YU46452B - PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES - Google Patents

PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES

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Publication number
YU46452B
YU46452B YU66888A YU66888A YU46452B YU 46452 B YU46452 B YU 46452B YU 66888 A YU66888 A YU 66888A YU 66888 A YU66888 A YU 66888A YU 46452 B YU46452 B YU 46452B
Authority
YU
Yugoslavia
Prior art keywords
piperazinyl
general formula
halogen
methyl
compound
Prior art date
Application number
YU66888A
Other languages
Serbo-Croatian (sh)
Other versions
YU66888A (en
Inventor
J. Hermecz
G. Kereszturi
L. Vasvari
A. Horvath
M. Balogh
P. Ritli
J. Sipos
A. Pajor
K. Marmarosi
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU871504A external-priority patent/HU198728B/en
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority to SI8810668A priority Critical patent/SI8810668A8/en
Publication of YU66888A publication Critical patent/YU66888A/en
Priority to HR930557A priority patent/HRP930557A2/en
Publication of YU46452B publication Critical patent/YU46452B/en

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Abstract

POSTUPAK ZA DOBIVANJE HINOLIN KARBOKSILNIH KISELINA I NJIHOVIH INTERMEDIJARA, opšte formule I gde R je piperazinil, 4-metil-piperazinil ili 4-etil-piperazinil grupa i njegovih farmaceutski prihvatljivih adicionih soli kiselina nazna čen time, što reaguje jedinjenje opšte formule II gde R1 i R2 su halogen, alifatična C2-6 aciloksi grupa, sa piperazinskim derivatom opšte formule III gde R3 je vodonik, metil ili etil grupa ili sa njegovom solju u prisustvu organskog rastvarača, poželjno amida kiseline, sulfoksida, ketona, alkohola, etra ili estra i u prisustvu agensa za vezivanje kiseline na temperaturi od 90-110В°C i tako dobiveno jedinjenje opšte formule IV gde R,R1 i R2 su kao što je dato napred, hidrolizuje u baznoj sredini posle ili bez izolovanja i ako se želi, tako dobiveno jedinjenje opšte formule I se prevodi u svoju farmaceutski prihvatljivu so ili se oslobadja slobodna kiselina iz njegove soli. Jedinjenja opšte formule IV gde R označava piperazinil, 4-metil-piperazinil ili 4-etil- piperazinil grupu, R1 i R2 označavaju halogen, alifatičnu aciloksi grupu koja sadrži 2 do 6 atoma ugljenika po izboru supstituisanu halogenom ili aromatičnu aciloksi grupu koja sadrži 7 do 11 atoma ugljenika. Prijava sadrži još 8 zavisnih zahteva.A process for the preparation of quinoline carboxylic acids and their intermediates, of general formula I wherein R is piperazinyl, a 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable acid addition salts thereof, wherein the compound of formula I reacts with R 2 is halogen, an aliphatic C 2-6 acyloxy group, with a piperazine derivative of general formula III wherein R 3 is hydrogen, methyl or ethyl group or with a salt thereof in the presence of an organic solvent, preferably an acid amide, sulfoxide, ketone, alcohol, ether or ester and in the presence acid binding agent at a temperature of 90-110V ° C and thus the compound of general formula IV wherein R, R 1 and R 2 are as given above, hydrolyzed in a basic medium after or without isolation and if desired, the compound of general formula thus obtained And it is converted into its pharmaceutically acceptable salt or the free acid is released from its salt. Compounds of general formula IV wherein R represents a piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group, R 1 and R 2 represent a halogen, an aliphatic acyloxy group containing 2 to 6 carbon atoms optionally substituted by halogen or an aromatic acyloxy group containing 7 to 11 carbon atoms. The application contains 8 more dependent requests.

YU66888A 1987-04-08 1988-04-04 PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES YU46452B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8810668A SI8810668A8 (en) 1987-04-08 1988-04-04 Process for producing cinnolinecarboxyclid acids
HR930557A HRP930557A2 (en) 1987-04-08 1993-03-26 Process for the preparation of quinoline carboxylic acids and their intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU871504A HU198728B (en) 1987-04-08 1987-04-08 Process for producing quinolinecarboxylic acid derivatives
HU150588 1988-02-26

Publications (2)

Publication Number Publication Date
YU66888A YU66888A (en) 1989-12-31
YU46452B true YU46452B (en) 1993-10-20

Family

ID=26317374

Family Applications (1)

Application Number Title Priority Date Filing Date
YU66888A YU46452B (en) 1987-04-08 1988-04-04 PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES

Country Status (1)

Country Link
YU (1) YU46452B (en)

Also Published As

Publication number Publication date
YU66888A (en) 1989-12-31

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