCEDURE FOR THE PREPARATION OF ACID 1-CICLOPROPIL-6-FLUORO-1, 4-DIHIDRO-7- (1S, 4S) -5-METHYL-2,5-DIAZABICICLO (2.2.1) HEPT-2-IL) -4 -OXO-3-QUINOLINCARBOXILICO AND ITS SALTS.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59122470A (en) * 1982-12-27 1984-07-14 Dai Ichi Seiyaku Co Ltd Preparation of quinoline-3-carboxylic acid derivative
US4550167A (en) * 1983-05-23 1985-10-29 Ethyl Corporation Preparation of 1-alkyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinoline carboxylic acid
JPS6078986A (en) * 1983-10-07 1985-05-04 Dai Ichi Seiyaku Co Ltd Preparation of oxazine derivative
JPS6165882A (en) * 1984-09-06 1986-04-04 Hokuriku Seiyaku Co Ltd 1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-7-piperazinyquinoline-3-carboxylic ester derivative and its preparation
JPS6185381A (en) * 1984-10-04 1986-04-30 Hokuriku Seiyaku Co Ltd Preparation of 1-ethyl-6, 8-difluoro-1, 4-dihydro-4-oxo-7-piperazinylquinoline-3-carboxylic acid derivative
CA1306750C (en) * 1985-12-09 1992-08-25 Istvan Hermecz Process for the preparation of quinoline carboxylic acide
HU196782B (en) * 1985-12-09 1989-01-30 Chinoin Gyogyszer Es Vegyeszet Process for production of quinoline carbonic acid
US4738800A (en) * 1986-03-26 1988-04-19 Ciba-Geigy Corporation Process for the preparation of 1,4-diamino-2,3-dicyanoanthraquinones
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
JPS6419069A (en) * 1987-07-14 1989-01-23 Dainippon Pharmaceutical Co Production of polyhalogenoquinoline derivative

Also Published As

Publication number Publication date
FR2640974B1 (en) 1994-02-18
YU243789A (en) 1991-02-28
ATA902489A (en) 1993-08-15
KR910700245A (en) 1991-03-14
GB2245562B (en) 1992-12-23
KR0146335B1 (en) 1998-08-17
HU203746B (en) 1991-09-30
JP2825641B2 (en) 1998-11-18
CN1043712A (en) 1990-07-11
AU4748090A (en) 1990-07-10
AU622256B2 (en) 1992-04-02
AT397385B (en) 1994-03-25
CN1031190C (en) 1996-03-06
GB2245562A (en) 1992-01-08
WO1990006922A1 (en) 1990-06-28
IL92821A0 (en) 1990-09-17
HUT52086A (en) 1990-06-28
GB9018360D0 (en) 1990-10-24
FR2640974A1 (en) 1990-06-29
JPH03502803A (en) 1991-06-27

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