YU46452B - PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES - Google Patents
PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATESInfo
- Publication number
- YU46452B YU46452B YU66888A YU66888A YU46452B YU 46452 B YU46452 B YU 46452B YU 66888 A YU66888 A YU 66888A YU 66888 A YU66888 A YU 66888A YU 46452 B YU46452 B YU 46452B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperazinyl
- general formula
- halogen
- methyl
- compound
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
POSTUPAK ZA DOBIVANJE HINOLIN KARBOKSILNIH KISELINA I NJIHOVIH INTERMEDIJARA, opšte formule I gde R je piperazinil, 4-metil-piperazinil ili 4-etil-piperazinil grupa i njegovih farmaceutski prihvatljivih adicionih soli kiselina nazna čen time, što reaguje jedinjenje opšte formule II gde R1 i R2 su halogen, alifatična C2-6 aciloksi grupa, sa piperazinskim derivatom opšte formule III gde R3 je vodonik, metil ili etil grupa ili sa njegovom solju u prisustvu organskog rastvarača, poželjno amida kiseline, sulfoksida, ketona, alkohola, etra ili estra i u prisustvu agensa za vezivanje kiseline na temperaturi od 90-110В°C i tako dobiveno jedinjenje opšte formule IV gde R,R1 i R2 su kao što je dato napred, hidrolizuje u baznoj sredini posle ili bez izolovanja i ako se želi, tako dobiveno jedinjenje opšte formule I se prevodi u svoju farmaceutski prihvatljivu so ili se oslobadja slobodna kiselina iz njegove soli. Jedinjenja opšte formule IV gde R označava piperazinil, 4-metil-piperazinil ili 4-etil- piperazinil grupu, R1 i R2 označavaju halogen, alifatičnu aciloksi grupu koja sadrži 2 do 6 atoma ugljenika po izboru supstituisanu halogenom ili aromatičnu aciloksi grupu koja sadrži 7 do 11 atoma ugljenika. Prijava sadrži još 8 zavisnih zahteva.A process for the preparation of quinoline carboxylic acids and their intermediates, of general formula I wherein R is piperazinyl, a 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable acid addition salts thereof, wherein the compound of formula I reacts with R 2 is halogen, an aliphatic C 2-6 acyloxy group, with a piperazine derivative of general formula III wherein R 3 is hydrogen, methyl or ethyl group or with a salt thereof in the presence of an organic solvent, preferably an acid amide, sulfoxide, ketone, alcohol, ether or ester and in the presence acid binding agent at a temperature of 90-110V ° C and thus the compound of general formula IV wherein R, R 1 and R 2 are as given above, hydrolyzed in a basic medium after or without isolation and if desired, the compound of general formula thus obtained And it is converted into its pharmaceutically acceptable salt or the free acid is released from its salt. Compounds of general formula IV wherein R represents a piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group, R 1 and R 2 represent a halogen, an aliphatic acyloxy group containing 2 to 6 carbon atoms optionally substituted by halogen or an aromatic acyloxy group containing 7 to 11 carbon atoms. The application contains 8 more dependent requests.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI8810668A SI8810668A8 (en) | 1987-04-08 | 1988-04-04 | Process for producing cinnolinecarboxyclid acids |
HR930557A HRP930557A2 (en) | 1987-04-08 | 1993-03-26 | Process for the preparation of quinoline carboxylic acids and their intermediates |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU871504A HU198728B (en) | 1987-04-08 | 1987-04-08 | Process for producing quinolinecarboxylic acid derivatives |
HU150588 | 1988-02-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU66888A YU66888A (en) | 1989-12-31 |
YU46452B true YU46452B (en) | 1993-10-20 |
Family
ID=26317374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU66888A YU46452B (en) | 1987-04-08 | 1988-04-04 | PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACIDS AND THEIR INTERMEDIATES |
Country Status (1)
Country | Link |
---|---|
YU (1) | YU46452B (en) |
-
1988
- 1988-04-04 YU YU66888A patent/YU46452B/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU66888A (en) | 1989-12-31 |
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